AutismKB 2.0

Annotation Detail for CENPN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CENPN ( BM039,C16orf60,CENP-N,FLJ13607,FLJ22660 )
Gene Full Name: centromere protein N
Band: 16q23.2
Quick LinksEntrez ID:55839; OMIM: 611509; Uniprot ID:CENPN_HUMAN; ENSEMBL ID: ENSG00000166451; HGNC ID: 30873
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CENPN mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of CENPN mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CENPN mRNAaffects expression 17484886
D004958 Estradiol Estradiol results in increased expression of CENPN mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of CENPN mRNAincreases expression 16474171
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CENPN mRNAaffects cotreatment|increases expression 17183730
D015741 Metribolone Metribolone results in increased expression of CENPN mRNAincreases expression 17010675
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of CENPN mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of CENPN mRNAincreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CENPN mRNAincreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CENPN mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9714514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.978875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000230 Adenocarcinoma Estradiol 4.5711473722
MESH:D000230 Adenocarcinoma Genistein 4.5711473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9917688650 18316065 18558336 17507914 18775368 20603192 19460635 15238991 18985861 18396377 16609825 19232924 18940202 18177632 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.318888407
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315845082 15665606 15380490
MESH:D001943 Breast Neoplasms bisphenol A 2.3717123778
MESH:D001943 Breast Neoplasms Estradiol 2.3718497071 19861407 14630087 17261762 17018787 17289903 16675129 12948864
MESH:D001943 Breast Neoplasms Genistein 2.3716541309 16873071 17200150
MESH:D001943 Breast Neoplasms Progesterone 2.3717614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516011737 18705752 16192424 15700767 10355542 15721981 16097048 15673190 16124888 16227642 3786805 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7316924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.4016332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 15668235 16354765 8697196 15340226
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5117688650 16575769 8888407
MESH:D003704 Dementia Polychlorinated Biphenyls 4.8416140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.427440962 19336974 9327722 7120509 2869522 19085960 21278145 3786805 16227642 11566570 17522070 6623471 4309450 3732212 7179309 16177239 10092053 15968718 6884620 15998439 10915739 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4219641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.7816402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.8011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.8011473722
MESH:D004715 Endometriosis Progesterone 9.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.3710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.717562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3415959796 61145 16239168 19224547 17595544 12795759 16045604 12631006
MESH:D005234 Fatty Liver Valproic Acid 8.3414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005909 Glioblastoma Genistein 3.3416598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 18606429 16959395 16354765 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation Progesterone 5.2015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.7316393666
MESH:D007333 Insulin Resistance Estradiol 7.7316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D007938 Leukemia Genistein 3.0918980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8811408273 11903743 17334410 16943688 17157831 16239168 21278145 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0716033810 18205269 20821823 12389079 17869086 16015684 18277467 12666154 17922224 18156304 12649538 15673190 16638106 17708605 14748882 12632514 15931870 18006644 18420326 17805973 14716833 12445418 14724832 18429990 16136751 14620537 18472332 18210741 12609069 10355542 17481882 13678700 11481614 15925388 18395095 15370692 18472094 15338365 17900296 18054572 16097048 18395914 15876570 18251166 18166357 15730626 18339082 16248980 18187930 12546737 15362042 18418968 18481824 12898905 15123356 17761835 17525996 16027843 17766677 18412020 17640975 14512876 16192424 17714472 12632512 17557913 17631135 15818738 17565644 18279442 16011737 17823541 17944888 14716496 18263696 17721639 18317297 18376398 16116963 17698563 18705752 15057751 15893842 15650968 15052691 12445421 12958196 15996030 12667390 15959796 17976157 12741479 12586293
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0717823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1115720792 17285989 16246199 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 10.421423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.5317203775 11408345 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.5314578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.5317203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction Genistein 2.9117141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.8717141266
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations bisphenol A 24.8716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 24.8716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.8716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.8714600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2116359493 8888407
MESH:D010024 Osteoporosis Genistein 3.3319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2316169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Estradiol 8.1519401270
MESH:D010051 Ovarian Neoplasms Genistein 8.1519005980
MESH:D010051 Ovarian Neoplasms Progesterone 8.1516525653 17393432
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4416702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.4310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.4311896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.4320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.0220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.0220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1116740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1116925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.1115721890
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8311044598 15475178 17978042 11738929 3137016 16876388 1511512 14763951
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved