AutismKB 2.0

Annotation Detail for PRKDC


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Basic Information Top
Gene Symbol:PRKDC ( DNA-PKcs,DNAPK,DNPK1,HYRC,HYRC1,XRCC7,p350 )
Gene Full Name: protein kinase, DNA-activated, catalytic polypeptide
Band: 8q11.21
Quick LinksEntrez ID:5591; OMIM: 600899; Uniprot ID:PRKDC_HUMAN; ENSEMBL ID: ENSG00000121031; HGNC ID: 9413
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
hsa04110Cell cycle
Pathway IDPathway Name
DNA Repair
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200174BARD1 signaling events
200169Class I PI3K signaling events mediated by Akt
No data
Pathway IDPathway Name
500055Nonhomologous End-joining (NHEJ)
500056Processing of DNA ends prior to end rejoining
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C479235 2-(morpholin-4-yl)benzo(h)chromen-4-one PARP1 protein affects the reaction [2-(morpholin-4-yl)benzo(h)chromen-4-one results in decreased activity of PRKDC protein]affects reaction|decreases activity 16556909
C479235 2-(morpholin-4-yl)benzo(h)chromen-4-one PRKDC protein affects the susceptibility to 2-(morpholin-4-yl)benzo(h)chromen-4-oneaffects response to substance 16556909
C086538 4-amino-1,8-naphthalimide PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]affects reaction|decreases activity 16556909
C086538 4-amino-1,8-naphthalimide PRKDC protein affects the susceptibility to 4-amino-1,8-naphthalimideaffects response to substance 16556909
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PRKDC mRNAdecreases expression 12419474
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of PRKDC mRNAdecreases expression 16514628
D001151 Arsenic PRKDC mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRKDC mRNAdecreases expression 20106945
20064835
C006780 bisphenol A bisphenol A results in increased expression of PRKDC mRNAincreases expression 15223131
D003474 Curcumin Curcumin results in decreased expression of PRKDC mRNAdecreases expression 17596214
C014347 decitabine decitabine affects the methylation of PRKDC geneaffects methylation 17630775
D002945 Cisplatin PRKDC mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|increases response to substance 18546291
D004317 Doxorubicin PRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]affects reaction|increases activity 18508926
D004317 Doxorubicin PRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]affects reaction|increases activity 18508926
D004317 Doxorubicin PRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP9 protein]affects reaction|increases activity 18508926
D004958 Estradiol Estradiol results in decreased expression of PRKDC mRNAdecreases expression 15223131
D004958 Estradiol Estradiol results in increased expression of PRKDC mRNAincreases expression 16514628
D005047 Etoposide Etoposide results in increased phosphorylation of PRKDC proteinincreases phosphorylation 17441964
D005047 Etoposide PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]increases phosphorylation|increases reaction 17441964
D005472 Fluorouracil PRKDC mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|increases response to substance 18546291
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of PRKDC mRNA]affects reaction|decreases expression 15016801
D005492 Folic Acid Folic Acid affects the expression of PRKDC mRNAaffects expression 16361273
C070081 fulvestrant fulvestrant results in decreased expression of PRKDC mRNAdecreases expression 16514628
C051890 irinotecan irinotecan results in increased phosphorylation of PRKDC proteinincreases phosphorylation 17441964
C015329 lycopene lycopene results in decreased expression of PRKDC mRNAdecreases expression 16886892
C006253 pirinixic acid pirinixic acid results in increased expression of PRKDC mRNAincreases expression 20059764
17950772
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PRKDC mRNA]increases expression|increases reaction 20059764
17950772
D020849 Raloxifene Raloxifene results in decreased expression of PRKDC mRNAdecreases expression 16514628
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL2 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL3 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL5 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CSF2 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CXCL1 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL10 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL12B protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL13 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL5 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of IL4 mRNA]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MKI67 protein]affects reaction|increases expression 17200189
D017632 Asbestos, Serpentine PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]affects reaction|increases expression 16571779
