AutismKB 2.0

Annotation Detail for MAP2K6


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Basic Information Top
Gene Symbol:MAP2K6 ( MAPKK6,MEK6,MKK6,PRKMK6,SAPKK3 )
Gene Full Name: mitogen-activated protein kinase kinase 6
Band: 17q24.3
Quick LinksEntrez ID:5608; OMIM: 601254; Uniprot ID:MP2K6_HUMAN; ENSEMBL ID: ENSG00000108984; HGNC ID: 6846
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa05145Toxoplasmosis
hsa04620Toll-like receptor signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Myogenesis
Signaling in Immune system
Pathway IDPathway Name
200034IL12-mediated signaling events
200182Trk receptor signaling mediated by the MAPK pathway
200007RhoA signaling pathway
200014p38 MAPK signaling pathway
200124IL6-mediated signaling events
200143Signaling mediated by p38-gamma and p38-delta
200067FAS (CD95) signaling pathway
200179Cellular roles of Anthrax toxin
200075IL1-mediated signaling events
200150CXCR3-mediated signaling events
200102Regulation of Androgen receptor activity
200190RAC1 signaling pathway
200057CDC42 signaling events
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00018EGF receptor signaling pathway
Pathway IDPathway Name
500453activated TAK1 mediates p38 MAPK activation
500490Interleukin-1 signaling
500556CDO in myogenesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MAP2K6 mRNAincreases expression 18648102
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
D000082 Acetaminophen Acetaminophen affects the expression of MAP2K6 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MAP2K6 proteinaffects expression 20106945
C412373 AG 1879 AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 20181660
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP2K6 mRNAaffects expression 16483693
D001149 Arsenates Arsenates results in decreased expression of MAP2K6 mRNAdecreases expression 12773770
C006632 arsenic trioxide arsenic trioxide results in increased phosphorylation of and results in increased activity of MAP2K6 proteinincreases activity|increases phosphorylation 16818652
C006632 arsenic trioxide MAP2K6 protein affects the susceptibility to arsenic trioxideaffects response to substance 16818652
C006632 arsenic trioxide MAP2K6 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]increases activity|increases phosphorylation|increases reaction 16818652
C015001 arsenite arsenite results in increased expression of MAP2K6 mRNAincreases expression 18191166
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of MAP2K6 mRNAdecreases expression 18687144
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 16407847
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAP2K6 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased phosphorylation of MAP2K6 proteinincreases phosphorylation 17003459
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNAaffects cotreatment|decreases expression 12634122
D003314 Corn Oil Corn Oil affects the expression of MAP2K6 mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of MAP2K6 mRNAdecreases expression 20106945
C007262 deoxynivalenol AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 20181660
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of MAP2K6 proteinincreases phosphorylation 20181660
D002945 Cisplatin MAP2K6 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004317 Doxorubicin Doxorubicin affects the activity of MAP2K6 proteinaffects activity 15870702
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of MAP2K6 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MAP2K6 mRNAdecreases expression 15834898
C020748 ferrous sulfate ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]increases phosphorylation|increases reaction 17172471
C020748 ferrous sulfate ferrous sulfate results in increased phosphorylation of MAP2K6 proteinincreases phosphorylation 17172471
C020748 ferrous sulfate Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
C020748 ferrous sulfate Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 17172471
D005372 Filipin Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
D005372 Filipin Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 17172471
D005372 Filipin Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
D005372 Filipin Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 17172471
D017313 Fenretinide Ascorbic Acid inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 16407847
D017313 Fenretinide Fenretinide results in increased phosphorylation of MAP2K6 proteinincreases phosphorylation 16407847
D007501 Iron Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
D007501 Iron Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein]decreases reaction|increases phosphorylation 17172471
D007501 Iron Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]increases phosphorylation|increases reaction 17172471
D007501 Iron Iron results in increased phosphorylation of MAP2K6 proteinincreases phosphorylation 17172471
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNAaffects cotreatment|decreases expression 12634122
C015329 lycopene lycopene results in decreased expression of MAP2K6 proteindecreases expression 17337101
D019216 Metals, Heavy Metals, Heavy results in decreased expression of MAP2K6 mRNAdecreases expression 12773770
D008727 Methotrexate MAP2K6 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased phosphorylation of MAP2K6 proteinincreases phosphorylation 15251176
D009151 Mustard Gas Mustard Gas affects the expression of MAP2K6 mRNAaffects expression 15651846
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of MAP2K6 mRNAdecreases expression 17616710
D010634 Phenobarbital Phenobarbital results in increased expression of MAP2K6 mRNAincreases expression 19270015
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of MAP2K6 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of MAP2K6 mRNAincreases expression 17404688
