AutismKB 2.0

Annotation Detail for PBK


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Basic Information Top
Gene Symbol:PBK ( CT84,FLJ14385,Nori-3,SPK,TOPK )
Gene Full Name: PDZ binding kinase
Band: 8p21.1
Quick LinksEntrez ID:55872; OMIM: 611210; Uniprot ID:TOPK_HUMAN; ENSEMBL ID: ENSG00000168078; HGNC ID: 18282
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2051Leukemia
2053Colon cancer
2239Lymphoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PBK mRNAincreases expression 19031421
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of PBK mRNAincreases expression 20713471
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PBK mRNAdecreases expression 16788091
D000082 Acetaminophen Acetaminophen results in decreased expression of PBK mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PBK proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PBK mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PBK mRNAdecreases expression 17942131
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PBK mRNAdecreases expression 20382639
C053541 bicalutamide bicalutamide results in decreased expression of PBK mRNAdecreases expression 15638997
C006780 bisphenol A bisphenol A affects the expression of PBK mRNAaffects expression 19490990
C006780 bisphenol A bisphenol A results in increased expression of PBK mRNAincreases expression 16474171
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of PBK mRNAdecreases expression 17942131
D002104 Cadmium Cadmium results in increased expression of PBK mRNAincreases expression 19031421
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PBK mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of PBK mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of PBK mRNAdecreases expression 17942131
D004958 Estradiol Estradiol results in decreased expression of PBK mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of PBK mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PBK mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PBK mRNAincreases expression 17942748
D005047 Etoposide PBK protein affects the susceptibility to Etoposideaffects response to substance 16217747
D019833 Genistein Genistein affects the expression of PBK mRNAaffects expression 18847459
D019833 Genistein Genistein results in increased expression of PBK mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of PBK mRNAincreases expression 20713471
D016685 Mitomycin PBK protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009532 Nickel Nickel results in increased expression of PBK mRNAincreases expression 19031421
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of PBK mRNA]affects reaction|increases expression 19555225
C006253 pirinixic acid pirinixic acid results in increased expression of PBK mRNAincreases expression 18301758
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of PBK mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of PBK mRNAincreases expression 18070364
C059514 resveratrol resveratrol results in decreased expression of PBK mRNAdecreases expression 15767336
D013629 Tamoxifen Tamoxifen affects the expression of PBK mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PBK mRNAincreases expression 17942748
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of PBK mRNAincreases expression 19031421
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of PBK mRNAincreases expression 19031421
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of PBK mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5715322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6016538975
MESH:D055371 Acute Lung Injury Nickel 8.3916166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.3918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.5320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.5311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5314692618
MESH:D000230 Adenocarcinoma Genistein 9.5311473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.356695378
MESH:D000236 Adenoma Methylcholanthrene 10.3510545420 6695378
MESH:D000236 Adenoma resveratrol 10.3515688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D000544 Alzheimer Disease Ozone 4.1615513908
MESH:D000544 Alzheimer Disease resveratrol 4.1616162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7915885639
MESH:D001169 Arthritis, Experimental resveratrol 6.7917115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4915570426
MESH:D001249 Asthma Ozone 2.5516373670 17854713
MESH:D050197 Atherosclerosis Cadmium 10.2215687053
MESH:D050197 Atherosclerosis Methylcholanthrene 10.2211922910
MESH:D050197 Atherosclerosis resveratrol 10.2216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.8814601052
MESH:D001862 Bone Resorption bisphenol A 3.6111985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 3.9815845082 15380490 15665606
MESH:D002545 Brain Ischemia resveratrol 4.0017600658
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 10.7611921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.7617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 10.7617123778
MESH:D001943 Breast Neoplasms Estradiol 10.7619861407 12948864 17018787 17289903 18497071 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms Etoposide 10.7616322251
MESH:D001943 Breast Neoplasms Genistein 10.7617200150 16541309 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 10.7617474063
MESH:D001943 Breast Neoplasms Nickel 10.7615986119
MESH:D001943 Breast Neoplasms Progesterone 10.7617614352 16175315 15562024
MESH:D001943 Breast Neoplasms resveratrol 10.7617651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 10.7620065188 20859285 18351453 16873071 19059307 19189210 19487384 20544844 19244106 19155303 16818667 19115204 18984771 19084267 17049068 19221464 19066611 17893378 19289846 19189212 18855134 19011961 18821012 15668708 20005174 21152245 16202921 15565566 19410462 19142967 19103187 18629630 16273361 18815881 19288272 20135344 18425577 19200415 17261762 11161223 21138602 20390343 18997820 17242785 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.7620435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 10.7615986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4615516495 18417511 18315731 14754758 19059883 16777450 17626835
MESH:D002100 Cachexia Ozone 4.4616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5116050911 16011737 15673190 16097048 15721981 10355542 16227642 16124888 15700767 18705752 16192424 3786805
MESH:D002277 Carcinoma Methylcholanthrene 7.6110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.333084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.3312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.3318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.3316924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.3316227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7117123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3116675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1420419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.1416227395
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.1418922899