D017632 Asbestos, Serpentine PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]affects reaction|increases expression 16571779
D014284 Triiodothyronine Triiodothyronine results in increased expression of PRKDC mRNAincreases expression 17403546
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 8.6615814532 17670903 12690470
MESH:D058186 Acute Kidney Injury Folic Acid 8.6616316344 17003819 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.2120127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 13.2117638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 13.2117418594
MESH:D000230 Adenocarcinoma Estradiol 13.2111473722
MESH:D000230 Adenocarcinoma Fluorouracil 13.2117638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.736695378
MESH:D000236 Adenoma Folic Acid 6.7316963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3516434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0817306315
MESH:D000419 Albuminuria Doxorubicin 11.0321441931
MESH:D000419 Albuminuria Raloxifene 11.0317451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9517887948
MESH:D000544 Alzheimer Disease Curcumin 6.6315590663
MESH:D000544 Alzheimer Disease Folic Acid 6.6317116317
MESH:D000544 Alzheimer Disease Raloxifene 6.6315800139
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0210965797
MESH:D000740 Anemia Fluorouracil 3.6016511603 15504547 17963324
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8316251483 12569548 18414634 16835338
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7116807698
MESH:D001195 Asbestosis Asbestos, Serpentine 5.5410751356
MESH:D050197 Atherosclerosis Arsenic 6.6512928151 19371607
MESH:D050197 Atherosclerosis Curcumin 6.6518704882
MESH:D001284 Atrophy fulvestrant 4.7211514358
MESH:D001321 Autistic Disorder Folic Acid 2.8421388746
MESH:D001327 Autoimmune Diseases Curcumin 4.3619761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0319483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 19.6314601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 19.6314601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 19.6314601052
MESH:D001862 Bone Resorption bisphenol A 3.7411985600
MESH:D001930 Brain Injuries Raloxifene 4.3416580743
MESH:D002545 Brain Ischemia Curcumin 4.2016770732
MESH:D001932 Brain Neoplasms Curcumin 8.5817596214
MESH:D001932 Brain Neoplasms Doxorubicin 8.5817150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.5820146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 9.5817123778
MESH:D001943 Breast Neoplasms Cisplatin 9.5818382427 19526202
MESH:D001943 Breast Neoplasms Curcumin 9.5818593918 19250217 18462866 16243823
MESH:D001943 Breast Neoplasms decitabine 9.5819208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 9.5817369602 18234424 15634643 16096432 17983394 19526202 15668708 18628466 16264153 15939500 16595493 15136595 16826403 16115903 15993339 11325840 18382427 15692762 15567936 16935488 15994142 18695136 17426702 16322301
MESH:D001943 Breast Neoplasms Estradiol 9.5817261762 16675129 17289903 17018787 19861407 18497071 14630087 12948864
MESH:D001943 Breast Neoplasms Etoposide 9.5816322251
MESH:D001943 Breast Neoplasms Fluorouracil 9.5815136595 18608205 18357371 16595493 16110121 16557594 19217205
MESH:D001943 Breast Neoplasms Folic Acid 9.5816777985
MESH:D001943 Breast Neoplasms fulvestrant 9.5818984771
MESH:D001943 Breast Neoplasms Raloxifene 9.5817261762 15572757 15775269 17893378 17242785 15758505 17952589 16912660 17595753 17049068 16837676 17440819
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.9216051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.9216051944
MESH:D002277 Carcinoma Curcumin 8.2218593918
MESH:D002277 Carcinoma Fluorouracil 8.2217121937
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5215504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.6717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.6717982673
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.6716023760 16234567 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.6718930000 17971768 17045692 16799960 16332177 17088986
MESH:D002278 Carcinoma in Situ bisphenol A 4.8617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.6312023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.6318414057
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.471485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.4718695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 21.4415504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 21.4420419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 21.446189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Curcumin 21.4418462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 21.4419215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 21.446189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 21.4416757204 16280240 17066447 18986760
