AutismKB 2.0

Annotation Detail for PRKCH


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Basic Information Top
Gene Symbol:PRKCH ( MGC26269,MGC5363,PKC-L,PKCL,PRKCL,nPKC-eta )
Gene Full Name: protein kinase C, eta
Band: 14q23.1
Quick LinksEntrez ID:5583; OMIM: 605437; Uniprot ID:KPCL_HUMAN; ENSEMBL ID: ENSG00000027075; HGNC ID: 9403
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04530Tight junction
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
Pathway IDPathway Name
200004Endothelins
200069Thromboxane A2 receptor signaling
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00018EGF receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P00005Angiogenesis
P043745HT2 type receptor mediated signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
rheumatoid arthritis
CARDIOVASCULAR
Brain Ischemia
IMMUNE
Stroke
Cerebral Hemorrhage
No data
Desease Name
Cerebral infarction, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PRKCH mRNAaffects cotreatment|decreases expression 17093179
D000082 Acetaminophen Acetaminophen affects the expression of PRKCH mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKCH mRNAaffects expression 16483693
D000661 Amphetamine Amphetamine results in increased expression of PRKCH mRNAincreases expression 16101753
C006632 arsenic trioxide arsenic trioxide results in increased expression of PRKCH mRNAincreases expression 20458559
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PRKCH mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRKCH mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PRKCH mRNAincreases expression 17032414
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of PRKCH mRNAdecreases expression 17452286
D003474 Curcumin Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003976 Diazinon Diazinon results in decreased expression of PRKCH mRNAdecreases expression 17452286
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PRKCH mRNAaffects cotreatment|decreases expression 17093179
D004052 Diethylnitrosamine [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNAaffects cotreatment|increases expression 16158176
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNAaffects cotreatment|increases expression 14656948
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of PRKCH mRNAincreases expression 17032414
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCH mRNAaffects cotreatment|increases expression 17942748
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNAaffects cotreatment|increases expression 16158176
D015073 2-Acetylaminofluorene [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNAaffects cotreatment|increases expression 14656948
D007213 Indomethacin Indomethacin results in increased expression of PRKCH proteinincreases expression 10702201
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PRKCH mRNAdecreases expression 16807920
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCH mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of PRKCH mRNAincreases expression 17431108
C025643 vinclozolin vinclozolin affects the expression of PRKCH mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7914514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D000230 Adenocarcinoma arsenic trioxide 10.1011798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 10.1016033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.1014692618
MESH:D000230 Adenocarcinoma Indomethacin 10.1016537180
MESH:D000236 Adenoma 2-Acetylaminofluorene 15.7710737359
MESH:D000236 Adenoma Diethylnitrosamine 15.776695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 15.7719555203
MESH:D000236 Adenoma Indomethacin 15.7711497255
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.956705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.8518056438 16434500 17620307 17162532 19052882 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8516835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.9716611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.9716487989
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0317887948
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3217225004
MESH:D000544 Alzheimer Disease Curcumin 4.4515590663
MESH:D000544 Alzheimer Disease Indomethacin 4.4515579461 17627676
MESH:D019969 Amphetamine-Related Disorders Amphetamine 6.0015010207 16459022 16916582 18475255
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D000855 Anorexia Amphetamine 4.9512183048 12005258 16084549 16101753
MESH:D001008 Anxiety Disorders vinclozolin 3.5819015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.7810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D018771 Arthralgia Indomethacin 5.112160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 7.4116807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 7.4111248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.4116292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis Curcumin 3.2818704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Curcumin 4.4319761891
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001477 Bartter Syndrome Indomethacin 4.9210684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.9816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.9816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001929 Brain Edema Indomethacin 4.9711481608
MESH:D002545 Brain Ischemia Curcumin 10.1716770732
MESH:D002545 Brain Ischemia Indomethacin 10.1712524144
