AutismKB 2.0

Annotation Detail for PRL


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Basic Information Top
Gene Symbol:PRL ( - )
Gene Full Name: prolactin
Band: 6p22.3
Quick LinksEntrez ID:5617; OMIM: 176760; Uniprot ID:PRL_HUMAN; ENSEMBL ID: ENSG00000172179; HGNC ID: 9445
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200009ErbB4 signaling events
200077Glucocorticoid receptor regulatory network
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C524478 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased expression of PRL mRNAdecreases expression 20419096
C524478 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased expression of PRL proteindecreases expression 20419096
C041594 4-nonylphenol 4-nonylphenol results in increased expression of PRL mRNAincreases expression 19463694
C041594 4-nonylphenol 4-nonylphenol results in increased secretion of PRL proteinincreases secretion 17174995
19463694
C041594 4-nonylphenol fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA]decreases reaction|increases expression 19463694
C041594 4-nonylphenol fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]decreases reaction|increases secretion 19463694
C080417 4-octylphenol 4-octylphenol results in increased expression of PRL mRNAincreases expression 19463694
C080417 4-octylphenol 4-octylphenol results in increased secretion of PRL proteinincreases secretion 19463694
C080417 4-octylphenol fulvestrant inhibits the reaction [4-octylphenol results in increased expression of PRL mRNA]decreases reaction|increases expression 19463694
C080417 4-octylphenol fulvestrant inhibits the reaction [4-octylphenol results in increased secretion of PRL protein]decreases reaction|increases secretion 19463694
C119737 8-prenylnaringenin 8-prenylnaringenin results in increased expression of PRL proteinincreases expression 16522720
C011512 alpha-naphthoflavone [Tetrachlorodibenzodioxin co-treated with alpha-naphthoflavone] affects the expression of PRL mRNAaffects cotreatment|affects expression 16188257
C010845 aluminum chloride aluminum chloride results in decreased expression of PRL proteindecreases expression 15202764
D000638 Amiodarone Amiodarone results in decreased expression of PRL mRNAdecreases expression 3427795
D000641 Ammonia Ammonia results in decreased expression of PRL proteindecreases expression 17119344
D000641 Ammonia Ammonia results in decreased secretion of PRL proteindecreases secretion 17119344
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRL mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of PRL mRNAdecreases expression 12558987
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of PRL mRNAdecreases expression 11440201
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of PRL proteindecreases expression 11440201
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of PRL mRNAincreases expression 11440201
C094645 aripiprazole aripiprazole results in decreased expression of PRL proteindecreases expression 19519261
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL protein]decreases expression|decreases reaction 16298753
D001280 Atrazine Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of PRL protein]decreases reaction|increases secretion 10696778
D001280 Atrazine Atrazine results in increased expression of PRL proteinincreases expression 11071396
C006780 bisphenol A bisphenol A results in increased expression of PRL mRNAincreases expression 19463694
C006780 bisphenol A bisphenol A results in increased expression of PRL proteinincreases expression 12810577
C006780 bisphenol A bisphenol A results in increased secretion of PRL proteinincreases secretion 19463694
15811834
17174995
C006780 bisphenol A fulvestrant inhibits the reaction [bisphenol A results in increased expression of PRL mRNA]decreases reaction|increases expression 19463694
C006780 bisphenol A fulvestrant inhibits the reaction [bisphenol A results in increased secretion of PRL protein]decreases reaction|increases secretion 19463694
C006780 bisphenol A Nifedipine inhibits the reaction [bisphenol A results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D015124 8-Bromo Cyclic Adenosine Monophosphate 1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]decreases reaction|increases expression 17065600
D015124 8-Bromo Cyclic Adenosine Monophosphate 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNAincreases expression 15774544
17065600
D015124 8-Bromo Cyclic Adenosine Monophosphate PLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]affects reaction|increases expression 17065600
D001971 Bromocriptine Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]decreases reaction|increases expression 15677882
D020001 1-Butanol 1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]decreases reaction|increases expression 17065600
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PRL mRNAincreases expression 12832660
D002330 Carmustine Carmustine results in decreased expression of PRL mRNAdecreases expression 15980968