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.2818640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.2817572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.4416651473 17974986 15476868 15792986 17131338 16278810 17519947 16952015 17329180 15811867 18627295 16269455 16731534 16455267 16612575 17007740 17308081 15505089 16364871 17382496 16242529 17928571 17924179 16109756 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9017334414 16243910
MESH:D002318 Cardiovascular Diseases Arsenic 11.8115738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Folic Acid 11.8116755160
MESH:D002318 Cardiovascular Diseases Raloxifene 11.8115775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.2018022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6818566989
MESH:D002779 Cholestasis pirinixic acid 2.7319176532
MESH:D002971 Cleft Lip Folic Acid 3.9121254359
MESH:D002972 Cleft Palate Folic Acid 3.528946559 21254359
MESH:D003072 Cognition Disorders Raloxifene 4.4915800139
MESH:D003092 Colitis Curcumin 4.0516804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.4318809619
MESH:D003110 Colonic Neoplasms Curcumin 8.1616340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 8.1617616700
MESH:D003110 Colonic Neoplasms Fluorouracil 8.1616510598 17169374 15001691 16340194 17725105 17018589 18772588 17172411 17016597 17287894
MESH:D003110 Colonic Neoplasms irinotecan 8.1617725105 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 8.2415273666
MESH:D015179 Colorectal Neoplasms decitabine 8.2418981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 8.2418802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 8.2418383874 18288408 18802399 15289873 15148649 14970324 16282729 18448328 17401013 17594712 20501625 18949393 17454858 16391804 17695437 16331619 18509181 17016601 16303861 17094418 16524972 17255274
MESH:D015179 Colorectal Neoplasms Folic Acid 8.2416963246 17245555 17087956 17116713 16985020
MESH:D015179 Colorectal Neoplasms irinotecan 8.2418259882 17159606 16391804 18509181 17454858 15273666 16303861
MESH:D016510 Corneal Neovascularization Curcumin 4.7718497527
MESH:D007644 Darier Disease Fluorouracil 4.6616733453
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0517474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.8418403477
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.8416886840
MESH:D003928 Diabetic Nephropathies Curcumin 14.4418204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.4419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.4417451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.4117416283
MESH:D004362 Drug Toxicity Cisplatin 8.1915033597 12231392 12649298 19839026
MESH:D004362 Drug Toxicity Doxorubicin 8.1918602426
MESH:D004381 Duodenal Ulcer Curcumin 3.9217351913
MESH:D004487 Edema pirinixic acid 6.5012083418
MESH:D004487 Edema Raloxifene 6.5015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.8715845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9919294695
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 17.1819148513
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.1817359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.1811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 17.1817301261
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 7.1217638652 15173087 16481741 15464296 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1216785472 16337965 16481741 15173087 17638652
MESH:D017889 Exfoliation Syndrome Folic Acid 5.3616504073
MESH:D005234 Fatty Liver Curcumin 12.5219297423
MESH:D005234 Fatty Liver pirinixic acid 12.5219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 12.5217473493
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4619069698
MESH:D005355 Fibrosis Curcumin 3.8618705752
MESH:D005534 Foot Diseases Arsenic 5.436392382
MESH:D005756 Gastritis Folic Acid 4.9617171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5618462866
MESH:D005901 Glaucoma Folic Acid 4.9516504073
MESH:D005909 Glioblastoma Curcumin 7.1317596214
MESH:D005909 Glioblastoma Doxorubicin 7.1317150277
MESH:D005910 Glioma Fluorouracil 2.8216145905
MESH:D006258 Head and Neck Neoplasms Cisplatin 23.2715464296 15102660
MESH:D006258 Head and Neck Neoplasms Curcumin 23.2718462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 23.2719215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 23.2715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 23.2715162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 4.1819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3115464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7620471113
