AutismKB 2.0

Annotation Detail for MAP2K2


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Basic Information Top
Gene Symbol:MAP2K2 ( FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2 )
Gene Full Name: mitogen-activated protein kinase kinase 2
Band: 19p13.3
Quick LinksEntrez ID:5605; OMIM: 601263; Uniprot ID:MP2K2_HUMAN; ENSEMBL ID: ENSG00000126934; HGNC ID: 6842
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-14MAP kinase cascade
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04320Dorso-ventral axis formation
hsa04540Gap junction
hsa04620Toll-like receptor signaling pathway
hsa04730Long-term depression
hsa05219Bladder cancer
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05216Thyroid cancer
hsa04114Oocyte meiosis
hsa05223Non-small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05020Prion diseases
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signalling by NGF
Axon guidance
Signaling by EGFR
Signaling by Insulin receptor
Signaling by PDGF
Signaling in Immune system
Pathway IDPathway Name
200184Downstream signaling in naive CD8+ T cells
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200004Endothelins
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200015GMCSF-mediated signaling events
200080mTOR signaling pathway
200082IL2-mediated signaling events
200145Nongenotropic Androgen signaling
200179Cellular roles of Anthrax toxin
200074Netrin-mediated signaling
200150CXCR3-mediated signaling events
200119ErbB2/ErbB3 signaling events
200113ErbB1 downstream signaling
200100Ceramide signaling pathway
Pathway IDPathway Name
P00053T cell activation
P00019Endothelin signaling pathway
P00018EGF receptor signaling pathway
P00010B cell activation
P00054Toll receptor signaling pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P04393Ras Pathway
Pathway IDPathway Name
500083RAF phosphorylates MEK
500086ERK2 activation
500100Signal transduction by L1
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Cardiofaciocutaneous syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased activity of MAP2K2 proteindecreases activity 16940797
16261397
C506698 2,5-dimethylcelecoxib 2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16123214
C506698 2,5-dimethylcelecoxib 2,5-dimethylcelecoxib results in decreased phosphorylation of MAP2K2 proteindecreases phosphorylation 16123214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAP2K2 mRNAaffects expression 21346803
C496751 4-(1H-imidazol-1-yl)retinoic acid 4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of MAP2K2 proteindecreases expression 17145897
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16510265
D000082 Acetaminophen Acetaminophen affects the expression of MAP2K2 mRNAaffects expression 17562736
C412373 AG 1879 AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16510265
D013196 Dihydrotestosterone bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]decreases reaction|increases activity|increases phosphorylation 15466214
D013196 Dihydrotestosterone Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 15466214
D013196 Dihydrotestosterone PD 98059 inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]decreases reaction|increases activity|increases phosphorylation 15466214
D000638 Amiodarone Amiodarone affects the expression of MAP2K2 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP2K2 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of MAP2K2 mRNAincreases expression 12420312
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of MAP2K2 proteinincreases expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 18314537
D001553 Benzbromarone Benzbromarone affects the expression of MAP2K2 mRNAaffects expression 19483382
C053541 bicalutamide bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C053541 bicalutamide bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 15466214
C053541 bicalutamide PD 98059 inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]decreases reaction|increases activity|increases phosphorylation 15466214
D000001 Calcimycin Calcimycin results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 16000378
D002118 Calcium Calcium affects the expression of MAP2K2 mRNAaffects expression 15913539
C105934 celecoxib celecoxib results in decreased phosphorylation of MAP2K2 proteindecreases phosphorylation 16123214
D002994 Clofibrate Clofibrate affects the expression of MAP2K2 mRNAaffects expression 19483382
C488583 Clostridium difficile lethal toxin B Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 11158304
D003024 Clozapine Clozapine results in increased expression of MAP2K2 mRNAincreases expression 14647396
D003024 Clozapine Clozapine results in decreased expression of MAP2K2 mRNAdecreases expression 15860345
C107676 deguelin deguelin results in decreased expression of MAP2K2 proteindecreases expression 19336726
