AutismKB 2.0

Annotation Detail for MAPK10


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Basic Information Top
Gene Symbol:MAPK10 ( FLJ12099,FLJ33785,JNK3,JNK3A,MGC50974,PRKM10,p493F12,p54bSAPK )
Gene Full Name: mitogen-activated protein kinase 10
Band: 4q21.3
Quick LinksEntrez ID:5602; OMIM: 602897; Uniprot ID:MK10_HUMAN; ENSEMBL ID: ENSG00000109339; HGNC ID: 6872
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04920Adipocytokine signaling pathway
hsa05160Hepatitis C
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa05142Chagas disease
hsa05145Toxoplasmosis
hsa04310Wnt signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05131Shigellosis
hsa04722Neurotrophin signaling pathway
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa04664Fc epsilon RI signaling pathway
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200031CD40/CD40L signaling
200016Noncanonical Wnt signaling pathway
200067FAS (CD95) signaling pathway
200091FoxO family signaling
200077Glucocorticoid receptor regulatory network
200119ErbB2/ErbB3 signaling events
200103p75(NTR)-mediated signaling
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00035Interferon-gamma signaling pathway
P00046Oxidative stress response
P00018EGF receptor signaling pathway
P00052TGF-beta signaling pathway
P00020FAS signaling pathway
P00010B cell activation
P00049Parkinson disease
P00047PDGF signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Epileptic encephalopathy, Lennox-Gastaut type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of MAPK10 mRNAincreases expression 19643169
C014949 acetylhydrazine acetylhydrazine results in decreased expression of MAPK10 mRNAdecreases expression 15282401
C412373 AG 1879 AG 1879 inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK10 protein]decreases reaction|increases activity 15574683
D013196 Dihydrotestosterone APOE gene polymorphism affects the reaction [Dihydrotestosterone affects the phosphorylation of MAPK10 protein]affects phosphorylation|affects reaction 17395708
D000841 Anisomycin Anisomycin results in increased activity of MAPK10 proteinincreases activity 10531305
D000841 Anisomycin Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein]decreases reaction|increases activity 10531305
D001149 Arsenates [Arsenates co-treated with chromium hexavalent ion] results in increased expression of MAPK10 proteinaffects cotreatment|increases expression 19895865
D001149 Arsenates [Arsenates co-treated with chromium hexavalent ion] results in increased phosphorylation of MAPK10 proteinaffects cotreatment|increases phosphorylation 19895865
D002330 Carmustine Carmustine results in decreased expression of MAPK10 mRNAdecreases expression 15980968
C074702 chromium hexavalent ion [Arsenates co-treated with chromium hexavalent ion] results in increased expression of MAPK10 proteinaffects cotreatment|increases expression 19895865
C074702 chromium hexavalent ion [Arsenates co-treated with chromium hexavalent ion] results in increased phosphorylation of MAPK10 proteinaffects cotreatment|increases phosphorylation 19895865
C074702 chromium hexavalent ion chromium hexavalent ion results in increased expression of MAPK10 proteinincreases expression 19895865
C074702 chromium hexavalent ion chromium hexavalent ion results in increased phosphorylation of MAPK10 proteinincreases phosphorylation 19895865
D015946 Ethylene Dibromide Ethylene Dibromide results in increased expression of MAPK10 mRNAincreases expression 15612046
D001728 Dicumarol Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein]decreases reaction|increases activity 10531305
D001728 Dicumarol Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]decreases reaction|increases activity 10531305
D001728 Dicumarol Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein]decreases reaction|increases activity 10531305
D001728 Dicumarol Dicumarol results in decreased activity of MAPK10 proteindecreases activity 10531305
D001728 Dicumarol NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]decreases activity|decreases reaction 10531305
D001728 Dicumarol hydroquinone inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]decreases activity|decreases reaction 10531305
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 proteinincreases activity|increases phosphorylation 16687611
D004317 Doxorubicin pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein]decreases reaction|increases activity|increases phosphorylation 16687611
D004642 Emodin Emodin results in increased expression of MAPK10 mRNAincreases expression 15612046
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MAPK10 mRNAaffects expression 17555576
D005419 Flavonoids Flavonoids results in increased expression of MAPK10 mRNAincreases expression 18035473
D019833 Genistein Genistein results in increased expression of MAPK10 mRNAincreases expression 16169203
