AutismKB 2.0

Annotation Detail for GABRQ


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Basic Information Top
Gene Symbol:GABRQ ( MGC129629,MGC129630,THETA )
Gene Full Name: gamma-aminobutyric acid (GABA) receptor, theta
Band: Xq28
Quick LinksEntrez ID:55879; OMIM: 300349; Uniprot ID:GBRT_HUMAN; ENSEMBL ID: ENSG00000147402; HGNC ID: 14454
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRQ mRNAaffects expression 16483693
D003975 Diazepam Diazepam results in increased expression of GABRQ mRNAincreases expression 15802192
C033457 phenobarbital quinidine phenobarbital quinidine results in increased expression of GABRQ mRNAincreases expression 15802192
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D001008 Anxiety Disorders Diazepam 5.5618313124 16284244
MESH:D002972 Cleft Palate Diazepam 4.513629520
MESH:D004421 Dystonia Diazepam 6.201851702
MESH:D004828 Epilepsies, Partial Diazepam 6.403922381
MESH:D004827 Epilepsy Diazepam 4.74821787
MESH:D004832 Epilepsy, Absence Diazepam 5.626401628 6426943
MESH:D012640 Seizures Diazepam 4.6415946322 10087439 9754883
MESH:D013375 Substance Withdrawal Syndrome Diazepam 5.899754883
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28504
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
    DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00842 potentiator Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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