AutismKB 2.0

Annotation Detail for DCP1A


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Basic Information Top
Gene Symbol:DCP1A ( FLJ21691,HSA275986,Nbla00360,SMAD4IP1,SMIF )
Gene Full Name: DCP1 decapping enzyme homolog A (S. cerevisiae)
Band: 3p21.1
Quick LinksEntrez ID:55802; OMIM: 607010; Uniprot ID:DCP1A_HUMAN; ENSEMBL ID: ENSG00000162290; HGNC ID: 18714
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of RNA
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
Pathway IDPathway Name
P00052TGF-beta signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000965 Antimony Antimony results in increased expression of DCP1A mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of DCP1A mRNAincreases expression 17547211
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of DCP1A mRNAaffects cotreatment|increases expression 17183730
D019800 Phenol Phenol results in increased expression of DCP1A mRNAincreases expression 17547211
C006253 pirinixic acid pirinixic acid results in increased expression of DCP1A mRNAincreases expression 18301758
C009277 sodium arsenate sodium arsenate results in increased phosphorylation of DCP1A proteinincreases phosphorylation 19084008
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in decreased expression of DCP1A mRNAdecreases expression 20056577
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DCP1A mRNAdecreases expression 17884332
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of DCP1A mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 2.5819211157
MESH:D001321 Autistic Disorder Valproic Acid 2.5818558336 17688650 20603192 18316065 19232924 16609825 18985861 18775368 15238991 17157402 17507914 18396377 19460635 18940202 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001859 Bone Neoplasms Phenol 5.4310556009
MESH:D001913 Bowen's Disease Phenol 6.0719293009
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D001991 Bronchitis Antimony 6.458768112
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Antimony 3.9810334427
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15668235 15340226 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.9810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9816575769 17688650 8888407
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D004283 Dog Diseases Antimony 5.9412019027
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 6.6418186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.641733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver pirinixic acid 8.4219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.4219224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D018149 Glucose Intolerance sodium arsenate 5.3019446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D055623 Keratosis, Actinic Phenol 6.7619293009
MESH:D007896 Leishmaniasis Antimony 4.9912019027 15220340 21182181 10953559 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.848889330 11475954 19141829
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.779643325 7854095 10651420 10881086 11370249
MESH:D007898 Leishmaniasis, Visceral Antimony 9.2611105143 1899875 7875148 20495762 7854095 7554475 8142506
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 9.2612707265
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.649834237
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008113 Liver Neoplasms pirinixic acid 4.4716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 11.3818186108
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 11.388888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects sodium arsenate 8.0610525206 11749123 19446573 18186108
MESH:D009436 Neural Tube Defects Valproic Acid 8.0616359493 8888407
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Phenol 4.3517610455
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010392 Pemphigus Phenol 6.7617163923 16522979
MESH:D010409 Penile Diseases Antimony 5.969643325
MESH:D010493 Pericarditis Antimony 6.4020465667
MESH:D010864 Pilonidal Sinus Phenol 6.7619655223 15622588
MESH:D011041 Poisoning Phenol 4.938825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.873137016 11738929 1511512 16876388 14763951 17978042 11044598 15475178
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Phenol 5.9618646496
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D014277 Trigeminal Neuralgia Phenol 6.7610223447 16527771
MESH:D014352 Trypanosomiasis Antimony 6.2515220340
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D014860 Warts Phenol 6.4219122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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