C004312 glycidol glycidol results in increased expression of MAPK10 mRNAincreases expression 15612046
C078131 GM 6001 GM 6001 inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK10 protein]decreases reaction|increases activity 15574683
D006861 Hydrogen Peroxide AG 1879 inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK10 protein]decreases reaction|increases activity 15574683
D006861 Hydrogen Peroxide GM 6001 inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK10 protein]decreases reaction|increases activity 15574683
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of MAPK10 proteinincreases activity 15574683
C031927 hydroquinone hydroquinone inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]decreases activity|decreases reaction 10531305
D008070 Lipopolysaccharides Lipopolysaccharides results in increased phosphorylation of MAPK10 proteinincreases phosphorylation 11543732
D008070 Lipopolysaccharides Quercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK10 protein]decreases reaction|increases phosphorylation 11543732
D008687 Metformin Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]decreases reaction|increases phosphorylation 16385087
C005219 methyl cellosolve methyl cellosolve results in increased expression of MAPK10 mRNAincreases expression 19643169
D009151 Mustard Gas Mustard Gas results in increased expression of MAPK10 mRNAincreases expression 15674843
D009638 Norepinephrine MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine]affects reaction|affects response to substance 16949803
D010656 Phenylephrine MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]affects reaction|affects response to substance 16949803
C121565 pifithrin pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein]decreases reaction|increases activity|increases phosphorylation 16687611
D011189 Potassium Chloride MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Potassium Chloride]affects reaction|affects response to substance 16949803
D011794 Quercetin Quercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK10 protein]decreases reaction|increases phosphorylation 11543732
D015125 Oxyquinoline Oxyquinoline results in increased expression of MAPK10 mRNAincreases expression 15612046
C017947 sodium arsenite sodium arsenite results in increased expression of MAPK10 proteinincreases expression 11446828
D013012 Sorbitol Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]decreases reaction|increases activity 10531305
D013012 Sorbitol Sorbitol results in increased activity of MAPK10 proteinincreases activity 10531305
C016766 sulforafan sulforafan results in increased phosphorylation of MAPK10 proteinincreases phosphorylation 16033772
C025462 sulindac sulfide sulindac sulfide results in increased expression of MAPK10 mRNAincreases expression 12734198
D013629 Tamoxifen Tamoxifen affects the expression of MAPK10 mRNAaffects expression 17555576
C025643 vinclozolin vinclozolin affects the expression of MAPK10 mRNAaffects expression 19015723
D024483 Vitamin K 3 Vitamin K 3 results in decreased activity of MAPK10 proteindecreases activity 10531305
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1714745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 8.216499820 6499823 6499796 6499812 7151721
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 8.216474471 6499812 3652986
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5717505938
MESH:D058186 Acute Kidney Injury pifithrin 4.5517670903
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.7018653653 11850527
MESH:D000230 Adenocarcinoma Doxorubicin 6.5217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5214692618
MESH:D000230 Adenocarcinoma Genistein 6.5211473722
MESH:D011125 Adenomatous Polyposis Coli sulforafan 4.9517942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5316712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.1921441931
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0018759972
MESH:D000743 Anemia, Hemolytic Quercetin 3.9117084956
MESH:D000748 Anemia, Macrocytic methyl cellosolve 5.973699323
MESH:D001008 Anxiety Disorders vinclozolin 3.3519015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8017460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4415885639
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.386499823 10689203 6499807
MESH:D053627 Asthenozoospermia methyl cellosolve 11.383987992
MESH:D001249 Asthma Mustard Gas 2.6010378619
MESH:D001259 Ataxia 2-ethoxyethanol 5.127151721
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6115336622
MESH:D001284 Atrophy 2-ethoxyethanol 10.2515850284 6499799
MESH:D001284 Atrophy methyl cellosolve 10.252626667 3699323 6705890
MESH:D001321 Autistic Disorder Norepinephrine 3.418570775
MESH:D001327 Autoimmune Diseases Quercetin 10.0719761891
MESH:D001327 Autoimmune Diseases sulforafan 10.0719761891
MESH:D053713 Azoospermia 2-ethoxyethanol 5.226492198 6499807