C062876 cetrorelix cetrorelix results in decreased expression of PRL proteindecreases expression 17638707
D002706 Chlordan Chlordan results in increased expression of PRL mRNAincreases expression 12030773
D002706 Chlordan Chlordan results in increased secretion of PRL proteinincreases secretion 12030773
D020111 Chlorodiphenyl (54% Chlorine) Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL protein]decreases expression|decreases reaction 16298753
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL proteindecreases expression 16298753
D020111 Chlorodiphenyl (54% Chlorine) Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL protein]decreases expression|decreases reaction 16298753
D002749 Chlorprothixene Chlorprothixene results in increased secretion of PRL proteinincreases secretion 10525070
D002996 Clomiphene Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D002996 Clomiphene Clomiphene inhibits the reaction [Estradiol results in increased secretion of PRL protein]decreases reaction|increases secretion 17054466
D003024 Clozapine Clozapine analog results in increased expression of PRL proteinincreases expression 11997696
D003300 Copper PRL protein promotes the reaction [ATP7A protein results in increased secretion of Copper]increases reaction|increases secretion 16741141
D003300 Copper PRL protein promotes the reaction [SLC31A1 protein results in increased secretion of Copper]increases reaction|increases secretion 16741141
D003375 Coumestrol Coumestrol results in increased secretion of PRL proteinincreases secretion 17174995
15811834
D003375 Coumestrol Nifedipine inhibits the reaction [Coumestrol results in increased secretion of PRL protein]decreases reaction|increases secretion 17174995
15811834
C007168 cyanazine cyanazine metabolite results in increased expression of PRL proteinincreases expression 11071396
C007168 cyanazine cyanazine results in increased expression of PRL proteinincreases expression 11071396
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in increased secretion of PRL proteinincreases secretion 17174995
D004026 Dieldrin Dieldrin results in increased secretion of PRL proteinincreases secretion 15811834
17174995
D004026 Dieldrin Nifedipine inhibits the reaction [Dieldrin results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRL mRNAincreases expression 15470002
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRL proteinincreases expression 16468032
15470002
D004054 Diethylstilbestrol Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]decreases reaction|increases expression 15677882
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRL mRNAincreases expression 15677882
12960047
17005392
12804517
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRL proteinincreases expression 15677882
12960047
D004054 Diethylstilbestrol Diethylstilbestrol results in increased secretion of PRL proteinincreases secretion 15811834
17174995
D004054 Diethylstilbestrol Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
17174995
D004054 Diethylstilbestrol vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]decreases reaction|increases expression 15677882
D016291 Dizocilpine Maleate Dizocilpine Maleate results in decreased expression of PRL proteindecreases expression 8404677
D004317 Doxorubicin Doxorubicin results in increased expression of PRL mRNAincreases expression 18681966
D004317 Doxorubicin Doxorubicin results in increased expression of PRL proteinincreases expression 18681966
D004726 Endosulfan Endosulfan results in increased expression of PRL mRNAincreases expression 12030773
D004726 Endosulfan Endosulfan results in increased secretion of PRL proteinincreases secretion 17174995
15811834
12030773
D004726 Endosulfan Nifedipine inhibits the reaction [Endosulfan results in increased secretion of PRL protein]decreases reaction|increases secretion 17174995
15811834
C074283 estradiol 3-benzoate Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of PRL protein]decreases reaction|increases secretion 10696778
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased secretion of PRL proteinincreases secretion 10696778
D004958 Estradiol Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D004958 Estradiol Clomiphene inhibits the reaction [Estradiol results in increased secretion of PRL protein]decreases reaction|increases secretion 17054466
D004958 Estradiol Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]increases reaction|increases secretion 17054466
D004958 Estradiol Estradiol results in increased secretion of PRL proteinincreases secretion 17054466
D004958 Estradiol [fulvestrant co-treated with Estradiol] results in increased secretion of PRL proteinaffects cotreatment|increases secretion 15950373
D004958 Estradiol PRL promoter mutant form affects the reaction [[Progesterone co-treated with Estradiol] results in increased expression of PRL mRNA]affects cotreatment|affects reaction|increases expression 17187171
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PRL mRNAaffects cotreatment|increases expression 17187171
