AutismKB 2.0

Annotation Detail for NDNL2


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Basic Information Top
Gene Symbol:NDNL2 ( HCA4,MAGEG1,MAGEL3,NSE3,NSMCE3 )
Gene Full Name: necdin-like 2
Band: 15q13.1
Quick LinksEntrez ID:56160; OMIM: 608243; Uniprot ID:MAGG1_HUMAN; ENSEMBL ID: ENSG00000185115; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200103p75(NTR)-mediated signaling
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NDNL2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NDNL2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NDNL2 mRNAdecreases expression 18648102
D003314 Corn Oil Corn Oil affects the expression of NDNL2 mRNAaffects expression 16360708
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of NDNL2 mRNAincreases expression 17490981
C006253 pirinixic acid pirinixic acid results in increased expression of NDNL2 mRNAincreases expression 17426115
D018038 Sodium Selenite Sodium Selenite results in increased expression of NDNL2 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.767296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.5219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.158156756 11298694 18759878 8970840 11906362 12868966 14531868 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.5818648102 9022650 11289319 9328219 18289764 7440962 6482804 16192314 18692083 9653073 6679447 8291058 1440618
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.5815131321
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver pirinixic acid 3.0419236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 18467677 16221962 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006968 Hypersensitivity, Delayed Corn Oil 6.2511484837
MESH:D007333 Insulin Resistance pirinixic acid 7.8816306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.8814714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.8016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.8016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.806582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.707678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.7015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.433712494 598648 6587162 1399818
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.707678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.6616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.664026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011230 Precancerous Conditions Corn Oil 5.3014668109
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3518760546
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.093712494 7505956 6582329 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.828074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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