Annotation Detail for PAG1
Basic Information
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| Gene Symbol: | PAG1 ( CBP,FLJ37858,MGC138364,PAG ) |
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| Gene Full Name: | phosphoprotein associated with glycosphingolipid microdomains 1 |
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| Band: | 8q21.13 |
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| Quick Links | Entrez ID:55824; OMIM: 605767; Uniprot ID:PAG1_HUMAN; ENSEMBL ID: ENSG00000076641; HGNC ID: 30043 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| Signaling by EGFR |
| Signaling in Immune system |
| Pathway ID | Pathway Name |
|---|
| 200083 | CXCR4-mediated signaling events |
| 200062 | TCR signaling in naive CD8+ T cells |
| 200022 | TCR signaling in naive CD4+ T cells |
| Pathway ID | Pathway Name |
|---|
| 500514 | Gab1 signalosome |
| 500479 | Phosphorylation of CD3 and TCR zeta chains |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of PAG1 mRNA | decreases expression | 20064835
|
| C051890 |
irinotecan |
irinotecan analog results in increased expression of PAG1 mRNA | increases expression | 18927307
|
| D013654 |
Taurine |
Taurine results in decreased expression of PAG1 mRNA | decreases expression | 16579726
|
| D014635 |
Valproic Acid |
Valproic Acid results in increased expression of PAG1 mRNA | increases expression | 19101580
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.11 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.35 | 19490988 |
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.06 | 20464547 20127859 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.86 | 6695378 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
5.96 | 17688650 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.90 | 17497229 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.64 | 19183758 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 18177632 19232924 16609825 18940202 18558336 18396377 18985861 17688650 15238991 17157402 18775368 19460635 20603192 17507914 18316065 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.24 | 20046352 17594078 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.63 | 8888407 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.99 | 20146248 17474063 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.13 | 20419170 |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.82 | 20734317 |
| MESH:D003110 |
Colonic Neoplasms |
|
irinotecan |
2.64 | 17725105 17287894 |
| MESH:D015179 |
Colorectal Neoplasms |
|
irinotecan |
2.36 | 16391804 16303861 17159606 17454858 15273666 18509181 18259882 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.91 | 16575769 8888407 17688650 |
| MESH:D058065 |
Diabetic Cardiomyopathies |
|
Taurine |
6.68 | 16025228 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Taurine |
4.82 | 9328219 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
4.82 | 19641884 1733752 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.51 | 1851702 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.71 | 17275665 3659116 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.64 | 16628512 3922381 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.11 | 18234410 20417680 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
3.96 | 6254150 7562514 6426943 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.86 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.69 | 3659116 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
2.08 | 16530937 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
3.72 | 19224547 14986274 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.61 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.64 | 8888407 18558336 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.83 | 20471113 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.50 | 17688650 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.20 | 17596541 16294345 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Taurine |
3.27 | 15893842 15931870 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
2.15 | 20195826 21137059 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
4.98 | 17228818 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 18816296 18520028 20464547 17053015 20869020 6695378 18569708 20064080 20135361 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.47 | 18765137 18803445 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.50 | 16381670 |
| MESH:D052016 |
Mucositis |
|
irinotecan |
5.64 | 17159606 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.45 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.35 | 17596541 |
| MESH:D009362 |
Neoplasm Metastasis |
|
irinotecan |
3.30 | 18259882 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.33 | 11141357 |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.37 | 16359493 8888407 |
| MESH:D009447 |
Neuroblastoma |
|
irinotecan |
3.65 | 8761367 |
| MESH:D017599 |
Neuroectodermal Tumors |
|
irinotecan |
5.36 | 8761367 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.46 | 20603192 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.91 | 17292933 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.26 | 11422049 12752131 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.64 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.10 | 19110320 15737665 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
2.99 | 17978042 1511512 11044598 14763951 16876388 15475178 3137016 11738929 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.52 | 19755658 10029692 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.09 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.26 | 12833885 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
2.63 | 20155912 2093021 |
| MESH:D013274 |
Stomach Neoplasms |
|
irinotecan |
2.63 | 15723263 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
5.96 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.15 | 3119515 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.30 | 17053015 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.20 | 8888407 |
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