AutismKB 2.0

Annotation Detail for PCDHA5


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Basic Information Top
Gene Symbol:PCDHA5 ( CNR6,CNRN6,CNRS6,CRNR6,PCDH-ALPHA5 )
Gene Full Name: protocadherin alpha 5
Band: 5q31.3
Quick LinksEntrez ID:56143; OMIM: 606311; Uniprot ID:PCDA5_HUMAN; ENSEMBL ID: ENSG00000081842,ENSG00000204965,ENSG00000239389,EN; HGNC ID: 8671
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001374 Azacitidine Azacitidine affects the methylation of PCDHA5 promoteraffects methylation 18204046
D005472 Fluorouracil Fluorouracil results in decreased expression of PCDHA5 proteindecreases expression 15585135
16803524
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.5117638652
MESH:D000740 Anemia Fluorouracil 4.2215504547 16511603 17963324
MESH:D001943 Breast Neoplasms Fluorouracil 2.4215136595 18357371 19217205 18608205 16595493 16110121 16557594
MESH:D002276 Carcinoid Tumor Fluorouracil 5.7416051944
MESH:D002277 Carcinoma Fluorouracil 3.9717121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1217045692 17971768 16332177 18930000 17088986 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.2018695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5917066447 16757204 16280240 18986760
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2917725105 16340194 16510598 17018589 18772588 17169374 15001691 17287894 17016597 17172411
MESH:D015179 Colorectal Neoplasms Azacitidine 2.9419934284
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9416524972 17094418 17695437 14970324 20501625 17255274 18802399 16391804 16331619 18949393 16282729 17454858 15148649 18509181 18448328 17016601 17401013 18288408 15289873 17594712 18383874 16303861
MESH:D007644 Darier Disease Fluorouracil 5.6816733453
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5416481741 16337965 17638652 15173087 16785472
MESH:D005910 Glioma Fluorouracil 3.0216145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.7015102660 18337622 15162350
MESH:D007680 Kidney Neoplasms Fluorouracil 3.7416985049
MESH:D007938 Leukemia Azacitidine 3.8919148494
MESH:D007951 Leukemia, Myeloid Azacitidine 5.1719077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.0618720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.8019299654
MESH:D008113 Liver Neoplasms Fluorouracil 2.6216603448 17045692 15113037 18383874
MESH:D008175 Lung Neoplasms Azacitidine 3.0021224363
MESH:D008175 Lung Neoplasms Fluorouracil 3.0015246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.6815086387
MESH:D009006 Monosomy Azacitidine 7.1519299654
MESH:D009062 Mouth Neoplasms Fluorouracil 4.0218986760 16757204
MESH:D009101 Multiple Myeloma Azacitidine 4.3118443271 19549372
MESH:D009190 Myelodysplastic Syndromes Azacitidine 4.2417596541 18720364 17611569 19805378
MESH:D009369 Neoplasms Fluorouracil 2.8018600527 16928823 18239605
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.7516436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7916500647 16929163 19003803 15113037
MESH:D011471 Prostatic Neoplasms Azacitidine 3.5618324645
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5619082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.4818722050 16160472 15538739 18286688
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 16424979 17172411 16951190 15786421 19015929 19084572 18396642 18567086 17498489
MESH:D014062 Tongue Neoplasms Fluorouracil 4.5016280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.3816803524
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018