AutismKB 2.0

Annotation Detail for MAPK11


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Basic Information Top
Gene Symbol:MAPK11 ( P38B,P38BETA2,PRKM11,SAPK2,SAPK2B,p38-2,p38Beta )
Gene Full Name: mitogen-activated protein kinase 11
Band: 22q13.33
Quick LinksEntrez ID:5600; OMIM: 602898; Uniprot ID:MK11_HUMAN; ENSEMBL ID: ENSG00000185386; HGNC ID: 6873
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa05142Chagas disease
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05131Shigellosis
hsa04722Neurotrophin signaling pathway
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Myogenesis
Signalling by NGF
Signaling in Immune system
Pathway IDPathway Name
200031CD40/CD40L signaling
200124IL6-mediated signaling events
200082IL2-mediated signaling events
200069Thromboxane A2 receptor signaling
200067FAS (CD95) signaling pathway
200090Rapid glucocorticoid signaling
200150CXCR3-mediated signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200029Plasma membrane estrogen receptor signaling
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00035Interferon-gamma signaling pathway
P00046Oxidative stress response
P04398p53 pathway feedback loops 2
P00018EGF receptor signaling pathway
P00052TGF-beta signaling pathway
P00010B cell activation
P00021FGF signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAPK11 mRNAdecreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MAPK11 mRNAdecreases expression 18648102
D019328 Buthionine Sulfoximine Buthionine Sulfoximine results in decreased expression of MAPK11 mRNAdecreases expression 17989939
D019328 Buthionine Sulfoximine Sodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]decreases expression|decreases reaction 17989939
D005480 Flurbiprofen MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]increases expression|increases reaction 18056468
D007052 Ibuprofen MAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]increases expression|increases reaction 18056468
C408604 PD 169316 PD 169316 results in decreased activity of MAPK11 proteindecreases activity 14685156
C059514 resveratrol resveratrol results in increased phosphorylation of MAPK11 proteinincreases phosphorylation 17015251
C059514 resveratrol tin protoporphyrin IX inhibits the reaction [resveratrol results in increased phosphorylation of MAPK11 protein]decreases reaction|increases phosphorylation 17015251
C093642 SB 203580 SB 203580 results in decreased activity of MAPK11 proteindecreases activity 14685156
18457675
D012643 Selenium Selenium results in increased expression of MAPK11 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK11 proteinincreases activity|increases phosphorylation 15504454
D018038 Sodium Selenite Sodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]decreases expression|decreases reaction 17989939
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MAPK11 mRNAdecreases expression 17989939
D018038 Sodium Selenite Sodium Selenite results in increased expression of MAPK11 mRNAincreases expression 19363675
D018038 Sodium Selenite Sodium Selenite results in increased expression of MAPK11 proteinincreases expression 19363675
D013629 Tamoxifen Tamoxifen results in decreased expression of MAPK11 mRNAdecreases expression 15590111
C032628 tin protoporphyrin IX tin protoporphyrin IX inhibits the reaction [resveratrol results in increased phosphorylation of MAPK11 protein]decreases reaction|increases phosphorylation 17015251
D014810 Vitamin E Vitamin E results in increased expression of MAPK11 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D058186 Acute Kidney Injury Ibuprofen 9.256375363
MESH:D058186 Acute Kidney Injury resveratrol 9.2516538975
MESH:D000230 Adenocarcinoma Ibuprofen 3.2610697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.943712494
MESH:D000236 Adenoma resveratrol 6.9415688382
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 5.1210680582
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0017306315 16712894
MESH:D000544 Alzheimer Disease Ibuprofen 4.6918351690
MESH:D000544 Alzheimer Disease resveratrol 4.6916183991 16162502
MESH:D000707 Anaphylaxis Ibuprofen 5.329532969
MESH:D001169 Arthritis, Experimental resveratrol 3.5317115116
MESH:D050197 Atherosclerosis resveratrol 3.3016873680 17967414
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D002545 Brain Ischemia Ibuprofen 10.8115837124
MESH:D002545 Brain Ischemia resveratrol 10.8117600658
MESH:D001943 Breast Neoplasms resveratrol 2.3217651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 2.3221138602 11161223 19059307 20544844 20005174 19011961 19103187 15565566 20859285 19221464 19244106 15668708 16818667 18855134 18821012 17893378 19289846 18815881 18425577 18351453 16273361 19189210 19288272 19155303 20390343 19189212 17049068 19115204 19200415 19084267 19410462 20135344 18984771 19142967 21152245 16202921 16873071 18629630 17440819 17242785 18997820 17261762 20065188 19487384 19066611
MESH:D002100 Cachexia Ibuprofen 5.5515141370
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.673581430 7296757
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.6716227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6716924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6716675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8916227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8918572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D002318 Cardiovascular Diseases resveratrol 3.5115458977
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.867505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.8619524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.199022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D003092 Colitis resveratrol 9.9016474422
MESH:D003092 Colitis Selenium 9.9017936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4616338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.7816507316
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 18759878 8970840 12868966 14531868 8156756 11906362 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8116873680
MESH:D003928 Diabetic Nephropathies resveratrol 9.2016286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.2019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.3818289764 16192314 18692083 9653073 18648102 11289319 8291058 6679447 7440962 6482804 9022650 9328219 1440618
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3815131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3815131321
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.7018450898 18446180 16133044
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema resveratrol 3.428985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.4717872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0819155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Ibuprofen 4.6615652904
MESH:D019446 Endotoxemia Ibuprofen 5.0511545620
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9217923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver Tamoxifen 3.2214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005334 Fever Ibuprofen 4.6316997862
