AutismKB 2.0

Annotation Detail for PRKCE


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Basic Information Top
Gene Symbol:PRKCE ( MGC125656,MGC125657,PKCE,nPKC-epsilon )
Gene Full Name: protein kinase C, epsilon
Band: 2p21
Quick LinksEntrez ID:5581; OMIM: 176975; Uniprot ID:KPCE_HUMAN; ENSEMBL ID: ENSG00000171132; HGNC ID: 9401
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04530Tight junction
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Hemostasis
Pathway IDPathway Name
200036LPA4-mediated signaling events
200184Downstream signaling in naive CD8+ T cells
200004Endothelins
200082IL2-mediated signaling events
200069Thromboxane A2 receptor signaling
200062TCR signaling in naive CD8+ T cells
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200011LPA receptor mediated events
200022TCR signaling in naive CD4+ T cells
200057CDC42 signaling events
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00018EGF receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P00005Angiogenesis
P043745HT2 type receptor mediated signaling pathway
P00002Alpha adrenergic receptor signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
hemoglobin
hematocrit
Desease Name
Hematological and biochemical traits
Hemoglobin
Hematocrit
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PRKCE mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PRKCE mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PRKCE mRNAaffects expression 21346803
D000079 Acetaldehyde PRKCE protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]affects reaction|decreases reaction|increases transport 17991733
D000079 Acetaldehyde PRKCE protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde]affects reaction|decreases response to substance 17991733
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKCE mRNAaffects expression 16483693
C061640 arjunolic acid arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein]decreases reaction|increases expression 19682444
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PRKCE mRNAincreases expression 17944540
C006780 bisphenol A bisphenol A results in increased expression of PRKCE mRNAincreases expression 12075121
D020122 tert-Butylhydroperoxide PRKCE protein affects the reaction [tert-Butylhydroperoxide results in decreased uptake of rubidium chloride]affects reaction|decreases uptake 14570699
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide affects the localization of PRKCE proteinaffects localization 14570699
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased phosphorylation of PRKCE proteinincreases phosphorylation 14570699
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKCE mRNAaffects cotreatment|decreases expression 20360939
D002118 Calcium PRKCE protein affects the reaction [F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]]affects reaction|increases abundance|increases activity|increases reaction 16793902
D002118 Calcium PRKCE protein affects the reaction [Oxygen deficiency results in increased abundance of Calcium]affects reaction|increases abundance 17087917
D002118 Calcium PRKCE protein affects the susceptibility to Calciumaffects response to substance 15242976
D002211 Capsaicin PRKCE protein affects the reaction [F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]]affects reaction|increases abundance|increases activity|increases reaction 16793902
C016299 chelerythrine [chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrinedecreases activity|decreases response to substance 12700091
D003024 Clozapine Clozapine results in increased expression of PRKCE mRNAincreases expression 15860345
D003474 Curcumin Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003474 Curcumin PRKCE protein results in decreased susceptibility to Curcumindecreases response to substance 14742295
C004742 daidzein daidzein affects the localization of and results in increased activity of PRKCE proteinaffects localization|increases activity 16972265
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKCE mRNAaffects cotreatment|decreases expression 20360939
D004075 Diglycerides Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]affects reaction|increases localization 18487437
D004280 Dobutamine PRKCE protein affects the susceptibility to Dobutamineaffects response to substance 15242976
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRKCE mRNAincreases expression 12075121
D019833 Genistein Genistein results in increased expression of PRKCE mRNAincreases expression 12075121
C007845 gingerol PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]affects reaction|increases expression 18058799
D006220 Haloperidol Haloperidol results in increased expression of PRKCE mRNAincreases expression 15860345
D006534 Heptachlor Epoxide Heptachlor Epoxide results in decreased expression of PRKCE protein alternative formdecreases expression 11170310
D006534 Heptachlor Epoxide Heptachlor Epoxide results in increased expression of PRKCE protein alternative formincreases expression 11246134
11170310
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]]decreases reaction|increases activity 17087917
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of PRKCE proteinincreases activity 17087917
D007213 Indomethacin Indomethacin results in increased expression of PRKCE proteinincreases expression 10702201
D007444 Inulin PRKCE protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]affects reaction|decreases reaction|increases transport 17991733
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PRKCE mRNAdecreases expression 15469884
D007854 Lead Lead results in decreased expression of PRKCE proteindecreases expression 16547843
C008261 lead acetate lead acetate results in decreased expression of PRKCE proteindecreases expression 16547843
