AutismKB 2.0

Annotation Detail for PRKD1


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Basic Information Top
Gene Symbol:PRKD1 ( PKC-MU,PKCM,PKD,PRKCM )
Gene Full Name: protein kinase D1
Band: 14q12
Quick LinksEntrez ID:5587; OMIM: 605435; Uniprot ID:KPCD1_HUMAN; ENSEMBL ID: ENSG00000184304; HGNC ID: 9407
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200084IGF1 pathway
200011LPA receptor mediated events
Pathway IDPathway Name
P00056VEGF signaling pathway
P00018EGF receptor signaling pathway
P00005Angiogenesis
Pathway IDPathway Name
500824Sphingolipid metabolism
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PRKD1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKD1 mRNAaffects expression 16483693
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKD1 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of PRKD1 mRNAdecreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRKD1 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKD1 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRKD1 mRNAdecreases expression 15894712
C070515 bisindolylmaleimide I bisindolylmaleimide I affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKD1 protein]affects phosphorylation|affects reaction 15380616
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRKD1 mRNAaffects expression 17484886
C081021 Go 6976 Go 6976 inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein]affects localization|decreases reaction|increases activity 19124542
C487498 Go 6983 Go 6983 affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKD1 protein]affects phosphorylation|affects reaction 15380616
C011875 ingenol dibenzoate ingenol dibenzoate results in increased activity of PRKD1 proteinincreases activity 15707588
D008345 Manganese Manganese results in increased expression of PRKD1 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of PRKD1 mRNAincreases expression 17175027
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of PRKD1 proteinincreases expression 11794376
C005219 methyl cellosolve methyl cellosolve metabolite results in increased expression of PRKD1 proteinincreases expression 11794376
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of PRKD1 mRNAincreases expression 12634122
D010100 Oxygen Oxygen deficiency results in increased expression of PRKD1 mRNAincreases expression 17175027
D010656 Phenylephrine Phenylephrine affects the localization of PRKD1 proteinaffects localization 19124542
D010656 Phenylephrine Phenylephrine results in increased activity of PRKD1 proteinincreases activity 19124542
D010656 Phenylephrine [Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 proteinaffects localization|increases activity 19124542
D013755 Tetradecanoylphorbol Acetate bisindolylmaleimide I affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKD1 protein]affects phosphorylation|affects reaction 15380616
D013755 Tetradecanoylphorbol Acetate Go 6983 affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKD1 protein]affects phosphorylation|affects reaction 15380616
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the phosphorylation of PRKD1 proteinaffects phosphorylation 15380616
D013755 Tetradecanoylphorbol Acetate Go 6976 inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein]affects localization|decreases reaction|increases activity 19124542
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of PRKD1 proteinaffects localization 19124542
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 proteinaffects localization|increases activity 19124542
D014212 Tretinoin Tretinoin results in increased expression of PRKD1 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 9.341761404 12805644 15959878 3652986 1761407
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 9.343652986 6499812 6474471
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury Oxygen 4.4916759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9720464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.513712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.323699323
MESH:D000756 Anemia, Sideroblastic Manganese 10.8916910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.8916910769
MESH:D000860 Anoxia Oxygen 5.0220872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0717460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.0516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D053627 Asthenozoospermia methyl cellosolve 5.493987992
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis Oxygen 3.7816391483
MESH:D001284 Atrophy methyl cellosolve 5.153699323 2626667 6705890
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.5716197459 16206674
MESH:D001919 Bradycardia Phenylephrine 4.5115306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Oxygen 2.0117263869
MESH:D001943 Breast Neoplasms Tretinoin 2.0116166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7416227642 16097048 15673190 16050911 15700767 3786805 15721981 16124888 16192424 16011737 10355542 18705752
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.553581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5518788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.551917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5220419170
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.5218922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5216051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 3.5111179087 11754973 17287366 15728586 16170337 17124262
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.017505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.012727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D002764 Cholecystitis methyl cellosolve 5.776499794
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.1119486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tretinoin 2.659407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms arsenite 2.5815037631
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.776499821 12530607
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829224671 10589399 9211117 16925845 8800419 17551590 9664655 9142499 9125849 14991402
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7711906362 8156756 14531868 8970840 2524372 11298694 18759878 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.848291058 18648102 18692083 7440962 9022650 9653073 18289764 9328219 6482804 1440618 6679447 11289319 16192314
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.846623471 16177239 7179309 17522070 15027814 9327722 11566570 7440962 6884620 16227642 15998439 15968718 10092053 10915739 3732212 3786805 21278145 19336974 7120509 19085960 4309450 2869522
MESH:D004417 Dyspnea Oxygen 4.8020016425
MESH:D004487 Edema bisindolylmaleimide I 7.578273558
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.5711698051 15177302 8113982 8273558 7812673 16716910 9599246