MESH:D001724 Birth Weight 2-ethoxyethanol 6.142884743 6499823
MESH:D001768 Blister Mustard Gas 4.7919167455
MESH:D001836 Body Weight Changes 2-ethoxyethanol 5.347151721 6499796
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3214601052
MESH:D001919 Bradycardia Phenylephrine 4.1815306635
MESH:D001932 Brain Neoplasms Carmustine 13.1616187019
MESH:D001932 Brain Neoplasms Doxorubicin 13.1617150277
MESH:D001932 Brain Neoplasms glycidol 13.1610528639 12562636
MESH:D001943 Breast Neoplasms Doxorubicin 2.7918628466 16826403 16096432 17369602 15136595 16935488 18382427 15634643 19526202 17983394 16264153 18234424 15939500 11325840 18695136 15994142 15567936 15692762 17426702 16322301 15668708 16115903 15993339 16595493
MESH:D001943 Breast Neoplasms Ethylene Dibromide 2.7911921183
MESH:D001943 Breast Neoplasms Genistein 2.7916541309 16873071 17200150
MESH:D001943 Breast Neoplasms glycidol 2.7911921183
MESH:D001943 Breast Neoplasms Quercetin 2.7918628248
MESH:D001943 Breast Neoplasms Tamoxifen 2.7919011961 19200415 21138602 19103187 19410462 18984771 19084267 17261762 15565566 19059307 18629630 21152245 19189212 19288272 15668708 16273361 19189210 19066611 19142967 17049068 18855134 16818667 17893378 18425577 18815881 19487384 19221464 19289846 20544844 20135344 16202921 19244106 19115204 20390343 11161223 16873071 18351453 20005174 18821012 20859285 19155303 20065188 17440819 18997820 17242785
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6017687719 10378619
MESH:D002105 Cadmium Poisoning Quercetin 5.1716962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4416051944
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1519066611
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.1616234567 16023760 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.1616924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.1619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.1616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.1616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3212391285
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6017234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.9816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.436189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3017572228
MESH:D006332 Cardiomegaly Norepinephrine 10.5411179087
MESH:D006332 Cardiomegaly Phenylephrine 10.5417124262 16170337 15728586 11754973 11179087 17287366
MESH:D006332 Cardiomegaly Quercetin 10.5419794523
MESH:D009202 Cardiomyopathies Doxorubicin 3.2917928571 16269455 16952015 15476868 17131338 17519947 17007740 15505089 15811867 17329180 17924179 16651473 16278810 18627295 16364871 17974986 15792986 16731534 17382496 17351982 16612575 16109756 16455267 17308081 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8117334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 6.6816332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.6816936243
MESH:D002375 Catalepsy Norepinephrine 5.178216760
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.7420056578 19524636
MESH:D002764 Cholecystitis 2-ethoxyethanol 12.406499794
MESH:D002764 Cholecystitis methyl cellosolve 12.406499794
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6011677210 16919318 15861022 17681005 17110522 16105132 17333356
MESH:D003110 Colonic Neoplasms Genistein 3.6617182828
MESH:D003110 Colonic Neoplasms Quercetin 3.6619056647 11134977 17148506 19440933 17191121 16640504 15741050
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6218802399 18259882
MESH:D015179 Colorectal Neoplasms Quercetin 2.6218852136 18095365
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.516499821 12530607
MESH:D003456 Cryptorchidism vinclozolin 3.9914966744
MESH:D003643 Death 2-ethoxyethanol 5.596499796
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0019031437
MESH:D003920 Diabetes Mellitus Metformin 5.0217446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4419496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.8416647724
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 4.8421186350
MESH:D003925 Diabetic Angiopathies Metformin 5.6716385087
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1719279558
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.4117416283
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 4.412862719
MESH:D004362 Drug Toxicity Doxorubicin 3.4018602426
MESH:D004487 Edema Mustard Gas 3.0011402378 11428631 9260866 11428647
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.146499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.7919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2216402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.1217359293
MESH:D016889 Endometrial Neoplasms Genistein 11.1211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.1220544844 17893378 19155303 16202921
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7818037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0317637181 15328337 15821434
MESH:D004827 Epilepsy Norepinephrine 4.11821787
MESH:C535500 Epileptic encephalopathy, Lennox-Gastaut type marker/mechanism
MESH:D004890 Erythema Mustard Gas 4.799357497
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.6115345470
MESH:D005234 Fatty Liver Tamoxifen 6.6119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0116709447
MESH:D005313 Fetal Death 2-ethoxyethanol 5.026499820 7198755 6499823 7151721 2884743
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.066499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 11.426499812 6499820
MESH:D005327 Fetal Resorption methyl cellosolve 11.426474471 6499812 6499821 3987992
MESH:D020567 Fetal Weight 2-ethoxyethanol 12.407151721 2884743 6499820
MESH:D020567 Fetal Weight methyl cellosolve 12.406499821 6499812 6474471
MESH:D005334 Fever Lipopolysaccharides 3.7011852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1614745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.2119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.2119069698
MESH:D005355 Fibrosis Emodin 8.2519474275
MESH:D005355 Fibrosis Quercetin 8.2519474275
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.133652986
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3116452187
MESH:D005909 Glioblastoma Carmustine 15.0316187019
MESH:D005909 Glioblastoma Doxorubicin 15.0317150277
MESH:D005909 Glioblastoma Genistein 15.0316598420
MESH:D005909 Glioblastoma Quercetin 15.0319804834
MESH:D005910 Glioma Quercetin 2.9017643826
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.2815692506
MESH:D006331 Heart Diseases Doxorubicin 7.3818006777 16330681 16495754 16144979 17875725 14766674 16879835 18674790 16244372 12587719 17888722 16707910 16244371
MESH:D006331 Heart Diseases pifithrin 7.3814766674
MESH:D006333 Heart Failure Doxorubicin 3.1217481944
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.416499821
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5715692506
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.0520172899 10514026
MESH:D006461 Hemolysis 2-ethoxyethanol 11.0919051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 11.0917874071
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0716366002
MESH:D006689 Hodgkin Disease Doxorubicin 6.4718501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.4712676792
MESH:D017588 Hyperandrogenism Metformin 5.6217062894 15356085
MESH:D006943 Hyperglycemia Quercetin 3.7211834736 18262572
MESH:D006973 Hypertension Phenylephrine 5.1612717712 8949925
MESH:D006973 Hypertension Quercetin 5.1618356687
MESH:D006984 Hypertrophy Phenylephrine 4.2312791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4516569931 16945680
MESH:D007022 Hypotension Norepinephrine 4.666740701
MESH:D020244 Infarction, Middle Cerebral Artery pifithrin 5.3119475672
MESH:D007247 Infertility, Female 2-ethoxyethanol 9.276499823
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.2712013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 18.536499823
MESH:D007248 Infertility, Male Ethinyl Estradiol 18.5317937319
MESH:D007248 Infertility, Male methyl cellosolve 18.533987992
MESH:D007248 Infertility, Male sodium arsenite 18.5312646999 15346721
MESH:D007248 Infertility, Male vinclozolin 18.5316467254
MESH:D007249 Inflammation Flavonoids 10.4017296493
MESH:D007249 Inflammation Lipopolysaccharides 10.4017963957 12878042 17255318 17237260 9205823
MESH:D007249 Inflammation Mustard Gas 10.4011428620 11428647 9260866 9357497 11428631 11402378 8975870 16001271 17524151
MESH:D007249 Inflammation Tamoxifen 10.4019457130
MESH:D007251 Influenza, Human Quercetin 4.1316624496
MESH:D007333 Insulin Resistance Metformin 4.5817062894
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2917255318
MESH:D007627 Keloid Quercetin 4.6017086741
MESH:D007674 Kidney Diseases Doxorubicin 12.8215369732 16775033 15699352
MESH:D007674 Kidney Diseases Ethylene Dibromide 12.8212628311
MESH:D007674 Kidney Diseases Quercetin 12.8216962696
MESH:D007674 Kidney Diseases sodium arsenite 12.8220008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.0316707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.0316518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.7518625569
MESH:D007938 Leukemia Genistein 5.9217468513 18980019
MESH:D007938 Leukemia Quercetin 5.9217468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.6917077332
MESH:D007970 Leukopenia Lipopolysaccharides 4.3315821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3616417039
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.236499821
MESH:D008064 Lipidoses Tamoxifen 2.8915342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.0616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Emodin 8.0615288473
