AutismKB 2.0

Annotation Detail for ASH1L


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Basic Information Top
Gene Symbol:ASH1L ( ASH1,ASH1L1,FLJ10504,KIAA1420,KMT2H )
Gene Full Name: ash1 (absent, small, or homeotic)-like (Drosophila)
Band: 1q22
Quick LinksEntrez ID:55870; OMIM: 607999; Uniprot ID:ASH1L_HUMAN; ENSEMBL ID: ENSG00000116539; HGNC ID: 19088
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00310Lysine degradation
hsa04530Tight junction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ASH1L mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ASH1L mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ASH1L mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ASH1L mRNAdecreases expression 19150397
D004317 Doxorubicin Doxorubicin results in decreased expression of ASH1L mRNAdecreases expression 17888722
D004958 Estradiol Estradiol results in decreased expression of ASH1L mRNAdecreases expression 20068009
C017947 sodium arsenite sodium arsenite results in increased expression of ASH1L mRNAincreases expression 16322246
C025643 vinclozolin vinclozolin affects the expression of ASH1L mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of ASH1L mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 4.6917418594
MESH:D000230 Adenocarcinoma Estradiol 4.6911473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3517306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.2416115903 15136595 11325840 15993339 19526202 15939500 15668708 18382427 17426702 16595493 15567936 16826403 16935488 15994142 18234424 15692762 17983394 16096432 17369602 18695136 15634643 16264153 16322301 18628466
MESH:D001943 Breast Neoplasms Estradiol 2.2418497071 17289903 19861407 12948864 14630087 16675129 17261762 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.263084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.2616234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.2616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.2616507464 15276417 17306315
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2716201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.046189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0418572023
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017519947 17974986 15476868 16269455 16242529 18627295 16455267 16651473 16364871 15505089 17308081 17382496 17329180 16109756 17131338 17924179 15792986 17351982 17007740 16731534 16278810 16952015 16612575 15811867 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0216243910 17334414
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.586135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.5820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.5818566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.5819524636 20056578
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6412392966 18071297 15619225 17906064 14986274 19739265 16081117 16177239 16109766 11739529 19420014 12705907 11834606 19085960 16227642 16781746 17522070 14725611 12958197 19416960 11421492 11287661 12153990 15968718 19923254 11743745 12540782 11461765 14550746 10915739 17562736 18713872 2444490 19370779 10774834 16485898 19164858 10663392 12594235 11529661 16393943
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.6417416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.1117359293
MESH:D016889 Endometrial Neoplasms Estradiol 8.1119148513 18566989 11473722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 3.6717875725 12587719 16495754 16330681 16244372 16707910 18006777 17888722 16879835 16144979 16244371 18674790 14766674
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D006689 Hodgkin Disease Doxorubicin 8.3118501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 8.3112676792
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007248 Infertility, Male sodium arsenite 7.4412646999 15346721
MESH:D007248 Infertility, Male vinclozolin 7.4416467254
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 15.6715629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 15.6715699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 15.6715618244
MESH:D007674 Kidney Diseases sodium arsenite 15.6720008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms Estradiol 8.1515610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6614659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6811587558 16611625 12587719 12969438 16610002 19014921 19784758 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.907678174
MESH:D008113 Liver Neoplasms sodium arsenite 4.9015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.616135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.6117085340 16842330
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms Doxorubicin 2.7017418594 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 2.7017077188 16712894 17306315 15276417 19931552
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.6815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6817203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008545 Melanoma Doxorubicin 3.5916827129
MESH:D008545 Melanoma sodium arsenite 3.5919082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0419429709 15857846
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009369 Neoplasms sodium arsenite 2.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2516889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 3.9816427766 11399458
MESH:D009436 Neural Tube Defects sodium arsenite 3.3112854658
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010051 Ovarian Neoplasms Estradiol 5.0819401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0817306315 15276417
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.5515897917 16729912 15749863 18437689 16888761 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 2.5516740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5516039940
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D012509 Sarcoma Doxorubicin 4.2517203757 15625365 17710206 18313854 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Doxorubicin 6.3115692506
MESH:D012878 Skin Neoplasms sodium arsenite 6.3118572023 19524636
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9315625365 17203757 16767912
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5817909728 16010429
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9216049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.9217653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.9216712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817638931 17334414 16364871 17678736
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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