D004026 Dieldrin Dieldrin results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 15888667
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 17974986
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 17974986
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 15288473
D004726 Endosulfan Endosulfan results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 15888667
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased phosphorylation of MAP2K2 proteindecreases phosphorylation 15778002
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAP2K2 mRNAincreases expression 16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP2K2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAP2K2 mRNAincreases expression 17351261
16174780
D005001 Ethionine Ethionine affects the expression of MAP2K2 mRNAaffects expression 19483382
C024352 fludarabine fludarabine results in increased activity of MAP2K2 proteinincreases activity 15059916
D019833 Genistein Genistein results in decreased phosphorylation of MAP2K2 proteindecreases phosphorylation 15781664
D006152 Cyclic GMP Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K2 protein]affects reaction|decreases activity|decreases phosphorylation 18225537
D006152 Cyclic GMP Cyclic GMP results in decreased phosphorylation of MAP2K2 proteindecreases phosphorylation 18225537
D006220 Haloperidol Haloperidol results in increased expression of MAP2K2 mRNAincreases expression 14647396
D006220 Haloperidol Haloperidol results in decreased expression of MAP2K2 mRNAdecreases expression 15860345
D006493 Heparin Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 14966081
D006493 Heparin Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 14966081
D006533 Heptachlor Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 15888667
D006820 Hyaluronic Acid Hyaluronic Acid analog results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 12402308
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 15288473
C067431 letrozole letrozole results in increased expression of MAP2K2 proteinincreases expression 15967659
D001556 Lindane Lindane results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 15888667
C009900 lipoteichoic acid lipoteichoic acid results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 19573522
C009900 lipoteichoic acid Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 19573522
C015329 lycopene lycopene results in decreased expression of MAP2K2 proteindecreases expression 17337101
D008353 Mannitol Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16510265
D008628 Mercury Mercury results in increased expression of MAP2K2 mRNAincreases expression 16823088
D008727 Methotrexate MAP2K2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MAP2K2 mRNAdecreases expression 19285098
C404397 NSC 680410 NSC 680410 affects the cleavage of MAP2K2 proteinaffects cleavage 14647418
C404397 NSC 680410 NSC 680410 results in decreased phosphorylation of MAP2K2 proteindecreases phosphorylation 14647418
C440229 Oleylethanolamide Oleylethanolamide promotes the reaction [ERBB2 protein binds to MAP2K2 protein modified form]affects binding|increases reaction 16269455
C440229 Oleylethanolamide Oleylethanolamide results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 16269455
C440229 Oleylethanolamide tyrphostin AG 1478 inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16269455
D009853 Omeprazole Omeprazole affects the expression of MAP2K2 mRNAaffects expression 19483382
C506614 PD 0325901 PD 0325901 results in decreased activity of MAP2K2 proteindecreases activity 19282848
C093973 PD 98059 PD 98059 inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C093973 PD 98059 PD 98059 inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]decreases reaction|increases activity|increases phosphorylation 15466214
C093973 PD 98059 PD 98059 inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 15466214
C093973 PD 98059 PD 98059 results in decreased activity of MAP2K2 proteindecreases activity 16116186
D010710 Phosphates Phosphates results in increased phosphorylation of and results in increased activity of MAP2K2 proteinincreases activity|increases phosphorylation 16763222
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP2K2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid affects the expression of MAP2K2 mRNAaffects expression 19483382
D015742 Propofol Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 19573522
D011441 Propylthiouracil Propylthiouracil affects the expression of MAP2K2 mRNAaffects expression 19483382
D012643 Selenium Selenium results in increased expression of MAP2K2 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of MAP2K2 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP2K2 mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K2 protein]increases phosphorylation|increases reaction 20479004
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 20479004
D013853 Thioacetamide Thioacetamide affects the expression of MAP2K2 mRNAaffects expression 19483382
D014303 Trinitrotoluene Trinitrotoluene affects the expression of MAP2K2 mRNAaffects expression 21346803
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16269455
C113580 U 0126 U 0126 results in decreased activity of MAP2K2 proteindecreases activity 15547725
15331595
15930308
C113580 U 0126 U 0126 promotes the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAP2K2 protein]increases activity|increases phosphorylation|increases reaction 14713289
C113580 U 0126 U 0126 results in decreased activity of MAP2K2 proteindecreases activity 15375559
16000378
C459559 vaticanol C vaticanol C results in decreased expression of and results in decreased phosphorylation of MAP2K2 proteindecreases expression|decreases phosphorylation 15725661
D014801 Vitamin A 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16510265
D014801 Vitamin A AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16510265
D014801 Vitamin A Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 16510265
D014801 Vitamin A Vitamin A results in increased phosphorylation of MAP2K2 proteinincreases phosphorylation 16510265
D002762 Cholecalciferol Cholecalciferol results in increased expression of MAP2K2 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 10.7312039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.7315322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 10.737525203
MESH:D000015 Abnormalities, Multiple Vitamin A 4.2810992263
MESH:D000138 Acidosis Ammonium Chloride 2.9218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2917505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.8517694057
MESH:D055371 Acute Lung Injury pirinixic acid 2.5318653653
MESH:D000230 Adenocarcinoma Doxorubicin 5.8817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.8814692618
MESH:D000230 Adenocarcinoma Genistein 5.8811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 7.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.7816835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.5219003578 16215675
MESH:D000380 Agranulocytosis Clozapine 4.4312649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases Heptachlor 7.3912661182
MESH:D000382 Agricultural Workers' Diseases Lindane 7.3912661182
MESH:D000419 Albuminuria Doxorubicin 3.9321441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.1211748828
MESH:D000740 Anemia Vitamin A 7.1216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.2316960172
MESH:D000799 Angioedema Acetaminophen 3.1910982225
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 4.7615146954
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.2518218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.2415885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 2.9217286800
MESH:D001249 Asthma Vitamin A 3.1316732791
MESH:D001281 Atrial Fibrillation Amiodarone 3.4118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Haloperidol 2.1619368416 18080171
MESH:D001321 Autistic Disorder Mercury 2.1617497416
MESH:D001327 Autoimmune Diseases Cholecalciferol 9.1616142846
MESH:D001327 Autoimmune Diseases Mercury 9.1616634805
MESH:D001778 Blood Coagulation Disorders Amiodarone 46.8419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 46.8419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 46.8419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 46.8419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 46.8419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 46.8419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 46.8419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 46.8412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 46.8419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.0514601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.2517150277
MESH:D001943 Breast Neoplasms 4-(1H-imidazol-1-yl)retinoic acid 5.9617387344 17145897
MESH:D001943 Breast Neoplasms deguelin 5.9618593368 17035597
MESH:D001943 Breast Neoplasms Dieldrin 5.9615770527 11859874
MESH:D001943 Breast Neoplasms Doxorubicin 5.9616322301 18628466 17426702 19526202 15994142 15136595 15567936 16096432 15692762 18695136 15993339 15939500 15668708 16264153 16935488 17983394 15634643 16115903 18382427 17369602 16826403 16595493 11325840 18234424
MESH:D001943 Breast Neoplasms Genistein 5.9616541309 17200150 16873071
MESH:D001943 Breast Neoplasms Heptachlor 5.968738476
MESH:D001943 Breast Neoplasms letrozole 5.9617892469 16002280
MESH:D001943 Breast Neoplasms Lindane 5.9614688026
MESH:D001943 Breast Neoplasms Methotrexate 5.9616978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.9620435547
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.3712794006
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 4.9617426644 17377406
MESH:D002276 Carcinoid Tumor Doxorubicin 4.1616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.823084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 11.821701930
MESH:D006528 Carcinoma, Hepatocellular deguelin 11.8218575727
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.8217876044 16234567 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.8216924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.8217997003
MESH:D002292 Carcinoma, Renal Cell celecoxib 5.9516369983
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.9516201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.256189445
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.2518922899
MESH:C535579 Cardiofaciocutaneous syndrome marker/mechanism 16439621 17703371
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.9818670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 7.2517382496 15476868 16952015 17351982 15811867 17329180 16269455 17131338 17928571 16731534 16109756 18627295 16455267 16651473 15792986 17308081 17007740 17519947 16278810 16364871 16242529 17924179 17974986 16612575 15505089
MESH:D009202 Cardiomyopathies Oleylethanolamide 7.2516269455
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 8.0719225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 8.0716243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 8.0710334427
MESH:D002318 Cardiovascular Diseases Genistein 2.8516332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.4418974383
MESH:D002375 Catalepsy Haloperidol 4.271977408 15215559
MESH:D002386 Cataract Acetaminophen 6.1410977129
MESH:D002386 Cataract Trinitrotoluene 6.1414694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.416135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 5.411399818
MESH:D002637 Chest Pain Omeprazole 4.4515447763
MESH:D015362 Child Nutrition Disorders Vitamin A 4.8216153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7316835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 7.7318291259
MESH:D002779 Cholestasis Ethinyl Estradiol 10.6816919318 17681005 16105132 17333356 11677210 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 10.6819176532
MESH:D002779 Cholestasis Vitamin A 10.6816175620
MESH:D019457 Chromosome Breakage Sodium Selenite 4.1215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.0912621046 15340226 16354765 8697196 15668235
MESH:D002972 Cleft Palate Vitamin A 5.0916054864
MESH:D003072 Cognition Disorders Clozapine 4.3417123785
MESH:D003092 Colitis Selenium 3.1617936198
MESH:D003110 Colonic Neoplasms celecoxib 5.1616004971
MESH:D003110 Colonic Neoplasms Genistein 5.1617182828
MESH:D003110 Colonic Neoplasms Vitamin A 5.1617219422 16267017
MESH:D015179 Colorectal Neoplasms celecoxib 2.8811197048 18349538
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8818802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.4617141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 7.4615095906
MESH:D056685 Costello Syndrome marker/mechanism 17703371
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.4512039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.4510992263
MESH:D003490 Cyanosis 2,6-dinitrotoluene 15.4018551238
MESH:D003490 Cyanosis Endosulfan 15.407900959
MESH:D003490 Cyanosis Trinitrotoluene 15.4018551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.6919747007
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.2520210726
MESH:D003704 Dementia Haloperidol 4.0011575062
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.2116823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0918249437
MESH:D003882 Dermatomyositis Methotrexate 4.5120191521
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.2316285004
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.2716506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 5.9816402076
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.9817107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9015331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.0321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.0316081117 2444490 12958197 16393943 19164858 11461765 19085960 16781746 15968718 14550746 12705907 16485898 16177239 10774834 17906064 14725611 11834606 10663392 14986274 12392966 12594235 12153990 18071297 18713872 17522070 19416960 16227642 11529661 10915739 11739529 11287661 19370779 16109766 19420014 11421492 11743745 19739265 12540782 19923254 17562736 15619225
MESH:D056486 Drug-Induced Liver Injury Amiodarone 21.0315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 21.0317416283
MESH:D056486 Drug-Induced Liver Injury Selenium 21.0315131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 21.0315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.0320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 21.0312963478
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 21.0321346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4419426721
MESH:D004362 Drug Toxicity Doxorubicin 6.4718602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.4711462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.1616146918
MESH:D004381 Duodenal Ulcer Omeprazole 3.7317151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 7.4916707586
MESH:D050171 Dyslipidemias Clozapine 7.4916402076
MESH:D004417 Dyspnea Endosulfan 4.633388749 7900959
MESH:C538011 Eales disease Vitamin A 4.979068938
MESH:D004480 Ectromelia Vitamin A 5.1716054864
MESH:D004487 Edema pirinixic acid 8.1912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.1912711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.1916716910 9599246 15177302 7812673 11698051 8113982 8273558
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.2515322242 18230668 16714409
MESH:D004646 Emphysema Endosulfan 5.907900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.5912538720
MESH:D004714 Endometrial Hyperplasia Genistein 3.9516402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.2017359293
MESH:D016889 Endometrial Neoplasms Genistein 6.2011473722
MESH:D004715 Endometriosis celecoxib 7.5015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.5010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5018037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5211564622
MESH:D005218 Fat Necrosis Thioacetamide 5.0716456712
MESH:D005234 Fatty Liver Amiodarone 14.1014986274
MESH:D005234 Fatty Liver Clofibrate 14.1019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1015345470
MESH:D005234 Fatty Liver pirinixic acid 14.1020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8311858732
MESH:D005327 Fetal Resorption Vitamin A 4.7116054864
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 3.9519069698
MESH:D005355 Fibrosis Emodin 7.0319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.0320067830
MESH:D005756 Gastritis Acetaminophen 3.0216983495
MESH:D005909 Glioblastoma Doxorubicin 5.8617150277
MESH:D005909 Glioblastoma Genistein 5.8616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9410696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.5216518429
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.0815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.6511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin A 5.6516080930 10992263
MESH:D006331 Heart Diseases Doxorubicin 3.0216707910 16244372 18006777 16879835 16244371 14766674 16330681 16495754 17888722 17875725 18674790 12587719 16144979
MESH:D006333 Heart Failure Doxorubicin 9.3317481944
MESH:D006333 Heart Failure pirinixic acid 9.3320558911
MESH:D006333 Heart Failure Selenium 9.3317162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3315692506
MESH:D006470 Hemorrhage Endosulfan 8.537900959
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 8.5311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 3.9917276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 3.6116456712
MESH:D006529 Hepatomegaly Amiodarone 15.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 15.6219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6212621046 15340226 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 15.6215817613
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.3616490937 16877224 16292552 15707848 17436238 16863852
MESH:D015658 HIV Infections Vitamin A 3.4616960176
MESH:D006679 HIV Seropositivity Vitamin A 4.9617209195
MESH:D006689 Hodgkin Disease Doxorubicin 2.8815147373 17606976 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3916959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.1916870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.308137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.6220558911
MESH:D006948 Hyperkinesis Clozapine 4.2716046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.6318850075 18670907
MESH:D006986 Hypervitaminosis A Vitamin A 5.5116054864
MESH:D007021 Hypospadias Ethinyl Estradiol 3.1816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 9.5318020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 9.538137927 18031379
MESH:D007247 Infertility, Female Dieldrin 8.3210630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.3212013081
MESH:D007248 Infertility, Male Endosulfan 8.858588293 9432128
MESH:D007248 Infertility, Male Ethinyl Estradiol 8.8517937319
MESH:D007248 Infertility, Male Trinitrotoluene 8.8512150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 3.9512200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.9515177302 7812673 11698051 7562506 8273558
MESH:D007251 Influenza, Human Selenium 3.5516624496
MESH:D007333 Insulin Resistance pirinixic acid 5.8316306350
MESH:D007333 Insulin Resistance Sodium Selenite 5.8314714311
