AutismKB 2.0

Annotation Detail for PRKG1


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Basic Information Top
Gene Symbol:PRKG1 ( CGKI,DKFZp686K042,FLJ36117,MGC71944,PGK,PKG,PRKG1B,PRKGR1B,cGKI-BETA,cGKI-alpha )
Gene Full Name: protein kinase, cGMP-dependent, type I
Band: 10q11.23-q21.1
Quick LinksEntrez ID:5592; OMIM: 176894; Uniprot ID:KGP1_HUMAN; ENSEMBL ID: ENSG00000185532; HGNC ID: 9414
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion
hsa04740Olfactory transduction
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
No data
Pathway IDPathway Name
P00019Endothelin signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C090937 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole results in increased expression of PRKG1 proteinincreases expression 11602670
C439285 (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride results in increased expression of PRKG1 proteinincreases expression 11602670
C055656 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects cotreatment|decreases reaction|increases expression 11799084
C055656 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in decreased expression of PRKG1 protein alternative formdecreases expression 11799084
C055656 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased activity of PRKG1 proteinincreases activity 11799084
C090860 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate binds to and results in decreased activity of PRKG1 proteinaffects binding|decreases activity 19542178
C016276 8-bromocyclic GMP 8-bromocyclic GMP results in increased activity of PRKG1 proteinincreases activity 19359370
C056165 acetovanillone acetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D000641 Ammonia PRKG1 protein affects the susceptibility to Ammoniaaffects response to substance 19393034
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKG1 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of PRKG1 mRNAdecreases expression 15894712
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKG1 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRKG1 mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKG1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRKG1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of PRKG1 mRNAincreases expression 16378109
D016572 Cyclosporine Cyclosporine results in increased expression of PRKG1 proteinincreases expression 16378109
D016572 Cyclosporine Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]decreases reaction|increases expression 16378109
D016572 Cyclosporine Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]decreases reaction|increases expression 16378109
D004041 Dietary Fats Dietary Fats results in increased expression of PRKG1 mRNAincreases expression 18042831
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D004610 Ellagic Acid Ellagic Acid results in decreased expression of PRKG1 mRNAdecreases expression 12002526
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PRKG1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PRKG1 mRNAdecreases expression 17942748
D005947 Glucose acetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D005947 Glucose diphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D005947 Glucose Glucose results in decreased expression of and results in decreased activity of PRKG1 proteindecreases activity|decreases expression 17320767
D005947 Glucose Glucose results in decreased expression of PRKG1 mRNAdecreases expression 17320767
D005947 Glucose manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D005947 Glucose Reactive Oxygen Species promotes the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|increases reaction 17320767
D005947 Glucose tempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D006152 Cyclic GMP Cyclic GMP results in increased activity of PRKG1 proteinincreases activity 18037907
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PRKG1 mRNAaffects cotreatment|increases expression 17183730
C097284 manganese(III)-tetrakis(4-benzoic acid)porphyrin manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
D005996 Nitroglycerin Nitroglycerin results in decreased expression of PRKG1 proteindecreases expression 11331261
D005996 Nitroglycerin Nitroglycerin results in decreased expression of PRKG1 proteindecreases expression 11331261
D005996 Nitroglycerin Nitroglycerin affects the expression of PRKG1 mRNAaffects expression 18037907
D005996 Nitroglycerin Nitroglycerin affects the expression of PRKG1 proteinaffects expression 18037907
D005996 Nitroglycerin Nitroglycerin results in increased activity of PRKG1 proteinincreases activity 18037907
D005996 Nitroglycerin Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]affects reaction|increases activity 18037907
D026423 S-Nitroso-N-Acetylpenicillamine [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects cotreatment|decreases reaction|increases expression 11799084
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 proteinincreases activity 11799084
C041786 palm oil palm oil results in increased expression of PRKG1 mRNAincreases expression 18042831
D010656 Phenylephrine [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects cotreatment|decreases reaction|increases expression 11799084
D010656 Phenylephrine FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]increases activity|increases reaction 19542178
D010656 Phenylephrine PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]decreases activity|increases reaction 19797176
D010656 Phenylephrine Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]decreases reaction|increases expression 16378109
D010656 Phenylephrine Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]decreases reaction|increases expression 16378109
D010656 Phenylephrine Phenylephrine results in decreased activity of PRKG1 proteindecreases activity 19797176
D010656 Phenylephrine Phenylephrine results in increased activity of PRKG1 proteinincreases activity 19542178
D010656 Phenylephrine [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects cotreatment|decreases reaction|increases expression 11799084
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKG1 mRNAaffects binding|decreases expression|increases activity 19710929
D017382 Reactive Oxygen Species Reactive Oxygen Species promotes the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|increases reaction 17320767
D013395 Sucrose Sucrose results in decreased expression of PRKG1 proteindecreases expression 17215582
C025463 sulindac sulfone sulindac sulfone results in increased expression of PRKG1 proteinincreases expression 11602670
16731751
D013481 Superoxides Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]affects reaction|increases activity 18037907
