AutismKB 2.0

Annotation Detail for MAP2K1


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Basic Information Top
Gene Symbol:MAP2K1 ( MAPKK1,MEK1,MKK1,PRKMK1 )
Gene Full Name: mitogen-activated protein kinase kinase 1
Band: 15q22.31
Quick LinksEntrez ID:5604; OMIM: 176872; Uniprot ID:MP2K1_HUMAN; ENSEMBL ID: ENSG00000169032; HGNC ID: 6840
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-14MAP kinase cascade
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04320Dorso-ventral axis formation
hsa04540Gap junction
hsa04620Toll-like receptor signaling pathway
hsa04730Long-term depression
hsa05219Bladder cancer
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05216Thyroid cancer
hsa04114Oocyte meiosis
hsa05223Non-small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05020Prion diseases
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signalling by NGF
Axon guidance
Signaling by EGFR
Signaling by Insulin receptor
Signaling by PDGF
Signaling in Immune system
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200184Downstream signaling in naive CD8+ T cells
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200004Endothelins
200005BCR signaling pathway
200128Neurotrophic factor-mediated Trk receptor signaling
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200015GMCSF-mediated signaling events
200088Ras signaling in the CD4+ TCR pathway
200120FOXM1 transcription factor network
200080mTOR signaling pathway
200081Class IB PI3K non-lipid kinase events
200082IL2-mediated signaling events
200145Nongenotropic Androgen signaling
200179Cellular roles of Anthrax toxin
200074Netrin-mediated signaling
200150CXCR3-mediated signaling events
200147Hedgehog signaling events mediated by Gli proteins
200119ErbB2/ErbB3 signaling events
200113ErbB1 downstream signaling
200110IFN-gamma pathway
200041EPHB forward signaling
200100Ceramide signaling pathway
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00053T cell activation
P00019Endothelin signaling pathway
P00018EGF receptor signaling pathway
P00010B cell activation
P00054Toll receptor signaling pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P04393Ras Pathway
Pathway IDPathway Name
500083RAF phosphorylates MEK
500085ERK1 activation
500100Signal transduction by L1
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Cardiofaciocutaneous syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased activity of MAP2K1 proteindecreases activity 18393446
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 12411397
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased activity of MAP2K1 proteindecreases activity 16467208
16261397
16940797
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 12411397
C506698 2,5-dimethylcelecoxib 2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16123214
C506698 2,5-dimethylcelecoxib 2,5-dimethylcelecoxib results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 16123214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAP2K1 mRNAaffects expression 21346803
C496751 4-(1H-imidazol-1-yl)retinoic acid 4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of MAP2K1 proteindecreases expression 17145897
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16510265
C072876 A 771726 A 771726 inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]decreases reaction|increases activity 9973483
D000255 Adenosine Triphosphate Adenosine Triphosphate binds to MAP2K1 proteinaffects binding 17693661
C412373 AG 1879 AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16510265
D013196 Dihydrotestosterone bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein]decreases reaction|increases activity|increases phosphorylation 15466214
D013196 Dihydrotestosterone Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 15466214
D013196 Dihydrotestosterone PD 98059 inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein]decreases reaction|increases activity|increases phosphorylation 15466214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP2K1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of MAP2K1 mRNAincreases expression 12420312
C031385 anthranilic acid anthranilic acid results in decreased activity of MAP2K1 proteindecreases activity 18393446
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 18314537
D017638 Asbestos, Crocidolite MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased expression of SCGB1A1 mRNA]affects reaction|increases expression 18192500
D017638 Asbestos, Crocidolite MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 18192500
D017638 Asbestos, Crocidolite MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 18192500
D017638 Asbestos, Crocidolite MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of COL1A1 mRNA]decreases reaction|increases expression 18192500
D017638 Asbestos, Crocidolite MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of COL3A1 mRNA]decreases reaction|increases expression 18192500
D017638 Asbestos, Crocidolite MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of IL6 mRNA]decreases reaction|increases expression 18192500
C035982 beryllium fluoride beryllium fluoride results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 11867686
C053541 bicalutamide bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C053541 bicalutamide bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 15466214
C053541 bicalutamide PD 98059 inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C400082 bortezomib [bortezomib co-treated with Butyrates] results in decreased expression of MAP2K1 proteinaffects cotreatment|decreases expression 12893773
C400082 bortezomib [bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 proteinaffects cotreatment|decreases expression 12893773
D002087 Butyrates [bortezomib co-treated with Butyrates] results in decreased expression of MAP2K1 proteinaffects cotreatment|decreases expression 12893773
D002087 Butyrates Butyrates results in decreased expression of MAP2K1 proteindecreases expression 12893773
D002087 Butyrates MAP2K1 protein mutant form results in decreased activity of [D 21266 co-treated with Butyrates]affects cotreatment|decreases activity 15781658
D000001 Calcimycin Calcimycin results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 16000378
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MAP2K1 mRNAaffects expression 17805973
D002392 Catechin Catechin results in decreased expression of MAP2K1 mRNAdecreases expression 15465739
D002392 Catechin Catechin results in decreased expression of MAP2K1 proteindecreases expression 15465739
D002392 Catechin Catechin results in increased expression of MAP2K1 mRNAincreases expression 15465739
C105934 celecoxib celecoxib results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 16123214
D002713 Chlorine Chlorine results in increased expression of MAP2K1 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNAaffects cotreatment|decreases expression 18636392
C503589 cis-9, trans-11-conjugated linoleic acid [cis-9, trans-11-conjugated linoleic acid co-treated with trans-10,cis-12-conjugated linoleic acid] results in increased phosphorylation of and results in increased activity of MAP2K1 proteinaffects cotreatment|increases activity|increases phosphorylation 17869086
C503589 cis-9, trans-11-conjugated linoleic acid cis-9, trans-11-conjugated linoleic acid results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 17869086
C488583 Clostridium difficile lethal toxin B Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 11158304
D003024 Clozapine Clozapine results in decreased expression of MAP2K1 mRNAdecreases expression 15860345
C105905 D 21266 MAP2K1 protein mutant form results in decreased activity of [D 21266 co-treated with Butyrates]affects cotreatment|decreases activity 15781658
C105905 D 21266 MAP2K1 protein mutant form results in decreased activity of [D 21266 co-treated with trichostatin A]affects cotreatment|decreases activity 15781658
C105905 D 21266 MAP2K1 protein mutant form results in decreased activity of [D 21266 co-treated with vorinostat]affects cotreatment|decreases activity 15781658
C014347 decitabine decitabine results in increased expression of MAP2K1 mRNAincreases expression 17785578
C107676 deguelin deguelin metabolite results in decreased expression of MAP2K1 proteindecreases expression 19139008
C107676 deguelin deguelin results in decreased expression of MAP2K1 proteindecreases expression 19139008
19336726
D004026 Dieldrin Dieldrin results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 15888667
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MAP2K1 mRNAincreases expression 15766595
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MAP2K1 mRNAincreases expression 16636312
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 17974986
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 17974986
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 15288473
D004726 Endosulfan Endosulfan results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 15888667
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 15778002
D004958 Estradiol Estradiol results in increased activity of MAP2K1 proteinincreases activity 15615701
D004958 Estradiol Estradiol results in increased activity of MAP2K1 proteinincreases activity 15615701
D004958 Estradiol Estradiol affects the expression of MAP2K1 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of MAP2K1 mRNAincreases expression 14664709
