AutismKB 2.0

Annotation Detail for CENPJ


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Basic Information Top
Gene Symbol:CENPJ ( BM032,CPAP,LAP,LIP1,MCPH6,MGC131581,MGC131582,MGC142222,MGC142224,SASS4,Sas-4 )
Gene Full Name: centromere protein J
Band: 13q12.12-q12.13
Quick LinksEntrez ID:55835; OMIM: 609279; Uniprot ID:CENPJ_HUMAN; ENSEMBL ID: ENSG00000151849; HGNC ID: 17272
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500380Centrosome maturation
500381Recruitment of mitotic centrosome proteins and complexes
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
No data
No data
Desease Name
Microcephaly, primary autosomal recessive, 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CENPJ mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CENPJ mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of CENPJ mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in increased expression of CENPJ mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of CENPJ mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of CENPJ mRNAincreases expression 16474171
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of CENPJ mRNAincreases expression 16474171
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 4.6611473722
MESH:D000230 Adenocarcinoma Genistein 4.6611473722
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9617123778
MESH:D001943 Breast Neoplasms Estradiol 1.9616675129 12948864 17261762 18497071 14630087 17018787 19861407 17289903
MESH:D001943 Breast Neoplasms Genistein 1.9617200150 16541309 16873071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7616924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.2218566989
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D003704 Dementia Polychlorinated Biphenyls 4.9816140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6514550746 11287661 12540782 14986274 19416960 15968718 11743745 10915739 11461765 12958197 10663392 14725611 11529661 17906064 19739265 16781746 12153990 17522070 17562736 16177239 10774834 11421492 16109766 19085960 16485898 18071297 16393943 11834606 11739529 16227642 19923254 12705907 18713872 12594235 2444490 19370779 16081117 15619225 19420014 19164858 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms Estradiol 8.0811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 8.0811473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007333 Insulin Resistance bisphenol A 8.0116393666
MESH:D007333 Insulin Resistance Estradiol 8.0116627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.8315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.8318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.8315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D007938 Leukemia Genistein 3.1417468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6317823541
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 19014921 12587719 19460945 16611625 19784758 11587558 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 3.761423854
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6516891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6512929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
OMIM:608393 MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 6 marker/mechanism
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2317141266
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 18.4816427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 18.4816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 18.4816427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1419005980
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4716702228
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.5120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.5120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1016740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1015256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.1015721890
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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