AutismKB 2.0

Annotation Detail for DBNDD2


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Basic Information Top
Gene Symbol:DBNDD2 ( C20orf35,CK1BP,HSMNP1 )
Gene Full Name: dysbindin (dystrobrevin binding protein 1) domain containing 2
Band: 20q13.12
Quick LinksEntrez ID:55861; OMIM: 611453; Uniprot ID:DBND2_HUMAN; ENSEMBL ID: ENSG00000204070,ENSG00000244274; HGNC ID: 15881
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DBNDD2 mRNAaffects expression 17562736
D005472 Fluorouracil DBNDD2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D019833 Genistein Genistein results in decreased expression of DBNDD2 mRNAdecreases expression 18847459
C006253 pirinixic acid pirinixic acid results in decreased expression of DBNDD2 mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Fluorouracil 4.8517638652
MESH:D000230 Adenocarcinoma Genistein 4.8511473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000740 Anemia Fluorouracil 4.1117963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.3219217205 15136595 16110121 18357371 18608205 16557594 16595493
MESH:D001943 Breast Neoplasms Genistein 2.3216873071 16541309 17200150
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.883084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8817088986 16799960 18930000 16332177 17971768 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8816924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5818986760 16757204 16280240 17066447
MESH:D002318 Cardiovascular Diseases Genistein 3.5616332659
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0417018589 15001691 17016597 16510598 18772588 17725105 17169374 17172411 17287894 16340194
MESH:D003110 Colonic Neoplasms Genistein 4.0417182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0020501625 18288408 17454858 17016601 18383874 16331619 18802399 18949393 17695437 17094418 16524972 17255274 16282729 14970324 18509181 16391804 15148649 15289873 16303861 17401013 17594712 18448328
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5616647724
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6715968718 16781746 17522070 11529661 11421492 11739529 16177239 11743745 19164858 18071297 17906064 14725611 16227642 11461765 16109766 19416960 11287661 12705907 12958197 17562736 12594235 14550746 10915739 10774834 19739265 12540782 16081117 18713872 19085960 12153990 14986274 15619225 11834606 16393943 19420014 2444490 19923254 12392966 10663392 16485898 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004714 Endometrial Hyperplasia Genistein 5.2216402032
MESH:D016889 Endometrial Neoplasms Genistein 3.6011473722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216785472 15173087 16481741 17638652 16337965
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005909 Glioblastoma Genistein 3.5016598420
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6418337622 15162350 15102660
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6516985049
MESH:D007938 Leukemia Genistein 3.1918980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.5317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5315474484
MESH:D008107 Liver Diseases Acetaminophen 1.7011587558 12969438 12587719 19784758 16611625 19014921 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 4.9316603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 4.9315890375 20007298 16377806
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1712929590 14578162
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9416757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction Genistein 6.1317141266
MESH:D009203 Myocardial Infarction pirinixic acid 6.1319151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.4317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.4316411023
MESH:D009369 Neoplasms Fluorouracil 5.5518239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 5.5517405874
MESH:D009421 Nervous System Malformations Genistein 4.5416427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010024 Osteoporosis Genistein 3.4719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.5516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6919005980
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7715113037 16929163 16500647 19003803
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3319082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 3.3315378649 16925846 15256057
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3815538739 18286688 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016424979 18567086 17522103 19084572 18396642 16951190 15786421 17172411 19015929 17498489
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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