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol results in increased secretion of PRL protein]decreases reaction|increases secretion 17054466
D004958 Estradiol Estradiol results in increased expression of PRL mRNAincreases expression 16188257
D004958 Estradiol Estradiol results in increased expression of PRL mRNAincreases expression 12804517
12030773
D004958 Estradiol Estradiol results in increased expression of PRL proteinincreases expression 11408345
16522720
17033158
D004958 Estradiol Estradiol results in increased secretion of PRL proteinincreases secretion 16614383
12030773
17174995
15811834
D004958 Estradiol Nifedipine inhibits the reaction [Estradiol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PRL mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRL mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRL mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant [fulvestrant co-treated with Estradiol] results in increased secretion of PRL proteinaffects cotreatment|increases secretion 15950373
C070081 fulvestrant fulvestrant results in decreased secretion of PRL proteindecreases secretion 15950373
C070081 fulvestrant [o,p'-DDT co-treated with fulvestrant] results in decreased expression of PRL mRNAaffects cotreatment|decreases expression 16188257
C070081 fulvestrant fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA]decreases reaction|increases expression 19463694
C070081 fulvestrant fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]decreases reaction|increases secretion 19463694
C070081 fulvestrant fulvestrant inhibits the reaction [4-octylphenol results in increased expression of PRL mRNA]decreases reaction|increases expression 19463694
C070081 fulvestrant fulvestrant inhibits the reaction [4-octylphenol results in increased secretion of PRL protein]decreases reaction|increases secretion 19463694
C070081 fulvestrant fulvestrant inhibits the reaction [bisphenol A results in increased expression of PRL mRNA]decreases reaction|increases expression 19463694
C070081 fulvestrant fulvestrant inhibits the reaction [bisphenol A results in increased secretion of PRL protein]decreases reaction|increases secretion 19463694
C070081 fulvestrant fulvestrant results in decreased expression of PRL mRNAdecreases expression 20419096
C070081 fulvestrant fulvestrant results in decreased expression of PRL proteindecreases expression 20419096
D006220 Haloperidol Haloperidol results in increased expression of PRL proteinincreases expression 18521575
11997696
11071396
D019808 Losartan Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]decreases reaction|increases secretion 14722030
D017258 Medroxyprogesterone Acetate Medroxyprogesterone Acetate results in increased expression of PRL mRNAincreases expression 15774544
D017258 Medroxyprogesterone Acetate Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of PRL mRNA]decreases reaction|increases expression 15774544
D008724 Methomyl Methomyl results in increased expression of PRL proteinincreases expression 11516254
D008731 Methoxychlor Methoxychlor affects the expression of PRL proteinaffects expression 2925022
D015735 Mifepristone Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of PRL mRNA]decreases reaction|increases expression 15774544
D015735 Mifepristone Mifepristone results in increased expression of PRL mRNAincreases expression 17584828
D009543 Nifedipine Nifedipine inhibits the reaction [bisphenol A results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D009543 Nifedipine Nifedipine inhibits the reaction [Coumestrol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
17174995
D009543 Nifedipine Nifedipine inhibits the reaction [Dieldrin results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D009543 Nifedipine Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
17174995
D009543 Nifedipine Nifedipine inhibits the reaction [Endosulfan results in increased secretion of PRL protein]decreases reaction|increases secretion 17174995
15811834
D009543 Nifedipine Nifedipine inhibits the reaction [Estradiol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D009543 Nifedipine Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D009543 Nifedipine Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
D009583 Nitrofurazone Nitrofurazone inhibits the reaction [TRH protein results in increased secretion of PRL protein]decreases reaction|increases secretion 3126094
D009583 Nitrofurazone Nitrofurazone results in increased expression of PRL proteinincreases expression 3126094
C025256 nonylphenol Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
C025256 nonylphenol nonylphenol results in increased secretion of PRL proteinincreases secretion 15811834
C016340 o,p'-DDT [o,p'-DDT co-treated with fulvestrant] results in decreased expression of PRL mRNAaffects cotreatment|decreases expression 16188257
C016340 o,p'-DDT o,p'-DDT results in increased expression of PRL mRNAincreases expression 16188257
C016340 o,p'-DDT Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein]decreases reaction|increases secretion 15811834
