AutismKB 2.0

Annotation Detail for PKN1


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Basic Information Top
Gene Symbol:PKN1 ( DBK,MGC46204,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1 )
Gene Full Name: protein kinase N1
Band: 19p13.12
Quick LinksEntrez ID:5585; OMIM: 601032; Uniprot ID:PKN1_HUMAN; ENSEMBL ID: ENSG00000123143; HGNC ID: 9405
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200007RhoA signaling pathway
200143Signaling mediated by p38-gamma and p38-delta
200102Regulation of Androgen receptor activity
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PKN1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PKN1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PKN1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of PKN1 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PKN1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of PKN1 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PKN1 mRNAdecreases expression 18042831
D009151 Mustard Gas Mustard Gas results in increased expression of PKN1 mRNAincreases expression 18955075
C041786 palm oil palm oil results in decreased expression of PKN1 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PKN1 mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0920146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0316705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0018551238 21346803
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema Mustard Gas 7.4511428647 11402378 9260866 11428631
MESH:D004487 Edema pirinixic acid 7.4512083418
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Dietary Fats 14.0817967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 14.0819236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.4212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.4218296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 19176532 18467677 19772884
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007249 Inflammation Dietary Fats 5.5320412841
MESH:D007249 Inflammation Mustard Gas 5.5317524151 11428647 11428620 16001271 8975870 11428631 9357497 9260866 11402378
MESH:D007333 Insulin Resistance Dietary Fats 7.6118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.717678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7121137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.7120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.642876786 2876784 6135515
MESH:D008171 Lung Diseases Mustard Gas 3.5618161513 18702808
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2417365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5718520028 20869020 20464547 17053015 18569708 20135361 6695378 18816296 20064080
MESH:D008175 Lung Neoplasms Mustard Gas 2.573148597 8781369
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2416966607 18303189 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009503 Neutropenia Mustard Gas 4.1516761898 7688884
MESH:D009765 Obesity Dietary Fats 4.5620518802 17217161 11836018 21332399 20132043 16723640 18674790 18457598 19632207
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1110923243
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.1017365031 17322281 15814490 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.1017266442 10334151 17894541 17720292 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012871 Skin Diseases Mustard Gas 2.7515451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4410029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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