AutismKB 2.0

Annotation Detail for EIF2AK2


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Basic Information Top
Gene Symbol:EIF2AK2 ( EIF2AK1,MGC126524,PKR,PRKR )
Gene Full Name: eukaryotic translation initiation factor 2-alpha kinase 2
Band: 2p22.2
Quick LinksEntrez ID:5610; OMIM: 176871; Uniprot ID:E2AK2_HUMAN; ENSEMBL ID: ENSG00000055332; HGNC ID: 9437
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Influenza Infection
Pathway IDPathway Name
200065Signaling events mediated by TCPTP
200100Ceramide signaling pathway
Pathway IDPathway Name
P00006Apoptosis signaling pathway
Pathway IDPathway Name
500919Inhibition of PKR
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EIF2AK2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of EIF2AK2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EIF2AK2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of EIF2AK2 mRNAincreases expression 14729362
15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of EIF2AK2 mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of EIF2AK2 mRNAincreases expression 15123359
C014347 decitabine decitabine affects the methylation of EIF2AK2 geneaffects methylation 17630775
C007262 deoxynivalenol EIF2AK2 protein promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]increases expression|increases reaction 18599499
C007262 deoxynivalenol deoxynivalenol results in decreased expression of EIF2AK2 mRNAdecreases expression 17090620
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF2AK2 mRNAincreases expression 12655037
D019833 Genistein Genistein results in increased expression of EIF2AK2 mRNAincreases expression 17341692
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of EIF2AK2 mRNAincreases expression 17616710
D011070 Poly I-C Poly I-C results in increased expression of EIF2AK2 mRNAincreases expression 17669408
D011794 Quercetin Quercetin results in increased phosphorylation of EIF2AK2 proteinincreases phosphorylation 16794257
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of EIF2AK2 mRNAdecreases expression 16678137
D012643 Selenium Selenium results in decreased expression of EIF2AK2 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of EIF2AK2 mRNAaffects expression 17440010
D014810 Vitamin E Vitamin E results in decreased expression of EIF2AK2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.977525203
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3614692618
MESH:D000230 Adenocarcinoma Genistein 4.3611473722
MESH:D000743 Anemia, Hemolytic Quercetin 4.2417084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0015336622
MESH:D001327 Autoimmune Diseases Quercetin 4.4219761891
MESH:D001943 Breast Neoplasms decitabine 2.0419208741 18320071
MESH:D001943 Breast Neoplasms Genistein 2.0417200150 16541309 16873071
MESH:D001943 Breast Neoplasms Quercetin 2.0418628248
MESH:D002105 Cadmium Poisoning Quercetin 5.5816962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.9810355542 16227642 15721981 15673190 16192424 16011737 15700767 16124888 18705752 3786805 16050911 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.9816050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6216705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6218788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6216924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.6212508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9717234771
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5919215824
MESH:D006332 Cardiomegaly Quercetin 3.3219794523
MESH:D002318 Cardiovascular Diseases Genistein 3.3016332659
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6314694615
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8817333356 17110522 15861022 17681005 11677210 16105132 16919318
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D003110 Colonic Neoplasms decitabine 5.9217616700
MESH:D003110 Colonic Neoplasms Genistein 5.9217182828
MESH:D003110 Colonic Neoplasms Quercetin 5.9215741050 17191121 11134977 17148506 19056647 16640504 19440933
MESH:D015179 Colorectal Neoplasms decitabine 2.7018981723
MESH:D015179 Colorectal Neoplasms Quercetin 2.7018095365 18852136
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1615095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7319496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.0421346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.0415998439 19085960 3732212 15968718 9327722 16177239 16227642 17522070 7179309 4309450 3786805 10915739 10092053 7440962 6884620 2869522 19336974 21278145 15027814 11566570 6623471 7120509
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0415131321
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.6116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3611473722
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7815878914 16805852 15547733 15547721 16510608 15623463 15264214 16704527 15150132
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.7115959796 12631006 61145 12795759 17595544 19224547 16239168 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7115345470
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9918705752
MESH:D005355 Fibrosis Quercetin 8.9919474275
MESH:D005909 Glioblastoma Genistein 7.3616598420
MESH:D005909 Glioblastoma Quercetin 7.3619804834
MESH:D005910 Glioma Quercetin 3.0517643826
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 5.0116524712 15173396
MESH:D006258 Head and Neck Neoplasms decitabine 3.4919215824
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9916080930
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.7817440010