D004976 Ethacrynic Acid Ethacrynic Acid results in increased expression of MAP2K1 proteinincreases expression 14556662
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MAP2K1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAP2K1 mRNAincreases expression 17108234
D005419 Flavonoids Flavonoids results in decreased expression of MAP2K1 mRNAdecreases expression 15465739
C024352 fludarabine fludarabine results in increased activity of MAP2K1 proteinincreases activity 15059916
C001277 geldanamycin geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]decreases reaction|increases activity 8816498
D019833 Genistein Genistein results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 15781664
D006152 Cyclic GMP Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K1 protein]affects reaction|decreases activity|decreases phosphorylation 18225537
D006152 Cyclic GMP Cyclic GMP results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 18225537
D006220 Haloperidol Haloperidol results in decreased expression of MAP2K1 mRNAdecreases expression 15860345
D006493 Heparin Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 14966081
D006493 Heparin Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 14966081
D006533 Heptachlor Heptachlor results in decreased expression of MAP2K1 proteindecreases expression 9704902
D006533 Heptachlor Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 15888667
D006820 Hyaluronic Acid Hyaluronic Acid analog results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 12402308
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of MAP2K1 proteinincreases activity 15242773
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 15288473
D007213 Indomethacin Indomethacin results in increased expression of MAP2K1 mRNAincreases expression 18299717
D007545 Isoproterenol MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA]affects reaction|increases expression 10888249
D007545 Isoproterenol MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 10888249
D007545 Isoproterenol MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 10888249
C067431 letrozole letrozole results in increased expression of MAP2K1 proteinincreases expression 15967659
D001556 Lindane Lindane results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 15888667
D008070 Lipopolysaccharides MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]increases expression|increases reaction 10469353
D008070 Lipopolysaccharides MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]increases expression|increases reaction 10469353
C009900 lipoteichoic acid lipoteichoic acid results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 19573522
C009900 lipoteichoic acid Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 19573522
D008094 Lithium [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 proteinincreases activity|increases phosphorylation 19159680
C015329 lycopene lycopene results in increased expression of MAP2K1 mRNAincreases expression 16886892
D008353 Mannitol Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16510265
C014659 methyl(acetoxymethyl)nitrosamine methyl(acetoxymethyl)nitrosamine results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 12693035
D008770 Methylnitrosourea Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 12693035
C008493 methylselenic acid methylselenic acid results in decreased expression of MAP2K1 mRNAdecreases expression 11830524
C008493 methylselenic acid methylselenic acid results in increased expression of MAP2K1 mRNAincreases expression 12517777
D009151 Mustard Gas Mustard Gas results in increased expression of MAP2K1 mRNAincreases expression 18955075
C040015 myricetin myricetin binds to and results in decreased activity of MAP2K1 proteinaffects binding|decreases activity 17693661
C040015 myricetin myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]decreases reaction|increases activity 17693661
D009605 Nitrosomethylurethane Nitrosomethylurethane results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 12693035
C404397 NSC 680410 NSC 680410 affects the cleavage of MAP2K1 proteinaffects cleavage 14647418
C404397 NSC 680410 NSC 680410 results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 14647418
C474055 octylphenol octylphenol results in increased activity of MAP2K1 proteinincreases activity 18417718
C474055 octylphenol U 0126 inhibits the reaction [octylphenol results in increased activity of MAP2K1 protein]decreases reaction|increases activity 18417718
C440229 Oleylethanolamide Oleylethanolamide promotes the reaction [ERBB2 protein binds to MAP2K1 protein modified form]affects binding|increases reaction 16269455
C440229 Oleylethanolamide Oleylethanolamide results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 16269455
C440229 Oleylethanolamide tyrphostin AG 1478 inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16269455
D010100 Oxygen MAP2K1 protein results in increased susceptibility to Oxygenincreases response to substance 10780954
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNAaffects cotreatment|decreases expression 18636392
C506614 PD 0325901 PD 0325901 results in decreased activity of MAP2K1 proteindecreases activity 19282848
C093973 PD 98059 PD 98059 results in decreased activity of MAP2K1 proteindecreases activity 15817663
C093973 PD 98059 PD 98059 inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C093973 PD 98059 PD 98059 inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C093973 PD 98059 PD 98059 inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 15466214
C093973 PD 98059 PD 98059 results in decreased activity of MAP2K1 proteindecreases activity 15313166
15179185
15955695
15184045
15242773
15896333
15666830
C093973 PD 98059 PD 98059 results in decreased activity of MAP2K1 proteindecreases activity 12663507
C093973 PD 98059 PD 98059 results in decreased activity of MAP2K1 proteindecreases activity 15631803
D010656 Phenylephrine MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects reaction|increases expression 10888249
D010656 Phenylephrine MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 10888249
D010656 Phenylephrine MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 10888249
D010710 Phosphates Phosphates results in increased phosphorylation of and results in increased activity of MAP2K1 proteinincreases activity|increases phosphorylation 16763222
D010936 Plant Extracts Plant Extracts results in decreased expression of MAP2K1 mRNAdecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of MAP2K1 mRNAdecreases expression 15465739
D015742 Propofol Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 19573522
C037219 quinoline quinoline results in decreased activity of MAP2K1 proteindecreases activity 18393446
C059514 resveratrol resveratrol results in increased activity of MAP2K1 proteinincreases activity 15615701
C059514 resveratrol resveratrol results in decreased activity of MAP2K1 proteindecreases activity 15698585
C059514 resveratrol resveratrol results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 16761963
C059514 resveratrol resveratrol results in increased activity of MAP2K1 proteinincreases activity 15615701
C085746 rottlerin rottlerin results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 15949478
C085746 rottlerin rottlerin results in decreased phosphorylation of MAP2K1 proteindecreases phosphorylation 15949478
D020123 Sirolimus Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D020123 Sirolimus Sirolimus inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 12411397
C017947 sodium arsenite sodium arsenite results in decreased expression of MAP2K1 mRNAdecreases expression 12016162
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MAP2K1 mRNAdecreases expression 16705456
C025462 sulindac sulfide MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]decreases phosphorylation|decreases reaction 15548677
C025462 sulindac sulfide MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]decreases phosphorylation|decreases reaction 15548677
C025462 sulindac sulfide MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]decreases reaction|increases activity|increases cleavage 15548677
C025462 sulindac sulfide MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]increases expression|increases reaction 16079301
C025463 sulindac sulfone MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]decreases phosphorylation|decreases reaction 15548677
C025463 sulindac sulfone MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]decreases phosphorylation|decreases reaction 15548677
C025463 sulindac sulfone MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]decreases reaction|increases activity|increases cleavage 15548677
D013629 Tamoxifen Tamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein]affects binding|increases reaction 20479004
D013739 Testosterone [Testosterone results in increased activity of RAF1 protein] which results in increased activity of MAP2K1 proteinincreases activity 20372086
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of MAP2K1 proteinincreases activity 15313166
D013749 Tetrachlorodibenzodioxin MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG protein]decreases expression|increases reaction 12758056
D013749 Tetrachlorodibenzodioxin MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]increases activity|increases reaction 12213569
D013755 Tetradecanoylphorbol Acetate PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein]increases phosphorylation|increases reaction 20479004
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 20479004
D013755 Tetradecanoylphorbol Acetate geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]decreases reaction|increases activity 8816498
D013755 Tetradecanoylphorbol Acetate myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]decreases reaction|increases activity 17693661
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 proteinincreases activity 8816498
17693661
C496197 trans-10,cis-12-conjugated linoleic acid [cis-9, trans-11-conjugated linoleic acid co-treated with trans-10,cis-12-conjugated linoleic acid] results in increased phosphorylation of and results in increased activity of MAP2K1 proteinaffects cotreatment|increases activity|increases phosphorylation 17869086
C012589 trichostatin A MAP2K1 protein mutant form results in decreased activity of [D 21266 co-treated with trichostatin A]affects cotreatment|decreases activity 15781658
C057693 troglitazone MAP2K1 protein promotes the reaction [troglitazone results in increased expression of ATF3 mRNA]increases expression|increases reaction 16079301
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16269455
C113580 U 0126 U 0126 results in decreased activity of MAP2K1 proteindecreases activity 15547725
15930308
15331595
18393446
C113580 U 0126 U 0126 inhibits the reaction [octylphenol results in increased activity of MAP2K1 protein]decreases reaction|increases activity 18417718
C113580 U 0126 U 0126 results in decreased activity of MAP2K1 proteindecreases activity 18417718
C113580 U 0126 U 0126 inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C113580 U 0126 U 0126 inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 12411397
C113580 U 0126 U 0126 promotes the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAP2K1 protein]increases activity|increases phosphorylation|increases reaction 14713289
C113580 U 0126 U 0126 results in decreased activity of MAP2K1 proteindecreases activity 15654950
15375559
16000378
D014638 Vanadates Vanadates results in increased expression of MAP2K1 proteinincreases expression 17874149
C459559 vaticanol C vaticanol C results in decreased expression of and results in decreased phosphorylation of MAP2K1 proteindecreases expression|decreases phosphorylation 15725661
D014801 Vitamin A 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16510265
D014801 Vitamin A AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16510265
D014801 Vitamin A Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 16510265
D014801 Vitamin A Vitamin A results in increased phosphorylation of MAP2K1 proteinincreases phosphorylation 16510265
C111237 vorinostat [bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 proteinaffects cotreatment|decreases expression 12893773
C111237 vorinostat MAP2K1 protein mutant form results in decreased activity of [D 21266 co-treated with vorinostat]affects cotreatment|decreases activity 15781658
C111237 vorinostat vorinostat results in decreased expression of MAP2K1 proteindecreases expression 12893773
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.0315322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.0910992263
MESH:D000138 Acidosis Ammonium Chloride 2.7218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0817505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.6517694057
MESH:D058186 Acute Kidney Injury resveratrol 3.1016538975
MESH:D055371 Acute Lung Injury Chlorine 10.9820601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 10.9818653653 11850527
MESH:D055371 Acute Lung Injury Oxygen 10.9816759491
MESH:D000230 Adenocarcinoma Doxorubicin 12.9417418594
MESH:D000230 Adenocarcinoma Estradiol 12.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9414692618
MESH:D000230 Adenocarcinoma Genistein 12.9411473722
MESH:D000230 Adenocarcinoma Indomethacin 12.9416537180
MESH:D000230 Adenocarcinoma Methylnitrosourea 12.9415688392 15113128
MESH:D000236 Adenoma Indomethacin 5.2211497255
MESH:D000236 Adenoma resveratrol 5.2215688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.5416835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 8.0819003578 16215675
MESH:D011125 Adenomatous Polyposis Coli sulindac sulfone 8.0816150858
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.8415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.0416712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.2216160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Heptachlor 6.7212661182
MESH:D000382 Agricultural Workers' Diseases Lindane 6.7212661182
MESH:D000419 Albuminuria Doxorubicin 3.7321441931
MESH:D016301 Alveolar Bone Loss Indomethacin 4.5117225004
MESH:D000544 Alzheimer Disease Indomethacin 12.0017627676 15579461
MESH:D000544 Alzheimer Disease Lithium 12.0019621015
MESH:D000544 Alzheimer Disease Ozone 12.0015513908
MESH:D000544 Alzheimer Disease Plant Extracts 12.0016962711
MESH:D000544 Alzheimer Disease resveratrol 12.0016183991 16162502
MESH:D000544 Alzheimer Disease sulindac sulfide 12.0018759972
MESH:D000686 Amyloidosis Diethylstilbestrol 3.6715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.4911748828
MESH:D000740 Anemia Vitamin A 6.4916960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.0416960172
MESH:D000860 Anoxia Oxygen 4.2120872349
MESH:D000987 Antisocial Personality Disorder Testosterone 4.997506515
MESH:D001014 Aortic Aneurysm Indomethacin 4.0410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.0410388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.3717460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.6411256880
MESH:D018771 Arthralgia Indomethacin 4.302160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 8.9615885639
MESH:D001169 Arthritis, Experimental Plant Extracts 8.9614686799
MESH:D001169 Arthritis, Experimental resveratrol 8.9617115116
MESH:D001172 Arthritis, Rheumatoid Indomethacin 3.8811248219
MESH:D001172 Arthritis, Rheumatoid Ozone 3.8815570426
MESH:D001249 Asthma Mustard Gas 5.9710378619
MESH:D001249 Asthma Ozone 5.9717854713 16373670
MESH:D001249 Asthma Vitamin A 5.9716732791
MESH:D050197 Atherosclerosis Oxygen 5.2016391483
MESH:D050197 Atherosclerosis resveratrol 5.2016873680 17967414
MESH:D001321 Autistic Disorder Haloperidol 2.8319368416 18080171
MESH:D001321 Autistic Disorder Sirolimus 2.8321115397
MESH:D001477 Bartter Syndrome Indomethacin 4.1510684365
MESH:D001714 Bipolar Disorder Lithium 3.8120338123 20046352 19153942 17594078
MESH:D001768 Blister Mustard Gas 4.3119167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.2812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.1615746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 3.8414601052
MESH:D001919 Bradycardia Isoproterenol 8.166740701
MESH:D001919 Bradycardia Phenylephrine 8.1615306635
MESH:D001929 Brain Edema Indomethacin 4.1611481608
MESH:D002545 Brain Ischemia Indomethacin 12.3012524144
MESH:D002545 Brain Ischemia Plant Extracts 12.3016041641
MESH:D002545 Brain Ischemia resveratrol 12.3017600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.0717150277
MESH:D001943 Breast Neoplasms 4-(1H-imidazol-1-yl)retinoic acid 17.5817387344 17145897
MESH:D001943 Breast Neoplasms decitabine 17.5819208741 18320071
MESH:D001943 Breast Neoplasms deguelin 17.5817035597 18593368
MESH:D001943 Breast Neoplasms Dieldrin 17.5815770527 11859874
MESH:D001943 Breast Neoplasms Diethylstilbestrol 17.5815324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 17.5816935488 18628466 15994142 18695136 11325840 19526202 17983394 15136595 16264153 15939500 18382427 16096432 16322301 15668708 17426702 18234424 15567936 16595493 16115903 15634643 15993339 16826403 17369602 15692762
MESH:D001943 Breast Neoplasms Estradiol 17.5812948864 19861407 17289903 17261762 14630087 18497071 16675129 17018787
MESH:D001943 Breast Neoplasms Genistein 17.5816873071 17200150 16541309
MESH:D001943 Breast Neoplasms Heptachlor 17.588738476
MESH:D001943 Breast Neoplasms Indomethacin 17.5817401462
MESH:D001943 Breast Neoplasms letrozole 17.5817892469 16002280
MESH:D001943 Breast Neoplasms Lindane 17.5814688026
MESH:D001943 Breast Neoplasms Methylnitrosourea 17.5816253758 11306469 14633655
MESH:D001943 Breast Neoplasms Oxygen 17.5817263869
MESH:D001943 Breast Neoplasms resveratrol 17.5817651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 17.5819221464 19155303 18997820 11161223 17049068 20135344 19410462 19011961 20390343 20005174 19289846 19142967 18815881 15668708 18821012 16202921 19244106 18351453 19059307 19084267 17440819 18629630 21138602 19115204 17261762 18984771 19200415 18855134 19487384 15565566 17242785 20544844 17893378 19189212 20859285 19189210 21152245 16873071 18425577 16818667 20065188 19103187 19288272 16273361 19066611
MESH:D001943 Breast Neoplasms Testosterone 17.5817261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 17.5820435547
MESH:D001943 Breast Neoplasms vorinostat 17.5816144943
MESH:D016535 Bronchial Hyperreactivity Ozone 6.7214754758 18417511 19059883 16777450 17626835 15516495 18315731
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 6.7212794006
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.1117687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 4.7517426644 17377406
MESH:D002056 Burns Indomethacin 3.8810459503
MESH:D002057 Burns, Chemical Plant Extracts 4.479625245
MESH:D002100 Cachexia Indomethacin 9.5911239499 15141370 16537180 15625704
