AutismKB 2.0

Annotation Detail for PRKCG


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Basic Information Top
Gene Symbol:PRKCG ( MGC57564,PKC-gamma,PKCC,PKCG,SCA14 )
Gene Full Name: protein kinase C, gamma
Band: 19q13.42
Quick LinksEntrez ID:5582; OMIM: 176980; Uniprot ID:KPCG_HUMAN; ENSEMBL ID: ENSG00000126583; HGNC ID: 9402
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04270Vascular smooth muscle contraction
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa05146Amoebiasis
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04530Tight junction
hsa04960Aldosterone-regulated sodium reabsorption
hsa04971Gastric acid secretion
hsa05223Non-small cell lung cancer
hsa05214Glioma
hsa04510Focal adhesion
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04070Phosphatidylinositol signaling system
hsa04666Fc gamma R-mediated phagocytosis
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Signalling by NGF
Hemostasis
Opioid Signalling
Pathway IDPathway Name
200004Endothelins
200069Thromboxane A2 receptor signaling
200142Retinoic acid receptors-mediated signaling
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00018EGF receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P00005Angiogenesis
P043745HT2 type receptor mediated signaling pathway
P00002Alpha adrenergic receptor signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00063Spinocerebellar ataxia
No data
Desease Name
spinocerebellar ataxia
PSYCH
NEUROLOGICAL
attention deficit hyperactivity disorder conduct disorder novelty seeking substance experimentation
No data
Desease Name
Spinocerebellar ataxia 14
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C500067 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol binds to and results in decreased activity of PRKCG proteinaffects binding|decreases activity 15771433
C059539 4'-N-benzoylstaurosporine 4'-N-benzoylstaurosporine results in decreased activity of PRKCG proteindecreases activity 15542774
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKCG mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKCG proteinaffects expression 16483693
D000661 Amphetamine Amphetamine affects the expression of PRKCG mRNAaffects expression 16101753
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of PRKCG mRNAincreases expression 17481689
C004742 daidzein daidzein results in increased activity of PRKCG proteinincreases activity 16972265
D008559 Memantine Memantine results in increased expression of PRKCG mRNAincreases expression 11169168
D016291 Dizocilpine Maleate Dizocilpine Maleate results in increased expression of PRKCG mRNAincreases expression 11169168
D007854 Lead Lead results in decreased expression of PRKCG proteindecreases expression 16547843
C008261 lead acetate lead acetate results in decreased expression of PRKCG proteindecreases expression 16547843
D008094 Lithium Lithium inhibits the reaction [PRKCG protein mutant form binds to PRKCG protein mutant form]affects binding|decreases reaction 20398063
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of PRKCG proteinincreases expression 11794376
C005219 methyl cellosolve methyl cellosolve metabolite results in increased expression of PRKCG proteinincreases expression 11794376
D009151 Mustard Gas Mustard Gas results in decreased expression of PRKCG proteindecreases expression 15681122
D010126 Ozone Ozone results in decreased expression of PRKCG mRNAdecreases expression 16330353
D010622 Phencyclidine Phencyclidine results in increased expression of PRKCG mRNAincreases expression 11169168
C052785 rebamipide rebamipide results in increased expression of PRKCG mRNAincreases expression 15104358
D020123 Sirolimus Sirolimus inhibits the reaction [PRKCG protein mutant form binds to PRKCG protein mutant form]affects binding|decreases reaction 20398063
D020123 Sirolimus Sirolimus results in increased degradation of PRKCG protein mutant formincreases degradation 20398063
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of PRKCG proteindecreases expression 15949478
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of PRKCG proteinincreases activity 15707588
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of PRKCG proteinaffects localization 14975926
