AutismKB 2.0

Annotation Detail for CAND1


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Basic Information Top
Gene Symbol:CAND1 ( DKFZp434M1414,FLJ10114,FLJ10929,FLJ38691,FLJ90441,KIAA0829,TIP120,TIP120A )
Gene Full Name: cullin-associated and neddylation-dissociated 1
Band: 12q14.3-q15
Quick LinksEntrez ID:55832; OMIM: 607727; Uniprot ID:CAND1_HUMAN; ENSEMBL ID: ENSG00000111530; HGNC ID: 30688
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
hippocampal atrophy
Desease Name
Hippocampal atrophy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CAND1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CAND1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CAND1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CAND1 mRNAdecreases expression 15336504
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of CAND1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CAND1 mRNAincreases expression 17108234
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of CAND1 mRNAaffects cotreatment|increases expression 17347304
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.3118926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 11.8318287403
MESH:D000138 Acidosis Ethanol 11.8311192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.7615451040 15451039
MESH:D000853 Anophthalmos Ethanol 5.1815513904
MESH:D001008 Anxiety Disorders Ethanol 4.2311141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D002056 Burns Ethanol 5.0116374292
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.3016705839
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.3015289165 15763234 18788625
MESH:D006332 Cardiomegaly Ethanol 3.5719332462
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0715861022 16105132 11677210 17681005 17110522 16919318 17333356
MESH:D002971 Cleft Lip Ethanol 3.7115513904
MESH:D002972 Cleft Palate Ethanol 3.2715513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3319302082 11873399 15451039 10194807 11198716 15451040 15513904
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.3118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.3111566570
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.8220426865
MESH:D004938 Esophageal Neoplasms Ethanol 4.8216704527
MESH:D005234 Fatty Liver Ethanol 15.0419236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0415345470
MESH:D005234 Fatty Liver Fish Oils 15.0418620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.1117920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.7016946407 10194807 15513904 15451040
MESH:D005756 Gastritis Ethanol 5.1415046732
MESH:D006930 Hyperalgesia Ethanol 3.9418783367
MESH:D006949 Hyperlipidemias Fish Oils 5.0615752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.9511484837
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007569 Jaw Abnormalities Ethanol 4.6915513904
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D007859 Learning Disorders Ethanol 4.5715451040
MESH:D017880 Limb Deformities, Congenital Ethanol 4.0117676605
MESH:D008103 Liver Cirrhosis Ethanol 3.5115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.4918295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3218166357
MESH:D008108 Liver Diseases, Alcoholic Ethanol 5.0117347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876786 6135515 2876784
MESH:D008569 Memory Disorders Ethanol 4.5215451040 18411066
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0512384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7118551238
MESH:D012640 Seizures Ethanol 6.719754883
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 3.8117189318 16755016 9562338 11906479 9211565 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.529754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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