C093642 SB 203580 SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNAaffects cotreatment|decreases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of MAP2K6 mRNAincreases expression 17879257
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MAP2K6 mRNAdecreases expression 16705456
D018038 Sodium Selenite Sodium Selenite results in increased expression of MAP2K6 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAP2K6 mRNAdecreases expression 14708085
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 11.9512039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.9515322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5317505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6015814532 17670903 12690470
MESH:D000230 Adenocarcinoma arsenic trioxide 19.0611798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 19.0620127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 19.0617638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 19.0617418594
MESH:D000230 Adenocarcinoma Estradiol 19.0611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 19.0614692618
MESH:D000230 Adenocarcinoma Fenretinide 19.0610697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.793712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.796695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.7317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4916712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.1621441931
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.2416640825
MESH:D000544 Alzheimer Disease Iron 4.8816640825 16563566
MESH:D000544 Alzheimer Disease Metals, Heavy 4.8817430250
MESH:D000740 Anemia Iron 7.7616434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7611748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.3016569441 17163184 17375513 17147795 17162259
MESH:D000756 Anemia, Sideroblastic Iron 4.4516910769
MESH:D000799 Angioedema Acetaminophen 3.4310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6819183758
MESH:D001145 Arrhythmias, Cardiac Iron 4.0216604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4115885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0017286800
MESH:D001249 Asthma Mustard Gas 2.5810378619
MESH:D001260 Ataxia Telangiectasia Iron 5.0415336622
MESH:D050197 Atherosclerosis Iron 3.4716632123 16640825
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001327 Autoimmune Diseases Metals, Heavy 5.7916045731
MESH:D001424 Bacterial Infections Iron 4.7916640825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.601440618 11289319
MESH:D001768 Blister Mustard Gas 4.7519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.4716206674
MESH:D001778 Blood Coagulation Disorders ferrous sulfate 13.476421970
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 10.6814601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.6814601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9217868700
MESH:D001930 Brain Injuries Progesterone 3.8615665606 15380490 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 7.9517150277
MESH:D001932 Brain Neoplasms Fenretinide 7.9516187019
MESH:D001943 Breast Neoplasms Ascorbic Acid 5.3616443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.3617474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 5.3618382427 19526202
MESH:D001943 Breast Neoplasms Doxorubicin 5.3615994142 15136595 18382427 19526202 16322301 18628466 15567936 18695136 16264153 16096432 16595493 16115903 17426702 15939500 18234424 17369602 15993339 11325840 16935488 17983394 16826403 15692762 15668708 15634643
MESH:D001943 Breast Neoplasms Estradiol 5.3617289903 16675129 12948864 14630087 17018787 19861407 18497071 17261762
MESH:D001943 Breast Neoplasms Fenretinide 5.3616601279
MESH:D001943 Breast Neoplasms Methotrexate 5.3616978400
MESH:D001943 Breast Neoplasms Progesterone 5.3615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.3620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5617687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9511589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4816835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.263581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.263084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 21.2621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 21.2614691202 16217749 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 21.2617982673
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 21.2618059187 17876044 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.2616924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 21.2617159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 21.2620007298 17173139 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 21.2617306315 16507464 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8912023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4619014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.887296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.8816201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.9320419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 12.9317066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.936189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 12.9316274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.9318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1418670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 7.2617974986 16364871 17924179 17351982 15811867 16455267 16731534 18627295 16242529 17329180 16952015 17519947 17007740 15476868 16612575 17131338 17928571 17308081 15792986 16651473 16278810 16109756 17382496 15505089 16269455
MESH:D009202 Cardiomyopathies Iron 7.2616640825
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.6817334414 16243910
MESH:D002311 Cardiomyopathy, Dilated Iron 5.6816604332
MESH:D002386 Cataract Acetaminophen 2.3410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 13.697505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.6912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.6918566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.6919524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.854080065