D013629 Tamoxifen Tamoxifen affects the expression of PRKG1 mRNAaffects expression 17555576
C001803 tempol tempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]decreases expression|decreases reaction 17320767
C004648 testosterone enanthate testosterone enanthate affects the expression of PRKG1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKG1 mRNAincreases expression 20159946
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PRKG1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1911752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.198875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6219490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury Superoxides 4.8018460982
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.8720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.466695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D011125 Adenomatous Polyposis Coli sulindac sulfone 5.0016150858
MESH:D000550 Amblyopia Valproic Acid 4.8917688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000756 Anemia, Sideroblastic Superoxides 5.3216910769
MESH:D001008 Anxiety Disorders Valproic Acid 3.3117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8217460149
MESH:D001161 Arteriosclerosis Dietary Fats 8.8015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0419460635 20603192 18396377 15238991 18316065 17507914 18177632 18940202 17688650 18985861 19232924 18558336 17157402 18775368 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 2.9020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.308888407
MESH:D001919 Bradycardia Phenylephrine 4.2015306635
MESH:D001929 Brain Edema Ammonia 5.9311481608 20217200 19393034
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8720435547
MESH:D001943 Breast Neoplasms Tamoxifen 1.8719189210 20135344 16873071 19059307 19084267 16273361 19142967 20005174 17440819 19066611 15668708 19103187 19189212 19200415 16202921 21138602 19011961 21152245 15565566 17261762 17893378 19244106 18815881 20065188 19115204 16818667 19221464 11161223 20859285 20390343 18855134 18997820 18351453 19288272 20544844 19487384 18821012 17242785 18425577 18629630 19289846 18984771 19155303 17049068 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4510355542 16050911 18705752 15700767 16097048 15721981 16011737 15673190 3786805 16192424 16124888 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.8318788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.8316924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfone 3.9618758305
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9520419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3217572228
MESH:D006332 Cardiomegaly Phenylephrine 6.2517124262 11179087 15728586 11754973 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2516120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.7820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.7812371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Cyclosporine 11.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.8916919318 15861022 16105132 17333356 17681005 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 11.8919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.968697196 15668235 16354765 12621046 15340226
MESH:D003110 Colonic Neoplasms arsenite 2.5315037631
MESH:D015179 Colorectal Neoplasms sulindac sulfone 3.3710666051 18059344 10416599 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7814669216 17141729
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 3.6915736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.698888407 16575769 17688650
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D017449 Dermatitis, Allergic Contact Ammonia 4.4416823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1919279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.576884620 19085960 19336974 2869522 21278145 9327722 15027814 11566570 10915739 15968718 10092053 6623471 7179309 15998439 3786805 4309450 7120509 17522070 3732212 7440962 16177239 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.571733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2118367378
MESH:D004421 Dystonia Valproic Acid 3.741851702
MESH:D004487 Edema pirinixic acid 5.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.8719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.8220544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.823659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.316426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.967750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.723659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.0320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver arsenite 38.0318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 38.0315959796 61145 12631006 19224547 16239168 17595544 16045604 12795759
MESH:D005234 Fatty Liver Cyclosporine 38.0319224547
MESH:D005234 Fatty Liver Dietary Fats 38.0319551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.0315345470
MESH:D005234 Fatty Liver pirinixic acid 38.0319236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 38.0314986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 38.0314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.818888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005355 Fibrosis arsenite 24.2018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 24.2018705752
MESH:D005355 Fibrosis Cyclosporine 24.2012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 24.2018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.2020067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006261 Headache Nitroglycerin 4.8411284996 11554966
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006501 Hepatic Encephalopathy Ammonia 5.5112420312 16338762 20549931
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.1619772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1616120746 12621046 15340226
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4017440010
MESH:D006849 Hydrocephalus Valproic Acid 4.5317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7015340226 16354765 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D020138 Hyperhomocysteinemia Superoxides 4.9812615666
MESH:D006949 Hyperlipidemias Dietary Fats 3.3021332399
MESH:D006973 Hypertension Cyclosporine 7.8210903974
MESH:D006973 Hypertension Phenylephrine 7.8212717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2916612254
MESH:D006984 Hypertrophy Phenylephrine 4.2512791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2617937319
MESH:D007249 Inflammation Dietary Fats 7.2320412841