D008070 Lipopolysaccharides Lipopolysaccharides affects the localization of and results in increased activity of PRKCE proteinaffects localization|increases activity 16330529
D008070 Lipopolysaccharides PRKCE protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]increases reaction|increases secretion 16330529
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in increased expression of PRKCE mRNA]decreases reaction|increases expression 19149911
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in increased expression of PRKCE mRNA]decreases reaction|increases expression 19149911
D008694 Methamphetamine Methamphetamine results in increased expression of PRKCE mRNAincreases expression 19149911
C030517 myxothiazol myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]decreases reaction|increases activity 17087917
C438686 N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine results in increased expression of PRKCE mRNAincreases expression 15588621
C438686 N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine results in increased expression of PRKCE proteinincreases expression 15588621
D010100 Oxygen GPX1 protein inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]decreases reaction|increases activity 17087917
D010100 Oxygen Hydrogen Peroxide inhibits the reaction [Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]]decreases reaction|increases activity 17087917
D010100 Oxygen myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]decreases reaction|increases activity 17087917
D010100 Oxygen Oxygen deficiency results in increased activity of PRKCE proteinincreases activity 17087917
D010100 Oxygen PRKCE gene mutant form results in decreased susceptibility to Oxygen deficiencydecreases response to substance 18638544
D010100 Oxygen PRKCE protein affects the reaction [Oxygen deficiency results in increased abundance of Calcium]affects reaction|increases abundance 17087917
D010100 Oxygen Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]decreases reaction|increases activity 17087917
D010656 Phenylephrine DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]decreases reaction|increases localization 18487437
D010656 Phenylephrine Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]affects reaction|increases localization 18487437
D010656 Phenylephrine Phenylephrine affects the localization of PRKCE proteinaffects localization 12003851
D010656 Phenylephrine Phenylephrine results in increased localization of PRKCE proteinincreases localization 18487437
D010656 Phenylephrine [chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrinedecreases activity|decreases response to substance 12700091
D010656 Phenylephrine GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]decreases reaction|increases activity|increases phosphorylation 16809552
D010656 Phenylephrine Phenylephrine affects the localization of PRKCE proteinaffects localization 12720544
D010656 Phenylephrine Phenylephrine results in increased expression of PRKCE proteinincreases expression 12720544
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE proteinincreases activity|increases phosphorylation 16809552
D010703 Phorbol Esters Phorbol Esters affects the localization of and results in increased activity of PRKCE proteinaffects localization|increases activity 14679204
D010852 Picrotoxin Picrotoxin results in decreased expression of PRKCE mRNAdecreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKCE mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone PRKCE protein promotes the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases reaction|increases secretion 17760987
D011374 Progesterone Progesterone results in decreased expression of PRKCE mRNAdecreases expression 17170212
D015237 Dinoprost PRKCE protein promotes the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases reaction|increases secretion 17760987
C052785 rebamipide rebamipide results in increased expression of PRKCE mRNAincreases expression 15104358
D012402 Rotenone Hydrogen Peroxide inhibits the reaction [Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]]decreases reaction|increases activity 17087917
D012402 Rotenone Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]decreases reaction|increases activity 17087917
C032710 rubidium chloride PRKCE protein affects the reaction [tert-Butylhydroperoxide results in decreased uptake of rubidium chloride]affects reaction|decreases uptake 14570699
C002979 selenomethylselenocysteine selenomethylselenocysteine results in decreased expression of PRKCE proteindecreases expression 10656618
D013311 Streptozocin arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein]decreases reaction|increases expression 19682444
D013311 Streptozocin Streptozocin results in increased expression of PRKCE proteinincreases expression 19682444
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which affects the localization of PRKCE proteinaffects binding|affects localization 15761253
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of PRKCE proteinaffects localization 14975926
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of and results in increased localization of PRKCE proteinincreases activity|increases localization 16793902
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of PRKCE proteinincreases activity 14975926
D013755 Tetradecanoylphorbol Acetate PRKCE protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of RAF1 protein]increases activity|increases reaction 14623285
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of PRKCE proteinaffects localization 12003851
D013893 Thiram Thiram results in decreased activity of PRKCE proteindecreases activity 15998240
