AutismKB 2.0

Annotation Detail for AXL


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Basic Information Top
Gene Symbol:AXL ( JTK11,UFO )
Gene Full Name: AXL receptor tyrosine kinase
Band: 19q13.2
Quick LinksEntrez ID:558; OMIM: 109135; Uniprot ID:UFO_HUMAN; ENSEMBL ID: ENSG00000167601; HGNC ID: 905
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1901Endometriosis
1934Cancer
2202Kidney tubular necrosis, acute
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol AXL protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AXL mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of AXL mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of AXL mRNAaffects expression 17562736
D000244 Adenosine Diphosphate AXL protein results in decreased susceptibility to Adenosine Diphosphatedecreases response to substance 15733062
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AXL mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AXL mRNAincreases expression 19150397
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AXL mRNAaffects cotreatment|decreases expression 20360939
C110904 capecitabine AXL protein results in decreased susceptibility to capecitabinedecreases response to substance 16734730
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of AXL mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AXL proteinincreases expression 16799993
C014347 decitabine [decitabine results in decreased methylation of AXL gene] which results in increased expression of AXLdecreases methylation|increases expression 18522535
D002945 Cisplatin Cisplatin results in increased expression of AXL mRNAincreases expression 16061661
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AXL mRNAaffects cotreatment|decreases expression 20360939
C025034 doxifluridine AXL protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
D004317 Doxorubicin AXL protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D006861 Hydrogen Peroxide AXL protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]increases phosphorylation|increases reaction 15123721
D006861 Hydrogen Peroxide GAS6 protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]increases phosphorylation|increases reaction 15123721
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased phosphorylation of AXL proteinincreases phosphorylation 15123721
D006861 Hydrogen Peroxide Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]decreases reaction|increases phosphorylation 15123721
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of AXL mRNAincreases expression 12634122
D010081 Oxazolone Oxazolone results in increased expression of AXL mRNAincreases expression 11379042
D017239 Paclitaxel AXL protein results in increased susceptibility to Paclitaxelincreases response to substance 16734730
D008926 Plicamycin Plicamycin results in decreased expression of AXLdecreases expression 18522535
D012643 Selenium Selenium results in decreased expression of AXL mRNAdecreases expression 19244175
D013311 Streptozocin Streptozocin results in increased expression of AXL proteinincreases expression 12644472
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AXL mRNAincreases expression 12377990
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of AXL mRNAdecreases expression 11379042
D014747 Vinblastine AXL protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in decreased expression of AXL mRNAdecreases expression 19244175
D014859 Warfarin Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]decreases reaction|increases phosphorylation 15123721
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6214514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.7517670903 12690470 15814532
MESH:D000230 Adenocarcinoma Cisplatin 4.5417638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 4.5417418594
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.233712494
MESH:D000236 Adenoma Diethylnitrosamine 6.236695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.2918056438 16434500 17162532 19052882 17620307 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2916835633
MESH:D000419 Albuminuria Doxorubicin 4.3221441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.4320032816 16210060 15855793 19187332 11077013 3040596 12684321 7684630 16792590 18394133 10797510 10934080 11467998 8156442 12585506 15590890 12762349 170078 6091946 11742282 6091945 15590891 17015710
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 11.2814601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.2814601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.3615867366
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms capecitabine 4.5518473752 12972520
MESH:D001943 Breast Neoplasms Cisplatin 4.5519526202 18382427
MESH:D001943 Breast Neoplasms decitabine 4.5519208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5517474063
MESH:D001943 Breast Neoplasms Doxorubicin 4.5515939500 15634643 17426702 18382427 18695136 15993339 16264153 16826403 15567936 16595493 16935488 16322301 17983394 18234424 17369602 15692762 15136595 15994142 15668708 19526202 16096432 11325840 16115903 18628466
MESH:D001943 Breast Neoplasms Paclitaxel 4.5516273361 11325840 15136595 16115903 16244791 18323546 18223236 18234424
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5520435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 4.5511921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.3612507178 15590891 8156442
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.1915700767 16097048 16227642 16011737 15673190 16124888 18705752 16192424 10355542 16050911 3786805 15721981
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.1916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 11.9216051944
MESH:D002276 Carcinoid Tumor Streptozocin 11.9216051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.507296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.503084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.5018788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.5017982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5017978847 16328049 16288022 16698587 18393292 10672840 17173139 16569478 19335982 20727157 21159647 20214788 17138121 16878318 17761372 19208518 19052882 18978308 18210153 16502159 19822196 18506893 16779866 19701751 3581430 17055752 19171122 16935385 19539802 18788625 3084413 20514400 10737359 19919837 20524982 16540662 20935162 18665156 20007298 19107877 19383236 20101231 17162532 16681979 18691550 18785209 18056438 18494052 20432363 11831363 16830150 20084675 19394651 18971187 19519916 17428255 20512989 19418558 16807293
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.5018059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.5016313753
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9612023789 16685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.277296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.271485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 10.271485588
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.2918337622 17066447 6189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.2919215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.296189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3816612575 17519947 17928571 17007740 15811867 17131338 16952015 16242529 17382496 16364871 17974986 16455267 16278810 16269455 17924179 17351982 16651473 17308081 16731534 18627295 15792986 17329180 15476868 15505089 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8717334414 16243910
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3616936243
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.807505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.8020889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.8017174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 14.802727394
MESH:D002543 Cerebral Hemorrhage Warfarin 5.6311061249
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.989022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0112621046 15340226 16354765 15668235 8697196
MESH:D003092 Colitis Selenium 3.5617936198
MESH:D003110 Colonic Neoplasms decitabine 2.3017616700
MESH:D015179 Colorectal Neoplasms capecitabine 8.1118473752 18448328
MESH:D015179 Colorectal Neoplasms Cisplatin 8.1115273666
MESH:D015179 Colorectal Neoplasms decitabine 8.1118981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 8.1118802399 18259882
MESH:D015179 Colorectal Neoplasms Paclitaxel 8.1118802399
MESH:D015179 Colorectal Neoplasms Vinblastine 8.1118802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D023903 Coronary Restenosis Warfarin 5.4612872399
MESH:D003329 Coronary Vasospasm capecitabine 5.5917465463
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.6120579077 20497562
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4119769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.5614531868 18759878 11906362 8970840 12868966 11298694 8156756 2524372
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 6.5612956900 15491423 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 14.652952479 3621924
MESH:D003877 Dermatitis, Contact Oxazolone 14.6512811023 15944321
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 14.6517010967
MESH:D003920 Diabetes Mellitus Streptozocin 4.5416285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.3011055810 12093613 15298345 7637645 18603373 19960420 11260395 1374869 8740154 6379147 17874149 19298542 16286809 17442507 15862027 12446591 19496084 16684804 12644472 2177838 18715473 15831366 12083368 19586609
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 6.1418603373
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 6.1418772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8820387270
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 6.8819586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8817107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.5016025228
MESH:D003928 Diabetic Nephropathies marker/mechanism 12644472
MESH:D003928 Diabetic Nephropathies Streptozocin 9.2619682444 19960420
MESH:D003928 Diabetic Nephropathies Warfarin 9.2612644472
MESH:D003930 Diabetic Retinopathy Streptozocin 5.2117662242
MESH:D003875 Drug Eruptions Warfarin 5.7514723717
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.616679447 18692083 9328219 6482804 16192314 11289319 1440618 9022650 18648102 18289764 8291058 9653073 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.6119164858 16781746 16485898 14725611 12594235 12958197 16177239 12705907 10774834 17906064 11834606 18071297 19085960 11461765 14986274 11421492 16393943 15968718 16227642 19416960 19420014 17522070 19370779 15619225 16081117 12540782 12392966 14550746 17562736 18713872 16109766 11739529 10915739 19923254 10663392 19739265 11287661 11743745 2444490 11529661 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.617179309 17522070 10915739 7120509 15027814 11566570 19085960 3786805 15968718 15998439 2869522 4309450 16177239 19336974 21278145 6623471 7440962 3732212 6884620 16227642 9327722 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.6119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 17.6117416283
MESH:D056486 Drug-Induced Liver Injury Selenium 17.6115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.6120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Cisplatin 12.8112231392 12649298 15033597 19839026
MESH:D004362 Drug Toxicity Doxorubicin 12.8118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.8111462148
MESH:C538011 Eales disease Vitamin E 4.479068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 16714409 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8819294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3117359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.438156442
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.943581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9420426865
MESH:D004938 Esophageal Neoplasms Cisplatin 9.9415464296 17638652 16785472 16481741 15173087
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.9416481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.5218447907
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.1516045604 61145 15959796 16239168 12631006 17595544 12795759 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 7.1521071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3619069698
MESH:D005355 Fibrosis Carbon Tetrachloride 7.8518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8520067830
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.4811794436
MESH:D005776 Gaucher Disease Warfarin 5.7412359135
MESH:D005909 Glioblastoma Doxorubicin 3.2017150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.1815102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 12.1819215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.1815692506
