AutismKB 2.0

Annotation Detail for MAPK4


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Basic Information Top
Gene Symbol:MAPK4 ( ERK3,Erk4,PRKM4,p63MAPK )
Gene Full Name: mitogen-activated protein kinase 4
Band: 18q21.1-q21.2
Quick LinksEntrez ID:5596; OMIM: 176949; Uniprot ID:MK04_HUMAN; ENSEMBL ID: ENSG00000141639; HGNC ID: 6878
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00056VEGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C430898 AGN 194204 AGN 194204 results in decreased expression of MAPK4 proteindecreases expression 15318936
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAPK4 mRNAaffects expression 16483693
D002087 Butyrates Butyrates results in decreased expression of MAPK4 mRNAdecreases expression 14674679
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK4 mRNAaffects cotreatment|decreases expression 12634122
D002118 Calcium Calcium affects the expression of MAPK4 mRNAaffects expression 15913539
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK4 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK4 mRNAaffects cotreatment|decreases expression 12634122
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK4 mRNAaffects cotreatment|decreases expression 12634122
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of MAPK4 mRNAincreases expression 12634122
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK4 mRNAaffects cotreatment|decreases expression 12634122
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of MAPK4 mRNAaffects cotreatment|decreases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MAPK4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAPK4 mRNAdecreases expression 16054899
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0017306315 16712894
MESH:D000544 Alzheimer Disease rosiglitazone 2.8619621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001169 Arthritis, Experimental Dexamethasone 3.5717659584
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9816507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3918572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.322727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.3219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 15340226 15668235 8697196 12621046
MESH:D003110 Colonic Neoplasms Butyrates 4.2715936596
MESH:D003110 Colonic Neoplasms Dexamethasone 4.2715824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.0217728286
MESH:D019465 Craniofacial Abnormalities lead acetate 4.0219769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.0210048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4812438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3517446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5417107852
MESH:D003967 Diarrhea Dexamethasone 3.767237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004485 Eczema Dexamethasone 4.5212438553
MESH:D004487 Edema Dexamethasone 11.9219703484
MESH:D004487 Edema rosiglitazone 11.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver rosiglitazone 3.9919196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.4519769572
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.097520565
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia rosiglitazone 3.9612083418
MESH:D006973 Hypertension Dexamethasone 5.3117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118850075 18670907
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.5418306037
MESH:D007248 Infertility, Male sodium arsenite 3.0212646999 15346721
MESH:D007249 Inflammation Dexamethasone 8.6011099482 8960868
MESH:D007249 Inflammation rosiglitazone 8.6012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6012878042 12200463
MESH:D007333 Insulin Resistance rosiglitazone 3.8316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.5418306037
MESH:D007674 Kidney Diseases Cadmium Chloride 6.5316962696
MESH:D007674 Kidney Diseases sodium arsenite 6.5320008137
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.1416316344
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.6516718785
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.6517347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6512878042
MESH:D008113 Liver Neoplasms sodium arsenite 4.5116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008171 Lung Diseases sodium arsenite 3.2119095001
MESH:D008175 Lung Neoplasms Dexamethasone 3.4915824018 11195469
MESH:D008175 Lung Neoplasms sodium arsenite 3.4917077188 16712894 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4919555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.4216827153
MESH:D008545 Melanoma sodium arsenite 2.0416487513 19082730
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4217261469
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.9717671175
MESH:D009101 Multiple Myeloma Dexamethasone 3.5415867202 15744524 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.579809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009369 Neoplasms sodium arsenite 2.5211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7420056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1812854658
MESH:D010024 Osteoporosis Calcium 3.8117882678
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4517306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms AGN 194204 3.6616000583
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.6616039940
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.6718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8412854658
MESH:D013272 Stomach Diseases Dexamethasone 4.4015472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.5415138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Butyrates 4.1117967635
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5216452187 11723127 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8211813266
MESH:D014605 Uveitis Dexamethasone 4.911336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30623
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA7000sorafenib
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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