C016340 o,p'-DDT o,p'-DDT results in increased secretion of PRL proteinincreases secretion 15811834
D010424 Pentobarbital Pentobarbital results in decreased expression of PRL proteindecreases expression 17638707
D010672 Phenytoin Phenytoin results in decreased expression of PRL mRNAdecreases expression 3734668
D010672 Phenytoin Phenytoin results in decreased expression of PRL proteindecreases expression 3734668
D011374 Progesterone PRL promoter mutant form affects the reaction [[Progesterone co-treated with Estradiol] results in increased expression of PRL mRNA]affects cotreatment|affects reaction|increases expression 17187171
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PRL mRNAaffects cotreatment|increases expression 17187171
D011374 Progesterone Progesterone results in increased expression of PRL mRNAincreases expression 16403803
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol results in increased secretion of PRL protein]decreases reaction|increases secretion 17054466
D020849 Raloxifene Raloxifene results in decreased secretion of PRL proteindecreases secretion 15950373
D012110 Reserpine Reserpine results in increased expression of PRL proteinincreases expression 11071396
D018967 Risperidone Risperidone results in increased expression of PRL proteinincreases expression 16730335
18080171
D012839 Simazine Simazine results in increased expression of PRL proteinincreases expression 11071396
C010513 stepholidine stepholidine results in increased expression of PRL proteinincreases expression 18521575
D014284 Triiodothyronine Triiodothyronine results in decreased expression of PRL mRNAdecreases expression 3734668
D014284 Triiodothyronine Triiodothyronine results in decreased expression of PRL proteindecreases expression 3734668
D013629 Tamoxifen Tamoxifen results in decreased secretion of PRL proteindecreases secretion 15950373
D013629 Tamoxifen Tamoxifen affects the expression of PRL mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen results in increased expression of PRL mRNAincreases expression 15470002
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRL mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with alpha-naphthoflavone] affects the expression of PRL mRNAaffects cotreatment|affects expression 16188257
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRL mRNAincreases expression 16188257
D014112 Toxaphene Toxaphene results in increased expression of PRL mRNAincreases expression 12804517
D014520 Urethane [Urethane co-treated with IFNG protein] results in increased expression of PRL mRNAaffects cotreatment|increases expression 12810352
D014638 Vanadates Vanadates results in increased expression of PRL proteinincreases expression 17874149
C048507 vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]decreases reaction|increases expression 15677882
D014810 Vitamin E Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL protein]decreases expression|decreases reaction 16298753
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8914745880
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 6.559677735 10563481 8986270 9118846 3425630 6195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5511752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.9118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2817505938
MESH:D000230 Adenocarcinoma Doxorubicin 8.4217418594
MESH:D000230 Adenocarcinoma Estradiol 8.4211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.4214692618
MESH:D000230 Adenocarcinoma Urethane 8.4218316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.0515814487
MESH:D000236 Adenoma Urethane 3.5910822126 16926031 6695378 10530776 11497255 17195641 17093202
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.7316835633
MESH:D000380 Agranulocytosis Clozapine 4.4214617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Atrazine 15.3711874814
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 15.3716487989
MESH:D000382 Agricultural Workers' Diseases Simazine 15.3712661182
MESH:D000382 Agricultural Workers' Diseases Toxaphene 15.3716132792
MESH:D000419 Albuminuria Doxorubicin 15.8821441931
MESH:D000419 Albuminuria Losartan 15.8812586211
MESH:D000419 Albuminuria Raloxifene 15.8817451421 17308373
MESH:D000544 Alzheimer Disease Copper 4.0116962711 16325427 16886094 17119284 16410023 16866297
MESH:D000544 Alzheimer Disease Raloxifene 4.0115800139
MESH:D000686 Amyloidosis Diethylstilbestrol 3.8615469931
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.8610694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.3811748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.3116614410
MESH:D001008 Anxiety Disorders Pentobarbital 4.2018313124 11141031
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.2418218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.5311256880
MESH:D001161 Arteriosclerosis Reserpine 8.5310729376
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.2415885639
MESH:D020817 Asperger Syndrome aripiprazole 9.9319519261