D014415 Tunicamycin Tunicamycin results in increased expression of PRKCE mRNAincreases expression 17127020
D014635 Valproic Acid Valproic Acid inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of PRKCE protein]decreases reaction|increases activity|increases phosphorylation 12807426
C025643 vinclozolin vinclozolin affects the expression of PRKCE mRNAaffects expression 19015723
C029297 vinylidene chloride vinylidene chloride results in increased expression of PRKCE proteinincreases expression 14565772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 15.797525203
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 15.7918926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.7915322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 15.798875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4219490988
MESH:D000138 Acidosis Ammonium Chloride 3.0018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3717505938
MESH:D058186 Acute Kidney Injury Capsaicin 4.0418460982
MESH:D055371 Acute Lung Injury Lipopolysaccharides 12.3411850527 18653653
MESH:D055371 Acute Lung Injury Oxygen 12.3416759491
MESH:D055371 Acute Lung Injury pirinixic acid 12.3418653653
MESH:D000230 Adenocarcinoma daidzein 8.7611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.7614692618
MESH:D000230 Adenocarcinoma Genistein 8.7611473722
MESH:D000230 Adenocarcinoma Indomethacin 8.7616537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.193712494
MESH:D000236 Adenoma Diethylnitrosamine 9.196695378 10737359
MESH:D000236 Adenoma Indomethacin 9.1911497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.0117620307 19061943 18056438 16434500 17162532 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.0116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.0116835633
MESH:D000380 Agranulocytosis Clozapine 4.5014617031 16160616 12649775
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5017887948
MESH:D000505 Alopecia Capsaicin 4.2717569567
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7917225004
MESH:D000544 Alzheimer Disease Curcumin 5.9115590663
MESH:D000544 Alzheimer Disease Indomethacin 5.9115579461 17627676
MESH:D000544 Alzheimer Disease Lithium 5.9119621015
MESH:D000550 Amblyopia Valproic Acid 4.6617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4611748828
MESH:D000860 Anoxia Oxygen 4.4920872349
MESH:D001008 Anxiety Disorders Valproic Acid 7.3517497229
MESH:D001008 Anxiety Disorders vinclozolin 7.3519015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.3110231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.3210388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6217460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9211256880
MESH:D018771 Arthralgia Indomethacin 4.592160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3015885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.3716807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.3711248219
MESH:D001249 Asthma Acetaldehyde 3.479600491
MESH:D050197 Atherosclerosis Curcumin 5.9218704882
MESH:D050197 Atherosclerosis Oxygen 5.9216391483
MESH:D001321 Autistic Disorder Haloperidol 2.3518080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.3518985861 19460635 17157402 18396377 17507914 18775368 17688650 19232924 18316065 18177632 18558336 16609825 15238991 20603192 18940202
MESH:D001327 Autoimmune Diseases Curcumin 3.9419761891
MESH:D001477 Bartter Syndrome Indomethacin 4.4310684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.4411289319 1440618
MESH:D001714 Bipolar Disorder Lithium 6.5719153942 17594078 20046352 20338123
MESH:D001714 Bipolar Disorder Valproic Acid 6.5717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.0812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.7515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.758888407
MESH:D001862 Bone Resorption bisphenol A 3.3611985600
MESH:D001919 Bradycardia Capsaicin 9.0318207255
MESH:D001919 Bradycardia Phenylephrine 9.0315306635
MESH:D001929 Brain Edema Indomethacin 4.4511481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7617868700
MESH:D001930 Brain Injuries Progesterone 3.7115665606 15845082 15380490
MESH:D002545 Brain Ischemia Capsaicin 13.9419211983
MESH:D002545 Brain Ischemia Curcumin 13.9416770732
MESH:D002545 Brain Ischemia Indomethacin 13.9412524144
MESH:D001932 Brain Neoplasms Curcumin 3.4517596214
MESH:D001943 Breast Neoplasms bisphenol A 7.3217123778
MESH:D001943 Breast Neoplasms Curcumin 7.3216243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.3217474063
MESH:D001943 Breast Neoplasms Genistein 7.3216873071 16541309 17200150
MESH:D001943 Breast Neoplasms gingerol 7.3217683926
MESH:D001943 Breast Neoplasms Heptachlor Epoxide 7.3215770527 8738476
MESH:D001943 Breast Neoplasms Indomethacin 7.3217401462
MESH:D001943 Breast Neoplasms Oxygen 7.3217263869
MESH:D001943 Breast Neoplasms Progesterone 7.3217614352 15562024 16175315
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 7.3218855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.3220435547
MESH:D002056 Burns Indomethacin 4.1510459503
MESH:D002100 Cachexia Indomethacin 4.4411239499 15141370 16537180 15625704
MESH:D002276 Carcinoid Tumor Streptozocin 5.0216051944
MESH:D002277 Carcinoma Curcumin 6.7818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.7816835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 7.5916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 7.597296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 7.5920214788 18056438 16288022 19052882 16569478 19418558 16878318 20432363 16502159 20007298 16935385 18494052 16830150 20524982 19208518 20084675 16540662 19383236 10672840 17428255 20514400 3581430 18978308 20101231 19701751 10737359 20512989 19335982 16698587 19519916 17173139 17162532 18506893 18665156 20727157 18785209 16328049 16807293 19919837 19822196 17138121 18971187 18210153 3084413 17978847 20935162 19539802 18393292 19171122 19107877 17055752 17761372 18788625 16779866 11831363 16681979 18691550 19394651 21159647