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D006561 Herpes Simplex resveratrol 4.2616876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006937 Hypercholesterolemia resveratrol 4.0617188708
MESH:D006949 Hyperlipidemias resveratrol 4.0916873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006984 Hypertrophy Ibuprofen 5.0316672835
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3517488730
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.9316133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7217600658
MESH:D007248 Infertility, Male sodium arsenite 3.0212646999 15346721
MESH:D007249 Inflammation Flurbiprofen 12.3411099482
MESH:D007249 Inflammation Ibuprofen 12.343291741
MESH:D007249 Inflammation resveratrol 12.3416366677
MESH:D007249 Inflammation Tamoxifen 12.3419457130
MESH:D007251 Influenza, Human resveratrol 19.2216624496
MESH:D007251 Influenza, Human Selenium 19.2216624496
MESH:D007251 Influenza, Human Vitamin E 19.2216624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3114714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007674 Kidney Diseases sodium arsenite 6.2920008137
MESH:D007674 Kidney Diseases Vitamin E 6.2912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.536582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.5318625569
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6116087638
MESH:D008064 Lipidoses Tamoxifen 3.1917567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5418564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5416169303
MESH:D008113 Liver Neoplasms resveratrol 7.6519321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 7.6515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 7.6516684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.563712494 598648 6587162 1399818
MESH:D008171 Lung Diseases sodium arsenite 7.5619095001
MESH:D008171 Lung Diseases Vitamin E 7.5616863852
MESH:D008175 Lung Neoplasms sodium arsenite 3.5119931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 3.5118625569
MESH:D008175 Lung Neoplasms Vitamin E 3.5111062179
MESH:D016393 Lymphoma, B-Cell resveratrol 10.4717088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 10.4714737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 10.2815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 10.2819428831
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 14.6310697514
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.6311606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 14.6315318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.6311731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma resveratrol 5.2117992120
MESH:D008545 Melanoma sodium arsenite 5.2116487513 19082730
MESH:D008545 Melanoma Tamoxifen 5.2119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008659 Metabolic Diseases resveratrol 4.4317112576
MESH:D009101 Multiple Myeloma resveratrol 3.5014749477 16490592 16267019 17049120 17935668 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9517962980
MESH:D009203 Myocardial Infarction resveratrol 3.0516317513 17188708 17125593 16525036 16456233 17015251
MESH:D017202 Myocardial Ischemia resveratrol 4.0517125593 17015251
MESH:D009205 Myocarditis resveratrol 4.8417322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.763581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009369 Neoplasms sodium arsenite 2.5211559025
MESH:D009374 Neoplasms, Experimental resveratrol 9.478985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.4720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019189210 19200415 19196722
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.086375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.4310961664
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.376679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.3712854658
MESH:D019636 Neurodegenerative Diseases resveratrol 3.8517652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4617929310
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010003 Osteoarthritis Ibuprofen 4.167009135
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3117513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4517306315 15276417
MESH:D010146 Pain Ibuprofen 3.973291741
MESH:D010149 Pain, Postoperative Ibuprofen 5.2416678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.5012384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.2616679765
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.1217409433
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.1217409433
MESH:D011471 Prostatic Neoplasms resveratrol 2.1217675339 16731767 17636462 15767336 17804756 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1216039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1218760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1215084515
MESH:D011507 Proteinuria Ibuprofen 4.686375363
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6816325855
MESH:D015427 Reperfusion Injury resveratrol 3.3016314181 17520802 17058453 15827377 16317513
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms resveratrol 6.0415837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 6.0418572023 19524636
MESH:D013088 Spermatocele Tamoxifen 4.3916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8412854658
MESH:D020521 Stroke Vitamin E 3.5616517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5316321402
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.926587162 7505956 6582329 1399818 3712494
MESH:D014062 Tongue Neoplasms resveratrol 4.2616227395
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.438074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.4311723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4317572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.7417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.7411813266
MESH:D014594 Uterine Neoplasms resveratrol 4.2017044934
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.2719057314
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.3717488730
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04912 GnRH signaling pathway
KEGG:05160 Hepatitis C
REACT:25035 Innate immune response mediated by toll like receptors
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04010 MAPK signaling pathway
REACT:21257 Metabolism of RNA
REACT:21303 Myogenesis
KEGG:04722 Neurotrophin signaling pathway
KEGG:04621 NOD-like receptor signaling pathway
KEGG:04380 Osteoclast differentiation
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04622 RIG-I-like receptor signaling pathway
KEGG:05131 Shigellosis
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30618
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA449247dexamethasone
    PA7000sorafenib
    PA450635nitric oxide
    PA448478l-arginine
    Drug Bank Top

    Simple Query:


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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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