MESH:D006330 Heart Defects, Congenital Folic Acid 6.7616524890 17286298
MESH:D006331 Heart Diseases Doxorubicin 7.5414766674 16144979 16707910 18674790 16244372 18006777 17888722 12587719 16330681 16495754 16879835 16244371 17875725
MESH:D006331 Heart Diseases Raloxifene 7.5411110106
MESH:D006333 Heart Failure Doxorubicin 6.7817481944
MESH:D006333 Heart Failure pirinixic acid 6.7820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006529 Hepatomegaly pirinixic acid 2.8716221962 19176532 18467677 19772884
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9117701891
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D006561 Herpes Simplex Etoposide 4.4310809021
MESH:D006679 HIV Seropositivity Folic Acid 5.3617209195
MESH:D006689 Hodgkin Disease Cisplatin 11.7916200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 11.7915147373 18501091 17606976
MESH:D006689 Hodgkin Disease Etoposide 11.7916135485 18180244 16200630 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006937 Hypercholesterolemia Curcumin 3.9318704882
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.3816865747 16395265 16397167 16755160 16433478
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3417050553
MESH:D006973 Hypertension Arsenic 5.4211953799 9931084 16076760
MESH:D006973 Hypertension Raloxifene 5.4217577099 15787275
MESH:D006987 Hypesthesia Arsenic 5.4316093927
MESH:D007248 Infertility, Male decitabine 6.9017581917
MESH:D007248 Infertility, Male fulvestrant 6.9011514358
MESH:D007249 Inflammation Curcumin 2.8318403477 17151092 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1618596194 18200517
MESH:D007333 Insulin Resistance bisphenol A 11.8216393666
MESH:D007333 Insulin Resistance Estradiol 11.8216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.8216306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.1010783313
MESH:D007642 Keratosis Arsenic 4.8616930632 12749816
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0115464296
MESH:D007674 Kidney Diseases Cisplatin 9.7815190930 18289764 12231392 12649298 19839026
MESH:D007674 Kidney Diseases Doxorubicin 9.7815699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 9.7815618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0316707910
MESH:D007680 Kidney Neoplasms Estradiol 7.1315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.1316985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6711231351
MESH:D007889 Leiomyoma Curcumin 10.7418555241
MESH:D007889 Leiomyoma Raloxifene 10.7416973256
MESH:D007938 Leukemia Curcumin 6.3918462866
MESH:D007938 Leukemia decitabine 6.3918980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0816106398
MESH:D007951 Leukemia, Myeloid decitabine 3.8817236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3618460780 19387464 17679729 19010910 18704418 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4717339181
MESH:D015458 Leukemia, T-Cell Curcumin 4.6316106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.8618006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8615474484
MESH:D008107 Liver Diseases Arsenic 6.5911134558
MESH:D008107 Liver Diseases Curcumin 6.5916956363
MESH:D008107 Liver Diseases Folic Acid 6.5916877991
MESH:D008113 Liver Neoplasms Arsenic 10.3116368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.3121137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 10.3117045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 10.3116377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 2.9416842330 17085340
MESH:D008171 Lung Diseases marker/mechanism 17200189
MESH:D008171 Lung Diseases Asbestos, Serpentine 4.2617200189
MESH:D008175 Lung Neoplasms Arsenic 10.4717306315 17976673 19168569
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 10.4711198217
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.4717053015 20064080 20464547 20135361 18520028 20869020 18569708 6695378 18816296
MESH:D008175 Lung Neoplasms Cisplatin 10.4717225452 11798837 6189445
MESH:D008175 Lung Neoplasms Curcumin 10.4719359593 18462866 16243823
MESH:D008175 Lung Neoplasms Doxorubicin 10.476189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 10.4715246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6615086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3017718048
MESH:D008223 Lymphoma Curcumin 17.1718462866
MESH:D008223 Lymphoma decitabine 17.1719470736
MESH:D008223 Lymphoma Doxorubicin 17.1716098063
MESH:D008223 Lymphoma Etoposide 17.1712854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6817654614
MESH:D016399 Lymphoma, T-Cell Curcumin 11.1316173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.1315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.8415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8411807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5616832597
