AutismKB 2.0

Annotation Detail for MAP2K5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP2K5 ( HsT17454,MAPKK5,MEK5,PRKMK5 )
Gene Full Name: mitogen-activated protein kinase kinase 5
Band: 15q23
Quick LinksEntrez ID:5607; OMIM: 602520; Uniprot ID:MP2K5_HUMAN; ENSEMBL ID: ENSG00000137764; HGNC ID: 6845
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04540Gap junction
hsa04722Neurotrophin signaling pathway
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200113ErbB1 downstream signaling
No data
Pathway IDPathway Name
500644Signalling to ERK5
Related Diseases/Disorders Top
No data
No data
Desease Name
restless legs syndrome
NEUROLOGICAL
Desease Name
Restless legs syndrome
Body mass index
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of MAP2K5 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen results in increased expression of MAP2K5 mRNAincreases expression 11752693
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP2K5 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of MAP2K5 mRNAincreases expression 18191166
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MAP2K5 mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAP2K5 mRNAdecreases expression 20106945
20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MAP2K5 mRNAdecreases expression 12419474
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MAP2K5 mRNAincreases expression 15963578
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MAP2K5 mRNAaffects expression 17805973
D003024 Clozapine Clozapine results in decreased expression of MAP2K5 mRNAdecreases expression 15860345
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MAP2K5 mRNAaffects cotreatment|decreases expression 18164116
D004958 Estradiol Estradiol affects the expression of MAP2K5 mRNAaffects expression 14699072
D005419 Flavonoids Flavonoids results in increased expression of MAP2K5 mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of MAP2K5 mRNAdecreases expression 15860345
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of MAP2K5 mRNAdecreases expression 12419474
C008493 methylselenic acid methylselenic acid results in increased expression of MAP2K5 mRNAincreases expression 12517777
D009151 Mustard Gas Mustard Gas affects the expression of MAP2K5 mRNAaffects expression 15651846
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP2K5 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAP2K5 mRNAincreases expression 19465110
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of MAP2K5 mRNAincreases expression 17951470
C029297 vinylidene chloride vinylidene chloride results in increased expression of MAP2K5 proteinincreases expression 14565772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.2111473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.916695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.9119389873
MESH:D000236 Adenoma Diethylnitrosamine 10.9110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.7918056438 19052882 17162532 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.7916835633
MESH:D000380 Agranulocytosis Clozapine 4.9714617031 12649775 16160616
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0510965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001249 Asthma Mustard Gas 2.6810378619
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1218080171 19368416
MESH:D001768 Blister Mustard Gas 5.0719167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9020146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9017474063
MESH:D001943 Breast Neoplasms Estradiol 1.9017289903 16675129 12948864 17261762 19861407 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9017687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6916124888 15721981 3786805 15673190 16192424 16227642 10355542 15700767 16050911 16011737 18705752 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.433084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.4318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.4316935385 18785209 19701751 19171122 19539802 16681979 20214788 18665156 19208518 16830150 16878318 17173139 10672840 16779866 20101231 20007298 20514400 20524982 17761372 16698587 19383236 21159647 17055752 10737359 19107877 17428255 18788625 19519916 18393292 19394651 16502159 20084675 18210153 20432363 16328049 16807293 19052882 18691550 3084413 19822196 19919837 17978847 17162532 19418558 20727157 16540662 16569478 19335982 3581430 18494052 11831363 20935162 17138121 16288022 18978308 18506893 20512989 18971187 18056438
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.4316924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4516936243
MESH:D002375 Catalepsy Haloperidol 4.821977408 15215559
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.4917174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.4918566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis pirinixic acid 2.7619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0712621046 15340226 16354765 15668235 8697196
MESH:D003072 Cognition Disorders Clozapine 4.8817123785
MESH:D003110 Colonic Neoplasms arsenite 2.5715037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7620210726
MESH:D003704 Dementia Haloperidol 4.5011575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.0416402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4715331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7615968718 10774834 17906064 2444490 11834606 19164858 11421492 12153990 18071297 16781746 10915739 11529661 14986274 12392966 19085960 16485898 12705907 10663392 15619225 11743745 19739265 19370779 11461765 12594235 19420014 17562736 12958197 11739529 16177239 14725611 17522070 18713872 16109766 14550746 19416960 12540782 16227642 16393943 11287661 19923254 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.766884620 10915739 19336974 16227642 15998439 17522070 3732212 7440962 11566570 4309450 7179309 2869522 15968718 15027814 19085960 21278145 6623471 9327722 7120509 10092053 16177239 3786805
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.7619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7620420201
MESH:D056486 Drug-Induced Liver Injury vinylidene chloride 11.763697828
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Clozapine 4.1216402076
MESH:D004487 Edema Mustard Gas 10.9511402378 11428631 11428647 9260866
MESH:D004487 Edema pirinixic acid 10.9512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8216714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.9211473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004890 Erythema Mustard Gas 5.079357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver arsenite 18.1218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1219224547 15959796 12631006 16239168 61145 17595544 12795759 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 18.1220387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 18.1220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005355 Fibrosis arsenite 14.3318296743
