AutismKB 2.0

Annotation Detail for ERBB2IP


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Basic Information Top
Gene Symbol:ERBB2IP ( ERBIN,LAP2 )
Gene Full Name: erbb2 interacting protein
Band: 5q12.3
Quick LinksEntrez ID:55914; OMIM: 606944; Uniprot ID:LAP2_HUMAN; ENSEMBL ID: ENSG00000112851; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04621NOD-like receptor signaling pathway
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of ERBB2IP mRNAaffects expression 18414638
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ERBB2IP mRNAdecreases expression 19150397
D011374 Progesterone Progesterone results in increased expression of ERBB2IP mRNAincreases expression 18037150
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ERBB2IP mRNA]affects reaction|decreases expression 16891777
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ERBB2IP mRNAdecreases expression 16891777
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ERBB2IP mRNAincreases expression 18691609
D014415 Tunicamycin Tunicamycin results in increased expression of ERBB2IP mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D020261 Arsenic Poisoning Arsenic 2.9418414634 16251483 12569548 16835338
MESH:D050197 Atherosclerosis Arsenic 3.4412928151 19371607
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.9517868700
MESH:D001930 Brain Injuries Progesterone 4.7415380490 15665606 15845082
MESH:D001943 Breast Neoplasms Progesterone 2.0217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3116507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7718922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.6817938729 19152805 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.6416973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215668235 12621046 16354765 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.9817187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2217692515
MESH:D004715 Endometriosis Progesterone 10.1116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.119294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3712621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16354765 8697196 18606429 16959395
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 5.6016076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6018850075 18670907
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8915869954
MESH:D007249 Inflammation Progesterone 5.5215869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5212878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007642 Keratosis Arsenic 5.5316930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 4.9316368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Arsenic 2.5019168569 17306315 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0717203775 11408345
MESH:D017202 Myocardial Ischemia Arsenic 9.9815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.9812213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects Arsenic 3.6716620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.3617306315
MESH:D010051 Ovarian Neoplasms Progesterone 5.3617393432 16525653
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5315371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11118676 11896295 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9518045962
MESH:D012871 Skin Diseases Arsenic 2.8216353154 17453740 19834688 16759981 15952646 17548696 17938729 16702368 17050553 18709164 6392382
MESH:D012878 Skin Neoplasms Arsenic 6.1815504454 16251483 17976673 17050553 19538983 17029826
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1816192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.8216503802 15862959
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9315987713 18640142 17306315 19429237 17976673 19322015 11144890
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:04621 NOD-like receptor signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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