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0617823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.0612741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.0618564211
MESH:D008113 Liver Neoplasms Quercetin 6.6718980244
MESH:D008113 Liver Neoplasms sodium arsenite 6.6715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 6.6716684651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 8.9016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental glycidol 8.9012692647 12562636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 8.9019519916
MESH:D008171 Lung Diseases chromium hexavalent ion 11.1416775837
MESH:D008171 Lung Diseases Mustard Gas 11.1418161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 11.1419095001
MESH:D055370 Lung Injury Lipopolysaccharides 3.6521114838
MESH:D008175 Lung Neoplasms chromium hexavalent ion 9.9016570259 16876463
MESH:D008175 Lung Neoplasms Doxorubicin 9.9017418594 6189445
MESH:D008175 Lung Neoplasms glycidol 9.9012692647 12562636
MESH:D008175 Lung Neoplasms Mustard Gas 9.908781369 3148597
MESH:D008175 Lung Neoplasms Quercetin 9.9016280456
MESH:D008175 Lung Neoplasms sodium arsenite 9.9017306315 16712894 15276417 17077188 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 9.9018625569
MESH:D008223 Lymphoma Doxorubicin 3.2016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2115621674
MESH:D008231 Lymphopenia methyl cellosolve 5.413699323
MESH:D015674 Mammary Neoplasms, Animal glycidol 9.3412692647 12562636 8818859
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3419428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 16.3715458769
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 16.3711921183
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.3712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental glycidol 16.3711921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.3714580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.1719453300
MESH:D008545 Melanoma Carmustine 9.0212393984
MESH:D008545 Melanoma Doxorubicin 9.0216827129
MESH:D008545 Melanoma sodium arsenite 9.0219082730 16487513
MESH:D008545 Melanoma Tamoxifen 9.0212393984 19393235
MESH:D008545 Melanoma Vitamin K 3 9.0219082730
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8115990972
MESH:D008654 Mesothelioma Doxorubicin 2.9117638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1715792986
MESH:D009062 Mouth Neoplasms glycidol 5.1112562636
MESH:D052016 Mucositis Doxorubicin 4.4217415656
MESH:D009203 Myocardial Infarction Doxorubicin 8.6615857846 19429709
MESH:D009203 Myocardial Infarction Genistein 8.6617141266
MESH:D009203 Myocardial Infarction Quercetin 8.6619595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8817141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 12.8815642760
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.8819207477
MESH:D009336 Necrosis 2-ethoxyethanol 4.9820172899
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.3518259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Quercetin 4.6415185748
MESH:D009369 Neoplasms sodium arsenite 4.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6319189210 19200415 19196722
MESH:D009401 Nephrosis Doxorubicin 4.4116636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6915640375 16889571
MESH:D009421 Nervous System Malformations Genistein 3.6816427766
MESH:D009436 Neural Tube Defects sodium arsenite 2.9012854658
MESH:D009447 Neuroblastoma Doxorubicin 3.0715555623
MESH:D020078 Neurogenic Inflammation Quercetin 4.0217929310
MESH:D009503 Neutropenia Mustard Gas 3.6316761898 7688884
MESH:D009669 Nose Neoplasms chromium hexavalent ion 9.1016876463
MESH:D009669 Nose Neoplasms Ethylene Dibromide 9.109385384
MESH:D009845 Oligospermia 2-ethoxyethanol 10.1520172899
MESH:D009845 Oligospermia methyl cellosolve 10.153987992
MESH:D010024 Osteoporosis Genistein 3.0319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.0116169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.0119495926
MESH:D012516 Osteosarcoma Doxorubicin 3.8215930896
MESH:D010051 Ovarian Neoplasms Genistein 7.2419005980
MESH:D010051 Ovarian Neoplasms Quercetin 7.2419005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.2415276417 17306315
MESH:D010190 Pancreatic Neoplasms Quercetin 2.7216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3511578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.7312065085
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7817638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1912224865 11605937
MESH:D011041 Poisoning Mustard Gas 3.4615727166
MESH:D011085 Polycystic Ovary Syndrome Metformin 5.2115356085 17062894
MESH:D011230 Precancerous Conditions Quercetin 3.6719056647
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 14.522884743 7198755 6499817
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 14.5212530607 6499817 7974496
