AutismKB 2.0

Annotation Detail for PPP2R2D


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Basic Information Top
Gene Symbol:PPP2R2D ( MDS026 )
Gene Full Name: protein phosphatase 2, regulatory subunit B, delta
Band: 10q26.3
Quick LinksEntrez ID:55844; OMIM: NA; Uniprot ID:2ABD_HUMAN; ENSEMBL ID: ENSG00000175470; HGNC ID: 23732
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa05142Chagas disease
hsa04530Tight junction
No data
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPP2R2D mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPP2R2D mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP2R2D mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP2R2D mRNAdecreases expression 19150397
D005419 Flavonoids Flavonoids results in decreased expression of PPP2R2D mRNAdecreases expression 18035473
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PPP2R2D mRNAdecreases expression 19285098
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of PPP2R2D mRNAincreases expression 17560707
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PPP2R2D mRNAincreases expression 17560707
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPP2R2D mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PPP2R2D mRNAincreases expression 18301758
17426115
D018038 Sodium Selenite Sodium Selenite results in increased expression of PPP2R2D mRNAincreases expression 18175754
D014635 Valproic Acid Valproic Acid results in increased expression of PPP2R2D mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 5.4515146954
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618396377 17157402 19232924 18775368 17507914 18316065 19460635 16609825 20603192 17688650 18558336 18177632 18985861 18940202 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.883084413
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3011421492 16081117 12594235 11739529 17562736 12705907 18713872 19739265 19370779 16177239 16485898 14550746 11834606 17906064 19164858 18071297 12392966 14725611 17522070 16109766 19420014 11743745 12153990 19416960 16227642 11461765 12958197 10915739 11529661 16781746 19923254 19085960 15619225 11287661 2444490 15968718 10663392 12540782 16393943 10774834 14986274
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3015131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.3019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema perfluorooctanoic acid 7.4517259670 12083418
MESH:D004487 Edema pirinixic acid 7.4512083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.133922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.717562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver pirinixic acid 8.1919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.1914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2918558336 8888407
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.3517162496
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.303609246
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 19772884 18467677 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 8.2416870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.2412083418
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D007249 Inflammation Flavonoids 5.6617296493
MESH:D007249 Inflammation perfluorooctanoic acid 5.6612083418
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.428812269
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6616610002 19460945 11587558 12969438 12587719 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.777678174
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 7.7714757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 7.7716377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.622876784 6135515 2876786
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.2116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.139802331
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 10.5617132714
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5620603192
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012640 Seizures Valproic Acid 6.2514763951 16876388 3137016 15475178 11044598 17978042 1511512 11738929
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3316049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
Pathway ID Pathway Name
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05160 Hepatitis C
REACT:33953 Metabolism of carbohydrates
KEGG:03015 mRNA surveillance pathway
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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