MESH:D019586 Intracranial Hypertension Vitamin A 5.1715955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.7616580747
MESH:D007674 Kidney Diseases Acetaminophen 7.8612587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 7.8615369732 15699352 16775033
MESH:D007674 Kidney Diseases Mercury 7.8617934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.0616707910
MESH:D007676 Kidney Failure, Chronic Selenium 8.0616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.4616705839
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.3916316344
MESH:D007805 Language Development Disorders Methotrexate 4.519562676
MESH:D007859 Learning Disorders Endosulfan 4.488157075
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.5719248655
MESH:D007938 Leukemia Genistein 2.6717468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5016085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell fludarabine 4.2618172266 17802794 18587576 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.4517077332
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 9.9616972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 9.9616972261
MESH:D015470 Leukemia, Myeloid, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 4.0017077328 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 4.7617077328
MESH:D017880 Limb Deformities, Congenital Vitamin A 3.8416054864
MESH:D008064 Lipidoses Amiodarone 6.6215342952 17567588
MESH:D008064 Lipidoses Clozapine 6.6217567588
MESH:D008103 Liver Cirrhosis Methotrexate 6.0214986274
MESH:D008103 Liver Cirrhosis Vitamin A 6.0216256175
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 13.3416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Emodin 13.3415288473
MESH:D008106 Liver Cirrhosis, Experimental Genistein 13.3417823541
MESH:D008106 Liver Cirrhosis, Experimental Heparin 13.3416904936
MESH:D008106 Liver Cirrhosis, Experimental inchinko-to 13.3415288473
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.3412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 13.3415075984 17629604 12557150 18295389 15288473 12891558 18615449 16343077 15474484 17292413 18395095 15288472 12531686 16097051 17127702 18380797 15334695 16248980 11481614 11172339 11682029 15095483 15362042 18606216 15465738 15316131 12679928 18032466 18416461 17355460 17050028 16126171 18263696 15716488 12175628 15078482 14739098 18458672 16489207 10677585 16511523 15158331 16098781 18031379 12085344
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 13.3416248980
MESH:D008107 Liver Diseases Acetaminophen 7.6819014921 11587558 19784758 19460945 12969438 16611625 12587719 16610002
MESH:D008107 Liver Diseases Lindane 7.681715830
MESH:D008107 Liver Diseases Thioacetamide 7.6815158337 18374380 16337175
MESH:D008107 Liver Diseases Vitamin A 7.6816175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.5316762690
MESH:D017114 Liver Failure, Acute Acetaminophen 7.7716871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 7.7715633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.157678174
MESH:D008113 Liver Neoplasms Dieldrin 11.158742319 9539021
MESH:D008113 Liver Neoplasms Heptachlor 11.152422723 9544696
MESH:D008113 Liver Neoplasms pirinixic acid 11.1515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.652876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.6517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6512151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 10.6517113696
MESH:D008133 Long QT Syndrome Amiodarone 3.0811989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 6.3412587719
MESH:D008171 Lung Diseases Vitamin A 6.3416863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.3818516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 9.3818516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.4117365036
MESH:D008175 Lung Neoplasms deguelin 4.1016288123 19336726
MESH:D008175 Lung Neoplasms Doxorubicin 4.1017418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.1019555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.1011807781
MESH:D008223 Lymphoma Doxorubicin 6.3416098063
MESH:D008223 Lymphoma Methotrexate 6.3417352296
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.4714737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.2617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.9415621674
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 17.9112104042 19196722
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.9115458769
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 17.9115375486
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.9112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 17.9115318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 17.918985016
MESH:D008545 Melanoma 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 4.8617992120
MESH:D008545 Melanoma Doxorubicin 4.8616827129