MESH:D001932 Brain Neoplasms Curcumin 3.8817596214
MESH:D001943 Breast Neoplasms Curcumin 2.3218462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3217474063
MESH:D001943 Breast Neoplasms Indomethacin 2.3217401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002056 Burns Indomethacin 4.6410459503
MESH:D002100 Cachexia Indomethacin 4.9415141370 15625704 11239499 16537180
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7215700767 16050911 16227642 16097048 15673190 16124888 15721981 16192424 3786805 16011737 10355542 18705752
MESH:D002277 Carcinoma Curcumin 13.7218593918
MESH:D002277 Carcinoma Dimethylnitrosamine 13.7219555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.7216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 13.9410737359 3084413 3581430 17761372 6705139
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.943084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.9415073043 14691202 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.9418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.9420512989 16878318 19418558 17978847 16830150 19539802 20101231 17173139 18691550 17138121 17162532 16807293 18056438 18393292 20524982 20214788 19107877 19052882 19383236 19394651 20432363 17761372 18978308 18788625 18494052 11831363 21159647 19519916 16698587 16288022 16681979 17055752 16779866 19701751 16502159 19919837 19822196 18506893 19208518 3084413 20727157 19171122 18971187 17428255 16328049 20935162 10737359 20514400 19335982 16935385 3581430 18785209 20007298 10672840 16569478 18210153 18665156 20084675 16540662
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 13.9416391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.941917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2918791128 11352223 14736730
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9518414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3417341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.7218462866
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 10.7216033868
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.7215482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.7216051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.1010977129
MESH:D002386 Cataract Tretinoin 7.1017460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.817505956 17174075 2727394 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002764 Cholecystitis Indomethacin 5.1111181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8217110522 16919318 15861022 11677210 17333356 16105132 17681005
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6715668235 8697196 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.679407595
MESH:D003092 Colitis Curcumin 9.4316804969 18200517 16782535
MESH:D003092 Colitis Tretinoin 9.4317035595
MESH:D003103 Coloboma Curcumin 4.4918809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0219359593 16340194
MESH:D003110 Colonic Neoplasms Indomethacin 4.0215936596 15625704 15786552 15963497 15637740 11260862
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6620501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.6612606626 11197048 17054584 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.8318497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D018352 Coronavirus Infections Indomethacin 5.6617302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.729125849 9224671 8800419 16925845 9664655 9211117 14991402 10589399 9142499 17551590
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.0418403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0417107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.9518204486
MESH:D003967 Diarrhea Indomethacin 3.737237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8111287661 10774834 19416960 16393943 14550746 18713872 11421492 12153990 19085960 11739529 16781746 16485898 14725611 17562736 17522070 19164858 12540782 2444490 12958197 15968718 12705907 19420014 10663392 19370779 10915739 11743745 19739265 19923254 14986274 15619225 16081117 12392966 11529661 12594235 16227642 11834606 17906064 16109766 16177239 18071297 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.8111566570 7440962 15027814 7120509 19336974 3786805 15998439 16177239 21278145 17522070 2869522 9327722 7179309 19085960 10092053 15968718 6884620 4309450 16227642 6623471 10915739 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.8119107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 11.818172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0918446180 16133044 18043480 16326151 17190690 12774134
MESH:D004381 Duodenal Ulcer Curcumin 9.2117351913
MESH:D004381 Duodenal Ulcer Indomethacin 9.2117045617 11595415 11595431 17329845 11535926 17351913 17202747 16699067 10671773 17151854 11991626
MESH:D004417 Dyspnea Diazinon 4.7416487989
MESH:D004487 Edema Indomethacin 6.7110653021 8985016 8273558 7907874 7990266 16100529 19703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0616569247
MESH:D004715 Endometriosis Indomethacin 8.8715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.879294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.4418509659
MESH:D004751 Enteritis Indomethacin 4.6917763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9217980183
MESH:D004802 Eosinophilia Indomethacin 3.9911298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.3312903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.3317016578