MESH:D006528 Carcinoma, Hepatocellular Genistein 7.5916924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 7.5916391822
MESH:D002278 Carcinoma in Situ bisphenol A 4.4217123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7814736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7618414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.647296757
MESH:D002292 Carcinoma, Renal Cell Indomethacin 5.6417341418
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.5818462866
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.5812636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 6.5818922899
MESH:D006332 Cardiomegaly Phenylephrine 5.7511754973 17287366 15728586 16170337 17124262 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.7518670907 18850075 16120746
MESH:D009202 Cardiomyopathies marker/mechanism 15242976
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 5.9010525098
MESH:D002318 Cardiovascular Diseases daidzein 10.0216332659
MESH:D002318 Cardiovascular Diseases Genistein 10.0216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.0216936243
MESH:D002375 Catalepsy Haloperidol 4.351977408 15215559
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.2814694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.856135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.857505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8520889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.852727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 16.8516192471
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7316835633
MESH:D002764 Cholecystitis Indomethacin 4.5911181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.899022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.8911677210 17333356 15861022 17681005 16919318 17110522 16105132
MESH:D002779 Cholestasis pirinixic acid 10.8919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8415668235 12621046 16354765 15340226 8697196
MESH:D003072 Cognition Disorders Clozapine 4.4117123785
MESH:D003092 Colitis Curcumin 3.6316782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.0418809619
MESH:D003110 Colonic Neoplasms Curcumin 5.1316340194 19359593
MESH:D003110 Colonic Neoplasms Genistein 5.1317182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.1315637740 15963497 11260862 15786552 15936596 15625704
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3512606626 17054584 11197048 18059344
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 7.5915095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.5914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3418497527
MESH:D018352 Coronavirus Infections Indomethacin 5.1417302372
MESH:D003371 Cough Capsaicin 4.6010350223
MESH:D019465 Craniofacial Abnormalities Lead 4.8419769572
MESH:D019465 Craniofacial Abnormalities lead acetate 4.8419769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.8410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.848888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 3.8014966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4718551238
MESH:D007644 Darier Disease Lithium 5.3420338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.3220210726
MESH:D003704 Dementia Haloperidol 8.8511575062
MESH:D003704 Dementia Lead 8.8516140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.2912868966 2524372 8156756 8970840 11906362 14531868 18759878 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.973621924 2952479
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.1919244398
MESH:D003920 Diabetes Mellitus Streptozocin 4.2516285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.0219298542 1374869 8740154 15862027 17874149 17442507 19586609 12093613 6379147 2177838 15831366 19960420 12083368 16684804 16286809 12446591 11260395 18603373 18715473 19496084 11055810 7637645 15298345 12644472
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.4318603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 18.2616402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 18.2618403477
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 18.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 18.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 18.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 18.2619647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 18.2617107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.1616025228
MESH:D003928 Diabetic Nephropathies arjunolic acid 12.7319682444
MESH:D003928 Diabetic Nephropathies Curcumin 12.7318204486
MESH:D003928 Diabetic Nephropathies Streptozocin 12.7319682444 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 3.9417187935
MESH:D003930 Diabetic Retinopathy Streptozocin 4.8917662242
MESH:D003967 Diarrhea Indomethacin 3.277237001 7907874
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9815331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.4921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.499328219 11289319 18692083 6679447 1440618 18289764 6482804 16192314 7440962 9653073 18648102 9022650 8291058
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.4921346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.4919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.491733752 19641884
MESH:D056486 Drug-Induced Liver Injury vinylidene chloride 15.493697828
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5818043480 16133044 18446180 17190690 16326151 12774134
MESH:D004381 Duodenal Ulcer Capsaicin 12.4111535926 10671773