MESH:D019584 Hot Flashes Vitamin E 4.0014716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006943 Hyperglycemia Quercetin 4.0318262572 11834736
MESH:D006973 Hypertension Quercetin 2.8618356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male decitabine 6.7317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7317937319
MESH:D007251 Influenza, Human Quercetin 18.8216624496
MESH:D007251 Influenza, Human Selenium 18.8216624496
MESH:D007251 Influenza, Human Vitamin E 18.8216624496
MESH:D007627 Keloid Quercetin 4.9717086741
MESH:D007674 Kidney Diseases Quercetin 6.3016962696
MESH:D007674 Kidney Diseases Vitamin E 6.3012488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.9816705839
MESH:D007938 Leukemia decitabine 10.5919235587 18980019
MESH:D007938 Leukemia Genistein 10.5917468513 18980019
MESH:D007938 Leukemia Quercetin 10.5917468513
MESH:D007951 Leukemia, Myeloid decitabine 4.0118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3819387464 18460780 18206229 19010910 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8116943688 21278145 17157831 16221502 11408273 16239168 11903743 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.7916011737 16638106 17698563 15931870 17976157 18339082 15959796 17761835 12389079 18277467 15893842 18251166 16015684 18472332 12445418 17922224 18054572 18376398 17565644 12632512 16116963 17766677 18263696 15818738 15650968 14748882 18317297 12546737 17525996 12898905 12667390 17708605 17900296 18412020 15996030 15673190 12586293 18210741 13678700 12649538 18205269 14620537 18481824 17869086 16097048 15123356 10355542 18187930 18166357 17714472 18279442 17823541 12741479 18472094 17721639 12632514 14716833 17481882 15052691 16192424 18429990 16136751 18156304 12666154 20821823 18395914 11481614 17805973 12609069 15362042 18395095 15370692 12958196 16248980 18705752 15730626 15057751 14512876 18420326 15338365 16027843 18006644 14724832 14716496 17944888 17557913 17640975 17631135 12445421 15925388 15876570 16033810 18418968
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.7917823541
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 6.7918166357
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.7912741479
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.7916169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0815720792 17285989 15830285 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7519294768
MESH:D008113 Liver Neoplasms Quercetin 4.7518980244
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.1119519916
MESH:D008171 Lung Diseases Vitamin E 3.1816863852
MESH:D008175 Lung Neoplasms Quercetin 2.6516280456
MESH:D008175 Lung Neoplasms Vitamin E 2.6511062179
MESH:D008223 Lymphoma decitabine 3.4219470736
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1715318939
MESH:D008545 Melanoma decitabine 2.2516505122 17785578
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D009101 Multiple Myeloma decitabine 3.3518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3819157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Genistein 5.9917141266
MESH:D009203 Myocardial Infarction Quercetin 5.9919595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.7117141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.7119207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009369 Neoplasms decitabine 5.3419470736 17925555 19116145
MESH:D009369 Neoplasms Quercetin 5.3415185748
MESH:D009421 Nervous System Malformations Genistein 4.0416427766
MESH:D020078 Neurogenic Inflammation Quercetin 4.3717929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1412819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.1414694615
MESH:D010024 Osteoporosis Genistein 3.2519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.1616169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.1619495926
MESH:D010051 Ovarian Neoplasms decitabine 8.0119331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 8.0119005980
MESH:D010051 Ovarian Neoplasms Quercetin 8.0119005980
MESH:D010190 Pancreatic Neoplasms decitabine 5.5219294695
MESH:D010190 Pancreatic Neoplasms Quercetin 5.5216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D011230 Precancerous Conditions Quercetin 3.9819056647
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Genistein 2.6615378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 2.6617292933 14715546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D012208 Rhabdomyosarcoma decitabine 4.4119155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.5816862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5318551238
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.698532709
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms decitabine 2.7419037991
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.7417575124 12958204
MESH:D020521 Stroke Vitamin E 3.5216517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013964 Thyroid Neoplasms decitabine 3.3317967635
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4116049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.4117616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.4116720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014604 Uveal Neoplasms decitabine 4.9417785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
REACT:6167 Influenza Infection
KEGG:05162 Measles
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33779
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA449972imiquimod
    PA449780glutathione
    PA450379mercaptopurine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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