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.0716154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.6419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 11.6419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.6417333356 15861022 16919318 16105132 17681005 11677210 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 4.3515894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9316354765 15340226 12621046 15668235 8697196
MESH:D003110 Colonic Neoplasms therapeutic 15037631
MESH:D003110 Colonic Neoplasms arsenite 3.9115037631
MESH:D003110 Colonic Neoplasms Iron 3.9116640825
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.4820501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.4815273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.4818259882 18802399
MESH:D015179 Colorectal Neoplasms Fenretinide 4.4817273769
MESH:D003139 Common Cold Ascorbic Acid 5.0617323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.0610525206
MESH:D019465 Craniofacial Abnormalities lead acetate 5.0619769572
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.0612039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0610048152 15322242 20055451
MESH:D003550 Cystic Fibrosis Methotrexate 3.8919747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7215213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.432524372 11906362 11298694 12868966 8970840 8156756 14531868 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.123621924 2952479
MESH:D003882 Dermatomyositis Methotrexate 4.7420191521
MESH:D003920 Diabetes Mellitus Iron 8.3516640825 16604332
MESH:D003920 Diabetes Mellitus Sodium Selenite 8.3516285004
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2316506275
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.6316506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 6.6316506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0917187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 10.559328219 6679447 6482804 18289764 1440618 18692083 8291058 16192314 9653073 7440962 11289319 18648102 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.5519416960 16177239 11461765 16781746 15619225 11421492 10663392 17522070 11739529 14725611 12540782 17906064 11529661 12392966 10774834 19085960 19420014 12705907 2444490 16393943 19370779 10915739 14550746 14986274 18713872 18071297 16485898 12958197 11743745 16081117 19923254 16227642 19739265 11287661 12594235 11834606 17562736 16109766 19164858 15968718 12153990
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 10.5517416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 10.5515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.5520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6819426721
MESH:D004362 Drug Toxicity Cisplatin 12.0315033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Doxorubicin 12.0318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.0311462148
MESH:D004421 Dystonia Phenobarbital 3.631851702
MESH:C538011 Eales disease Ascorbic Acid 5.069068938
MESH:D004487 Edema Mustard Gas 5.6611428647 9260866 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.6612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.7617692515
MESH:D016643 Encephalopathy, Bovine Spongiform Metals, Heavy 6.9016481041
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.6417359293
MESH:D016889 Endometrial Neoplasms Estradiol 6.6418566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 7.7616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.769294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7418037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.713659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.463922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.206401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.857750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.613659116
MESH:D004890 Erythema Mustard Gas 4.759357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 12.553581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.5512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.5516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.5517638652 15464296 16481741 15173087 16785472
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.5515547733 16805852 15623463 15547721 15264214 15878914 16510608 15150132 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7111564622
MESH:D005234 Fatty Liver arsenic trioxide 20.8315073043
MESH:D005234 Fatty Liver arsenite 20.8318296743
MESH:D005234 Fatty Liver Cyclosporine 20.8319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8315345470
MESH:D005234 Fatty Liver Iron 20.8316640825
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.0019769572
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.606705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1819069698
MESH:D005355 Fibrosis arsenite 12.5018296743
MESH:D005355 Fibrosis Cyclosporine 12.5012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.5020067830
MESH:D005621 Friedreich Ataxia Iron 5.0316604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8816904648
MESH:D005756 Gastritis Acetaminophen 3.2616983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.818708960
MESH:D005909 Glioblastoma Doxorubicin 6.6817150277
MESH:D005909 Glioblastoma Fenretinide 6.6816187019
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.6915173396 16524712
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.667505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.7516518429
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.1215102660 15464296
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.1215692506
MESH:D034381 Hearing Loss Cisplatin 3.9619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0915464296
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 9.9116080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.9120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9111294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.2012587719 18006777 17888722 16244372 16144979 16879835 18674790 14766674 16244371 16495754 16330681 17875725 16707910
MESH:D006333 Heart Failure Doxorubicin 3.0917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5415692506
MESH:D006432 Hemochromatosis Iron 4.1917255318 16574947 17236123 16604332 16640825 17053826
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006486 Hemosiderosis Iron 4.8016604332
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.136705139
MESH:D006525 Hepatitis, Viral, Human Iron 5.0516640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.5417182432
MESH:D006529 Hepatomegaly Iron 12.2716890145
MESH:D006529 Hepatomegaly Phenobarbital 12.2716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.2716120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D015658 HIV Infections Iron 3.4516597321
MESH:D006689 Hodgkin Disease Cisplatin 10.3816200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 10.3818501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 10.3812676792
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.638697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.3816870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5415034207
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.4011484837
MESH:D006973 Hypertension Cyclosporine 4.3910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.3918850075 18670907
MESH:D007006 Hypogonadism Iron 4.1116640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4116945680 16569931
MESH:D007037 Hypothyroidism Iron 4.6816640825
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0015869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7317937319
MESH:D007248 Infertility, Male sodium arsenite 5.7312646999 15346721
MESH:D007249 Inflammation Mustard Gas 7.089260866 11428647 11428620 9357497 8975870 11402378 17524151 11428631 16001271
MESH:D007249 Inflammation Progesterone 7.0815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.0812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.5416627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 6.5414714311
MESH:D019189 Iron Metabolism Disorders Iron 4.6617163184
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.609022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0315604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7315464296
MESH:D007674 Kidney Diseases Acetaminophen 25.1512587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 25.1516962696
MESH:D007674 Kidney Diseases Cisplatin 25.1512649298 19839026 12231392 18289764 15190930
MESH:D007674 Kidney Diseases Cyclosporine 25.1518776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 25.1516775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 25.1515618244
MESH:D007674 Kidney Diseases sodium arsenite 25.1520008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7916707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.466582329
MESH:D007680 Kidney Neoplasms Cyclosporine 10.4612371664
MESH:D007680 Kidney Neoplasms Estradiol 10.4615610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3811231351
MESH:D007805 Language Development Disorders Methotrexate 4.739562676
MESH:D007938 Leukemia arsenic trioxide 2.6215070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7416085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0719850784 16467208 16968895 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9517649720 15622746 11468182 19225113 16112521 11161223 19075265 12018890 16823087 16891316 17712046 16331271 17107899 17217047 9834237 15748426 16330433 17869043 12712474 12679006 19035177 15336539 19642359 15213294 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9716882451
MESH:D007972 Leukoplakia, Oral Fenretinide 5.6316707609
MESH:D020961 Lewy Body Disease Iron 5.0316563566
MESH:D008103 Liver Cirrhosis arsenite 13.9618296743
MESH:D008103 Liver Cirrhosis Iron 13.9616640825
MESH:D008103 Liver Cirrhosis Methotrexate 13.9614986274
MESH:D008103 Liver Cirrhosis Phenobarbital 13.9621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.949327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.5916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Metals, Heavy 4.5915383259
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5912878042
MESH:D008107 Liver Diseases Acetaminophen 3.5419460945 16611625 19784758 12587719 12969438 16610002 19014921 11587558
MESH:D008107 Liver Diseases Phenobarbital 3.5419363144
MESH:D008108 Liver Diseases, Alcoholic Iron 4.6117207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8817185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.3215890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 19.3214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.3221137059 20195826
MESH:D008113 Liver Neoplasms Iron 19.3216640825 20302851
MESH:D008113 Liver Neoplasms Phenobarbital 19.3219812893 21047994 8742319 19073162 19482888 15975961
MESH:D008113 Liver Neoplasms sodium arsenite 19.3216712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.3216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 24.30598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 24.308603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 24.3020377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 24.3018544905
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 24.3017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 24.301399818 2563599 17172636 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 24.3012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0415213294
MESH:D008171 Lung Diseases Ascorbic Acid 10.8816863852
MESH:D008171 Lung Diseases Mustard Gas 10.8818702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 10.8819095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.6118516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.6317365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.1114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 19.1119825857 11798837