MESH:D020817 Asperger Syndrome Risperidone 9.9316401163
MESH:D001259 Ataxia 1-Butanol 4.987820390
MESH:D050197 Atherosclerosis Losartan 6.1910821809
MESH:D050197 Atherosclerosis Phenytoin 6.1915136057
MESH:D001281 Atrial Fibrillation Amiodarone 3.4019698954 18651412
MESH:D001284 Atrophy fulvestrant 4.2311514358
MESH:D001289 Attention Deficit Disorder with Hyperactivity aripiprazole 7.8517069544
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 7.8518349709
MESH:D001321 Autistic Disorder marker/mechanism 18207134
MESH:D001321 Autistic Disorder aripiprazole 2.6217069544
MESH:D001321 Autistic Disorder Haloperidol 2.6218080171 19368416
MESH:D001321 Autistic Disorder Risperidone 2.6219154706 18349709 16379507 17929164 19368416 16239862 17069546 15492353 16730335 19232924 18026891 17019624 15930063 16948927 16601648 15994720 18775368 18278980 18080171 19013209 15543515
MESH:D001480 Basal Ganglia Diseases Bromocriptine 6.1115303389
MESH:D001714 Bipolar Disorder Risperidone 4.1518278980 19154706
MESH:D001778 Blood Coagulation Disorders Amiodarone 7.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.1112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.0414601052
MESH:D001862 Bone Resorption bisphenol A 3.2811985600
MESH:D001929 Brain Edema Ammonia 5.6111481608 20217200 19393034
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.6717868700
MESH:D001930 Brain Injuries Progesterone 8.8615380490 15845082 15665606
MESH:D001930 Brain Injuries Raloxifene 8.8616580743
MESH:D001932 Brain Neoplasms Carmustine 11.6016187019
MESH:D001932 Brain Neoplasms Copper 11.6017079463
MESH:D001932 Brain Neoplasms Doxorubicin 11.6017150277
MESH:D001943 Breast Neoplasms Ascorbic Acid 11.0416443354
MESH:D001943 Breast Neoplasms bisphenol A 11.0417123778
MESH:D001943 Breast Neoplasms Copper 11.0417079463 15986119
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 11.0415061365
MESH:D001943 Breast Neoplasms Dieldrin 11.0415770527 11859874
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.0417129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 11.0416264153 15634643 15939500 15668708 18695136 15567936 16096432 15993339 18382427 17369602 16935488 16322301 18628466 16115903 15136595 17426702 11325840 16826403 15692762 16595493 18234424 17983394 19526202 15994142
MESH:D001943 Breast Neoplasms Estradiol 11.0412948864 17261762 17289903 17018787 14630087 19861407 18497071 16675129
MESH:D001943 Breast Neoplasms fulvestrant 11.0418984771
MESH:D001943 Breast Neoplasms Progesterone 11.0415562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 11.0415775269 17893378 16837676 15758505 17595753 15572757 17261762 16912660 17049068 17440819 17952589 17242785
MESH:D001943 Breast Neoplasms Reserpine 11.0411921183
MESH:D001943 Breast Neoplasms Tamoxifen 11.0419084267 20005174 16873071 18984771 15565566 20135344 17440819 21152245 17049068 17261762 18351453 18997820 19011961 17242785 19487384 18821012 18815881 19244106 19221464 19289846 19142967 16818667 18855134 19200415 19189212 19103187 16202921 19288272 15668708 19155303 20544844 20390343 19189210 20065188 18629630 20859285 19115204 19066611 21138602 19059307 17893378 18425577 19410462 11161223 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.0420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 7.8410355542 15721981 16124888 16227642 18705752 16192424 16097048 16050911 3786805 15700767 16011737 15673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 7.8416050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.1516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8719066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 7.3118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 7.3115948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 7.3117876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 7.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 7.3116924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.3417123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.821485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.426189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.6117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.6117572228
MESH:D006332 Cardiomegaly Copper 9.3917327471
MESH:D006332 Cardiomegaly Losartan 9.3915969258 12586211
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.3916120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.0817351982 17007740 16731534 16278810 17974986 16952015 17924179 16612575 18627295 16242529 17308081 17519947 17382496 15792986 16651473 16455267 15476868 17131338 16109756 17928571 15505089 15811867 17329180 16364871 16269455
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.0615710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.0616243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 2.9815775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.4318974383
MESH:D002375 Catalepsy Haloperidol 4.2615215559 1977408
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.3218566989