MESH:D005355 Fibrosis Carbon Tetrachloride 14.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3320067830
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.9719772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006948 Hyperkinesis Clozapine 4.8216046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007249 Inflammation Diethylnitrosamine 11.6018785209
MESH:D007249 Inflammation Flavonoids 11.6017296493
MESH:D007249 Inflammation Mustard Gas 11.6011428631 8975870 9260866 17524151 11402378 9357497 11428647 11428620 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6012878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.0016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.0016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007674 Kidney Diseases Acetaminophen 9.9815629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007674 Kidney Diseases vinylidene chloride 9.987839370
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1916518626
MESH:D007680 Kidney Neoplasms Estradiol 2.9115610895
MESH:D008064 Lipidoses Clozapine 3.9017567588
MESH:D008103 Liver Cirrhosis arsenite 10.8118296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.8111903743 11408273 16239168 16943688 21278145 17157831 17334410 17174718 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.8118407596 19638242 20032147 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8312632514 17869086 17557913 12632512 13678700 12958196 12666154 17944888 17823541 16027843 12898905 18263696 14512876 17766677 15370692 18317297 17708605 18420326 14748882 15650968 15730626 17525996 15673190 11481614 18205269 18705752 16248980 12445421 17761835 20821823 12389079 16192424 18210741 15057751 17698563 16136751 15925388 14724832 14620537 17900296 15338365 15893842 18006644 17631135 18395914 12667390 16015684 12586293 18412020 16033810 12546737 18156304 18472332 16011737 17805973 16097048 15818738 17481882 14716496 18472094 18251166 14716833 18376398 15959796 18277467 17976157 17714472 18187930 18054572 17721639 15931870 18279442 12445418 12649538 16638106 15362042 16116963 17565644 15876570 18481824 18429990 17640975 15123356 15052691 15996030 18339082 12741479 12609069 18166357 17922224 18418968 18395095 10355542
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8312878042
MESH:D008107 Liver Diseases Acetaminophen 6.3419460945 12587719 12969438 11587558 19014921 16610002 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3416964402 17285989 16246199 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.1416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5520195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 17.5521295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.5519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.5519090486 19294768 16942905 19812893 20492335 20101389 20405173 19254457 20583210 20452335 19833225 15175105 19427195 18648771 12112319 20501860 19551842 18754104 19850985 18978307 20434301 19690152 21278145 18977376 19256749 20118626 20137499 19426721 19996281 18644402 2422723 19638242 15885732 19499222 21071580 19255062 10737359 2862719 21167192 9163691 19642983 21047994 19073162 12771043
MESH:D008113 Liver Neoplasms pirinixic acid 17.5520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.5516984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.6718164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.6719126423 18775883 9362446 16267830 19004024 18544905 3124819 19539802 17942915 21159647 18308698 18079962 18282651 17174075 18253720 19009564 2563599 18164116 18093689 17854601 16842330 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.6712151625
MESH:D008171 Lung Diseases Mustard Gas 3.3918161513 18702808
MESH:D055370 Lung Injury vinylidene chloride 5.323697828
MESH:D008175 Lung Neoplasms arsenite 6.4816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4818816296 17053015 20464547 20135361 18569708 18520028 20064080 20869020 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.4820970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 6.488781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5011807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D001523 Mental Disorders Clozapine 8.0816856516
MESH:D001523 Mental Disorders Haloperidol 8.0816856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3419142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0216411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.539029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6811141357
MESH:D009369 Neoplasms pirinixic acid 4.6817405874
MESH:D009389 Neovascularization, Pathologic arsenite 9.8715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.8717289903
MESH:D009421 Nervous System Malformations Estradiol 9.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D009503 Neutropenia Mustard Gas 3.897688884 16761898
MESH:D009765 Obesity Clozapine 4.6318515891 19142110
MESH:D009765 Obesity pirinixic acid 4.6320558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3916540662
MESH:D010212 Papilloma Hydrogen Peroxide 4.0012065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.4211550810
MESH:D011041 Poisoning Mustard Gas 3.7115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.472563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6317292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.6316740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6316205645
MESH:D011537 Pruritus Mustard Gas 4.0118058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.8711575062
MESH:D011618 Psychotic Disorders Clozapine 8.9415331141
MESH:D011618 Psychotic Disorders Haloperidol 8.9411575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8917894541 17620002 17266442 17720292 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012559 Schizophrenia Clozapine 4.0518855531 18806925 20107430 11151749 20580759 20521320 17726453 17667964 11763009 19369910 20452607 17123785 20521326 16141801 20168265
MESH:D012559 Schizophrenia Haloperidol 4.0518513383 19369910 20107430 1830565
MESH:D012871 Skin Diseases Mustard Gas 2.6916961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.2310029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.2312065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.238532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.312093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3118456281
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6220210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.927505956
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1417053015
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Clozapine 4.3920521320 20107430 16141801 17502770 20564506 16402076
MESH:D015431 Weight Loss Clozapine 4.9917933447
Pathway ID Pathway Name
KEGG:04540 Gap junction
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30590
    • No data
    Releated disease ID Related disease Name
    PA445528Restless Legs Syndrome
    PA445062Neoplasms
    PA445528Restless Legs Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved