AutismKB 2.0

Annotation Detail for C3orf10


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Basic Information Top
Gene Symbol:C3orf10 ( MDS027,hHBrk1 )
Gene Full Name: chromosome 3 open reading frame 10
Band: 3p25.3
Quick LinksEntrez ID:55845; OMIM: 611183; Uniprot ID:BRK1_HUMAN; ENSEMBL ID: ; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
200190RAC1 signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in decreased expression of C3ORF10 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of C3ORF10 mRNAdecreases expression 16705744
D019833 Genistein Genistein results in increased expression of C3ORF10 mRNAincreases expression 16705744
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 4.7511473722
MESH:D000230 Adenocarcinoma Genistein 4.7511473722
MESH:D001943 Breast Neoplasms Estradiol 2.2016675129 18497071 17261762 17289903 19861407 12948864 14630087 17018787
MESH:D001943 Breast Neoplasms Genistein 2.2017200150 16541309 16873071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.2616924424
MESH:D002318 Cardiovascular Diseases Genistein 3.5916332659
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.5612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.5618566989
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D003110 Colonic Neoplasms Genistein 2.3417182828
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5616647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D004714 Endometrial Hyperplasia Genistein 5.3316402032
MESH:D016889 Endometrial Neoplasms Estradiol 8.4111473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 8.4111473722
MESH:D005234 Fatty Liver Cyclosporine 3.3419224547
MESH:D005355 Fibrosis Cyclosporine 3.7912168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D005909 Glioblastoma Genistein 3.5216598420
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007333 Insulin Resistance Estradiol 3.2316393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.698314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.6915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.5912371664
MESH:D007680 Kidney Neoplasms Estradiol 8.5915610895
MESH:D007938 Leukemia Genistein 3.2118980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6617823541
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.9816891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.9812929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009203 Myocardial Infarction Genistein 3.0017141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.6816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.6817141266
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 11.7816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 11.7816427766
MESH:D010024 Osteoporosis Genistein 3.5019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.6116169203
MESH:D010051 Ovarian Neoplasms Estradiol 5.2619401270
MESH:D010051 Ovarian Neoplasms Genistein 5.2619005980
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2016740699
MESH:D011471 Prostatic Neoplasms Genistein 3.2015256057 15378649 16925846
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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