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 6.8816332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.8815458977
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 19.0917332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.0912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.0918566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 19.0916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Cyclosporine 12.1619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.1611677210 16919318 17333356 17681005 17110522 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 12.1619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9915668235 16354765 12621046 15340226 8697196
MESH:D003092 Colitis resveratrol 3.8616474422
MESH:D003110 Colonic Neoplasms Genistein 3.7517182828
MESH:D003110 Colonic Neoplasms resveratrol 3.7516338953
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8815531428
MESH:D015179 Colorectal Neoplasms resveratrol 2.8816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5716507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4516140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.6917244072 17100760 19470301
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact Nickel 4.382952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5516873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.0916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.6819279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.6816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.6216177239 17906064 19923254 11287661 11743745 19416960 2444490 18071297 19370779 10663392 16393943 12153990 16081117 11421492 18713872 11461765 17562736 14986274 19420014 16227642 11529661 16781746 12540782 12958197 19164858 16109766 12594235 11834606 19085960 19739265 12392966 12705907 14550746 14725611 15968718 10915739 15619225 17522070 11739529 10774834 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.6210915739 3786805 19085960 3732212 17522070 15027814 15968718 7179309 2869522 19336974 6623471 11566570 9327722 7120509 16227642 10092053 16177239 6884620 21278145 7440962 15998439 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004487 Edema pirinixic acid 14.4212083418
MESH:D004487 Edema resveratrol 14.428985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.4211000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 14.428273558 11698051 8113982 9599246 16716910 15177302 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.7412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.7417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 19.7417872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.7419031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3116402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.4111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.4111473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.4116202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Progesterone 8.1316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1310568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5717923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.9815959796 61145 12795759 16045604 12631006 17595544 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 21.9819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.9815345470
MESH:D005234 Fatty Liver pirinixic acid 21.9820131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 21.9819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9019069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6614633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.1218705752
MESH:D005355 Fibrosis Cyclosporine 13.1212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1220067830
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Genistein 3.0816598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.3518467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3516120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006561 Herpes Simplex Etoposide 9.1710809021
MESH:D006561 Herpes Simplex resveratrol 9.1716876885
MESH:D015658 HIV Infections Nickel 3.6717263646
MESH:D006689 Hodgkin Disease Etoposide 3.6416200630 16135485 18180244 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7616354765 15340226 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006937 Hypercholesterolemia resveratrol 3.7617188708
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006949 Hyperlipidemias resveratrol 3.7716873680
MESH:D006973 Hypertension Cyclosporine 4.5810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.5715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.5717600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3117937319
MESH:D007249 Inflammation Nickel 18.0716166738
MESH:D007249 Inflammation Progesterone 18.0715869954
MESH:D007249 Inflammation resveratrol 18.0716366677
MESH:D007249 Inflammation Tamoxifen 18.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.0712200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 18.0711698051 8273558 15177302 7812673 7562506
MESH:D007251 Influenza, Human resveratrol 4.2616624496
MESH:D007333 Insulin Resistance bisphenol A 11.2716393666
MESH:D007333 Insulin Resistance Estradiol 11.2716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.2716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1215629191 12587719
MESH:D007674 Kidney Diseases Cadmium 13.1216322080 16962696 16226777
MESH:D007674 Kidney Diseases Cyclosporine 13.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.1215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.0712371664
MESH:D007680 Kidney Neoplasms Estradiol 11.0715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.0718625569
MESH:D007938 Leukemia Genistein 2.8917468513 18980019
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4016087638
MESH:D008064 Lipidoses Tamoxifen 2.9615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6617334410 16221502 16943688 11903743 16239168 17157831 11408273 21278145 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2416027843 15818738 16011737 17869086 15362042 17714472 14716833 12649538 17976157 15730626 18420326 15370692 15338365 18472332 18263696 18251166 17631135 18277467 17708605 14724832 18481824 18472094 17805973 18376398 16033810 12546737 17721639 16015684 12958196 15650968 16248980 14748882 16192424 14512876 17766677 11481614 18205269 18317297 17761835 16116963 12586293 16136751 13678700 12632514 18156304 12389079 18339082 18006644 18279442 12445418 18187930 14620537 15052691 17823541 15123356 17557913 12609069 20821823 17944888 18705752 18395095 18412020 15673190 17922224 18166357 17565644 18418968 15925388 16097048 16638106 18210741 12898905 17525996 15057751 17900296 18395914 17640975 15893842 12667390 17481882 10355542 12666154 15996030 17698563 12741479 15931870 12445421 18054572 18429990 14716496 15959796 12632512 15876570
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.2417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2412878042
MESH:D008107 Liver Diseases Acetaminophen 6.2412969438 16610002 11587558 16611625 19460945 19784758 12587719 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2417285989 15830285 16964402 15720792 16246199
