AutismKB 2.0

Annotation Detail for SULF2


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Basic Information Top
Gene Symbol:SULF2 ( DKFZp313E091,FLJ44488,FLJ90554,HSULF-2,KIAA1247,MGC126411 )
Gene Full Name: sulfatase 2
Band: 20q13.12
Quick LinksEntrez ID:55959; OMIM: 610013; Uniprot ID:SULF2_HUMAN; ENSEMBL ID: ENSG00000196562; HGNC ID: 20392
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
Desease Name
PSYCH
Attention deficit hyperactivity disorder (time to onset)
Desease Name
Attention deficit hyperactivity disorder (time to onset)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene affects the expression of SULF2 mRNAaffects expression 17070881
C035314 1-nitropropane 1-nitropropane results in increased expression of SULF2 mRNAincreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of SULF2 mRNAincreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in increased expression of SULF2 mRNAincreases expression 17070881
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SULF2 mRNAaffects expression 21346803
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in decreased expression of SULF2 mRNAdecreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in increased expression of SULF2 mRNAincreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of SULF2 mRNAdecreases expression 17070881
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SULF2 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SULF2 mRNAincreases expression 20106945
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA]decreases reaction|increases expression 18200517
D004041 Dietary Fats Dietary Fats results in decreased expression of SULF2 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of SULF2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SULF2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SULF2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SULF2 mRNAaffects cotreatment|increases expression 17942748
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of SULF2 mRNAincreases expression 17070881
D019833 Genistein Genistein results in increased expression of SULF2 mRNAincreases expression 18847459
D007501 Iron Iron deficiency results in increased expression of SULF2 mRNAincreases expression 20368581
C041786 palm oil palm oil results in decreased expression of SULF2 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SULF2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SULF2 mRNAincreases expression 18301758
18445702
17426115
D013629 Tamoxifen Tamoxifen affects the expression of SULF2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SULF2 mRNAaffects cotreatment|increases expression 17942748
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNAincreases expression 18200517
D014807 Vitamin D Vitamin D affects the expression of SULF2 mRNAaffects expression 20368581
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7011752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.8411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8414692618
MESH:D000230 Adenocarcinoma Genistein 9.8411473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.6710737359
MESH:D000236 Adenoma Benzo(a)pyrene 6.676695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.866705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9317887948
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.5016640825
MESH:D000544 Alzheimer Disease Curcumin 4.4915590663
MESH:D000544 Alzheimer Disease Iron 4.4916563566 16640825
MESH:D000740 Anemia Iron 8.4816434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4811748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.5116569441 17162259 17147795 17163184 17375513
MESH:D000756 Anemia, Sideroblastic Iron 4.6716910769
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001145 Arrhythmias, Cardiac Iron 4.2416604332
MESH:D001161 Arteriosclerosis Dietary Fats 9.4115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7016807698
MESH:D001260 Ataxia Telangiectasia Iron 5.3015336622
MESH:D050197 Atherosclerosis Curcumin 6.7818704882
MESH:D050197 Atherosclerosis Iron 6.7816632123 16640825
MESH:D001321 Autistic Disorder Iron 2.8017352947
MESH:D001327 Autoimmune Diseases Curcumin 4.3419761891
MESH:D001424 Bacterial Infections Iron 5.0416640825
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D002545 Brain Ischemia Curcumin 4.1816770732
MESH:D001932 Brain Neoplasms Curcumin 3.8017596214
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 4.6211921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6217474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 4.6218593918 19250217 16243823 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 4.6220435547
MESH:D001943 Breast Neoplasms Estradiol 4.6217289903 17261762 17018787 16675129 19861407 14630087 18497071 12948864
MESH:D001943 Breast Neoplasms Genistein 4.6216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tamoxifen 4.6219066611 21138602 20135344 17440819 15668708 19200415 18815881 19011961 17893378 16873071 20005174 17261762 19244106 19084267 19189212 19288272 19155303 17049068 18821012 21152245 18629630 19410462 19289846 20859285 19059307 19487384 16202921 20390343 19103187 16273361 18855134 17242785 18997820 20544844 18425577 19115204 18984771 18351453 11161223 16818667 19221464 15565566 19189210 19142967 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002277 Carcinoma Curcumin 7.8818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.0810737359 6705139 17761372 3084413 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.0812619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.0816924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.0816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9318414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.5918462866
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 16120746 18670907
MESH:D009202 Cardiomyopathies Iron 3.9516640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4116604332
MESH:D002318 Cardiovascular Diseases Genistein 3.2016332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.326135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.3218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3711677210 17681005 16105132 16919318 15861022 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 12621046 8697196 15668235 15340226
MESH:D003092 Colitis Curcumin 9.4518200517 16782535 16804969
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.4516867261 18200517 17991707 11698051 17936198 16474422 18023891 16804969 16782535
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3917276891
MESH:D003103 Coloboma Curcumin 4.4118809619
MESH:D003110 Colonic Neoplasms Curcumin 5.8316340194 19359593
MESH:D003110 Colonic Neoplasms Genistein 5.8317182828
MESH:D003110 Colonic Neoplasms Iron 5.8316640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7518497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003920 Diabetes Mellitus Iron 4.3216640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3116506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.9918403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.9916647724
MESH:D003924 Diabetes Mellitus, Type 2 Iron 9.9916506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.9917107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.2818204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.2819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.2819279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.1318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 6.1320517888 15804453 16445897
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9017351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3418367378
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.4619031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.8911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.8911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.8920544844 17893378 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Curcumin 28.9219297423
MESH:D005234 Fatty Liver Dietary Fats 28.9218296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9215345470
MESH:D005234 Fatty Liver Iron 28.9216640825
MESH:D005234 Fatty Liver pirinixic acid 28.9219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 28.9219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0319069698
MESH:D005355 Fibrosis Curcumin 19.9818705752
MESH:D005355 Fibrosis Dietary Fats 19.9818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.9820067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 19.9817994277
MESH:D005621 Friedreich Ataxia Iron 5.2816640825 16604332
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5418462866
MESH:D005909 Glioblastoma Curcumin 7.0617596214
MESH:D005909 Glioblastoma Genistein 7.0616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5518462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.166705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.276705139
MESH:D006432 Hemochromatosis Iron 4.3816574947 17236123 17255318 16604332 16640825 17053826
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006486 Hemosiderosis Iron 5.0616604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.3216640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.7917182432
MESH:D006529 Hepatomegaly Iron 13.6216890145
MESH:D006529 Hepatomegaly pirinixic acid 13.6218467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6216120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8917701891
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D015658 HIV Infections Iron 3.5916597321
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 18606429 15340226 16354765 16959395
MESH:D006937 Hypercholesterolemia Curcumin 8.7718704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.7721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518670907 18850075
MESH:D007006 Hypogonadism Iron 4.3016640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007037 Hypothyroidism Iron 4.9316640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3917937319
MESH:D007249 Inflammation Curcumin 11.3216956363 17151092 18403477
MESH:D007249 Inflammation Dietary Fats 11.3220412841
MESH:D007249 Inflammation Tamoxifen 11.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.3212200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.4918596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.4918200517
MESH:D007333 Insulin Resistance Dietary Fats 11.7211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.7216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.7216306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.4617994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0910783313
MESH:D019189 Iron Metabolism Disorders Iron 4.8917163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Estradiol 2.5015618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6916705839
MESH:D007680 Kidney Neoplasms Estradiol 11.6915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.6918625569
MESH:D007889 Leiomyoma Curcumin 4.4318555241
MESH:D007938 Leukemia Curcumin 6.3418462866
MESH:D007938 Leukemia Genistein 6.3417468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0716106398
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 3.7720368581
MESH:D015458 Leukemia, T-Cell Curcumin 4.6116106398
MESH:D020961 Lewy Body Disease Iron 5.2816563566
MESH:D008064 Lipidoses Tamoxifen 3.0517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6918296743
MESH:D008103 Liver Cirrhosis Iron 6.6916640825
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.4917355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4912878042
MESH:D008107 Liver Diseases Curcumin 2.5816956363
MESH:D008108 Liver Diseases, Alcoholic Iron 4.8516737972 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.987678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 24.9814678523 10737359 16273603 11376686 10672840 18001218
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.9818177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.9820195826 21137059
MESH:D008113 Liver Neoplasms Iron 24.9816640825 20302851