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.5218042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5718220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9116729912 16868541 18437689 15749863 15897917 16888761
MESH:D011471 Prostatic Neoplasms Genistein 1.9115378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 1.9117292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011472 Prostatitis vinclozolin 4.5718629315
MESH:D011537 Pruritus Ethinyl Estradiol 8.3016919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.3018058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7810334151 17894541 17266442 17720292 17620002
MESH:D051437 Renal Insufficiency Doxorubicin 3.8617922066
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4910835634
MESH:D012509 Sarcoma Doxorubicin 3.6718313854 16767912 17710206 15625365 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.8914601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4217846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.1716862918
MESH:D012852 Sinusitis Phenylephrine 4.347327846
MESH:D012871 Skin Diseases Mustard Gas 2.6212880345 16961503 15451306
MESH:D012878 Skin Neoplasms Doxorubicin 12.2415692506
MESH:D012878 Skin Neoplasms glycidol 12.2412562636 12692647
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.2412065085
MESH:D012878 Skin Neoplasms sodium arsenite 12.2418572023 19524636
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2117203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 10.3116709447
MESH:D013088 Spermatocele Tamoxifen 10.3116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5112854658
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 3.773768853
MESH:D013274 Stomach Neoplasms glycidol 3.7712562636 8818859 11397402 12692647
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.066499799
MESH:D013345 Subarachnoid Hemorrhage pifithrin 5.6818364113
MESH:D013610 Tachycardia Norepinephrine 5.093261545
MESH:D013733 Testicular Diseases 2-ethoxyethanol 9.8410048760 10514026 6499806
MESH:D013733 Testicular Diseases methyl cellosolve 9.846499806
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8515669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.1116010429 17909728
MESH:D013964 Thyroid Neoplasms glycidol 7.1112562636
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.7017653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 10.7016720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.7016452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.708653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4511813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.3414692618
MESH:D014594 Uterine Neoplasms glycidol 14.3412562636 12692647
MESH:D014594 Uterine Neoplasms sulindac sulfide 14.3418645019
MESH:D014652 Vascular Diseases sodium arsenite 4.0617056641
MESH:D020301 Vasospasm, Intracranial pifithrin 5.2518364113
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8617638931 17334414 16364871 17678736
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05210 Colorectal cancer
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04510 Focal adhesion
KEGG:04912 GnRH signaling pathway
KEGG:05160 Hepatitis C
KEGG:04910 Insulin signaling pathway
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04621 NOD-like receptor signaling pathway
KEGG:04380 Osteoclast differentiation
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:04622 RIG-I-like receptor signaling pathway
KEGG:05131 Shigellosis
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04930 Type II diabetes mellitus
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30617
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA7000sorafenib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01782 - 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
    DB02388 - Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
    DB03084 - Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
    DB03623 - 9-(4-Hydroxyphenyl)-2,7-Phenanthroline
    DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
    DB06933 - N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide
    DB07010 - N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
    DB07217 - N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
    DB08005 - 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide
    DB08010 - (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime
    DB08011 - (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime
    DB08015 - (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime
    DB08021 - 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide
    DB08023 - N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
    DB08025 - N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE
    DB08026 - 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
    DB08555 - 1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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