MESH:D004938 Esophageal Neoplasms Indomethacin 7.3311005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.6716938888 9664655
MESH:D005221 Fatigue Amphetamine 5.5419890266
MESH:D005234 Fatty Liver arsenic trioxide 24.0115073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.0115959796 12631006 17595544 16045604 12795759 19224547 61145 16239168
MESH:D005234 Fatty Liver Curcumin 24.0119297423
MESH:D005234 Fatty Liver Diethylnitrosamine 24.0121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.0115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005334 Fever Indomethacin 4.0610431976 17627676 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.8310962813
MESH:D005355 Fibrosis Carbon Tetrachloride 27.1018705752
MESH:D005355 Fibrosis Curcumin 27.1018705752
MESH:D005355 Fibrosis Indomethacin 27.1017994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.1020067830
MESH:D005355 Fibrosis Tretinoin 27.1017994277
MESH:D005499 Folliculitis Indomethacin 5.1111298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005756 Gastritis Acetaminophen 10.9616983495
MESH:D005756 Gastritis Indomethacin 10.9615046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6318462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005909 Glioblastoma Curcumin 11.7417596214
MESH:D005909 Glioblastoma Indomethacin 11.7412870263
MESH:D005909 Glioblastoma Tretinoin 11.7417312396
MESH:D005910 Glioma Indomethacin 3.2016487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006073 Gout Indomethacin 5.2911248219
MESH:D006258 Head and Neck Neoplasms Curcumin 12.7818462866 18829502
MESH:D006258 Head and Neck Neoplasms Indomethacin 12.7815482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.7816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.429664655 14991402
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.266705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.346705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5115633222
MESH:D006505 Hepatitis Carbon Tetrachloride 9.4019110552 19900420
MESH:D006505 Hepatitis Diazinon 9.4016487989
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6215135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8312621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9817701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 18606429 16354765 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 12.7616870215
MESH:D006930 Hyperalgesia Indomethacin 12.7612727271
MESH:D006930 Hyperalgesia Tretinoin 12.7616870215
MESH:D034321 Hyperamylasemia Indomethacin 5.6617883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006937 Hypercholesterolemia Curcumin 3.9918704882
MESH:D006940 Hyperemia Indomethacin 4.9412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006948 Hyperkinesis Amphetamine 5.371977408 14960337
MESH:D006949 Hyperlipidemias Indomethacin 4.1017546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.9718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2916133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.3216133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Diazinon 11.0612948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.0617937319
MESH:D007248 Infertility, Male vinclozolin 11.0616467254
MESH:D007249 Inflammation Curcumin 11.7217151092 16956363 18403477
MESH:D007249 Inflammation Diethylnitrosamine 11.7218785209
MESH:D007249 Inflammation Indomethacin 11.723291741 7812673 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7212878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1818200517 18596194
MESH:D007410 Intestinal Diseases Indomethacin 9.6715831440 10210152 18236018 11713966 11855677 15610444 17994277 17329856 11686837
MESH:D007410 Intestinal Diseases Tretinoin 9.6717994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.1610783313
MESH:D019586 Intracranial Hypertension Indomethacin 5.3215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7317551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.9716133968 10574470 18306037
MESH:D007674 Kidney Diseases Acetaminophen 6.0115629191 12587719
MESH:D007674 Kidney Diseases Indomethacin 6.0117190690
MESH:D007889 Leiomyoma Curcumin 4.5118555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8511703811 12228301 10320625
MESH:D007938 Leukemia arsenic trioxide 10.3415070760
MESH:D007938 Leukemia Curcumin 10.3418462866
MESH:D007938 Leukemia Tretinoin 10.3417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.5617077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.5616106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.3914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.3910785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.1120471514 16968895 16467208 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 6.1118360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1117596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4919225113 16891316 12679006 16112521 17869043 16966277 15622746 16823087 16331271 11468182 17712046 19075265 12712474 17649720 17217047 17107899 19642359 15213294 15748426 11161223 16330433 9834237 12018890 19035177 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4917506722 19642359 16891316 17339181 17712046 17217047 17649720 16140955 16788101 15748426 19035177 17107899 12679006 16766008 16823087 17368321 19075265 19225113 17294898 19029980 9834237 16331271 17361223 16935935 17301526
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.5016882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.5016106398
