Annotation Detail for ARHGAP15
Basic Information Top
| Gene Symbol: | ARHGAP15 ( BM046 ) |
|---|---|
| Gene Full Name: | Rho GTPase activating protein 15 |
| Band: | 2q22.2-q22.3 |
| Quick Links | Entrez ID:55843; OMIM: 610578; Uniprot ID:RHG15_HUMAN; ENSEMBL ID: ENSG00000075884; HGNC ID: 21030 |
| Relate to Another Database: | SFARIGene; denovo-db |
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| Pathway ID | Pathway Name |
|---|---|
| Signaling by Rho GTPases |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| P00047 | PDGF signaling pathway |
| No data |
| No data |
| No data |
| Desease Name |
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| quantitative traits |
| Desease Name |
|---|
| Quantitative traits |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000638 | Amiodarone | Amiodarone results in increased expression of ARHGAP15 mRNA | increases expression | 19774075 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of ARHGAP15 mRNA | decreases expression | 20064835 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of ARHGAP15 mRNA | increases expression | 17005392 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 2.06 | 20464547 20127859 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 2.88 | 6695378 | |
| MESH:D000686 | Amyloidosis | Diethylstilbestrol | 5.06 | 15469931 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 4.73 | 19183758 | |
| MESH:D001145 | Arrhythmias, Cardiac | Amiodarone | 4.25 | 18057881 18218290 20041841 | |
| MESH:D001281 | Atrial Fibrillation | Amiodarone | 4.23 | 19698954 18651412 | |
| MESH:D001778 | Blood Coagulation Disorders | Amiodarone | 4.38 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.20 | 20146248 17474063 | |
| MESH:D001943 | Breast Neoplasms | Diethylstilbestrol | 2.20 | 17129689 15324884 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylstilbestrol | 2.28 | 15948411 16924424 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 2.14 | 20419170 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Amiodarone | 3.01 | 19225199 15710769 | |
| MESH:D002341 | Carotid Artery Thrombosis | Amiodarone | 5.83 | 18974383 | |
| MESH:D003456 | Cryptorchidism | Diethylstilbestrol | 5.14 | 16002989 12952375 | |
| MESH:D056486 | Drug-Induced Liver Injury | Amiodarone | 2.48 | 15265979 18218290 | |
| MESH:D004714 | Endometrial Hyperplasia | Diethylstilbestrol | 5.43 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | Diethylstilbestrol | 3.73 | 15700306 16804899 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 2.09 | 16530937 | |
| MESH:D005234 | Fatty Liver | Amiodarone | 4.00 | 14986274 | |
| MESH:D052776 | Female Urogenital Diseases | Diethylstilbestrol | 3.89 | 16611131 16534752 16513791 15751030 16002989 | |
| MESH:D005833 | Genital Neoplasms, Female | Diethylstilbestrol | 5.69 | 16452187 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 2.85 | 20471113 | |
| MESH:D006529 | Hepatomegaly | Amiodarone | 4.40 | 15265979 | |
| MESH:D006937 | Hypercholesterolemia | Amiodarone | 4.36 | 9751232 8137927 | |
| MESH:D006965 | Hyperplasia | Diethylstilbestrol | 5.09 | 12960047 14722030 | |
| MESH:D007021 | Hypospadias | Diethylstilbestrol | 5.23 | 16002989 | |
| MESH:D007037 | Hypothyroidism | Amiodarone | 5.17 | 18020914 17991464 | |
| MESH:D007246 | Infertility | Diethylstilbestrol | 4.94 | 15036965 | |
| MESH:D007680 | Kidney Neoplasms | Diethylstilbestrol | 3.85 | 15003126 16762066 14681315 | |
| MESH:D007859 | Learning Disorders | Diethylstilbestrol | 4.71 | 17184923 | |
| MESH:D008064 | Lipidoses | Amiodarone | 3.82 | 17567588 15342952 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 5.11 | 20195826 21137059 | |
| MESH:D008113 | Liver Neoplasms | Diethylstilbestrol | 5.11 | 16712894 15890375 | |
| MESH:D008133 | Long QT Syndrome | Amiodarone | 3.92 | 17391786 15350150 11989578 | |
| MESH:D008171 | Lung Diseases | Amiodarone | 3.65 | 12587719 | |
| MESH:D017563 | Lung Diseases, Interstitial | Amiodarone | 5.34 | 18516814 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 1.57 | 18816296 20135361 20869020 6695378 18569708 18520028 20064080 17053015 20464547 | |
| MESH:D008181 | Lupus Nephritis | Diethylstilbestrol | 5.89 | 15166399 | |
| MESH:D008223 | Lymphoma | Diethylstilbestrol | 3.78 | 15700306 | |
| MESH:D052801 | Male Urogenital Diseases | Diethylstilbestrol | 6.38 | 16002989 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 3.53 | 16381670 | |
| MESH:D009181 | Mycoses | Amiodarone | 5.77 | 12754197 17974566 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 5.74 | 11141357 | |
| MESH:D009369 | Neoplasms | Diethylstilbestrol | 5.74 | 15313581 | |
| MESH:D009421 | Nervous System Malformations | Diethylstilbestrol | 4.72 | 11399458 | |
| MESH:D010900 | Pituitary Diseases | Diethylstilbestrol | 6.04 | 14722030 | |
| MESH:D010911 | Pituitary Neoplasms | Diethylstilbestrol | 5.32 | 16977796 15687265 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Diethylstilbestrol | 4.85 | 17184923 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 3.20 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Diethylstilbestrol | 3.20 | 17136230 15046698 15846301 | |
| MESH:D011658 | Pulmonary Fibrosis | Amiodarone | 2.98 | 12490602 11597910 12832656 | |
| OMIM:609620 | SHORT QT SYNDROME 1 | Amiodarone | 5.83 | 18724381 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 2.54 | 19755658 10029692 | |
| MESH:D013088 | Spermatocele | Diethylstilbestrol | 5.58 | 16709447 16002989 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 1.56 | 20155912 2093021 | |
| MESH:D013276 | Stomach Ulcer | Amiodarone | 3.79 | 18087811 | |
| MESH:D013610 | Tachycardia | Amiodarone | 4.87 | 11238279 | |
| MESH:D017180 | Tachycardia, Ventricular | Amiodarone | 4.77 | 19225199 | |
| MESH:D013959 | Thyroid Diseases | Amiodarone | 5.62 | 19731979 | |
| MESH:D013971 | Thyrotoxicosis | Amiodarone | 5.51 | 18020914 19584973 | |
| MESH:D016171 | Torsades de Pointes | Amiodarone | 4.93 | 17467628 11989578 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 5.61 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Diethylstilbestrol | 5.61 | 16452187 17306315 16712894 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Diethylstilbestrol | 4.48 | 16175088 | |
| MESH:D014591 | Uterine Diseases | Diethylstilbestrol | 6.04 | 14652134 | |
| MESH:D014594 | Uterine Neoplasms | Diethylstilbestrol | 4.65 | 15809267 16690809 | |
| MESH:D014625 | Vaginal Neoplasms | Diethylstilbestrol | 5.09 | 16002989 16513791 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:11044 | Signaling by Rho GTPases |
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