AutismKB 2.0

Annotation Detail for SCN3B


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Basic Information Top
Gene Symbol:SCN3B ( HSA243396,SCNB3 )
Gene Full Name: sodium channel, voltage-gated, type III, beta
Band: 11q24.1
Quick LinksEntrez ID:55800; OMIM: 608214; Uniprot ID:SCN3B_HUMAN; ENSEMBL ID: ENSG00000166257; HGNC ID: 20665
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SCN3B mRNAincreases expression 16788091
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SCN3B proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCN3B mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of SCN3B mRNAdecreases expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SCN3B proteindecreases expression 12629582
D016572 Cyclosporine Cyclosporine results in increased expression of SCN3B mRNAincreases expression 20106945
C052570 cyfluthrin cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017160 cypermethrin cypermethrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C044267 fenpropathrin fenpropathrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017690 fenvalerate fenvalerate affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D008345 Manganese Manganese results in increased expression of SCN3B mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of SCN3B mRNAincreases expression 17175027
D010126 Ozone Ozone results in decreased expression of SCN3B mRNAdecreases expression 17095637
D012964 Sodium cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium cypermethrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium fenpropathrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium fenvalerate affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium [SCN3A protein binds to SCN3B protein] which results in increased transport of Sodiumaffects binding|increases transport 18538810
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000382 Agricultural Workers' Diseases cypermethrin 5.0016487989
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000756 Anemia, Sideroblastic Manganese 11.2116910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.2116910769
MESH:D020261 Arsenic Poisoning Arsenic 2.8812569548 16251483 16835338 18414634
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6517854713 16373670
MESH:D050197 Atherosclerosis Arsenic 3.2819371607 12928151
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7217626835 19059883 18417511 16777450 15516495 18315731 14754758
MESH:D053840 Brugada Syndrome marker/mechanism
MESH:D002100 Cachexia Ozone 4.8216183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8515700767 16050911 18705752 16192424 16124888 3786805 15673190 10355542 16227642 15721981 16011737 16097048
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6217687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7118788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7018922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.4817938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3618022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5612371664
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0517522070 6884620 15968718 16227642 19085960 10092053 9327722 3786805 2869522 15998439 21278145 6623471 4309450 3732212 16177239 7179309 10915739 7440962 15027814 19336974 11566570 7120509
MESH:D004417 Dyspnea cypermethrin 5.4816487989
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.8916239168 12631006 17595544 16045604 19224547 61145 15959796 12795759
MESH:D005234 Fatty Liver Cyclosporine 7.8919224547
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9118705752
MESH:D005355 Fibrosis Cyclosporine 8.9112168785 12639820
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Manganese 3.9517043766
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0519900420 19110552
MESH:D006505 Hepatitis cypermethrin 10.0516487989
MESH:D006529 Hepatomegaly fenvalerate 5.0815602828
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006973 Hypertension Arsenic 5.369931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 5.3610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007299 Insect Bites and Stings cypermethrin 6.0715189238
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007642 Keratosis Arsenic 5.0712749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.3718776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5917339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8317334410 16943688 11408273 17157831 21278145 11903743 16239168 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7417823541 16027843 18395095 18429990 17766677 18472094 12609069 14748882 13678700 18395914 18317297 17714472 18205269 12546737 14724832 15996030 15893842 15123356 16097048 17481882 12389079 15931870 11481614 18277467 17900296 18339082 18166357 15338365 14512876 18251166 18187930 15818738 16033810 18412020 17944888 17557913 15052691 16248980 17565644 12586293 16116963 17708605 16015684 15673190 18006644 18472332 14716496 12741479 15925388 18376398 18705752 17761835 18481824 18210741 18279442 12649538 12666154 17869086 16638106 15730626 17721639 17805973 18156304 16136751 10355542 12632514 17631135 15362042 12632512 12898905 16192424 20821823 12667390 17525996 12958196 18418968 17698563 18263696 14716833 15370692 15057751 15876570 12445418 15959796 12445421 17640975 18054572 17976157 17922224 14620537 16011737 18420326 15650968
MESH:D008107 Liver Diseases Arsenic 6.8811134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.8815720792 17285989 16964402 16246199 15830285
MESH:D008107 Liver Diseases cypermethrin 6.8815991261
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.6518177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms Arsenic 7.6516368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6519294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.108603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1012014681 15583823
MESH:D008171 Lung Diseases Ozone 3.4119066396 8266340
MESH:D055370 Lung Injury Ozone 3.9220417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5914755239
MESH:D008175 Lung Neoplasms Arsenic 3.5917306315 19168569 17976673
MESH:D008175 Lung Neoplasms Ozone 3.597614698 8597069
MESH:D020149 Manganese Poisoning Manganese 5.6216551646 19453300 16568477
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008679 Metaplasia Ozone 5.2010496685
MESH:D009069 Movement Disorders Manganese 5.0716551646
MESH:D017202 Myocardial Ischemia Arsenic 4.0315371236
MESH:D009369 Neoplasms fenvalerate 3.992895627
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.3116551646
MESH:D009436 Neural Tube Defects Arsenic 3.4916620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.7617306315
MESH:D010243 Paralysis fenvalerate 6.088952708
MESH:D010300 Parkinson Disease Manganese 3.3911181820
MESH:D020734 Parkinsonian Disorders Manganese 4.5216140633
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0716905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 4.2016369182
MESH:D011014 Pneumonia Ozone 4.4818007984 18929643 18381685
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011471 Prostatic Neoplasms Arsenic 3.6016140617
MESH:D011507 Proteinuria Arsenic 4.0621343184
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D012871 Skin Diseases Arsenic 2.7618709164 17050553 16353154 15952646 19834688 16702368 17548696 6392382 17938729 16759981 17453740
MESH:D012878 Skin Neoplasms Arsenic 3.0317050553 19538983 16251483 17976673 17029826 15504454
MESH:D014202 Tremor fenvalerate 5.668952708
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8415987713 19322015 18640142 11144890 19429237 17976673 17306315
MESH:D014570 Urologic Diseases cypermethrin 5.9616487989
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA130546912
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    PA443459Atrial Fibrillation
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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