D013893 Thiram Thiram results in decreased activity of PRKCG proteindecreases activity 15998240
C052920 trimethylarsine oxide trimethylarsine oxide results in increased expression of PRKCG mRNAincreases expression 17481689
C025643 vinclozolin vinclozolin results in increased expression of PRKCG mRNAincreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 9.023652986 1761407 12805644 15959878 1761404
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 9.026474471 6499812 3652986
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D000230 Adenocarcinoma daidzein 3.3911473722
MESH:D000544 Alzheimer Disease Lithium 4.6119621015
MESH:D000544 Alzheimer Disease Ozone 4.6115513908
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.9316916582 18475255 16459022 15010207
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.223699323
MESH:D000855 Anorexia Amphetamine 4.8912183048 16084549 16101753 12005258
MESH:D001008 Anxiety Disorders vinclozolin 3.5319015723
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5315570426
MESH:D053627 Asthenozoospermia methyl cellosolve 5.393987992
MESH:D001249 Asthma Mustard Gas 4.9510378619
MESH:D001249 Asthma Ozone 4.9517854713 16373670
MESH:D001284 Atrophy methyl cellosolve 5.062626667 6705890 3699323
MESH:D001321 Autistic Disorder Memantine 3.4217690064
MESH:D001321 Autistic Disorder Sirolimus 3.4221115397
MESH:D001714 Bipolar Disorder Lithium 4.2619153942 20338123 20046352 17594078
MESH:D001768 Blister Mustard Gas 5.0319167455
MESH:D001943 Breast Neoplasms Cacodylic Acid 3.6117474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5715516495 17626835 18315731 16777450 14754758 19059883 18417511
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8517687719 10378619
MESH:D002100 Cachexia Ozone 4.6116183385
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 3.1519335982
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 5.2419435901
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.2418922899
MESH:D002318 Cardiovascular Diseases daidzein 4.1616332659
MESH:D002764 Cholecystitis methyl cellosolve 5.676499794
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.7012530607 6499821
MESH:D019465 Craniofacial Abnormalities Lead 3.6519769572
MESH:D019465 Craniofacial Abnormalities lead acetate 3.6519769572
MESH:D003456 Cryptorchidism vinclozolin 4.2114966744
MESH:D007644 Darier Disease Lithium 5.7820338123
MESH:D003704 Dementia Lead 5.1316140633
MESH:D002658 Developmental Disabilities Memantine 5.7217016714
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.6119244398
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 3.4016647724
MESH:D004487 Edema Mustard Gas 6.9011428631 9260866 11402378 11428647
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.909599246 11698051 15177302 7812673 16716910 8273558 8113982
MESH:D016889 Endometrial Neoplasms daidzein 4.2211473722
MESH:D007172 Erectile Dysfunction daidzein 4.8914972507
MESH:D004890 Erythema Mustard Gas 5.039357497
MESH:D004892 Erythema Multiforme Thiram 6.5216750123
MESH:D020329 Essential Tremor Lead 5.8018007985 14594619
MESH:D005221 Fatigue Amphetamine 5.4719890266
MESH:D005317 Fetal Growth Retardation Lead 11.2819769572
MESH:D005317 Fetal Growth Retardation lead acetate 11.2819769572
MESH:D005327 Fetal Resorption methyl cellosolve 5.426499821 6499812 6474471 3987992
MESH:D020567 Fetal Weight methyl cellosolve 5.676474471 6499812 6499821
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 12.063652986
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 12.063652986
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1716417039
MESH:D006258 Head and Neck Neoplasms Sirolimus 4.3719435901
MESH:D006330 Heart Defects, Congenital Lithium 4.1519638421
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.656499821
MESH:D006461 Hemolysis methyl cellosolve 5.3217874071
MESH:D006948 Hyperkinesis Amphetamine 5.3014960337 1977408
MESH:D006973 Hypertension daidzein 3.6217169123
MESH:D006984 Hypertrophy Sirolimus 5.1119211884
MESH:D007246 Infertility Thiram 5.716420938
MESH:D007248 Infertility, Male Lead 11.1116780224
MESH:D007248 Infertility, Male methyl cellosolve 11.113987992
MESH:D007248 Infertility, Male vinclozolin 11.1116467254
