Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MLL5 mRNA | decreases expression | 19150397
|
D004958 |
Estradiol |
Estradiol results in decreased expression of MLL5 mRNA | decreases expression | 20068009
|
D005472 |
Fluorouracil |
MLL5 protein affects the susceptibility to Fluorouracil | affects response to substance | 18818388
|
D010656 |
Phenylephrine |
Phenylephrine results in decreased expression of MLL5 mRNA | decreases expression | 18158353
|
C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of MLL5 mRNA | decreases expression | 17426115
|
D013749 |
Tetrachlorodibenzodioxin |
Tetrachlorodibenzodioxin affects the expression of MLL5 mRNA | affects expression | 18691609
|
C025643 |
vinclozolin |
vinclozolin affects the expression of MLL5 mRNA | affects expression | 19015723
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.24 | 14514962 11752688 15322242 |
MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.42 | 18653653 |
MESH:D000230 |
Adenocarcinoma |
|
Estradiol |
4.64 | 11473722 |
MESH:D000230 |
Adenocarcinoma |
|
Fluorouracil |
4.64 | 17638652 |
MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
11.26 | 16434500 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
11.26 | 16835633 |
MESH:D000740 |
Anemia |
|
Fluorouracil |
9.58 | 17963324 15504547 16511603 |
MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
9.58 | 11748828 |
MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
3.86 | 19015723 |
MESH:D001145 |
Arrhythmias, Cardiac |
|
Phenylephrine |
4.38 | 17460149 |
MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
9.73 | 19483382 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
9.73 | 12125929 |
MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.23 | 15340226 |
MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
2.93 | 15746008 |
MESH:D001919 |
Bradycardia |
|
Phenylephrine |
4.94 | 15306635 |
MESH:D001943 |
Breast Neoplasms |
|
Estradiol |
1.85 | 14630087 16675129 17289903 19861407 17018787 17261762 18497071 12948864 |
MESH:D001943 |
Breast Neoplasms |
|
Fluorouracil |
1.85 | 16595493 15136595 18608205 18357371 16557594 16110121 19217205 |
MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.85 | 20435547 |
MESH:D002181 |
Candidiasis, Vulvovaginal |
|
Estradiol |
4.86 | 16111702 |
MESH:D002276 |
Carcinoid Tumor |
|
Fluorouracil |
5.11 | 16051944 |
MESH:D002277 |
Carcinoma |
|
Fluorouracil |
8.94 | 17121937 |
MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
8.94 | 16835633 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Estradiol |
3.19 | 16924424 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Fluorouracil |
3.19 | 16332177 18930000 17045692 17088986 17971768 16799960 |
MESH:D002292 |
Carcinoma, Renal Cell |
|
Fluorouracil |
3.13 | 18695887 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Fluorouracil |
2.55 | 18986760 16757204 16280240 17066447 |
MESH:D006332 |
Cardiomegaly |
|
Phenylephrine |
7.34 | 16170337 17124262 17287366 11754973 11179087 15728586 |
MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
7.34 | 18850075 18670907 16120746 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7.26 | 20889678 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
Estradiol |
7.26 | 18566989 |
MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.41 | 16835633 |
MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.03 | 19176532 |
MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.20 | 15668235 15340226 12621046 8697196 16354765 |
MESH:D003110 |
Colonic Neoplasms |
|
Fluorouracil |
2.27 | 16510598 18772588 15001691 17287894 17725105 17018589 17172411 17016597 17169374 16340194 |
MESH:D015179 |
Colorectal Neoplasms |
|
Fluorouracil |
2.00 | 14970324 16331619 18448328 17401013 17255274 16282729 18288408 18509181 17016601 17695437 17594712 16303861 18949393 18383874 15289873 15148649 16391804 17454858 17094418 16524972 20501625 18802399 |
MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.31 | 14669216 17141729 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.26 | 20055451 10048152 15322242 |
MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.67 | 14966744 |
MESH:D007644 |
Darier Disease |
|
Fluorouracil |
5.19 | 16733453 |
MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.53 | 18249437 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.72 | 17107852 |
MESH:D003928 |
Diabetic Nephropathies |
|
Estradiol |
3.66 | 19279558 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
1.59 | 20420201 |
MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
2.96 | 11462148 |
MESH:D004487 |
Edema |
|
pirinixic acid |
7.48 | 12083418 |
MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
7.48 | 11000095 12711302 |
MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.35 | 18230668 15322242 16714409 |
MESH:D016889 |
Endometrial Neoplasms |
|
Estradiol |
3.15 | 11473722 18566989 19148513 |
MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.29 | 9294722 10568697 |
MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.71 | 20426865 |
MESH:D004938 |
Esophageal Neoplasms |
|
Fluorouracil |
4.71 | 16785472 15173087 17638652 16337965 16481741 |
MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.21 | 11564622 |
MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.04 | 20131406 19236843 |
MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
3.81 | 11858732 |
MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
3.31 | 20067830 |
MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.33 | 16973722 |
MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
5.74 | 16417039 |
MESH:D005910 |
Glioma |
|
Fluorouracil |
2.96 | 16145905 |
MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
5.04 | 10696789 |
MESH:D006258 |
Head and Neck Neoplasms |
|
Fluorouracil |
3.56 | 18337622 15162350 15102660 |
MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
2.46 | 11294989 10048152 |
MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.69 | 20558911 |
MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.62 | 11000095 |
MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
9.48 | 19772884 18467677 19176532 16221962 |
MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
9.48 | 15340226 12621046 16120746 |
MESH:D006558 |
Herpes Genitalis |
|
Estradiol |
5.48 | 15709030 |
MESH:D019584 |
Hot Flashes |
|
Estradiol |
4.19 | 17088409 |
MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.49 | 8697196 16354765 16959395 18606429 15340226 |
MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.45 | 20558911 |
MESH:D006973 |
Hypertension |
|
Phenylephrine |
5.60 | 12717712 8949925 |
MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
5.60 | 18670907 18850075 |
MESH:D006984 |
Hypertrophy |
|
Phenylephrine |
4.84 | 12791704 18502941 |
MESH:D007248 |
Infertility, Male |
|
vinclozolin |
3.21 | 16467254 |
MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
1.98 | 12878042 12200463 |
MESH:D007333 |
Insulin Resistance |
|
Estradiol |
7.77 | 16627594 16393666 |
MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
7.77 | 16306350 |
MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.62 | 16580747 |
MESH:D007674 |
Kidney Diseases |
|
Estradiol |
2.72 | 15618244 |
MESH:D007680 |
Kidney Neoplasms |
|
Estradiol |
8.27 | 15610895 |
MESH:D007680 |
Kidney Neoplasms |
|
Fluorouracil |
8.27 | 16985049 |
MESH:D007938 |
Leukemia |
marker/mechanism |
|
| 18818388 |
MESH:D007951 |
Leukemia, Myeloid |
marker/mechanism |
|
| 18854576 |
MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
5.13 | 16417039 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Estradiol |
3.52 | 14659978 14716833 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
3.52 | 15474484 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
3.52 | 12878042 |
MESH:D008113 |
Liver Neoplasms |
|
Fluorouracil |
7.89 | 16603448 17045692 15113037 18383874 |
MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
7.89 | 20007298 16377806 15890375 |
MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
7.89 | 16984957 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
2.26 | 12151625 |
MESH:D008175 |
Lung Neoplasms |
|
Fluorouracil |
2.41 | 15246190 |
MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
2.41 | 19555203 11884234 |
MESH:D008178 |
Lupus Erythematosus, Cutaneous |
|
Fluorouracil |
5.19 | 15086387 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Estradiol |
2.72 | 11807958 11408345 16891317 17203775 |
MESH:D020149 |
Manganese Poisoning |
|
Estradiol |
4.93 | 19453300 |
MESH:D009062 |
Mouth Neoplasms |
|
Fluorouracil |
3.84 | 18986760 16757204 |
MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.86 | 16239165 |
MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.24 | 19151258 |
MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.24 | 12213967 |
MESH:D015428 |
Myocardial Reperfusion Injury |
|
Estradiol |
8.96 | 16810080 |
MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
8.96 | 16411023 |
MESH:D009369 |
Neoplasms |
|
Fluorouracil |
5.39 | 16928823 18600527 18239605 |
MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.39 | 17405874 |
MESH:D009389 |
Neovascularization, Pathologic |
|
Estradiol |
4.13 | 17289903 |
MESH:D009421 |
Nervous System Malformations |
|
Estradiol |
10.58 | 16427766 11399458 |
MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
10.58 | 14600291 |
MESH:D020258 |
Neurotoxicity Syndromes |
|
Fluorouracil |
3.61 | 16436463 |
MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
MESH:D010051 |
Ovarian Neoplasms |
|
Estradiol |
2.29 | 19401270 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Fluorouracil |
2.74 | 16929163 19003803 16500647 15113037 |
MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
4.69 | 12520081 |
MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
3.89 | 18163543 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
10.84 | 11118676 11222880 11896295 11399792 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
10.84 | 18220299 19015723 18042343 |
MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.33 | 18220299 |
MESH:D019048 |
Prostatic Intraepithelial Neoplasia |
|
Estradiol |
4.17 | 20887781 |
MESH:D011471 |
Prostatic Neoplasms |
|
Estradiol |
3.21 | 16740699 |
MESH:D011471 |
Prostatic Neoplasms |
|
Fluorouracil |
3.21 | 18626508 19082440 |
MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.33 | 18629315 |
MESH:D012004 |
Rectal Neoplasms |
|
Fluorouracil |
4.26 | 18722050 18286688 15538739 16160472 |
MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.50 | 19058328 |
MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.17 | 18990726 |
MESH:D012852 |
Sinusitis |
|
Phenylephrine |
5.10 | 7327846 |
MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
2.15 | 16192470 |
MESH:D013274 |
Stomach Neoplasms |
|
Fluorouracil |
2.00 | 19084572 18396642 17172411 17522103 19015929 16951190 18567086 16424979 17498489 15786421 |
MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.35 | 12697716 |
MESH:D013978 |
Tibial Fractures |
|
Estradiol |
5.13 | 19048282 |
MESH:D014062 |
Tongue Neoplasms |
|
Fluorouracil |
4.25 | 16280240 |
MESH:D002583 |
Uterine Cervical Neoplasms |
|
Fluorouracil |
4.14 | 16803524 |
MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
5.04 | 12125929 |
MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
4.69 | 15886252 |