MESH:D008545 Melanoma PD 0325901 4.8619282848
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9419513568
MESH:D001523 Mental Disorders Clozapine 9.8416856516
MESH:D001523 Mental Disorders Haloperidol 9.8416856516
MESH:D001523 Mental Disorders Phosphates 9.8412686366
MESH:D008654 Mesothelioma Asbestos, Crocidolite 8.4816966607 18303189 16166281
MESH:D008654 Mesothelioma Doxorubicin 8.4817638057
MESH:D008654 Mesothelioma Selenium 8.4815107826
MESH:D024821 Metabolic Syndrome X Clozapine 3.8819142101
MESH:D020326 Migraine without Aura Cyclic GMP 5.3911304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9215792986
MESH:D052016 Mucositis Doxorubicin 10.3917415656
MESH:D052016 Mucositis Methotrexate 10.3917488658
MESH:D009101 Multiple Myeloma 2,5-dimethylcelecoxib 9.9616123214
MESH:D009101 Multiple Myeloma celecoxib 9.9616123214
MESH:D009101 Multiple Myeloma Vitamin A 9.9616374440
MESH:D009135 Muscular Diseases pirinixic acid 2.8816239165
MESH:D009181 Mycoses Amiodarone 4.2512754197 17974566
MESH:D009203 Myocardial Infarction Doxorubicin 7.6519429709 15857846
MESH:D009203 Myocardial Infarction Genistein 7.6517141266
MESH:D009203 Myocardial Infarction pirinixic acid 7.6519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 6.7117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.7116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.567678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 8.5618551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.6618259882
MESH:D009369 Neoplasms deguelin 11.9817764071
MESH:D009369 Neoplasms Dieldrin 11.988820588
MESH:D009369 Neoplasms Lindane 11.9816818664 12807735
MESH:D009369 Neoplasms lycopene 11.9817051425
MESH:D009369 Neoplasms pirinixic acid 11.9817405874
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 4.7819196722
MESH:D009401 Nephrosis Doxorubicin 4.1416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.4515640375 16889571
MESH:D009421 Nervous System Malformations Genistein 7.5816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.5814600291
MESH:D009436 Neural Tube Defects Vitamin A 3.6217400914
MESH:D009447 Neuroblastoma Doxorubicin 2.9015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.3418514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.319802331
MESH:D009634 Noonan Syndrome marker/mechanism 17703371
MESH:D009765 Obesity Clozapine 4.0119142110 18515891
MESH:D009765 Obesity pirinixic acid 4.0120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.3616049721
MESH:D009784 Occupational Diseases Trinitrotoluene 7.3614694615 12819281 17852074
MESH:D010024 Osteoporosis Calcium 6.0617882678
MESH:D010024 Osteoporosis Genistein 6.0619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.4916169203
MESH:D012516 Osteosarcoma Doxorubicin 3.5915930896
MESH:D010051 Ovarian Neoplasms Genistein 4.5119005980
MESH:D010051 Ovarian Neoplasms U 0126 4.5116211241
MESH:D010146 Pain Acetaminophen 1.8916870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 2.8715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0911578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.688330346 12065085 18404319 18922899
MESH:D010300 Parkinson Disease Dieldrin 3.2611181820 17291500 16112328 16809432 11445065
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5017983394
MESH:D010954 Plasmacytoma Selenium 4.2315087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.2710923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.5611118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms bicalutamide 3.1219011039 17914592 18487222 19240160 15638997
MESH:D011471 Prostatic Neoplasms celecoxib 3.1217908994 15570007
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.1217024972
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.1216729912 15897917 16868541 18437689 15749863 16888761
MESH:D011471 Prostatic Neoplasms Genistein 3.1215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Heptachlor 3.1212661182
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 3.1216864594
MESH:D011471 Prostatic Neoplasms Lindane 3.1214688026 12661182
MESH:D011471 Prostatic Neoplasms lycopene 3.1215084515 17337101
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1218760546
MESH:D011537 Pruritus Ethinyl Estradiol 2.6815861022 16919318
MESH:D011565 Psoriasis Methotrexate 3.1717410198
MESH:D011595 Psychomotor Agitation Haloperidol 4.3311575062
MESH:D011618 Psychotic Disorders Clozapine 7.5515331141
MESH:D011618 Psychotic Disorders Haloperidol 7.5511575062
MESH:D011658 Pulmonary Fibrosis Amiodarone 4.9012832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 4.9017975199 17365031 17322281 15814490
MESH:D051437 Renal Insufficiency Doxorubicin 8.4217922066
MESH:D051437 Renal Insufficiency Methotrexate 8.4217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.0419058328