MESH:D007249 Inflammation Mustard Gas 5.2811428647 16001271 17524151 11402378 9357497 8975870 9260866 11428631 11428620
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.288273558 7562506 11698051 15177302 7812673
MESH:D007410 Intestinal Diseases rebamipide 5.0511686837
MESH:D007855 Lead Poisoning Lead 5.8016700817
MESH:D007859 Learning Disorders Lead 5.0616384672
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6016417039
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 8.7812805644 15959878
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 8.786499821
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 3.0717050028
MESH:D008171 Lung Diseases Mustard Gas 7.3318161513 18702808
MESH:D008171 Lung Diseases Ozone 7.338266340 19066396
MESH:D055370 Lung Injury Ozone 3.7220417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.568781369 3148597
MESH:D008175 Lung Neoplasms Ozone 3.567614698 8597069
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.5611807781
MESH:D008231 Lymphopenia methyl cellosolve 5.653699323
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.278985016
MESH:D008545 Melanoma Sirolimus 3.2019282848
MESH:D008569 Memory Disorders Lead 5.0416384672 17263510
MESH:D008679 Metaplasia Ozone 4.9810496685
MESH:D009062 Mouth Neoplasms Sirolimus 4.6019435901
MESH:D009203 Myocardial Infarction Lithium 3.8716288908
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.5415183010
MESH:D009503 Neutropenia Mustard Gas 3.8516761898 7688884
MESH:D009845 Oligospermia methyl cellosolve 5.053987992
MESH:D010009 Osteochondrodysplasias Thiram 5.4315518828 15899490 17954590
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.0915976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.168330346 18404319 12065085 18922899
MESH:D010300 Parkinson Disease Sirolimus 3.6919682553
MESH:D010538 Peritonitis Ozone 4.0016369182
MESH:D011014 Pneumonia Ozone 4.2618929643 18007984 18381685
MESH:D011041 Poisoning Memantine 9.2115824473
MESH:D011041 Poisoning Mustard Gas 9.2115727166
MESH:D011297 Prenatal Exposure Delayed Effects Lead 15.9116384672
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 15.9112530607 7974496 6499817
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.9118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8018220299
MESH:D011471 Prostatic Neoplasms Thiram 5.0819789329
MESH:D011472 Prostatitis vinclozolin 4.8018629315
MESH:D011537 Pruritus Mustard Gas 3.9618058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8810334151 17620002 17266442 17894541 17720292
MESH:D012640 Seizures Dizocilpine Maleate 6.8212660363 17157343 11218047
MESH:D012640 Seizures Lithium 6.8219660546
MESH:D012871 Skin Diseases Mustard Gas 2.6816961503 15451306 12880345
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.2218404319 8985016 8330346 11807781 12065085
MESH:D020754 Spinocerebellar Ataxias marker/mechanism 20398063
MESH:D013226 Status Epilepticus Lithium 5.6619570321 19951488 19430551
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.291977408
MESH:D013272 Stomach Diseases rebamipide 5.1416184426
MESH:D013274 Stomach Neoplasms rebamipide 3.2115993841
MESH:D013576 Syndactyly methoxyacetic acid 5.501761404 1761407
MESH:D013733 Testicular Diseases methoxyacetic acid 10.666499806 18486176
MESH:D013733 Testicular Diseases methyl cellosolve 10.666499806
MESH:D014202 Tremor Lead 5.3621145352
MESH:D014402 Tuberous Sclerosis Sirolimus 5.4418495876 21115397
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 3.6815537745
MESH:D014605 Uveitis Sirolimus 5.501336536
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:05146 Amoebiasis
KEGG:04020 Calcium signaling pathway
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:05214 Glioma
KEGG:04724 Glutamatergic synapse
REACT:604 Hemostasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:05223 Non-small cell lung cancer
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:05200 Pathways in cancer
KEGG:04070 Phosphatidylinositol signaling system
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
KEGG:04530 Tight junction
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
KEGG:05110 Vibrio cholerae infection
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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