AutismKB 2.0

Annotation Detail for PRKX


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Basic Information Top
Gene Symbol:PRKX ( PKX1 )
Gene Full Name: protein kinase, X-linked
Band: Xp22.33
Quick LinksEntrez ID:5613; OMIM: 300083; Uniprot ID:PRKX_HUMAN; ENSEMBL ID: ENSG00000183943; HGNC ID: 9441
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa05146Amoebiasis
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04742Taste transduction
hsa04340Hedgehog signaling pathway
hsa04740Olfactory transduction
hsa04062Chemokine signaling pathway
hsa05020Prion diseases
hsa04210Apoptosis
hsa05110Vibrio cholerae infection
No data
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04377Beta1 adrenergic receptor signaling pathway
P04386Histamine H2 receptor mediated signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043735HT1 type receptor mediated signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PRKX mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PRKX mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PRKX proteinaffects expression 20106945
D001104 Arbutin Arbutin results in decreased expression of PRKX mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PRKX mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of PRKX mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of PRKX mRNAincreases expression 16144937
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PRKX mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PRKX mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in decreased expression of PRKX mRNAdecreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PRKX mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of PRKX mRNAincreases expression 17404688
D014415 Tunicamycin Tunicamycin results in increased expression of PRKX mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.5917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015845082 15665606 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.8916675129 14630087 17289903 18497071 12948864 17018787 17261762 19861407
MESH:D001943 Breast Neoplasms Progesterone 1.8916175315 15562024 17614352
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.683084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6821507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6816924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8217110522 16919318 15861022 16105132 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5115824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2817728286
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.5412438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D003967 Diarrhea Dexamethasone 3.827237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8116227642 16177239 19370779 16081117 11421492 12705907 17522070 16109766 15619225 19739265 17562736 17906064 11834606 14725611 19420014 18071297 19923254 15968718 14550746 19085960 14986274 10663392 10774834 10915739 12540782 11287661 12958197 19416960 2444490 18713872 19164858 16781746 12153990 11461765 11529661 16393943 11743745 12392966 11739529 12594235 16485898
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004485 Eczema Dexamethasone 4.5912438553
MESH:D004487 Edema Dexamethasone 7.2819703484
MESH:D004487 Edema pirinixic acid 7.2812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.4617692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0519148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 3.8716134523
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Cyclosporine 13.6519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6515345470
MESH:D005234 Fatty Liver pirinixic acid 13.6519236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.107520565
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.4510903974
MESH:D006973 Hypertension Dexamethasone 5.4517042910
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dexamethasone 5.5311099482 8960868
MESH:D007249 Inflammation Progesterone 5.5315869954
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.3318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.3315618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.5816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008107 Liver Diseases Acetaminophen 1.6516611625 11587558 12969438 19460945 19784758 12587719 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.6215890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6220195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.6220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.808603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5620464547 18520028 20135361 20064080 18569708 20869020 6695378 17053015 18816296
MESH:D008175 Lung Neoplasms Dexamethasone 3.5615824018 11195469
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2917203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.5815744524 16118317 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.609809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.7816427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D010051 Ovarian Neoplasms Estradiol 4.9719401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9717393432 16525653
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6021297632
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0817292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0816740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1318379247 11700416
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4119755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4315862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 4.4715472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Dexamethasone 3.5915138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 12.361336536
MESH:D014605 Uveitis Dexamethasone 12.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04210 Apoptosis
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05414 Dilated cardiomyopathy
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
KEGG:04340 Hedgehog signaling pathway
KEGG:04910 Insulin signaling pathway
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
KEGG:04740 Olfactory transduction
KEGG:04114 Oocyte meiosis
KEGG:05020 Prion diseases
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04970 Salivary secretion
KEGG:04742 Taste transduction
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
KEGG:05110 Vibrio cholerae infection
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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