AutismKB 2.0

Annotation Detail for RNF130


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Basic Information Top
Gene Symbol:RNF130 ( G1RZFP,GOLIATH,GP,MGC117241,MGC138647,MGC99542 )
Gene Full Name: ring finger protein 130
Band: 5q35.3
Quick LinksEntrez ID:55819; OMIM: NA; Uniprot ID:GOLI_HUMAN; ENSEMBL ID: ENSG00000113269; HGNC ID: 18280
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RNF130 mRNAdecreases expression 20498004
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RNF130 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNF130 mRNAaffects cotreatment|increases expression 17942748
D020849 Raloxifene Raloxifene results in decreased expression of RNF130 mRNAdecreases expression 15576828
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNF130 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000419 Albuminuria Raloxifene 5.1017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8620146248 17474063
MESH:D001943 Breast Neoplasms Raloxifene 1.8615572757 17440819 17595753 15775269 17242785 15758505 17893378 17049068 16912660 17261762 17952589 16837676
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.4717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1711677210 16105132 17333356 17681005 15861022 16919318 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 12621046 16354765 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3017451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Raloxifene 8.2915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.2912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.8512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.8515845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.3115345470
MESH:D005234 Fatty Liver Raloxifene 9.3117473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0511294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7718606429 15340226 16354765 8697196 16959395
MESH:D006973 Hypertension Raloxifene 5.6317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7320195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2717053015 6695378 18520028 20869020 20464547 20135361 18569708 18816296 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2711884234 19555203
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009101 Multiple Myeloma Raloxifene 3.7116497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010024 Osteoporosis Raloxifene 3.6119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 15579764 17893378 15758505
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2216536755 15731164 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.9415861022 16919318
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5917572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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