MESH:D002493 Central Nervous System Diseases Phenytoin 4.664080065
MESH:D014355 Chagas Disease Nitrofurazone 6.5211354658
MESH:D002659 Child Development Disorders, Pervasive aripiprazole 4.5919519261
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.3811677210 16105132 15861022 17681005 17333356 16919318 17110522
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.2211748493
MESH:D002971 Cleft Lip Phenytoin 3.782227380
MESH:D002972 Cleft Palate Phenytoin 8.202227380 3877104 1687470 10789828 6856622 6862529
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.2015668235 15340226 12621046 16354765 8697196
MESH:D002972 Cleft Palate Urethane 8.2012810352
MESH:D003072 Cognition Disorders Clozapine 9.5817123785
MESH:D003072 Cognition Disorders Raloxifene 9.5815800139
MESH:D003103 Coloboma Phenytoin 4.579212184
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003139 Common Cold Ascorbic Acid 4.8117323712
MESH:D000013 Congenital Abnormalities Phenytoin 7.5410627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.5414669216 17141729
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.3519952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.3515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.3519769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9412952375 16002989
MESH:D003490 Cyanosis Endosulfan 4.917900959
MESH:D016757 Death, Sudden, Cardiac Haloperidol 9.4620210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 9.4620210726
MESH:D003704 Dementia Haloperidol 8.6111575062
MESH:D003704 Dementia Risperidone 8.6111575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6117474826
MESH:D017449 Dermatitis, Allergic Contact Ammonia 4.1616823706
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.0516506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.0516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.0517107852
MESH:D003928 Diabetic Nephropathies Estradiol 11.8219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 11.8215920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.8219279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.8617187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 12.2415331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 12.2416379507
MESH:D053207 Diurnal Enuresis Risperidone 6.0117822346
MESH:D004314 Down Syndrome Risperidone 4.5818349709
OMIM:607208 DRAVET SYNDROME Phenytoin 4.7511748493
MESH:D003875 Drug Eruptions Phenytoin 4.8715024534
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.4018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.4015968718 10915739 17522070 10092053 21278145 6884620 19085960 3786805 16177239 15998439 4309450 15027814 11566570 7120509 2869522 3732212 9327722 7179309 19336974 6623471 16227642 7440962
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.4017851650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.4017416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4020420201
MESH:D004362 Drug Toxicity Doxorubicin 6.4518602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.4511462148
MESH:D050171 Dyslipidemias Clozapine 3.7016402076
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 8.9016487989
MESH:D004417 Dyspnea Endosulfan 8.903388749 7900959
MESH:C538011 Eales disease Ascorbic Acid 10.879068938
MESH:C538011 Eales disease Vitamin E 10.879068938
MESH:D004487 Edema Raloxifene 4.9715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 4.9711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.2418230668 15322242 16714409
MESH:D004646 Emphysema Endosulfan 5.897900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 22.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 22.2417654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 22.2417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 22.2415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 22.2419031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.0416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 14.0915700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 14.0917359293
MESH:D016889 Endometrial Neoplasms Estradiol 14.0919148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 14.0916202921 19155303 20544844 17893378
MESH:D004715 Endometriosis Mifepristone 12.0516134523
MESH:D004715 Endometriosis Progesterone 12.0516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.0510568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.4918037988
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.5820235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.576251365 1399206
MESH:D004828 Epilepsies, Partial Phenytoin 4.2611558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.57821787 20417680 11434505
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.423659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5111564622
MESH:D005234 Fatty Liver Amiodarone 18.5214986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.5217595544 16239168 19224547 12631006 16045604 15959796 61145 12795759
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.5215345470