MESH:D008113 Liver Neoplasms pirinixic acid 24.9816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 24.9816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.9816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.386135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 13.386150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.388603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3812151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 10.4211376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.4214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.426695378 20464547 20869020 18816296 20135361 18569708 20064080 17053015 18520028
MESH:D008175 Lung Neoplasms Curcumin 10.4216243823 19359593 18462866
MESH:D008175 Lung Neoplasms Iron 10.4216640825
MESH:D008175 Lung Neoplasms Tamoxifen 10.4218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4219555203 11884234
MESH:D008223 Lymphoma Curcumin 3.4818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5416173963
MESH:D008268 Macular Degeneration Iron 3.9016640825
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6119428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 13.5211921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.5216891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.5212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.5219196723 19196722 11731420 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.1419453300
MESH:D008545 Melanoma Curcumin 3.3717885582 18462866
MESH:D008545 Melanoma Tamoxifen 3.3719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0315990972
MESH:D008569 Memory Disorders Curcumin 4.0117263510
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D009101 Multiple Myeloma Curcumin 3.4119372569
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.5217086897
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009181 Mycoses Iron 5.3216640825
MESH:D009203 Myocardial Infarction Genistein 5.4717141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4719151258
MESH:D017202 Myocardial Ischemia Iron 8.7716604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 19.3616810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 19.3617141266
MESH:D015428 Myocardial Reperfusion Injury Iron 19.3616604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 19.3616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4618551238 7678174
MESH:D009336 Necrosis 2-nitropropane 10.4612195237
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2218495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5711141357
MESH:D009369 Neoplasms pirinixic acid 4.5717405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.3412497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3419200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009404 Nephrotic Syndrome Iron 4.3917178036
MESH:D009421 Nervous System Malformations Estradiol 15.5116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.5116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4818462866
MESH:D019636 Neurodegenerative Diseases Iron 4.1216604332 17296847
MESH:D009765 Obesity Curcumin 7.2119297423
MESH:D009765 Obesity Dietary Fats 7.2117217161 19632207 16723640 18457598 21332399 18674790 20132043 11836018 20518802
MESH:D009765 Obesity pirinixic acid 7.2120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D010003 Osteoarthritis Iron 3.8816640825
MESH:D010024 Osteoporosis Curcumin 16.2718719352
MESH:D010024 Osteoporosis Genistein 16.2719401787
MESH:D010024 Osteoporosis Iron 16.2716640825 16648989
MESH:D010024 Osteoporosis Vitamin D 16.2717882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D010051 Ovarian Neoplasms Curcumin 7.6819020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 7.6819401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6819005980
MESH:D010190 Pancreatic Neoplasms Curcumin 2.8817440100 19196508 19401701
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0617698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010212 Papilloma Iron 4.3312065085
MESH:D020447 Parasomnias Iron 5.8717352947
MESH:D010300 Parkinson Disease Iron 3.2716563566 16640825
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010900 Pituitary Diseases Iron 5.5216604332
MESH:D011041 Poisoning Iron 4.1516604332
MESH:D017119 Porphyria Cutanea Tarda Iron 10.5316640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.5318163543
MESH:D011225 Pre-Eclampsia Iron 4.3116640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Curcumin 1.8718156803 18226269 10851300 15129424 12497104 11398177 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8715256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011528 Protozoan Infections Iron 5.8716640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.3919168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012148 Restless Legs Syndrome Iron 4.4316930377
MESH:D012509 Sarcoma Curcumin 3.9818462866
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4418551238
MESH:D018805 Sepsis Curcumin 3.9518389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0919755658 10029692
MESH:D012878 Skin Neoplasms Iron 9.0912065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0616709447
MESH:D013088 Spermatocele Tamoxifen 11.0616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013276 Stomach Ulcer Curcumin 3.3616631530 19188055
MESH:D013398 Sudden Infant Death Iron 5.3016640825
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014376 Tuberculosis Iron 3.9916597321
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.1916049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 15.191399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.1917053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.1918593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.198653321 16712894 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.1118462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D015430 Weight Gain Dietary Fats 3.6116723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134902131
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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