AutismKB 2.0

Annotation Detail for HR


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Basic Information Top
Gene Symbol:HR ( ALUNC,AU,FLJ98880,HSA277165,MUHH,MUHH1 )
Gene Full Name: hairless homolog (mouse)
Band: 8p21.3
Quick LinksEntrez ID:55806; OMIM: 602302; Uniprot ID:HAIR_HUMAN; ENSEMBL ID: ENSG00000168453; HGNC ID: 5172
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Alopecia universalis
Hypotrichosis, hereditary, Marie Unna type, 1
Atrichia with papular lesions
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HR mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in decreased expression of HR mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of HR mRNAincreases expression 16002434
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of HR exonincreases mutagenesis 16455232
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of HR geneincreases mutagenesis 16461637
16724327
D005419 Flavonoids Flavonoids results in decreased expression of HR mRNAdecreases expression 18035473
C041786 palm oil palm oil results in decreased expression of HR mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma Ethylnitrosourea 3.886695378
MESH:D000505 Alopecia marker/mechanism 16455232
MESH:C537055 Alopecia universalis marker/mechanism
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
OMIM:209500 ATRICHIA WITH PAPULAR LESIONS marker/mechanism
MESH:D001927 Brain Diseases Ethylnitrosourea 5.1914991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.5916436596 16357521 15144691 18412241 16651633
MESH:D001943 Breast Neoplasms Calcitriol 2.2911237771
MESH:D001943 Breast Neoplasms Dietary Fats 2.2920435547
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9316003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.5017160924
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.5018357618
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D005234 Fatty Liver Dietary Fats 3.5619551842 17967931 18296743 19004024
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0216436596
MESH:D005910 Glioma Ethylnitrosourea 3.5916651633 16357521 18412241
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007249 Inflammation Dietary Fats 5.6920412841
MESH:D007249 Inflammation Flavonoids 5.6917296493
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.2017379185
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.636695378 16019985 17703301 16271038
MESH:D008223 Lymphoma Ethylnitrosourea 4.1615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.4715375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7010838139 10767621 18041768
OMIM:146550 MARIE UNNA HEREDITARY HYPOTRICHOSIS 1 marker/mechanism 19122663
MESH:D008579 Meningioma Ethylnitrosourea 6.5017943659
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.8216707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.8816003739 17160924 16651423
MESH:D009765 Obesity Dietary Fats 2.3418674790 17217161 11836018 21332399 20132043 20518802 16723640 18457598 19632207
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.5017160924
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4918247401 12479363 15754350 16289102 16644109
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.6215790496
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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