MESH:D034381 Hearing Loss Cisplatin 4.1019898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2315464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.1716080930
MESH:D006331 Heart Diseases Doxorubicin 7.5916495754 16330681 18006777 16144979 16879835 16244371 17875725 12587719 16707910 17888722 18674790 14766674 16244372
MESH:D006331 Heart Diseases Streptozocin 7.5912093613
MESH:D006333 Heart Failure Doxorubicin 6.7917481944
MESH:D006333 Heart Failure Selenium 6.7917162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7015692506
MESH:D006406 Hematoma Warfarin 6.4817493413
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 9.8211000095
MESH:D006470 Hemorrhage Warfarin 9.8218429757
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.506705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5019900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216863852 16490937
MESH:D006689 Hodgkin Disease Cisplatin 11.3516170182 16200630
MESH:D006689 Hodgkin Disease Doxorubicin 11.3518501091 17606976 15147373
MESH:D006689 Hodgkin Disease Vinblastine 11.3518501091 18180244
MESH:D019584 Hot Flashes Vitamin E 3.7414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.4011019492 10880147
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D006976 Hypertension, Pulmonary Warfarin 4.6512359135
MESH:D007248 Infertility, Male decitabine 3.0517581917
MESH:D007249 Inflammation Diethylnitrosamine 4.5118785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5112878042 12200463
MESH:D007251 Influenza, Human Selenium 10.1916624496
MESH:D007251 Influenza, Human Vitamin E 10.1916624496
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.3910783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9115464296
MESH:D007674 Kidney Diseases Acetaminophen 22.1912587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 22.1915369732
MESH:D007674 Kidney Diseases Cisplatin 22.1912649298 19839026 18289764 12231392 15190930
MESH:D007674 Kidney Diseases Doxorubicin 22.1915369732 15699352 16775033
MESH:D007674 Kidney Diseases Streptozocin 22.1912093613
MESH:D007674 Kidney Diseases Vitamin E 22.1912488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 15.5616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 15.5616518626
MESH:D007676 Kidney Failure, Chronic Selenium 15.5616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.786582329
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5611231351
MESH:D007938 Leukemia decitabine 2.9618980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D007951 Leukemia, Myeloid decitabine 3.8018454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3418704418 19387464 17679729 18206229 19010910 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2318055864
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.8416766008
MESH:D008080 Liposarcoma Paclitaxel 4.6117353645
MESH:D054068 Livedo Reticularis Warfarin 6.4818280355
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1917157831 16239168 11903743 17174718 16943688 21278145 11408273 16221502 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1918665156 20032147 19638242 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.069327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7312546737 18418968 18339082 16097048 18187930 15893842 17922224 17900296 15996030 18205269 12958196 13678700 17631135 18279442 18210741 17721639 12898905 18263696 12649538 15650968 12632514 10355542 15362042 15959796 18412020 15052691 15931870 17565644 16248980 18156304 17714472 18429990 17557913 18317297 12632512 17976157 17805973 16027843 16192424 16116963 12741479 16011737 15730626 15876570 18395914 17640975 18251166 12445421 12586293 12667390 15818738 16033810 15338365 17525996 17761835 18006644 16638106 18420326 17708605 17823541 15123356 11481614 18376398 18054572 15673190 12666154 17766677 14512876 14748882 14716496 15057751 17869086 17698563 20821823 17481882 18395095 15925388 18705752 18472332 12445418 17944888 18472094 14724832 12609069 18277467 16136751 15370692 14620537 18166357 12389079 14716833 18481824 16015684
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.7316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.7316169303
MESH:D008107 Liver Diseases Acetaminophen 6.1119460945 16610002 19014921 16611625 12969438 19784758 12587719 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1115720792 16246199 15830285 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.8819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 6.8819812893 18648771 12112319 19499222 12771043 19426721 19073162 18977376 19690152 21071580 21047994 20101389 19833225 19642983 18644402 19255062 20452335 19254457 20137499 20583210 18754104 2862719 20434301 21278145 16942905 15175105 18978307 19294768 20118626 19638242 20501860 21167192 15885732 19996281 19427195 19256749 19090486 20405173 2422723 9163691 19551842 20492335 10737359 19850985
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.8816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.14598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.1412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.1418308698 3124819 9362446 19126423 16842330 18544905 19519916 18775883 16267830 18093689 19539802 18079962 19009564 17854601 18282651 21159647 17174075 19004024 18253720 18164116 17942915 2563599
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.1416842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.1412151625
MESH:D008171 Lung Diseases Vitamin E 3.0316863852
MESH:D008175 Lung Neoplasms Cisplatin 6.2917225452 6189445 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.2920970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 6.296189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.2911062179
MESH:D008223 Lymphoma decitabine 7.1919470736
MESH:D008223 Lymphoma Doxorubicin 7.1916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.3517654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.3514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.7115458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.7115318939
MESH:D008545 Melanoma Cisplatin 9.3817023156 16809738 16248763 16432458 15577323 18176117 18332650 18505091 11135225 12393984 12374674 17761969 12883367
MESH:D008545 Melanoma decitabine 9.3817785578 16505122
MESH:D008545 Melanoma Doxorubicin 9.3816827129
MESH:D008545 Melanoma Paclitaxel 9.3812040289 12025231 16342250