MESH:D002100 Cachexia Ozone 9.5916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.9616192424 16124888 16011737 16227642 16050911 16097048 3786805 15700767 18705752 15673190 10355542 15721981
MESH:D002276 Carcinoid Tumor Doxorubicin 3.9516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6719066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 29.0516705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 29.0518788625
MESH:D006528 Carcinoma, Hepatocellular deguelin 29.0518575727
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 29.0516924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 29.0517876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 29.0516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 29.0516924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 29.0516391822
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 29.0518834353
MESH:D006528 Carcinoma, Hepatocellular quinoline 29.05598648
MESH:D006528 Carcinoma, Hepatocellular resveratrol 29.0519321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 29.0519335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 29.0517306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 29.0516924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 8.6211053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 8.6216675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.5014736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 7.0816052434
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 7.0812391285
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfone 7.0818758305
MESH:D002292 Carcinoma, Renal Cell celecoxib 8.1816369983
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 8.1816201981 1485588
MESH:D002292 Carcinoma, Renal Cell Indomethacin 8.1817341418
MESH:D002294 Carcinoma, Squamous Cell decitabine 16.5619215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.566189445
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 16.5615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell resveratrol 16.5616227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 16.5619435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.5618572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 16.5618922899
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.8617572228
MESH:C535579 Cardiofaciocutaneous syndrome marker/mechanism 16439621 17703371
MESH:D006332 Cardiomegaly Isoproterenol 11.907544033 11179087
MESH:D006332 Cardiomegaly Phenylephrine 11.9016170337 11754973 17287366 15728586 11179087 17124262
MESH:D006332 Cardiomegaly Plant Extracts 11.9017645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.9016120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 6.6917519947 17974986 16269455 16952015 16731534 16242529 16455267 17382496 17351982 15811867 15476868 17007740 18627295 17924179 17131338 16278810 17329180 16612575 16109756 15792986 15505089 17928571 17308081 16651473 16364871
MESH:D009202 Cardiomyopathies Oleylethanolamide 6.6916269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.5716243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 8.5716332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 8.5716936243
MESH:D002318 Cardiovascular Diseases resveratrol 8.5715458977
MESH:D002375 Catalepsy Haloperidol 4.071977408 15215559
MESH:D002386 Cataract Adenosine Triphosphate 6.4015003327
MESH:D002386 Cataract Methylnitrosourea 6.4012484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.886135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.8818566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 10.887505956 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.8820056578 19524636
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.2920678186
MESH:D015362 Child Nutrition Disorders Vitamin A 4.6116153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.4316835633
MESH:D002764 Cholecystitis Indomethacin 4.3011181007
MESH:D002779 Cholestasis Ethinyl Estradiol 6.0617333356 11677210 16105132 15861022 17681005 17110522 16919318
MESH:D002779 Cholestasis Vitamin A 6.0616175620
MESH:D019457 Chromosome Breakage Sodium Selenite 3.9215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.6416354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Vitamin A 4.6416054864
MESH:D003072 Cognition Disorders Clozapine 4.1417123785
MESH:D003092 Colitis resveratrol 3.3116474422
MESH:D003110 Colonic Neoplasms Butyrates 16.0115936596
MESH:D003110 Colonic Neoplasms celecoxib 16.0116004971
MESH:D003110 Colonic Neoplasms decitabine 16.0117616700
MESH:D003110 Colonic Neoplasms Genistein 16.0117182828
MESH:D003110 Colonic Neoplasms Indomethacin 16.0115637740 15963497 11260862 15786552 15936596 15625704
MESH:D003110 Colonic Neoplasms polyphenols 16.0116293270
MESH:D003110 Colonic Neoplasms resveratrol 16.0116338953
MESH:D003110 Colonic Neoplasms Vitamin A 16.0116267017 17219422
MESH:D015179 Colorectal Neoplasms celecoxib 6.5118349538 11197048
MESH:D015179 Colorectal Neoplasms decitabine 6.5118981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.5118802399 18259882
MESH:D015179 Colorectal Neoplasms Indomethacin 6.5118059344 12606626 17054584 11197048
MESH:D015179 Colorectal Neoplasms resveratrol 6.5116550006
MESH:D015179 Colorectal Neoplasms sulindac sulfone 6.5110416599 11197048 18059344 10666051
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.3314669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.1516507316
MESH:D018352 Coronavirus Infections Indomethacin 4.8517302372
MESH:D056685 Costello Syndrome marker/mechanism 17703371
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin A 2.4310992263
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.7512952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.7118551238
MESH:D003490 Cyanosis Endosulfan 8.717900959
MESH:D007644 Darier Disease Lithium 5.0620338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.0520210726
MESH:D003704 Dementia Haloperidol 3.8111575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.5319031437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 4.9119244398
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.0516285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.0616873680
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.1716506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.7416402076
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.7416647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.7417107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 7.7416023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.8112601628
MESH:D003928 Diabetic Nephropathies Estradiol 15.4619279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 15.4619706694
MESH:D003928 Diabetic Nephropathies resveratrol 15.4616286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.4619279558
MESH:D003967 Diarrhea Indomethacin 5.937237001 7907874
MESH:D003967 Diarrhea vorinostat 5.9320479100
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.6915331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 13.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.1819085960 15998439 4309450 19336974 15968718 6623471 2869522 3732212 16177239 7120509 17522070 11566570 21278145 16227642 10915739 7179309 9327722 6884620 7440962 3786805 10092053 15027814
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.1817416283
MESH:D056486 Drug-Induced Liver Injury polyphenols 13.1819370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 13.1815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.1820420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 13.1814986274
MESH:D004362 Drug Toxicity Doxorubicin 5.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 5.8911462148
MESH:D015352 Dry Eye Syndromes Vitamin A 4.9516146918
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.3018043480 16326151 18446180 12774134 16133044 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.3411595415 16699067 17329845 17202747 17151854 11595431 17045617 17351913 11535926 11991626 10671773
MESH:D050171 Dyslipidemias Clozapine 3.5316402076
MESH:D004417 Dyspnea Chlorine 12.4920016425
MESH:D004417 Dyspnea Endosulfan 12.497900959 3388749
MESH:D004417 Dyspnea Oxygen 12.4920016425
MESH:C538011 Eales disease Vitamin A 4.769068938
MESH:D004480 Ectromelia Vitamin A 4.9616054864
MESH:D004487 Edema Indomethacin 17.307990266 16100529 8985016 7907874 10653021 19703484 8273558
MESH:D004487 Edema Mustard Gas 17.3011428631 9260866 11402378 11428647
MESH:D004487 Edema Plant Extracts 17.3012787963
MESH:D004487 Edema resveratrol 17.308985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.3012711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 17.3015177302 7812673 11698051 8273558 16716910 9599246 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.0415322242 18230668 16714409
MESH:D004646 Emphysema Endosulfan 5.697900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.7112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 10.7117872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.7119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 11.1619294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 11.1619294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.0816402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.0816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.8715700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.8717359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.8719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 16.8711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.8719155303 17893378 16202921 20544844
MESH:D004715 Endometriosis celecoxib 11.1315652904
MESH:D004715 Endometriosis Indomethacin 11.1315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 11.1310568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 11.1918037988
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 11.1915268973
MESH:D019446 Endotoxemia Indomethacin 7.8518509659
MESH:D019446 Endotoxemia Lipopolysaccharides 7.8515821434 15328337 17637181
MESH:D004751 Enteritis Indomethacin 3.8916328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 9.6217980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 9.6217923197
MESH:D004802 Eosinophilia Indomethacin 3.2411298111
MESH:D004827 Epilepsy Plant Extracts 3.2219700373 19439326
MESH:D004890 Erythema Mustard Gas 4.319357497
MESH:D004938 Esophageal Neoplasms Indomethacin 2.5411005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.3411564622
MESH:D005221 Fatigue vorinostat 4.7520479100
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.5715959796 17595544 16045604 61145 12631006 16239168 12795759 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.5715345470
MESH:D005234 Fatty Liver Plant Extracts 12.5715975614
MESH:D005234 Fatty Liver Tamoxifen 12.5719224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.2616002989 16513791 16534752 16611131 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.2616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6311858732
MESH:D005327 Fetal Resorption Vitamin A 4.5016054864
MESH:D005334 Fever Indomethacin 6.8617627676 10431976 11852909
MESH:D005334 Fever Lipopolysaccharides 6.869205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.6814745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 8.6319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 8.6319069698
MESH:D005354 Fibrosarcoma Indomethacin 9.3910962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 9.3911555667
MESH:D005355 Fibrosis Carbon Tetrachloride 14.5318705752
MESH:D005355 Fibrosis Emodin 14.5319474275
MESH:D005355 Fibrosis Indomethacin 14.5317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.5320067830
MESH:D005391 Firesetting Behavior Testosterone 4.997506515
MESH:D005499 Folliculitis Indomethacin 4.3011298111
MESH:D005739 Gas Poisoning Chlorine 9.1720016425
MESH:D005739 Gas Poisoning Oxygen 9.1720016425
MESH:D005756 Gastritis Indomethacin 3.8915046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.0016452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.0016452187
MESH:D005909 Glioblastoma Doxorubicin 19.8917150277
MESH:D005909 Glioblastoma Genistein 19.8916598420
MESH:D005909 Glioblastoma Indomethacin 19.8912870263
MESH:D005909 Glioblastoma myricetin 19.8919804834
MESH:D005909 Glioblastoma Testosterone 19.8917162496
MESH:D005909 Glioblastoma trichostatin A 19.8918801729
MESH:D005910 Glioma Indomethacin 5.0616487511 18371953
MESH:D005910 Glioma Methylnitrosourea 5.069825942
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.5811849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7310696789
MESH:D006073 Gout Indomethacin 4.5011248219
MESH:D006258 Head and Neck Neoplasms decitabine 13.4019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 13.4015692506
MESH:D006258 Head and Neck Neoplasms Indomethacin 13.4015482327
MESH:D006258 Head and Neck Neoplasms Sirolimus 13.4019435901
MESH:D006330 Heart Defects, Congenital Lithium 8.3519638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.3510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin A 8.3516080930 10992263
MESH:D006331 Heart Diseases Doxorubicin 2.8616144979 18006777 16244372 17875725 18674790 16879835 12587719 14766674 16707910 16495754 16244371 16330681 17888722
MESH:D006333 Heart Failure Doxorubicin 8.7217481944
MESH:D006333 Heart Failure Isoproterenol 8.7218097624
MESH:D006333 Heart Failure Plant Extracts 8.7218097624
MESH:D006390 Hemangioendothelioma quinoline 5.04598648
MESH:D006394 Hemangiosarcoma Doxorubicin 7.0815692506
MESH:D006394 Hemangiosarcoma quinoline 7.08598648
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.6316366002
MESH:D006470 Hemorrhage Endosulfan 7.887900959
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 7.8811000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.8015633222
MESH:D006505 Hepatitis Carbon Tetrachloride 2.8019110552 19900420
MESH:D019698 Hepatitis C, Chronic Indomethacin 3.8715135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.0915340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.2416490937 16877224 17436238 15707848 16292552 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.1715709030
MESH:D006561 Herpes Simplex Plant Extracts 7.3310715843
MESH:D006561 Herpes Simplex resveratrol 7.3316876885
MESH:D006628 Hirsutism Testosterone 4.7917019078
MESH:D015658 HIV Infections Plant Extracts 5.4012878215
MESH:D015658 HIV Infections Vitamin A 5.4016960176
MESH:D006679 HIV Seropositivity Vitamin A 4.7517209195
MESH:D006689 Hodgkin Disease Doxorubicin 5.0918501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 5.0912676792
MESH:D019584 Hot Flashes Estradiol 7.4917088409
MESH:D019584 Hot Flashes Plant Extracts 7.4914716179 16566672 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1818606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Indomethacin 3.0912727271
MESH:D034321 Hyperamylasemia Indomethacin 4.8517883296
MESH:D017588 Hyperandrogenism Testosterone 4.4517019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.6816899240
MESH:D006934 Hypercalcemia bortezomib 4.6818089816
MESH:D006937 Hypercholesterolemia resveratrol 3.2417188708
MESH:D006940 Hyperemia Indomethacin 4.1612524144
MESH:D020138 Hyperhomocysteinemia Catechin 7.4817292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 7.4816484555
MESH:D006948 Hyperkinesis Clozapine 4.0616046005
MESH:D006949 Hyperlipidemias Indomethacin 11.0917546600
MESH:D006949 Hyperlipidemias Plant Extracts 11.0915268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 11.0916873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.6114722030 12960047
MESH:D006973 Hypertension Phenylephrine 3.928949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 3.9218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.2615338365
MESH:D006984 Hypertrophy Isoproterenol 13.4912791704
MESH:D006984 Hypertrophy Phenylephrine 13.4918502941 12791704
MESH:D006984 Hypertrophy Sirolimus 13.4919211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.5517488730
MESH:D006986 Hypervitaminosis A Vitamin A 5.3016054864
MESH:D007006 Hypogonadism Testosterone 3.9412002444
MESH:D007018 Hypopituitarism Testosterone 5.3417426086
MESH:D007021 Hypospadias Diethylstilbestrol 8.4916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 8.4916945680 16569931
MESH:D007022 Hypotension Isoproterenol 4.026740701
MESH:D007077 Ileal Diseases Indomethacin 4.1618306037 10574470
MESH:D007079 Ileitis Indomethacin 4.5010651667 16133968 10647630
MESH:D007174 Impulse Control Disorders Testosterone 4.997506515
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.5116133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.8217600658
MESH:D007246 Infertility Diethylstilbestrol 3.5515036965
MESH:D007247 Infertility, Female Dieldrin 7.6710630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 7.6712013081
MESH:D007248 Infertility, Male decitabine 14.5917581917
MESH:D007248 Infertility, Male Endosulfan 14.599432128 8588293
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.5917937319
MESH:D007248 Infertility, Male Methylnitrosourea 14.597193160
MESH:D007248 Infertility, Male sodium arsenite 14.5912646999 15346721
MESH:D007249 Inflammation Flavonoids 26.2117296493
MESH:D007249 Inflammation Indomethacin 26.213291741 12568917 7812673
MESH:D007249 Inflammation Lipopolysaccharides 26.2117237260 9205823 12878042 17255318 17963957
MESH:D007249 Inflammation Mustard Gas 26.2111428620 11428631 9260866 11402378 8975870 16001271 17524151 9357497 11428647
MESH:D007249 Inflammation Plant Extracts 26.2112787963 15997105 19332304 16366677
MESH:D007249 Inflammation polyphenols 26.2116366677
MESH:D007249 Inflammation resveratrol 26.2116366677
MESH:D007249 Inflammation Tamoxifen 26.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 26.2112878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 26.217812673 15177302 8273558 7562506 11698051
MESH:D007251 Influenza, Human resveratrol 3.6916624496
MESH:D007333 Insulin Resistance Estradiol 5.3916627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 5.3914714311
MESH:D007410 Intestinal Diseases Indomethacin 3.5118236018 17329856 15610444 11713966 11855677 15831440 17994277 10210152 11686837
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.8712351151 12584176 12628509
MESH:D019586 Intracranial Hypertension Indomethacin 11.3215241188
MESH:D019586 Intracranial Hypertension Vitamin A 11.3215955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.8417255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.5616580747
MESH:D007579 Jejunal Diseases Indomethacin 4.1616133968 10574470 18306037
MESH:D007674 Kidney Diseases Doxorubicin 9.8916775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 9.8915618244
MESH:D007674 Kidney Diseases Indomethacin 9.8917190690
MESH:D007674 Kidney Diseases sodium arsenite 9.8920008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 7.5616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 7.5616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.9716705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.9714681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.9715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.9718625569
MESH:D007859 Learning Disorders Diethylstilbestrol 7.3817184923
MESH:D007859 Learning Disorders Endosulfan 7.388157075
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.2012228301 11703811 10320625
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 7.7012970779
MESH:D007938 Leukemia decitabine 7.7019235587 18980019
MESH:D007938 Leukemia Genistein 7.7018980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 11.3616085563
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 11.3616085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell fludarabine 4.1318172266 17802794 18587576 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 8.0118089816
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 8.0117077332
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 9.2816972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 9.2816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.2615631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid decitabine 3.2319117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 9.0516467208 17077328
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 9.0520471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 9.0519010910 18206229 18460780 18704418 17679729 19387464
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 9.0518360721
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 9.0518206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.6018055864
MESH:D015473 Leukemia, Promyelocytic, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 6.4717077328
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.4716087638
MESH:D007964 Leukocytosis Indomethacin 4.5116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 4.8517980183
MESH:D007970 Leukopenia Lipopolysaccharides 3.8515821434
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 6.6515526292
MESH:D017880 Limb Deformities, Congenital Vitamin A 6.6516054864
MESH:D008064 Lipidoses Clozapine 5.9117567588
MESH:D008064 Lipidoses Tamoxifen 5.9117567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 4.8511479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 8.1021278145 16943688 17334410 11903743 16239168 16221502 17157831 17174718 11408273
MESH:D008103 Liver Cirrhosis Plant Extracts 8.1017157831
MESH:D008103 Liver Cirrhosis Vitamin A 8.1016256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 26.1317481882 10355542 15818738 17823541 12389079 16011737 12632514 15057751 14620537 12958196 15931870 15650968 18472094 18187930 18376398 14716496 17922224 15893842 14748882 16033810 12445418 13678700 17714472 16097048 18054572 18205269 18251166 17900296 12546737 18317297 18412020 17766677 17869086 18279442 15925388 20821823 15338365 15052691 12898905 16116963 15730626 18156304 17805973 18705752 16638106 11481614 18472332 14512876 17698563 14716833 12649538 18263696 12586293 15876570 18210741 15959796 15996030 17944888 15673190 18166357 16136751 17640975 18277467 12445421 16248980 15370692 17557913 18481824 17708605 17525996 18006644 17721639 12741479 12667390 16015684 18418968 17761835 18420326 18395914 16192424 15123356 17565644 15362042 12632512 18429990 17631135 16027843 12609069 18339082 18395095 12666154 14724832 17976157
MESH:D008106 Liver Cirrhosis, Experimental cis-9, trans-11-conjugated linoleic acid 26.1317869086
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 26.1316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Emodin 26.1315288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 26.1314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 26.1317823541
MESH:D008106 Liver Cirrhosis, Experimental Heparin 26.1316904936
MESH:D008106 Liver Cirrhosis, Experimental inchinko-to 26.1315288473
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 26.1318194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 26.1312878042
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 26.1315479170
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 26.1317050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 26.1318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 26.1312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 26.1316248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.1215830285 15720792 17285989 16964402 16246199
MESH:D008107 Liver Diseases Lindane 9.121715830
MESH:D008107 Liver Diseases Plant Extracts 9.1217034775
MESH:D008107 Liver Diseases polyphenols 9.1216698588
MESH:D008107 Liver Diseases Vitamin A 9.1216175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.3316762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.3315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 2.9416899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 25.017678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 25.0119294768
MESH:D008113 Liver Neoplasms Dieldrin 25.018742319 9539021
MESH:D008113 Liver Neoplasms Diethylstilbestrol 25.0116712894 15890375
MESH:D008113 Liver Neoplasms Heptachlor 25.012422723 9544696
MESH:D008113 Liver Neoplasms Plant Extracts 25.0119168119
MESH:D008113 Liver Neoplasms resveratrol 25.0119812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 25.0115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 25.0116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.0116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.412876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.4117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.4112151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 12.4117113696
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.6316080182
MESH:D008171 Lung Diseases Mustard Gas 12.5218161513 18702808
MESH:D008171 Lung Diseases Ozone 12.528266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 12.5219095001
MESH:D008171 Lung Diseases Vitamin A 12.5216863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 14.9217365036
MESH:D055370 Lung Injury Lipopolysaccharides 14.9221114838
MESH:D055370 Lung Injury Oxygen 14.9218339021
MESH:D055370 Lung Injury Ozone 14.9220417186
MESH:D008175 Lung Neoplasms deguelin 16.0416288123 19336726
MESH:D008175 Lung Neoplasms Doxorubicin 16.0417418594 6189445
MESH:D008175 Lung Neoplasms Indomethacin 16.0411053908 11497255 16537180
MESH:D008175 Lung Neoplasms Methylnitrosourea 16.0418062963
MESH:D008175 Lung Neoplasms Mustard Gas 16.048781369 3148597
MESH:D008175 Lung Neoplasms Ozone 16.048597069 7614698
MESH:D008175 Lung Neoplasms Plant Extracts 16.0420869020
MESH:D008175 Lung Neoplasms sodium arsenite 16.0416712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 16.0418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.0411884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 16.0411807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.3015166399
MESH:D008223 Lymphoma bortezomib 16.6116098063
MESH:D008223 Lymphoma decitabine 16.6119470736
MESH:D008223 Lymphoma Diethylstilbestrol 16.6115700306
MESH:D008223 Lymphoma Doxorubicin 16.6116098063
MESH:D008223 Lymphoma Methylnitrosourea 16.6111418001 16257854
MESH:D016393 Lymphoma, B-Cell bortezomib 18.0516675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 18.0514633661
MESH:D016393 Lymphoma, B-Cell resveratrol 18.0517088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 18.0514737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 6.5017654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 6.5014749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.7415621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 4.8520479100
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.6516002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.2115688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.2119428831
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 26.7812104042 19196722
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 26.7815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 26.7811807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 26.7815375486
MESH:D008325 Mammary Neoplasms, Experimental Genistein 26.7814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 26.7810767621 19196723 11807958 16944150 15113128 11751437 16619500 10838139 15313902 16051031 14999141 16827153 17131329 15688392 12931682 17020996 14633655
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 26.7811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 26.7816827153 19196722 11731420 14580682 19196723
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 26.788985016
MESH:D020149 Manganese Poisoning Estradiol 9.7819453300
MESH:D020149 Manganese Poisoning Tamoxifen 9.7819453300
MESH:D008527 Medulloblastoma bortezomib 3.8119213072
MESH:D008545 Melanoma 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 16.6617992120
MESH:D008545 Melanoma decitabine 16.6616505122 17785578
MESH:D008545 Melanoma Doxorubicin 16.6616827129
MESH:D008545 Melanoma PD 0325901 16.6619282848
MESH:D008545 Melanoma resveratrol 16.6617992120
MESH:D008545 Melanoma Sirolimus 16.6619282848
MESH:D008545 Melanoma sodium arsenite 16.6616487513 19082730
MESH:D008545 Melanoma Tamoxifen 16.6612393984 19393235
MESH:D008545 Melanoma trichostatin A 16.6616505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3415990972
MESH:D001523 Mental Disorders Clozapine 8.7016856516
MESH:D001523 Mental Disorders Haloperidol 8.7016856516
MESH:D001523 Mental Disorders Phosphates 8.7012686366
MESH:D008654 Mesothelioma Asbestos, Crocidolite 4.9818303189 16966607 16166281
MESH:D008654 Mesothelioma Doxorubicin 4.9817638057
MESH:D008659 Metabolic Diseases resveratrol 3.6017112576
MESH:D024821 Metabolic Syndrome X Clozapine 3.6919142101
MESH:D008679 Metaplasia Ozone 4.2410496685
MESH:D008881 Migraine Disorders Indomethacin 3.0411903285
MESH:D020326 Migraine without Aura Cyclic GMP 5.1911304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.7215792986
MESH:D009062 Mouth Neoplasms Indomethacin 6.9412636206
MESH:D009062 Mouth Neoplasms Sirolimus 6.9419435901
MESH:D052016 Mucositis Doxorubicin 3.9417415656
MESH:D009101 Multiple Myeloma 2,5-dimethylcelecoxib 24.1716123214
MESH:D009101 Multiple Myeloma bortezomib 24.1719112201 19372569 19112817
MESH:D009101 Multiple Myeloma celecoxib 24.1716123214
MESH:D009101 Multiple Myeloma decitabine 24.1718172295
MESH:D009101 Multiple Myeloma resveratrol 24.1716267019 16490592 17164350 17049120 14749477 17935668
MESH:D009101 Multiple Myeloma trichostatin A 24.1718172295
MESH:D009101 Multiple Myeloma Vitamin A 24.1716374440
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.0217962980
MESH:D009190 Myelodysplastic Syndromes decitabine 2.8318608210 19157545 16882708 19010910
MESH:D009203 Myocardial Infarction Doxorubicin 13.1519429709 15857846
MESH:D009203 Myocardial Infarction Genistein 13.1517141266
MESH:D009203 Myocardial Infarction Isoproterenol 13.1515740881 16538859 19172585 19595682 16584858 16697266 17052832
MESH:D009203 Myocardial Infarction Lithium 13.1516288908
MESH:D009203 Myocardial Infarction resveratrol 13.1516525036 17015251 17188708 16317513 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 6.6717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.6712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 6.2317141266
MESH:D009205 Myocarditis resveratrol 3.9117322642
MESH:D009325 Nausea vorinostat 4.6620479100
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.0218551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 10.0618259882
MESH:D009362 Neoplasm Metastasis Indomethacin 10.0611053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis quinoline 10.06598648
MESH:D009362 Neoplasm Metastasis Tamoxifen 10.0619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1619410462
MESH:D009369 Neoplasms decitabine 19.5019470736 19116145 17925555
MESH:D009369 Neoplasms deguelin 19.5017764071
MESH:D009369 Neoplasms Dieldrin 19.508820588
MESH:D009369 Neoplasms Diethylstilbestrol 19.5015313581
MESH:D009369 Neoplasms Lindane 19.5012807735 16818664
MESH:D009369 Neoplasms lycopene 19.5017051425
MESH:D009369 Neoplasms Methylnitrosourea 19.5015533788
MESH:D009369 Neoplasms sodium arsenite 19.5011559025
MESH:D009374 Neoplasms, Experimental Indomethacin 15.0915625704 10663608
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 15.0912696579
MESH:D009374 Neoplasms, Experimental resveratrol 15.098985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 15.0920056578
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 8.3219196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.3219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 2.8917289903
MESH:D009401 Nephrosis Doxorubicin 3.9416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.2716889571 15640375
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.8711399458
MESH:D009421 Nervous System Malformations Estradiol 16.8716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 16.8716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.8714600291
MESH:D009436 Neural Tube Defects sodium arsenite 5.6512854658
MESH:D009436 Neural Tube Defects Vitamin A 5.6517400914
MESH:D009442 Neurilemmoma Methylnitrosourea 4.6411555667
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.3517168769
MESH:D009447 Neuroblastoma Doxorubicin 2.7515555623
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.3712349958
MESH:D019636 Neurodegenerative Diseases resveratrol 6.3717652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.6117929310
MESH:D009503 Neutropenia Mustard Gas 3.1916761898 7688884
MESH:D009634 Noonan Syndrome marker/mechanism 17703371
MESH:D009765 Obesity Clozapine 4.1718515891 19142110
MESH:D009765 Obesity Plant Extracts 4.1719056576 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.306374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.6916049721
MESH:D010003 Osteoarthritis Indomethacin 3.097009135
MESH:D010024 Osteoporosis anthranilic acid 6.1717042918
MESH:D010024 Osteoporosis Genistein 6.1719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 7.5316169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 7.5317513867
MESH:D012516 Osteosarcoma Doxorubicin 3.4115930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.2216211241
MESH:D010051 Ovarian Neoplasms decitabine 17.2219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 17.2219401270
MESH:D010051 Ovarian Neoplasms Genistein 17.2219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.2217306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 17.2219331143
MESH:D010051 Ovarian Neoplasms U 0126 17.2216211241
MESH:D010146 Pain Indomethacin 2.8017440234 13679232 17627676 3291741
MESH:D010149 Pain, Postoperative Indomethacin 3.8218702446 12538197
MESH:D010190 Pancreatic Neoplasms decitabine 9.0919294695
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 9.0916965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 9.0915976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 9.0919294695
MESH:D010195 Pancreatitis Indomethacin 3.1515028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.8911578682
MESH:D010212 Papilloma Hydrogen Peroxide 11.0212065085
MESH:D010212 Papilloma Plant Extracts 11.0215173996 16517061
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 11.0218922899 12065085 18404319 8330346
MESH:D010257 Paraneoplastic Syndromes Indomethacin 4.8516537180
MESH:D010300 Parkinson Disease Dieldrin 4.7611181820 11445065 17291500 16809432 16112328
MESH:D010300 Parkinson Disease Sirolimus 4.7619682553
MESH:D020734 Parkinsonian Disorders Indomethacin 3.3712349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 4.8511903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.3812520081
MESH:D010437 Peptic Ulcer Indomethacin 4.3011148446
MESH:D010518 Periodontitis Indomethacin 4.0517225004
MESH:D010538 Peritonitis Ozone 3.3116369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.2917983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.8415687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.0610923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.2917638057
MESH:D011014 Pneumonia Lipopolysaccharides 8.3012224865 11605937
MESH:D011014 Pneumonia Ozone 8.3018381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.0315727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7518163543
MESH:D047928 Premature Birth Indomethacin 4.2917000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 11.4617184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 11.4616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.4611118676 11399792 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 9.6717616702
MESH:D055728 Primary Myelofibrosis trichostatin A 9.6717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.2920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 8.2920887781
MESH:D011471 Prostatic Neoplasms bicalutamide 11.5918487222 19240160 15638997 17914592 19011039
MESH:D011471 Prostatic Neoplasms celecoxib 11.5917908994 15570007
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 11.5915046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 11.5915749863 15897917 16888761 16729912 16868541 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 11.5916740699
MESH:D011471 Prostatic Neoplasms Genistein 11.5915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Heptachlor 11.5912661182
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 11.5916864594
MESH:D011471 Prostatic Neoplasms Lindane 11.5912661182 14688026
MESH:D011471 Prostatic Neoplasms lycopene 11.5917337101 15084515
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 11.5915682402 12376480
MESH:D011471 Prostatic Neoplasms methylselenic acid 11.5916205645
MESH:D011471 Prostatic Neoplasms Plant Extracts 11.5914666653 17804756
MESH:D011471 Prostatic Neoplasms resveratrol 11.5917804756 17636462 17675339 17718901 16731767 15767336
MESH:D011471 Prostatic Neoplasms sodium arsenite 11.5916039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 11.5918760546
MESH:D011471 Prostatic Neoplasms sulindac sulfone 11.5915570007 17908994
MESH:D011471 Prostatic Neoplasms Tamoxifen 11.5915067354
MESH:D011471 Prostatic Neoplasms trichostatin A 11.5919789329 18798265
MESH:D011471 Prostatic Neoplasms vorinostat 11.5917218635
MESH:D011507 Proteinuria Indomethacin 3.3811849393
MESH:D011537 Pruritus Ethinyl Estradiol 6.7415861022 16919318
MESH:D011537 Pruritus Mustard Gas 6.7418058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.1311575062
MESH:D011618 Psychotic Disorders Clozapine 6.9715331141
MESH:D011618 Psychotic Disorders Haloperidol 6.9711575062
MESH:D011654 Pulmonary Edema Isoproterenol 4.3910903255
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 7.0217322281 17975199 17365031 15814490
MESH:D011658 Pulmonary Fibrosis Mustard Gas 7.0217894541 10334151 17266442 17620002 17720292
MESH:D011658 Pulmonary Fibrosis troglitazone 7.0218162602