MESH:D008545 Melanoma Cisplatin 7.1716432458 12393984 16809738 15577323 17023156 18332650 17761969 18176117 16248763 11135225 18505091 12883367 12374674
MESH:D008545 Melanoma Curcumin 7.1718462866 17885582
MESH:D008545 Melanoma decitabine 7.1716505122 17785578
MESH:D008545 Melanoma Doxorubicin 7.1716827129
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6415990972
MESH:D008569 Memory Disorders Curcumin 4.0317263510
MESH:D008654 Mesothelioma Cisplatin 6.2817638057
MESH:D008654 Mesothelioma Doxorubicin 6.2817638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4315863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.1918986760 16757204
MESH:D052016 Mucositis Doxorubicin 11.9817415656
MESH:D052016 Mucositis irinotecan 11.9817159606
MESH:D009101 Multiple Myeloma Curcumin 11.6919372569
MESH:D009101 Multiple Myeloma decitabine 11.6918172295
MESH:D009101 Multiple Myeloma Raloxifene 11.6916497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3116882708 19010910 19157545 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 5.5315857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.5319151258
MESH:D017202 Myocardial Ischemia Arsenic 3.8815371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D009232 Myxoma Raloxifene 5.4316343187
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2418495463
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9318259882
MESH:D009362 Neoplasm Metastasis irinotecan 5.9318259882
MESH:D009369 Neoplasms Benzo(a)pyrene 18.9811141357
MESH:D009369 Neoplasms Cisplatin 18.9816773208
MESH:D009369 Neoplasms decitabine 18.9817925555 19470736 19116145
MESH:D009369 Neoplasms Fluorouracil 18.9818239605 16928823 18600527
MESH:D009369 Neoplasms lycopene 18.9817051425
MESH:D009369 Neoplasms pirinixic acid 18.9817405874
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 4.7211704859
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4012497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3615464296
MESH:D009401 Nephrosis Doxorubicin 4.6416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8915640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 9.3211399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 9.3216427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.5018462866
MESH:D009436 Neural Tube Defects Arsenic 7.4716620997
MESH:D009436 Neural Tube Defects Folic Acid 7.4717438019
MESH:D009447 Neuroblastoma Cisplatin 11.158761367
MESH:D009447 Neuroblastoma Doxorubicin 11.1515555623
MESH:D009447 Neuroblastoma irinotecan 11.158761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 11.038761367
MESH:D017599 Neuroectodermal Tumors irinotecan 11.038761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.2517056641
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3516436463
MESH:D009503 Neutropenia Folic Acid 4.3816322990
MESH:D009765 Obesity Curcumin 4.4919297423
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D010024 Osteoporosis Curcumin 7.1518719352
MESH:D010024 Osteoporosis Raloxifene 7.1517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1017823083 15579764 15758505 17893378
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010049 Ovarian Diseases bisphenol A 4.8611985600
MESH:D010051 Ovarian Neoplasms Arsenic 14.5617306315
MESH:D010051 Ovarian Neoplasms Cisplatin 14.5619769630 17225452 15464296 6897625
MESH:D010051 Ovarian Neoplasms Curcumin 14.5619020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 14.5619259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 14.5619401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.8619003803
MESH:D010190 Pancreatic Neoplasms Curcumin 15.8617440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 15.8619294695
MESH:D010190 Pancreatic Neoplasms Etoposide 15.8619003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.8619003803 16929163 16500647 15113037
MESH:D010523 Peripheral Nervous System Diseases Arsenic 9.6416093927
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 9.6415464296
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8615371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.3711550810
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.5610923243
MESH:D010997 Pleural Neoplasms Cisplatin 13.5017638057
MESH:D010997 Pleural Neoplasms Doxorubicin 13.5017638057
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8210548101
MESH:D055728 Primary Myelofibrosis decitabine 4.6017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.1520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.1520887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17196815
MESH:D011471 Prostatic Neoplasms Arsenic 3.5116140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5116740699
MESH:D011471 Prostatic Neoplasms Curcumin 3.5118226269 10851300 18156803 15129424 11398177 12497104 18769126