MESH:D008175 Lung Neoplasms arsenite 19.1116809336
MESH:D008175 Lung Neoplasms Ascorbic Acid 19.1116401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.1120135361 18569708 18520028 20464547 20869020 18816296 17053015 6695378 20064080
MESH:D008175 Lung Neoplasms Cisplatin 19.116189445 11798837 17225452
MESH:D008175 Lung Neoplasms Doxorubicin 19.1117418594 6189445
MESH:D008175 Lung Neoplasms Iron 19.1116640825
MESH:D008175 Lung Neoplasms Mustard Gas 19.118781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 19.1117077188 16712894 15276417 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.1119555203 11884234
MESH:D008223 Lymphoma Doxorubicin 6.9516098063
MESH:D008223 Lymphoma Methotrexate 6.9517352296
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.6814737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1715621674
MESH:D008268 Macular Degeneration Iron 3.7516640825
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.1515458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.1511807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 12.1510697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.1511408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.0719453300
MESH:D008545 Melanoma Cisplatin 6.6718505091 16248763 18176117 17023156 16432458 17761969 12374674 16809738 18332650 11135225 12883367 15577323 12393984
MESH:D008545 Melanoma Doxorubicin 6.6716827129
MESH:D008545 Melanoma Fenretinide 6.6716270382
MESH:D008545 Melanoma sodium arsenite 6.6719082730 16487513
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1719513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 9.3116166281 16966607 18303189
MESH:D008654 Mesothelioma Cisplatin 9.3117638057
MESH:D008654 Mesothelioma Doxorubicin 9.3117638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3716801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1315792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7516381670
MESH:D009062 Mouth Neoplasms Fenretinide 7.7516274795
MESH:D052016 Mucositis Doxorubicin 11.1617415656
MESH:D052016 Mucositis Methotrexate 11.1617488658
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8219549372 19417148 15949261 14977855 11468182
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.2617086897
MESH:D009181 Mycoses Iron 5.0516640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9016105982 16882451
MESH:D009203 Myocardial Infarction Doxorubicin 2.7715857846 19429709
MESH:D017202 Myocardial Ischemia Iron 8.1016604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7016810080
MESH:D015428 Myocardial Reperfusion Injury Iron 7.7016604332
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0717484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.263581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.2618259882
MESH:D009369 Neoplasms Benzo(a)pyrene 13.5211141357
MESH:D009369 Neoplasms Cisplatin 13.5216773208
MESH:D009369 Neoplasms Fenretinide 13.5217353921 15958647
MESH:D009369 Neoplasms lycopene 13.5217051425
MESH:D009369 Neoplasms sodium arsenite 13.5211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2720056578
MESH:D009389 Neovascularization, Pathologic arsenite 8.8015738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.8017289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0815464296
MESH:D009401 Nephrosis Doxorubicin 4.3716899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 13.8418481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 13.8416889571 15640375
MESH:D009404 Nephrotic Syndrome Iron 13.8417178036
MESH:D009421 Nervous System Malformations Estradiol 8.1811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.586679447
MESH:D009436 Neural Tube Defects arsenic trioxide 10.5810525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.5812854658
MESH:D009447 Neuroblastoma Cisplatin 6.428761367
MESH:D009447 Neuroblastoma Doxorubicin 6.4215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4218514411
MESH:D019636 Neurodegenerative Diseases Iron 7.4217296847 16604332
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.298761367
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.2716303764
MESH:D009503 Neutropenia Mustard Gas 3.6016761898 7688884
MESH:D009765 Obesity Ascorbic Acid 3.0417217161
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.074026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.603988306
MESH:D010003 Osteoarthritis Iron 3.7216640825
MESH:D010018 Osteomalacia Phenobarbital 3.9617016548
MESH:D010024 Osteoporosis Iron 3.6116640825 16648989
MESH:D012516 Osteosarcoma Doxorubicin 3.7915930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.0219769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 17.0219769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 17.0219401270
MESH:D010051 Ovarian Neoplasms Fenretinide 17.0216133793
MESH:D010051 Ovarian Neoplasms Progesterone 17.0216525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.0217306315 15276417
MESH:D010146 Pain Acetaminophen 2.0816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.0815580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.0819003803
MESH:D010190 Pancreatic Neoplasms Fenretinide 11.0815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.0816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.157296757
MESH:D010212 Papilloma Iron 8.1512065085
MESH:D010235 Paraganglioma arsenic trioxide 3.7919927285
MESH:D020447 Parasomnias Iron 5.6017352947
MESH:D010300 Parkinson Disease Iron 3.1716640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9215464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.066228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7417983394
MESH:D010900 Pituitary Diseases Iron 5.2616604332
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5010923243
MESH:D010997 Pleural Neoplasms Cisplatin 12.5517638057
MESH:D010997 Pleural Neoplasms Doxorubicin 12.5517638057