MESH:D007964 Leukocytosis Indomethacin 5.3216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6617980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6611479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4917157831 16221502 11903743 16239168 21278145 11408273 17174718 16943688 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4918522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.6518277467 15876570 17823541 15996030 17869086 12445421 12445418 17640975 14512876 18251166 16011737 17900296 12389079 15362042 17557913 12741479 15650968 13678700 18395914 18205269 16015684 12958196 14748882 18339082 17922224 14724832 18054572 17708605 12666154 16033810 17565644 12632512 15959796 20821823 18317297 17721639 12649538 15052691 15338365 17714472 16638106 17766677 15931870 12586293 17698563 18279442 18263696 15123356 14716496 17761835 18412020 17944888 15370692 14716833 14620537 18376398 18472094 15057751 12898905 18705752 18006644 16192424 18472332 16027843 15730626 15818738 17481882 18420326 17805973 17631135 18210741 18156304 12632514 18395095 15925388 18429990 12546737 12609069 15893842 11481614 16136751 18187930 15673190 12667390 17976157 17525996 16248980 10355542 16116963 16097048 18418968 18166357 18481824
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.6518006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.6516270385 17203207 18567088 15723089 18095165 14709902 15763062 15798949 15842777 15577212 17881167 15383259 16544323 15161499 15744066 17465448 18210741 15369754 17666798 18672772 12918455 17534399 18637143 15571005 12925901 14568256 17036385 15067225 15298665 16603200 17432682 16169303 18629640 16570917 15086199 14643895 15081153 17201889 18364076 15479170 15504291 14726149 17640959 15864749 15366600 16627068 15793283 17724770 17719030 17348192 17196135 16042886 18237412 18239293 15339415 15942678 14659978 16009107 18371158 15591649 15099470 17198567 15733078 15138612 15492853
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.6518194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.6516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 12.3719460945 16610002 19784758 12587719 12969438 11587558 19014921 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.3716246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Chlorpyrifos 12.3715991261
MESH:D008107 Liver Diseases Curcumin 12.3716956363
MESH:D008107 Liver Diseases Diethylnitrosamine 12.3717034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.9217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.9216899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 15.9217457977
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 17.6814678523 18001218 10737359 16273603 11376686 10672840
MESH:D008113 Liver Neoplasms arsenic trioxide 17.6814682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.6819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.6820452335 19833225 19690152 20501860 12112319 19254457 19812893 18978307 9163691 20118626 19499222 15175105 20405173 19427195 18644402 20101389 19638242 15885732 19256749 19073162 20492335 18648771 10737359 18977376 18754104 20583210 19294768 19642983 21278145 19996281 12771043 2422723 19426721 19090486 20137499 19255062 21071580 19850985 16942905 20434301 21167192 2862719 19551842 21047994
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 17.683113478 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.6816984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 22.856150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.8520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.8512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.8518093689 18775883 19126423 16267830 21159647 17942915 16842330 18544905 17174075 19009564 19519916 19539802 18253720 18079962 18308698 18164116 18282651 9362446 19004024 17854601 3124819 2563599
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.856150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.8512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 10.6011376686
MESH:D008175 Lung Neoplasms arsenic trioxide 10.6019825857 11798837
MESH:D008175 Lung Neoplasms Curcumin 10.6016243823 19359593 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.6021163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.6016061637 19555203 11884234
MESH:D008175 Lung Neoplasms Indomethacin 10.6011053908 11497255 16537180
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.6011884234 19555203
MESH:D008223 Lymphoma Curcumin 3.5418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6316173963
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Curcumin 3.4417885582 18462866
MESH:D008545 Melanoma Tretinoin 3.4416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008569 Memory Disorders Curcumin 4.0917263510
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008881 Migraine Disorders Indomethacin 3.6311903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.9412636206
MESH:D009101 Multiple Myeloma arsenic trioxide 7.2819417148 19549372 14977855 15949261 11468182
MESH:D009101 Multiple Myeloma Curcumin 7.2819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8617962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.1116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.1118495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.873581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.8711239499 11053908 16537180