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5116729912 15897917 15749863 18437689 16868541 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 3.5116740699
MESH:D011471 Prostatic Neoplasms Etoposide 3.5117172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5119082440 18626508
MESH:D011471 Prostatic Neoplasms lycopene 3.5115084515 17337101
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5116220300 16536755 15731164
MESH:D011507 Proteinuria Arsenic 3.8821343184
MESH:D011629 Puberty, Precocious bisphenol A 4.6510548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.4119168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.7818569384 15511213
MESH:D011693 Purpura Raloxifene 5.4315770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9015538739 18286688 16160472 18722050
MESH:D051437 Renal Insufficiency Cisplatin 16.5115464296
MESH:D051437 Renal Insufficiency Doxorubicin 16.5117922066
MESH:D051437 Renal Insufficiency Folic Acid 16.5115728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9018379247 10666014
MESH:D012208 Rhabdomyosarcoma decitabine 4.2819155313
MESH:D012509 Sarcoma Curcumin 9.1818462866
MESH:D012509 Sarcoma Doxorubicin 9.1815625365 17710206 16767912 17203757 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Cisplatin 16.6514601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 16.6514601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 16.6514601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
MESH:D012559 Schizophrenia Folic Acid 2.8816641680
MESH:D018805 Sepsis Curcumin 3.9718389075
MESH:D012871 Skin Diseases Arsenic 5.2217050553 18709164 16702368 19834688 17548696 16759981 17938729 16353154 17453740 15952646 6392382
MESH:D012871 Skin Diseases Folic Acid 5.2218709164
MESH:D012878 Skin Neoplasms Arsenic 9.2116251483 15504454 17050553 19538983 17029826 17976673
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2110029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 9.2115692506
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2115464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4417203757 16767912 15625365
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3616361298
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.152093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 8.1518396642 17522103 15958060
MESH:D013274 Stomach Neoplasms decitabine 8.1519037991
MESH:D013274 Stomach Neoplasms Fluorouracil 8.1516424979 16951190 18567086 17172411 17522103 19015929 18396642 15786421 19084572 17498489
MESH:D013274 Stomach Neoplasms Folic Acid 8.1517171786
MESH:D013274 Stomach Neoplasms irinotecan 8.1515723263
MESH:D013276 Stomach Ulcer Curcumin 3.3819188055 16631530
MESH:D020521 Stroke Folic Acid 8.6616517955
MESH:D020521 Stroke Raloxifene 8.6616837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.8516684133 16045194
MESH:D013736 Testicular Neoplasms Cisplatin 4.5117225452 15464296
MESH:D013964 Thyroid Neoplasms decitabine 7.0917967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.0917909728 16010429
MESH:D013978 Tibial Fractures Estradiol 13.2819048282
MESH:D013978 Tibial Fractures Raloxifene 13.2819048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8716280240
MESH:D001749 Urinary Bladder Neoplasms Arsenic 23.3818640142 11144890 15987713 19322015 19429237 17976673 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 23.3817053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 23.3815464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 23.3818593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 23.3819087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 23.3817653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 23.3817572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.1318462866
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.2616803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.2616803524
MESH:D014591 Uterine Diseases bisphenol A 4.8814652134
MESH:D014604 Uveal Neoplasms decitabine 4.7817785578
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4815577323
MESH:D014652 Vascular Diseases Arsenic 4.6017056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.0816837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917638931 16364871 17678736 17334414
MESH:D014839 Vomiting Cisplatin 4.5911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4316343187
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:216 DNA Repair
KEGG:03450 Non-homologous end-joining
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33776
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445204Ovarian Neoplasms
    Releated drug ID Related drug Name
    PA448926chlorambucil
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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