MESH:D004381 Duodenal Ulcer Curcumin 12.4117351913
MESH:D004381 Duodenal Ulcer Indomethacin 12.4117351913 11595415 17202747 17151854 16699067 17045617 11991626 17329845 10671773 11535926 11595431
MESH:D050171 Dyslipidemias Clozapine 3.7716402076
MESH:D004417 Dyspnea Oxygen 4.2620016425
MESH:D004421 Dystonia Valproic Acid 3.531851702
MESH:D004487 Edema Indomethacin 12.3616100529 10653021 7907874 8273558 19703484 8985016 7990266
MESH:D004487 Edema pirinixic acid 12.3612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.3611000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 12.368113982 15177302 8273558 16716910 7812673 11698051 9599246
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.2617692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.0216402032
MESH:D016889 Endometrial Neoplasms daidzein 6.7111473722
MESH:D016889 Endometrial Neoplasms Genistein 6.7111473722
MESH:D004715 Endometriosis Indomethacin 12.4515652904
MESH:D004715 Endometriosis Progesterone 12.4516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.459294722 10568697
MESH:D019446 Endotoxemia Indomethacin 8.7818509659
MESH:D019446 Endotoxemia Lipopolysaccharides 8.7815328337 17637181 15821434
MESH:D004751 Enteritis Indomethacin 4.1717763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4317980183
MESH:D004802 Eosinophilia Indomethacin 3.5111298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.6017275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.343922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.6220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.116254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.503659116
MESH:D007172 Erectile Dysfunction daidzein 4.4814972507
MESH:D004892 Erythema Multiforme Thiram 6.0716750123
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5416302075
MESH:D004935 Esophageal Diseases Capsaicin 5.1419566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.223581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.2220426865
MESH:D004938 Esophageal Neoplasms Indomethacin 6.2211005569
MESH:D020329 Essential Tremor Lead 5.3618007985 14594619
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5811564622
MESH:D005234 Fatty Liver Curcumin 19.3119297423
MESH:D005234 Fatty Liver Diethylnitrosamine 19.3121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.3115345470
MESH:D005234 Fatty Liver pirinixic acid 19.3119236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 19.3114986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3116575769
MESH:D005317 Fetal Growth Retardation Lead 15.4519769572
MESH:D005317 Fetal Growth Retardation lead acetate 15.4519769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 15.4518558336 8888407
MESH:D005334 Fever Dinoprost 12.6711852909
MESH:D005334 Fever Indomethacin 12.6711852909 10431976 17627676
MESH:D005334 Fever Lipopolysaccharides 12.6711852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.446705139
MESH:D005354 Fibrosarcoma Indomethacin 4.3310962813
MESH:D005355 Fibrosis Curcumin 11.7318705752
MESH:D005355 Fibrosis Indomethacin 11.7317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.7320067830
MESH:D005499 Folliculitis Indomethacin 4.5911298111
MESH:D005739 Gas Poisoning Oxygen 4.6420016425
MESH:D005756 Gastritis Indomethacin 4.1715046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1418462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7216417039
MESH:D005909 Glioblastoma Capsaicin 13.8718405923
MESH:D005909 Glioblastoma Curcumin 13.8717596214
MESH:D005909 Glioblastoma Genistein 13.8716598420
MESH:D005909 Glioblastoma Indomethacin 13.8712870263
MESH:D005910 Glioma Indomethacin 2.9818371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8311849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.517505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0210696789
MESH:D006073 Gout Indomethacin 4.7811248219
MESH:D006258 Head and Neck Neoplasms Curcumin 6.7718462866 18829502
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.7715482327
MESH:D006356 Heartburn Capsaicin 5.1419566590
MESH:D006330 Heart Defects, Congenital Lithium 5.9419638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9410048152 11294989
MESH:D006331 Heart Diseases Streptozocin 3.8712093613
MESH:D006333 Heart Failure Dobutamine 6.2317440445
MESH:D006333 Heart Failure pirinixic acid 6.2320558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.8916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8311000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0615633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.986705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1415135802
MESH:D006529 Hepatomegaly pirinixic acid 6.4418467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.4415340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4917701891
MESH:D006849 Hydrocephalus Valproic Acid 4.3017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4716959395 8697196 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Capsaicin 6.9317434803 17043245
MESH:D006930 Hyperalgesia Indomethacin 6.9312727271
MESH:D034321 Hyperamylasemia Indomethacin 5.1417883296
MESH:D006937 Hypercholesterolemia Curcumin 3.5518704882
MESH:D006940 Hyperemia Indomethacin 4.4412524144
MESH:D006943 Hyperglycemia pirinixic acid 2.6920558911
MESH:D006948 Hyperkinesis Clozapine 9.9516046005
MESH:D006948 Hyperkinesis Methamphetamine 9.9517658665
MESH:D006949 Hyperlipidemias Indomethacin 3.6417546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.3915034207
MESH:D006973 Hypertension daidzein 7.3617169123