MESH:D009369 Neoplasms Tretinoin 2.3816946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 4.0710663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4812497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3014600291
MESH:D009421 Nervous System Malformations Tretinoin 9.309125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.5718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1610525206
MESH:D009436 Neural Tube Defects Tretinoin 7.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 19.6918514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 19.6915183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 19.6920387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 19.6912349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1215081274
MESH:D009765 Obesity Curcumin 2.7319297423
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.116374098
MESH:D010003 Osteoarthritis Indomethacin 3.637009135
MESH:D010024 Osteoporosis Curcumin 3.4318719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 7.8318462866 19020741
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8316936753
MESH:D010146 Pain Acetaminophen 10.9516870215
MESH:D010146 Pain Indomethacin 10.9517627676 13679232 3291741 17440234
MESH:D010146 Pain Tretinoin 10.9516870215
MESH:D010149 Pain, Postoperative Indomethacin 4.6212538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.1615580305
MESH:D010190 Pancreatic Neoplasms Curcumin 12.1617440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.1616540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.1615976015
MESH:D010195 Pancreatitis Indomethacin 3.8615028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6616537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6611903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0911148446
MESH:D010518 Periodontitis Indomethacin 4.8617225004
MESH:D011041 Poisoning Diazinon 4.2917603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.492563599
MESH:D047928 Premature Birth Indomethacin 5.0617000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2811118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.2818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.4619131511
MESH:D011471 Prostatic Neoplasms Curcumin 3.4612497104 18769126 11398177 10851300 18156803 18226269 15129424
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011507 Proteinuria Indomethacin 9.1211849393
MESH:D011507 Proteinuria Tretinoin 9.1216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2515861022 16919318
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.4719168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9610666014 18379247
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.5716611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8416611668 17119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416116481 16283617
MESH:D012509 Sarcoma Curcumin 4.0618462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D018805 Sepsis Curcumin 4.0218389075
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.036418539
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.258532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2516192470
MESH:D012878 Skin Neoplasms Tretinoin 9.2516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2112587719
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.371977408
MESH:D013272 Stomach Diseases Indomethacin 4.3616280098 10486359 18209964 10215738 17638125 10192188 16184426 15472012 15038085 17160473 17207306 16113693 18545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.3517007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.3518456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.3516033868
MESH:D013274 Stomach Neoplasms Indomethacin 6.3515609394
MESH:D013274 Stomach Neoplasms Tretinoin 6.3517261132
MESH:D013276 Stomach Ulcer Curcumin 7.3719188055 16631530
MESH:D013276 Stomach Ulcer Indomethacin 7.3712077510 18087811 16397915 11595415 15104355 18237397 16252198 16169175 16755016 11595431 18543354 17895592 16150113 18209962 17918041 11729361 17135157 18299717 12500499 11523592 15138204 16631530 1323529 17654042 10750652 17657623 17627676 14567935 15255614 18726076 10423059 11906479 18431645 12467913 10878458 18181030 12498302 12787963 11145282 17977527 16934674 18193104
OMIM:601367 STROKE, ISCHEMIC marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.7119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.717505956
MESH:D013964 Thyroid Neoplasms Indomethacin 16.7114736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Tretinoin 16.7117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D014456 Ulcer Indomethacin 4.8317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.3715867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.3712845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.3718593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.2018462866
MESH:D014570 Urologic Diseases Diazinon 5.2216487989
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4815869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D014839 Vomiting Indomethacin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
Pathway ID Pathway Name
REACT:604 Hemostasis
REACT:14797 Signaling by GPCR
KEGG:04530 Tight junction
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33767
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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