MESH:D008545 Melanoma Vinblastine 9.3815577320 16432458 17761969 16809738 16248763 18505091 12374674 15577323 18332650 18176117
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008654 Mesothelioma Cisplatin 9.7417638057
MESH:D008654 Mesothelioma Doxorubicin 9.7417638057
MESH:D008654 Mesothelioma Selenium 9.7415107826
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6617671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D052016 Mucositis Doxorubicin 4.5617415656
MESH:D009101 Multiple Myeloma decitabine 7.0618172295
MESH:D009101 Multiple Myeloma Paclitaxel 7.0614749477
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2519157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 2.8615857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D009336 Necrosis Warfarin 5.3214723717
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 16.993581430
MESH:D009362 Neoplasm Metastasis capecitabine 16.9912972520
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 16.999029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 16.9918259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 16.9915867366
MESH:D009369 Neoplasms capecitabine 7.9516374040
MESH:D009369 Neoplasms Cisplatin 7.9516773208
MESH:D009369 Neoplasms decitabine 7.9519116145 17925555 19470736
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.511670384
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2615464296
MESH:D009401 Nephrosis Doxorubicin 4.5416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8116889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.776679447
MESH:D009447 Neuroblastoma Cisplatin 6.768761367
MESH:D009447 Neuroblastoma Doxorubicin 6.7615555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.478761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D009503 Neutropenia Vinblastine 4.3617378895
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.706482804 4026338
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 8.7012585506 18394133 11077013 8156442 6091945 3040596 6091946
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010014 Osteolysis Paclitaxel 4.7515867366
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010051 Ovarian Neoplasms Cisplatin 7.6515464296 19769630 17225452 6897625
MESH:D010051 Ovarian Neoplasms decitabine 7.6519259094 19331143
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.6511161223
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.2319003803
MESH:D010190 Pancreatic Neoplasms decitabine 8.2319294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.2316540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.577296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.5712065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0915464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D010997 Pleural Neoplasms Cisplatin 13.1617638057
MESH:D010997 Pleural Neoplasms Doxorubicin 13.1617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.362563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611399792 11222880 11896295 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.5017616702
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7716729912 16888761 15897917 15749863 18437689 16868541
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.7717172428 16729912 16356831 17136230
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7715084515
MESH:D020151 Protein C Deficiency Warfarin 6.1218376272
MESH:D011655 Pulmonary Embolism Warfarin 6.1219300499
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.3914606601
MESH:D051437 Renal Insufficiency Cisplatin 9.6315464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.6317922066
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.297692837 16940033 20219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.8918447907
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.1919155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.3819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.0512617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.2819075512
MESH:D012509 Sarcoma Doxorubicin 3.7916767912 17710206 18313854 17203757 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.7214601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.7216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.6412269725
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Doxorubicin 8.9015692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.9012065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1115464296
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.2819075512 19050374
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3417203757 16767912 15625365
MESH:D013274 Stomach Neoplasms Cisplatin 4.5918396642 17522103 15958060
MESH:D013274 Stomach Neoplasms decitabine 4.5919037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5918456281
MESH:D013274 Stomach Neoplasms Paclitaxel 4.5918506536 18396642
MESH:D020521 Stroke Vitamin E 8.5416517955
MESH:D020521 Stroke Warfarin 8.5419300499
MESH:D024801 Tauopathies Paclitaxel 4.5816930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.4215464296 17225452
MESH:D013923 Thromboembolism Warfarin 5.9318698879 16960144
MESH:D019851 Thrombophilia Warfarin 5.3817493413
MESH:D013927 Thrombosis Warfarin 4.9311307788 17245631 11518727 15720958 17672075 19300499
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.717505956 6582329 6587162 3712494 1399818
MESH:D013964 Thyroid Neoplasms decitabine 15.7117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.717505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.7117909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.248074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.2417225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.2417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.2417653716
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.0116803524
MESH:D014604 Uveal Neoplasms decitabine 4.6817785578
MESH:D014625 Vaginal Neoplasms Cisplatin 10.5615577323
MESH:D014625 Vaginal Neoplasms Vinblastine 10.5615577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D014657 Vasculitis Warfarin 5.6420337814
MESH:D054556 Venous Thromboembolism Warfarin 6.1418776969
MESH:D020246 Venous Thrombosis Warfarin 5.3015733061 14723717
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0017678736 17638931 17334414 16364871
MESH:D014839 Vomiting Cisplatin 4.4911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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