MESH:D006973 Hypertension Phenylephrine 7.368949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.3618670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.0512791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2616569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.4518306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7810651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7916133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8515869954
MESH:D007246 Infertility Thiram 5.306420938
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.1117937319
MESH:D007248 Infertility, Male Lead 9.1116780224
MESH:D007248 Infertility, Male vinclozolin 9.1116467254
MESH:D007249 Inflammation Capsaicin 22.9616956363
MESH:D007249 Inflammation Curcumin 22.9616956363 17151092 18403477
MESH:D007249 Inflammation Diethylnitrosamine 22.9618785209
MESH:D007249 Inflammation Indomethacin 22.9612568917 7812673 3291741
MESH:D007249 Inflammation Lipopolysaccharides 22.9617237260 17255318 12878042 17963957 9205823
MESH:D007249 Inflammation Progesterone 22.9615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.9612200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 22.9615177302 7812673 7562506 8273558 11698051
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9518200517 18596194
MESH:D007333 Insulin Resistance bisphenol A 6.0316393666
MESH:D007333 Insulin Resistance pirinixic acid 6.0316306350
MESH:D007410 Intestinal Diseases Indomethacin 8.5811686837 15831440 15610444 17329856 17994277 11713966 10210152 18236018 11855677
MESH:D007410 Intestinal Diseases rebamipide 8.5811686837
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 8.4610783313
MESH:D007414 Intestinal Neoplasms Curcumin 8.4610783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.7915241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1117255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.449022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8316580747
MESH:D007579 Jejunal Diseases Indomethacin 4.4510574470 18306037 16133968
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 11.8015369732
MESH:D007674 Kidney Diseases Indomethacin 11.8017190690
MESH:D007674 Kidney Diseases Streptozocin 11.8012093613
MESH:D007674 Kidney Diseases vinylidene chloride 11.807839370
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.7716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 5.8316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 5.836582329
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.4716316344
MESH:D007855 Lead Poisoning Lead 5.3616700817
MESH:D007859 Learning Disorders Lead 4.6416384672
MESH:D007889 Leiomyoma Curcumin 4.0518555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4411703811 12228301 10320625
MESH:D007938 Leukemia Curcumin 5.5518462866
MESH:D007938 Leukemia Genistein 5.5518980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.7016106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5010785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.6518360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6516294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.6116766008
MESH:D015458 Leukemia, T-Cell Curcumin 4.2216106398
MESH:D007964 Leukocytosis Indomethacin 4.7916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1417980183
MESH:D007970 Leukopenia Lipopolysaccharides 4.1315821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1716417039
MESH:D008064 Lipidoses Clozapine 3.5517567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1411479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.4920032147 18665156 18407596 19638242 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.829327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 7.5017355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Genistein 7.5017823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.5018194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.5012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.5012878042
MESH:D008107 Liver Diseases Capsaicin 5.6916956363
MESH:D008107 Liver Diseases Curcumin 5.6916956363
MESH:D008107 Liver Diseases Diethylnitrosamine 5.6917034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.597678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.592862719 12112319 15885732 18648771 18754104 20434301 18978307 20137499 20118626 15175105 19427195 19638242 19812893 21167192 20492335 21278145 10737359 12771043 21047994 20583210 19551842 19690152 19833225 18977376 20405173 19996281 18644402 19499222 20501860 19426721 19642983 19850985 19090486 19255062 20452335 20101389 2422723 19294768 16942905 19254457 21071580 19073162 9163691 19256749
MESH:D008113 Liver Neoplasms Heptachlor Epoxide 11.5911246134
MESH:D008113 Liver Neoplasms pirinixic acid 11.5920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.032876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.036587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.039362446 16842330 2563599 19009564 18253720 16267830 21159647 18282651 18164116 17854601 19126423 19539802 18093689 18308698 17942915 3124819 18544905 18079962 17174075 19004024 18775883 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.0312151625
MESH:D008133 Long QT Syndrome Dobutamine 4.3019353679
MESH:D008171 Lung Diseases Dobutamine 4.1416638327
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.6917228818
MESH:D055370 Lung Injury Lipopolysaccharides 12.3521114838
MESH:D055370 Lung Injury Oxygen 12.3518339021
MESH:D055370 Lung Injury vinylidene chloride 12.353697828
MESH:D008175 Lung Neoplasms Acetaldehyde 7.3417372256
MESH:D008175 Lung Neoplasms Curcumin 7.3419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.3420512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Indomethacin 7.3416537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.3419555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.3411807781
MESH:D008223 Lymphoma Curcumin 3.1818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1416173963
MESH:D008325 Mammary Neoplasms, Experimental Genistein 11.2614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.2617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 11.2615318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 11.268985016
MESH:D008545 Melanoma Curcumin 2.3317885582 18462866
MESH:D008569 Memory Disorders Curcumin 8.3317263510
MESH:D008569 Memory Disorders Lead 8.3316384672 17263510
MESH:D001523 Mental Disorders Clozapine 6.5216856516
MESH:D001523 Mental Disorders Haloperidol 6.5216856516
MESH:D024821 Metabolic Syndrome X Clozapine 3.9419142101
MESH:D008881 Migraine Disorders Indomethacin 6.3411903285
MESH:D008881 Migraine Disorders Valproic Acid 6.3418765137 18803445
MESH:D009062 Mouth Neoplasms Indomethacin 3.5512636206
MESH:D009101 Multiple Myeloma Capsaicin 6.4517505005
MESH:D009101 Multiple Myeloma Curcumin 6.4519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.3517962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.528888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8117596541
MESH:D009203 Myocardial Infarction Genistein 8.0517141266
MESH:D009203 Myocardial Infarction Lithium 8.0516288908
MESH:D009203 Myocardial Infarction pirinixic acid 8.0519151258
MESH:D017202 Myocardial Ischemia Dobutamine 7.8812447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.8812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 6.9217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.9216411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.3018551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 3.8318495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.023581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.023581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 8.0211053908 11239499 16537180
MESH:D009369 Neoplasms pirinixic acid 1.6717405874
MESH:D009374 Neoplasms, Experimental Indomethacin 3.5910663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.9612497104
MESH:D009410 Nerve Degeneration Rotenone 3.4415790535 17356569 18619942
MESH:D009421 Nervous System Malformations bisphenol A 13.3116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 13.3116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.3114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.0518462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 5.976679447
MESH:D009436 Neural Tube Defects Valproic Acid 5.9716359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0320387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.0312349958
MESH:D020078 Neurogenic Inflammation Capsaicin 4.5717961222
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5420387270
MESH:D009765 Obesity Capsaicin 9.2619056576
MESH:D009765 Obesity Clozapine 9.2618515891 19142110
MESH:D009765 Obesity Curcumin 9.2619297423
MESH:D009765 Obesity pirinixic acid 9.2620558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.596374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.3116049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.314026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 12.3114694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.443988306
MESH:D010003 Osteoarthritis Indomethacin 3.317009135
MESH:D010009 Osteochondrodysplasias Thiram 5.0917954590 15899490 15518828
MESH:D010024 Osteoporosis Calcium 9.8717882678
MESH:D010024 Osteoporosis Curcumin 9.8718719352
MESH:D010024 Osteoporosis Genistein 9.8719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.5616169203
MESH:D010049 Ovarian Diseases bisphenol A 4.4211985600
MESH:D010051 Ovarian Neoplasms Curcumin 6.7518462866 19020741
MESH:D010051 Ovarian Neoplasms Genistein 6.7519005980
MESH:D010051 Ovarian Neoplasms Progesterone 6.7516525653 17393432
MESH:D010146 Pain Capsaicin 5.8817084039 17434803 18987195 19081190 17043245 16996476
MESH:D010146 Pain Indomethacin 5.883291741 13679232 17440234 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.1018702446 12538197
MESH:D010190 Pancreatic Neoplasms Curcumin 7.3619401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.3616540662
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.3615976015
MESH:D010195 Pancreatitis Indomethacin 3.4117883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 12.457296757
MESH:D010212 Papilloma Hydrogen Peroxide 12.4512065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 12.4518922899 12065085 8330346 18404319
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1416537180
MESH:D010300 Parkinson Disease Rotenone 2.7518619942 19114014 11535288 15451049 11445065 18191903 19232380 16140633 16412576
MESH:D020734 Parkinsonian Disorders Indomethacin 7.7412349958
MESH:D020734 Parkinsonian Disorders Rotenone 7.7418197244 15927086 15574749 15795934
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1411903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6712520081
MESH:D010437 Peptic Ulcer Indomethacin 4.5811148446
MESH:D010518 Periodontitis Indomethacin 4.3417225004
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.896228378
MESH:D011014 Pneumonia Lipopolysaccharides 3.9911605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.072563599
MESH:D047928 Premature Birth Indomethacin 4.5717000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 24.5010548101
MESH:D011297 Prenatal Exposure Delayed Effects Lead 24.5016384672
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 24.5011399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 24.5020603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 24.5019015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.3718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7020887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3616740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.3618226269 12497104 11398177 18769126 15129424 10851300 18156803