MESH:D011041 Poisoning Iron 7.7616604332
MESH:D011041 Poisoning Mustard Gas 7.7615727166
MESH:D017119 Porphyria Cutanea Tarda Iron 9.7416640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.7418163543
MESH:D011230 Precancerous Conditions Corn Oil 13.5014668109
MESH:D011230 Precancerous Conditions Cyclosporine 13.5012371664
MESH:D011230 Precancerous Conditions Phenobarbital 13.502563599
MESH:D011225 Pre-Eclampsia Iron 4.1116640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7911896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3417292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.3416888761 16729912 16868541 18437689 15749863 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.3416740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.3417024972
MESH:D011471 Prostatic Neoplasms lycopene 2.3415084515 17337101
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3416039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.3418760546
MESH:D011528 Protozoan Infections Iron 5.6016640825
MESH:D011537 Pruritus Ethinyl Estradiol 8.1715861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.1718058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.0812752131
MESH:D011565 Psoriasis Cyclosporine 5.3916882103
MESH:D011565 Psoriasis Methotrexate 5.3917410198
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.9214606601
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.3517975199 17365031 17322281 15814490
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.3510334151 17894541 17620002 17266442 17720292
MESH:D051437 Renal Insufficiency Cisplatin 14.9615464296
MESH:D051437 Renal Insufficiency Doxorubicin 14.9617922066
MESH:D051437 Renal Insufficiency Methotrexate 14.9617352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012148 Restless Legs Syndrome Iron 4.2416930377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.103692021
MESH:D012162 Retinal Degeneration Fenretinide 8.1016303925
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1916849425
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7018045962
MESH:D012509 Sarcoma Doxorubicin 3.6416767912 17710206 15625365 15675481 18313854 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 15.0516646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 15.0514601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 15.0514601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3817846226
MESH:D012640 Seizures Phenobarbital 2.433137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.416407741
MESH:D012871 Skin Diseases Ascorbic Acid 4.9118709164
MESH:D012871 Skin Diseases Mustard Gas 4.9115451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 24.1110029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 24.1115692506
MESH:D012878 Skin Neoplasms Fenretinide 24.1116467112
MESH:D012878 Skin Neoplasms Iron 24.1112065085
MESH:D012878 Skin Neoplasms sodium arsenite 24.1118572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 24.118532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 24.1116192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9315464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1717203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5316709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8716503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.3617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.362093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.3617522103 18396642 15958060
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.3617575124 12958204
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.5418726076
MESH:D020521 Stroke Ascorbic Acid 3.9716403987 16517955
MESH:D013398 Sudden Infant Death Iron 5.0416640825
MESH:D013576 Syndactyly Methotrexate 4.659562676
MESH:D013736 Testicular Neoplasms Cisplatin 4.2615464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 14.586587162 6582329 3712494 1399818 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.5819014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 14.5817909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.581399818
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5615213294
MESH:D014376 Tuberculosis Iron 3.8316597321
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 21.508074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 21.5020435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 21.5017053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 21.5015464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 21.5017653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 21.5016720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 21.5016452187 11723127 16712894 17306315
MESH:D014581 Urticaria Acetaminophen 2.6110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.9916803524
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 13.9916154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.9911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9214692618
MESH:D014605 Uveitis Cyclosporine 3.571336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2115577323
MESH:D014652 Vascular Diseases sodium arsenite 4.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8317678736 17638931 17334414 16364871
MESH:D014839 Vomiting Cisplatin 4.3011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0317120751
Pathway ID Pathway Name
REACT:21350 Activation of p38 alpha/beta MAPK
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04912 GnRH signaling pathway
KEGG:04010 MAPK signaling pathway
REACT:21303 Myogenesis
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30591
    • No data
    Releated disease ID Related disease Name
    PA443815Crohn Disease
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA449972imiquimod
    PA164743471adenosine triphosphate
    PA450635nitric oxide
    PA449247dexamethasone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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