MESH:D007249 Inflammation Tamoxifen 7.2319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.2312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 6.5118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.5116306350
MESH:D007410 Intestinal Diseases Superoxides 5.1110210152
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.6819381132
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Cyclosporine 6.0718776723 8314463 10903974
MESH:D007674 Kidney Diseases tempol 6.0717640563
MESH:D007680 Kidney Neoplasms Cyclosporine 6.3912371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.3918625569
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0916294345 17596541
MESH:D008064 Lipidoses Tamoxifen 2.9117567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 9.9918296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.9917334410 16943688 21278145 16221502 11408273 11903743 17174718 16239168 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 9.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.5418054572 15057751 15052691 17565644 18412020 15362042 17698563 15730626 16638106 15893842 12389079 11481614 12649538 15123356 18006644 17721639 17823541 18429990 14620537 17766677 18420326 12667390 15925388 18705752 18251166 18166357 16011737 15338365 18472332 16116963 12609069 18279442 18277467 15996030 14748882 12958196 16097048 14716833 15959796 15673190 14716496 18481824 16033810 16248980 14512876 12632514 12666154 10355542 17976157 18418968 12898905 18187930 17922224 17631135 15370692 20821823 17708605 17805973 17900296 16192424 12445418 17640975 17714472 18205269 15931870 14724832 16136751 12586293 18472094 15876570 18376398 12445421 16015684 18317297 17481882 18339082 18395095 16027843 12546737 17525996 18395914 18210741 17761835 18156304 15818738 13678700 17557913 17944888 17869086 18263696 12741479 12632512 15650968
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.5418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0015830285 17285989 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4014706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.7721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.7719294768
MESH:D008113 Liver Neoplasms pirinixic acid 12.7715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 12.7716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.7716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.0615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.0612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9217228818
MESH:D008175 Lung Neoplasms arsenite 4.4816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.4820135361 17053015 18816296 18520028 18569708 20064080 20464547 20869020 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 4.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.4819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.4111731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.2019453300
MESH:D008545 Melanoma 8-bromocyclic GMP 6.9618004088
MESH:D008545 Melanoma Glucose 6.9614993021
MESH:D008545 Melanoma Reactive Oxygen Species 6.9617992120
MESH:D008545 Melanoma Tamoxifen 6.9612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.423537620
MESH:D008881 Migraine Disorders Valproic Acid 2.9518765137 18803445
MESH:D020326 Migraine without Aura Cyclic GMP 10.4011304026
MESH:D020326 Migraine without Aura Nitroglycerin 10.4014659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.728888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9617596541
MESH:D009203 Myocardial Infarction Nitroglycerin 5.5314729435
MESH:D009203 Myocardial Infarction pirinixic acid 5.5319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6916411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.2511141357
MESH:D009369 Neoplasms pirinixic acid 4.2517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.0715738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8914600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.918888407 16359493
MESH:D009765 Obesity Dietary Fats 4.1320132043 21332399 17217161 18674790 18457598 11836018 20518802 19632207 16723640
MESH:D009765 Obesity pirinixic acid 4.1320558911
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 3.5715580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3311118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.3320603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8417292933
MESH:D011471 Prostatic Neoplasms sulindac sulfone 2.8415570007 17908994
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8415067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9816919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.1911422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D015427 Reperfusion Injury pirinixic acid 6.4619058328
MESH:D015427 Reperfusion Injury Superoxides 6.4618460982
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012174 Retinitis Pigmentosa manganese(III)-tetrakis(4-benzoic acid)porphyrin 4.5116849425
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0219110320 15737665
MESH:D012640 Seizures Valproic Acid 2.5214763951 17978042 11044598 1511512 3137016 16876388 11738929 15475178
MESH:D012852 Sinusitis Phenylephrine 4.367327846
MESH:D012878 Skin Neoplasms 8-bromocyclic GMP 12.3618004088
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.3619755658 10029692
MESH:D012878 Skin Neoplasms Glucose 12.3614993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.3616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4116709447
MESH:D013088 Spermatocele Tamoxifen 10.4116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7019457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1912833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D014178 Translocation, Genetic Valproic Acid 4.8917262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.183119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.5317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.5316712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.318888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9814692618
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D015430 Weight Gain Dietary Fats 3.4516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
KEGG:04540 Gap junction
REACT:604 Hemostasis
KEGG:04730 Long-term depression
KEGG:04740 Olfactory transduction
KEGG:04970 Salivary secretion
REACT:6900 Signaling in Immune system
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33777
    • No data
    Releated disease ID Related disease Name
    PA447288Essential hypertension
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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