MESH:D011471 Prostatic Neoplasms Genistein 2.3615256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Thiram 2.3619789329
MESH:D011472 Prostatitis vinclozolin 4.3718629315
MESH:D011507 Proteinuria Indomethacin 3.6411849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.7516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 3.9612752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 4.4011575062
MESH:D011618 Psychotic Disorders Clozapine 7.7615331141
MESH:D011618 Psychotic Disorders Haloperidol 7.7611575062
MESH:D011629 Puberty, Precocious bisphenol A 4.2210548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.0319168576
MESH:D015427 Reperfusion Injury Capsaicin 5.8019211983 18460982
MESH:D015427 Reperfusion Injury pirinixic acid 5.8019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.7618379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 7.7617627322 18339021
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.943692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.6519155313
MESH:D012220 Rhinitis Acetaldehyde 4.2617050345
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012509 Sarcoma Curcumin 3.6218462866
MESH:D012559 Schizophrenia Clozapine 5.0317667964 20580759 20168265 18806925 16141801 20521320 20521326 20452607 11763009 20107430 17726453 18855531 19369910 11151749 17123785
MESH:D012559 Schizophrenia Haloperidol 5.0319369910 18513383 1830565 20107430
MESH:D012559 Schizophrenia Valproic Acid 5.0319110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 10.9318551238
MESH:D012640 Seizures Lithium 10.9319660546
MESH:D012640 Seizures Picrotoxin 10.938954991 8635557
MESH:D012640 Seizures Valproic Acid 10.931511512 11738929 11044598 14763951 3137016 15475178 17978042 16876388
MESH:D018805 Sepsis Curcumin 3.6118389075
MESH:D012852 Sinusitis Phenylephrine 4.147327846
MESH:D012878 Skin Neoplasms gingerol 14.8019481070
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.8012065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.808532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.8016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.8012065085 8985016 11807781 18404319 8330346
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3716709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7215862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.3419490988
MESH:D013226 Status Epilepticus Lithium 10.7519951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 10.7512833885
MESH:D013272 Stomach Diseases Indomethacin 8.8516113693 15472012 18209964 15038085 10192188 17638125 10486359 16280098 10215738 17160473 18545984 17207306 16184426
MESH:D013272 Stomach Diseases rebamipide 8.8516184426
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2318456281
MESH:D013274 Stomach Neoplasms Indomethacin 3.2315609394
MESH:D013274 Stomach Neoplasms rebamipide 3.2315993841
MESH:D013276 Stomach Ulcer Curcumin 5.9219188055 16631530
MESH:D013276 Stomach Ulcer Indomethacin 5.9214567935 17918041 18431645 16150113 11523592 17895592 18726076 16169175 17654042 18543354 12500499 17135157 16397915 17657623 11145282 11906479 16252198 10423059 18237397 10878458 11595415 10750652 11595431 17977527 15104355 16631530 17627676 1323529 18209962 16934674 12077510 18193104 18299717 12787963 11729361 16755016 12498302 18181030 12467913 18087811 15255614 15138204
MESH:D019966 Substance-Related Disorders bisphenol A 3.4216684133 16045194
MESH:D013398 Sudden Infant Death Oxygen 4.9812563064
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.1720210726
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.1517997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.6715821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 9.506582329 6587162 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.507505956
MESH:D013964 Thyroid Neoplasms Indomethacin 9.5011352223 14736730 18791128
MESH:D016171 Torsades de Pointes Dobutamine 4.7919353679
MESH:D014178 Translocation, Genetic Valproic Acid 4.6617262798
MESH:D014202 Tremor Lead 4.9221145352
MESH:D014456 Ulcer Indomethacin 4.3317380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.963119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 6.8716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 6.878074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 6.8718593936
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.098888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.7018462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7510091137
MESH:D014591 Uterine Diseases bisphenol A 4.4314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7714692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0314671159 15869587
MESH:D014839 Vomiting Indomethacin 4.1711897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6715886252
MESH:D015430 Weight Gain Clozapine 3.9917502770 20564506 20107430 16402076 16141801 20521320
MESH:D015431 Weight Loss Clozapine 4.5117933447
Pathway ID Pathway Name
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
REACT:604 Hemostasis
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
KEGG:04530 Tight junction
KEGG:04930 Type II diabetes mellitus
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33765
    • No data
    Releated disease ID Related disease Name
    PA446459Myocardial Ischemia
    PA444645Ischemia
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449659flumazenil
    PA448073ethanol
    PA450644nitroglycerin
    PA451406nitroprusside
    PA449748gemcitabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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