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.1616877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2318990726
MESH:D012509 Sarcoma Doxorubicin 3.4317203757 15625365 15675481 16767912 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.6316326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1517846226
MESH:D012559 Schizophrenia Clozapine 3.6618806925 18855531 19369910 20452607 11151749 20521326 16141801 11763009 17667964 20107430 17123785 17726453 20580759 20168265 20521320
MESH:D012559 Schizophrenia Haloperidol 3.661830565 19369910 20107430 18513383
MESH:D012640 Seizures 2,6-dinitrotoluene 10.4718551238
MESH:D012640 Seizures Endosulfan 10.4710698677 7539098
MESH:D012640 Seizures Lindane 10.477539098 15475178 12842176
MESH:D012640 Seizures Trinitrotoluene 10.4718551238
MESH:D012772 Shock, Septic lipoteichoic acid 5.4519573522
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.4418724381
MESH:D012851 Sinus Thrombosis, Intracranial Heparin 5.4312269725
MESH:D012871 Skin Diseases Vitamin A 3.1618709164
MESH:D012878 Skin Neoplasms deguelin 10.8216041863
MESH:D012878 Skin Neoplasms Doxorubicin 10.8215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.8216192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 10.8218404319 12065085 8985016 11807781 8330346
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9416767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.2916709447
MESH:D013163 Splenomegaly Trinitrotoluene 4.5715817613
MESH:D013272 Stomach Diseases Omeprazole 3.9718545984
MESH:D013274 Stomach Neoplasms celecoxib 3.1715609394
MESH:D013276 Stomach Ulcer Amiodarone 5.7018087811
MESH:D013276 Stomach Ulcer Omeprazole 5.7011906479 17977527 15991576 10750652 16755016 18237397
MESH:D013576 Syndactyly Methotrexate 4.429562676
MESH:D013610 Tachycardia Amiodarone 3.6811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 8.5119225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 8.5120210726
MESH:D013742 Tetanus Propofol 5.782903605
MESH:D013921 Thrombocytopenia Heparin 4.8916893407 16651880
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 7.6715669648
MESH:D013927 Thrombosis Heparin 7.6716893407
MESH:D013959 Thyroid Diseases Amiodarone 9.8819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.8812697716
MESH:D013964 Thyroid Neoplasms 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 9.4916940797
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.4917909728 16010429
MESH:D013964 Thyroid Neoplasms Propylthiouracil 9.4915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.2318020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 3.5517467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.2016049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 4.2017653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.6810091137
MESH:D014581 Urticaria Acetaminophen 2.3910982225
MESH:D014594 Uterine Neoplasms celecoxib 7.8318645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.8314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9412125929
MESH:D014657 Vasculitis Heparin 5.4320337814
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.6017678736 17638931 17334414 16364871
MESH:D014802 Vitamin A Deficiency Vitamin A 4.6816175781 16960172 16146918
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5915886252
MESH:D015430 Weight Gain Clozapine 3.9220107430 17502770 16402076 20521320 20564506 16141801
MESH:D015431 Weight Loss Clozapine 4.4417933447
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
REACT:18266 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:05219 Bladder cancer
KEGG:05220 Chronic myeloid leukemia
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04540 Gap junction
KEGG:05214 Glioma
KEGG:04912 GnRH signaling pathway
REACT:25035 Innate immune response mediated by toll like receptors
KEGG:04910 Insulin signaling pathway
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
KEGG:05218 Melanoma
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
KEGG:05020 Prion diseases
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:9417 Signaling by EGFR
REACT:498 Signaling by Insulin receptor
REACT:32280 Signaling by PDGF
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
KEGG:05216 Thyroid cancer
KEGG:04620 Toll-like receptor signaling pathway
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30587
    • No data
    Releated disease ID Related disease Name
    PA444985Multiple Myeloma
    PA152208657Cardio-facio-cutaneous Syndrome
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445062Neoplasms
    PA445123Noonan Syndrome
    Releated drug ID Related drug Name
    PA7000sorafenib
    PA10804imatinib
    PA449780glutathione
    PA450635nitric oxide
    PA450631nifedipine
    PA164743471adenosine triphosphate
    PA448948chloroquine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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