MESH:D008107 Liver Diseases Tetrachloroethylene 6.2417267091
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6116899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.052125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.0521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.0519294768
MESH:D008113 Liver Neoplasms Mitomycin 24.0515113037
MESH:D008113 Liver Neoplasms pirinixic acid 24.0520007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 24.0519812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 24.0516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.0516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.138603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.1312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 21.13598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 21.131423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.1312151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 21.137955063
MESH:D008171 Lung Diseases Ozone 3.1919066396 8266340
MESH:D055370 Lung Injury Ozone 3.5820417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.1314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.1320869020 18520028 18569708 20135361 18816296 6695378 20064080 17053015 20464547
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.1316337739 20970405 7750092 10545420 15390079 11893704 17909032 6695378 20512841 21163286 9230183 16271038 1399818
MESH:D008175 Lung Neoplasms Ozone 10.137614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 10.1318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1319555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 10.1311807781
MESH:D008223 Lymphoma Etoposide 3.7312556972 12854902
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.0715688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.0719428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 25.7811921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 25.7811408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 25.7814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 25.7811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 25.788985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 25.7811731420 19196723 14580682 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 25.788985016
MESH:D020149 Manganese Poisoning Estradiol 11.7019453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7019453300
MESH:D008545 Melanoma resveratrol 3.2817992120
MESH:D008545 Melanoma Tamoxifen 3.2812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008659 Metabolic Diseases resveratrol 4.1317112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D008679 Metaplasia Ozone 4.8210496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9816381670
MESH:D009101 Multiple Myeloma resveratrol 3.2714749477 17164350 16490592 16267019 17049120 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009203 Myocardial Infarction Genistein 8.8117141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.8119151258
MESH:D009203 Myocardial Infarction resveratrol 8.8117188708 17015251 16525036 16456233 17125593 16317513
MESH:D017202 Myocardial Ischemia resveratrol 8.2817015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.9516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.9517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.9516411023
MESH:D009205 Myocarditis resveratrol 4.4817322642
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.5911141357
MESH:D009369 Neoplasms pirinixic acid 7.5917405874
MESH:D009369 Neoplasms Tetrachloroethylene 7.5911911487
MESH:D009374 Neoplasms, Experimental resveratrol 3.738985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0519348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.2516427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.2511399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.2516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.2514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6018514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6017652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1417929310
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D010024 Osteoporosis Genistein 3.0819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.3016169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.3017513867
MESH:D010049 Ovarian Diseases bisphenol A 4.7111985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.3919401270
MESH:D010051 Ovarian Neoplasms Genistein 7.3919005980
MESH:D010051 Ovarian Neoplasms Progesterone 7.3916525653 17393432
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms Etoposide 8.3419003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.3415113037
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.3415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.0218922899 18404319 12065085 8330346
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.2916702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1015687053
MESH:D010538 Peritonitis Ozone 3.8616369182
MESH:D011014 Pneumonia Ozone 4.1218007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.6710548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 14.6716679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.6711222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4317292933
MESH:D011471 Prostatic Neoplasms bicalutamide 3.4318487222 19240160 15638997 19011039 17914592
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4316740699
MESH:D011471 Prostatic Neoplasms Cadmium 3.4317075824
MESH:D011471 Prostatic Neoplasms Estradiol 3.4316740699
MESH:D011471 Prostatic Neoplasms Etoposide 3.4317172428
MESH:D011471 Prostatic Neoplasms Genistein 3.4315256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 3.4315721890
MESH:D011471 Prostatic Neoplasms resveratrol 3.4317804756 17675339 17636462 16731767 15767336 17718901
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.4315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5110548101
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1119058328
MESH:D015427 Reperfusion Injury resveratrol 6.1117520802 15827377 16317513 16314181 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012512 Sarcoma, Ewing's Etoposide 4.4414601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5019755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 12.5015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.508330346 12065085 18404319 11807781 8985016
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013088 Spermatocele Tamoxifen 10.6116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9419457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.7116045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms resveratrol 3.9716227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.6317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.6317572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.8617473185
MESH:D014591 Uterine Diseases bisphenol A 4.7214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6114692618
MESH:D014594 Uterine Neoplasms resveratrol 8.6117044934
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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