MESH:D004489 Edema, Cardiac Tretinoin 4.4418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0816569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.323581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3216530937
MESH:D005124 Eye Abnormalities Tretinoin 3.549664655 16938888
MESH:D005234 Fatty Liver arsenite 7.9118296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.9112631006 16045604 12795759 19224547 17595544 61145 15959796 16239168
MESH:D005327 Fetal Resorption methyl cellosolve 5.526499812 6499821 3987992 6474471
MESH:D020567 Fetal Weight methyl cellosolve 5.776499812 6474471 6499821
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D005355 Fibrosis arsenite 14.6918296743
MESH:D005355 Fibrosis Carbon Tetrachloride 14.6918705752
MESH:D005355 Fibrosis Tretinoin 14.6917994277
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 12.353652986
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 12.353652986
MESH:D005739 Gas Poisoning Oxygen 5.1920016425
MESH:D005909 Glioblastoma Manganese 7.3517043766
MESH:D005909 Glioblastoma Tretinoin 7.3517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5814991402 9664655
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.746499821
MESH:D006461 Hemolysis methyl cellosolve 5.4217874071
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.096705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0919110552 19900420
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Phenylephrine 3.0512717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D006984 Hypertrophy Phenylephrine 4.5118502941 12791704
MESH:D007248 Infertility, Male methyl cellosolve 4.063987992
MESH:D007249 Inflammation bisindolylmaleimide I 5.838273558
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.837562506 8273558 11698051 15177302 7812673
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 3.8617551590 15992940
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.936582329
MESH:D007938 Leukemia Tretinoin 2.7517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1219075265 17712046 16823087 16140955 17506722 17368321 16891316 15748426 12679006 16331271 17294898 17301526 19029980 16766008 17649720 16935935 19035177 17217047 17361223 9834237 17107899 17339181 19642359 19225113 16788101
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 13.8015959878 12805644
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 13.806499821
MESH:D017880 Limb Deformities, Congenital Tretinoin 13.809224671
MESH:D008103 Liver Cirrhosis arsenite 6.7518296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7511408273 16239168 16221502 21278145 17174718 16943688 11903743 17157831 17334410
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4810355542 16248980 15123356 17922224 18420326 15673190 11481614 16011737 15876570 18210741 18205269 17708605 17721639 16097048 12546737 14716496 17525996 18263696 16192424 17823541 16027843 12666154 17631135 15370692 18705752 14512876 18279442 14620537 12898905 12649538 17944888 16638106 16116963 17698563 17766677 18472094 18339082 17761835 17565644 15052691 18481824 15818738 15362042 16033810 12741479 12389079 18317297 18006644 18166357 14748882 17557913 17805973 18187930 15931870 18429990 15730626 12958196 15338365 18418968 18395095 13678700 17869086 18395914 18277467 18376398 18054572 12445421 17481882 15057751 15925388 17714472 14716833 18156304 15959796 17640975 16136751 12667390 12632514 12586293 12445418 15893842 17900296 14724832 17976157 20821823 12609069 12632512 18472332 18412020 16015684 15996030 18251166 15650968
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4818397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0715720792 16246199 16964402 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4619294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.82598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.8212014681 15583823
MESH:D055370 Lung Injury Oxygen 4.4718339021
MESH:D008175 Lung Neoplasms arsenite 3.5616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5618816296 20135361 20464547 20064080 18569708 20869020 17053015 18520028 6695378
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.5611807781
MESH:D008231 Lymphopenia methyl cellosolve 5.743699323
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.338985016
MESH:D020149 Manganese Poisoning Manganese 5.4916551646 19453300 16568477
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.8517671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009069 Movement Disorders Manganese 4.9716551646
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.453581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9211141357
MESH:D009369 Neoplasms Tretinoin 4.9216946489 16594593
MESH:D009389 Neovascularization, Pathologic arsenite 4.3815738583
MESH:D009410 Nerve Degeneration Manganese 4.2416551646
MESH:D009421 Nervous System Malformations Tretinoin 3.749125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.136679447
MESH:D009436 Neural Tube Defects Tretinoin 7.139142499
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009845 Oligospermia methyl cellosolve 5.143987992
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3316936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.4615976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.267296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 9.2612065085 18922899 18404319 8330346
MESH:D010300 Parkinson Disease Manganese 3.3611181820
MESH:D020734 Parkinsonian Disorders Manganese 4.4316140633
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 4.916499817 7974496 12530607
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9917292933
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.4717627322 18339021
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616283617 16116481
MESH:D012852 Sinusitis Phenylephrine 4.677327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4310029692 19755658
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.4312065085 18404319 11807781 8330346 8985016
MESH:D012878 Skin Neoplasms Tretinoin 9.4316467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.342093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3417261132
MESH:D013398 Sudden Infant Death Oxygen 5.5112563064
MESH:D013576 Syndactyly methoxyacetic acid 5.591761404 1761407
MESH:D013733 Testicular Diseases methoxyacetic acid 10.986499806 18486176
MESH:D013733 Testicular Diseases methyl cellosolve 10.986499806
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.026582329 1399818 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.918074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9117053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33771
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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