MESH:D051437 Renal Insufficiency Doxorubicin 3.4017922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.7216325855
MESH:D015427 Reperfusion Injury resveratrol 2.7816314181 16317513 15827377 17520802 17058453
MESH:D012120 Respiration Disorders Chlorine 4.3518579056
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 3.7317627322 18339021
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 4.9516877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.1210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0218990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 3.7418172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 4.6411555667
MESH:D012208 Rhabdomyosarcoma decitabine 3.6119155313
MESH:D012509 Sarcoma Doxorubicin 3.2417203757 15675481 17710206 18313854 15625365 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.4416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 3.9417846226
MESH:D012559 Schizophrenia Clozapine 3.4419369910 18806925 20168265 11763009 20521320 18855531 17123785 20521326 17667964 20580759 16141801 17726453 11151749 20452607 20107430
MESH:D012559 Schizophrenia Haloperidol 3.4419369910 1830565 18513383 20107430
MESH:D012640 Seizures 2,6-dinitrotoluene 9.1418551238
MESH:D012640 Seizures Endosulfan 9.147539098 10698677
MESH:D012640 Seizures Lindane 9.147539098 12842176 15475178
MESH:D012640 Seizures Lithium 9.1419660546
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.3416631401
MESH:D012772 Shock, Septic lipoteichoic acid 5.2519573522
MESH:D012852 Sinusitis Phenylephrine 3.867327846
MESH:D012851 Sinus Thrombosis, Intracranial Heparin 5.2212269725
MESH:D012871 Skin Diseases Mustard Gas 4.3012880345 16961503 15451306
MESH:D012871 Skin Diseases Vitamin A 4.3018709164
MESH:D012878 Skin Neoplasms deguelin 23.4416041863
MESH:D012878 Skin Neoplasms Doxorubicin 23.4415692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 23.4412065085
MESH:D012878 Skin Neoplasms Plant Extracts 23.4416517061 15173996
MESH:D012878 Skin Neoplasms resveratrol 23.4415837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 23.4419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 23.4416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 23.4412065085 8985016 8330346 11807781 18404319
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.7417203757 15625365 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 15.1716002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 15.1716709447
MESH:D013088 Spermatocele Tamoxifen 15.1716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.1919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.1112854658
MESH:D013226 Status Epilepticus Lithium 4.9219430551 19951488 19570321
MESH:D013272 Stomach Diseases Indomethacin 3.5815038085 16113693 10215738 18545984 10486359 10192188 15472012 17638125 17160473 16280098 17207306 16184426 18209964
MESH:D013274 Stomach Neoplasms celecoxib 4.9115609394
MESH:D013274 Stomach Neoplasms decitabine 4.9119037991
MESH:D013274 Stomach Neoplasms Indomethacin 4.9115609394
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.9118593901 15930296 16257854
MESH:D013274 Stomach Neoplasms troglitazone 4.9115930296
MESH:D013276 Stomach Ulcer Indomethacin 5.2316169175 15255614 17627676 11729361 10750652 18299717 18431645 11595431 18543354 18209962 10423059 18087811 10878458 11595415 1323529 11523592 16631530 15104355 11906479 16252198 16397915 12500499 15138204 18181030 16150113 12467913 12077510 12787963 17918041 14567935 17895592 18237397 16755016 18726076 17135157 17654042 17977527 11145282 18193104 12498302 16934674 17657623
MESH:D013276 Stomach Ulcer Plant Extracts 5.2317135157 15255614 18237397 12787963 18193104
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.7216321402
MESH:D013398 Sudden Infant Death Oxygen 4.7012563064
MESH:D017180 Tachycardia, Ventricular Haloperidol 3.9020210726
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 10.4117997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 10.4117997062
MESH:D013742 Tetanus Propofol 5.572903605
MESH:D013921 Thrombocytopenia Heparin 12.1516651880 16893407
MESH:D013921 Thrombocytopenia Lipopolysaccharides 12.1515821434
MESH:D013921 Thrombocytopenia vorinostat 12.1520479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.8311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 7.0515669648
MESH:D013927 Thrombosis Heparin 7.0516893407
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.3811418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0412697716
MESH:D013964 Thyroid Neoplasms 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 19.3416940797
MESH:D013964 Thyroid Neoplasms Butyrates 19.3417967635
MESH:D013964 Thyroid Neoplasms decitabine 19.3417967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 19.3416010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 19.3418791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 19.343078959 7505956
MESH:D013978 Tibial Fractures Estradiol 3.8219048282
MESH:D014062 Tongue Neoplasms resveratrol 3.4616227395
MESH:D014402 Tuberous Sclerosis Sirolimus 4.7518495876 21115397
MESH:D014456 Ulcer Indomethacin 4.0517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.2616049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.2617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.2616712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.2617653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.2617306315 11723127 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.2616712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.4710091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 11.6016175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 11.6017473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 11.6011813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.3014652134
MESH:D014594 Uterine Neoplasms celecoxib 21.5418645019
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 21.5416690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 21.5414692618
MESH:D014594 Uterine Neoplasms resveratrol 21.5417044934
MESH:D014594 Uterine Neoplasms sulindac sulfide 21.5418645019
MESH:D014604 Uveal Neoplasms decitabine 4.0517785578
MESH:D014605 Uveitis Sirolimus 4.771336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.6116513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 3.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7312125929
MESH:D014657 Vasculitis Heparin 5.2220337814
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 17.7417678736 17638931 17334414 16364871
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 17.7418097624
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 17.7418097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 17.7417488730
MESH:D020257 Ventricular Remodeling Isoproterenol 10.0518097624
MESH:D020257 Ventricular Remodeling Plant Extracts 10.0518097624
MESH:D014802 Vitamin A Deficiency Vitamin A 4.4816175781 16146918 16960172
MESH:D014839 Vomiting Indomethacin 3.8911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3815886252
MESH:D015430 Weight Gain Clozapine 3.7317502770 20521320 20107430 16141801 20564506 16402076
MESH:D015431 Weight Loss Clozapine 4.2317933447
MESH:D014947 Wounds and Injuries Plant Extracts 3.5420213670 19894650
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
REACT:18266 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:05219 Bladder cancer
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:05210 Colorectal cancer
KEGG:04320 Dorso-ventral axis formation
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:05214 Glioma
KEGG:04912 GnRH signaling pathway
KEGG:04910 Insulin signaling pathway
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
KEGG:05218 Melanoma
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:04114 Oocyte meiosis
KEGG:04380 Osteoclast differentiation
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:05020 Prion diseases
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:9417 Signaling by EGFR
REACT:498 Signaling by Insulin receptor
REACT:16888 Signaling by PDGF
REACT:32280 Signaling by PDGF
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
KEGG:05216 Thyroid cancer
KEGG:04620 Toll-like receptor signaling pathway
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30584
    • No data
    Releated disease ID Related disease Name
    PA444985Multiple Myeloma
    PA447216Schizophrenia
    PA445062Neoplasms
    PA152208657Cardio-facio-cutaneous Syndrome
    PA445123Noonan Syndrome
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA7000sorafenib
    PA451578tacrolimus
    PA448497aspirin
    PA448515azathioprine
    PA450379mercaptopurine
    PA452233antipsychotics
    PA151917011valinomycin
    PA449780glutathione
    PA450635nitric oxide
    PA450631nifedipine
    PA448948chloroquine
    PA10804imatinib
    PA164743471adenosine triphosphate
    PA449167cyclosporine
    PA451096prednisolone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02152 - K-252a Enzyme Inhibitors
    DB03115 - 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
    DB06892 - (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
    DB07046 - 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
    DB07101 - N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
    DB08130 - N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
    DB08208 - 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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