MESH:D005234 Fatty Liver Raloxifene 18.5217473493
MESH:D005234 Fatty Liver Tamoxifen 18.5219224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.7815751030 16513791 16534752 16002989 16611131
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.7816709447
MESH:D005313 Fetal Death Phenytoin 8.6410627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.6411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8814745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.2919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.2919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 6.5118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.5120067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3016452187
MESH:D005885 Gingival Hyperplasia Phenytoin 5.029029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.5714659971 16390469
MESH:D005909 Glioblastoma Carmustine 6.0816187019
MESH:D005909 Glioblastoma Doxorubicin 6.0817150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.0715692506
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 9.0216080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.0211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 9.0216080930
MESH:D006331 Heart Diseases Doxorubicin 10.1516879835 16144979 16244372 16244371 18006777 17888722 16495754 14766674 17875725 16707910 16330681 12587719 18674790
MESH:D006331 Heart Diseases Raloxifene 10.1511110106
MESH:D006331 Heart Diseases Urethane 10.1516046796
MESH:D006333 Heart Failure Doxorubicin 6.3917481944
MESH:D006333 Heart Failure Losartan 6.3910979640
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3215692506
MESH:D006470 Hemorrhage Endosulfan 8.507900959
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 8.5011000095
MESH:D006501 Hepatic Encephalopathy Ammonia 5.2312420312 16338762 20549931
MESH:D006505 Hepatitis Carbon Tetrachloride 7.7419900420 19110552
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 7.7416487989
MESH:D006521 Hepatitis, Chronic Copper 4.6217338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.5417276780 16607473 17182432 19888908 17109627
MESH:D006529 Hepatomegaly Amiodarone 6.4615265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.4612621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 5.2016490937 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.2016490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.3715709030
MESH:D006561 Herpes Simplex Chlorprothixene 5.481682908
MESH:D006689 Hodgkin Disease Doxorubicin 2.8815147373 17606976 18501091
MESH:D019584 Hot Flashes 8-prenylnaringenin 13.5017088409
MESH:D019584 Hot Flashes Estradiol 13.5017088409
MESH:D019584 Hot Flashes Vitamin E 13.5014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3816354765 15340226 18606429 8697196 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8816899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.298137927 9751232
MESH:D006943 Hyperglycemia Risperidone 4.6018278980
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.1210459572
MESH:D006948 Hyperkinesis Clozapine 4.2616046005
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8014722030 12960047
MESH:D006973 Hypertension Losartan 10.0814597852 12586211 12512695 10090350 15969258
MESH:D006973 Hypertension Nifedipine 10.0820102058
MESH:D006973 Hypertension Raloxifene 10.0815787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.0818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4515338365
MESH:D007021 Hypospadias Diethylstilbestrol 9.1416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.1416945680 16569931
MESH:D007035 Hypothermia Reserpine 5.651977408
MESH:D007037 Hypothyroidism Amiodarone 3.8818020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.7715869954
MESH:D007246 Infertility Diethylstilbestrol 3.7415036965
MESH:D007247 Infertility, Female Dieldrin 8.3010630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.3012013081
MESH:D007248 Infertility, Male Atrazine 34.0012948887
MESH:D007248 Infertility, Male Chlordan 34.009432128
MESH:D007248 Infertility, Male Clomiphene 34.0019371211
MESH:D007248 Infertility, Male Coumestrol 34.0016892005
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 34.0017192596 12948891
MESH:D007248 Infertility, Male Endosulfan 34.009432128 8588293
MESH:D007248 Infertility, Male Ethinyl Estradiol 34.0017937319
MESH:D007248 Infertility, Male fulvestrant 34.0011514358
MESH:D007248 Infertility, Male Methoxychlor 34.0011955947 16467254
MESH:D007249 Inflammation Losartan 8.9212586211
MESH:D007249 Inflammation Progesterone 8.9215869954
MESH:D007249 Inflammation Tamoxifen 8.9219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9212200463 12878042
MESH:D007251 Influenza, Human Vitamin E 3.5616624496
MESH:D007333 Insulin Resistance bisphenol A 5.9316393666
MESH:D007333 Insulin Resistance Estradiol 5.9316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.7516580747
MESH:D007674 Kidney Diseases Doxorubicin 7.7815369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 7.7815618244
MESH:D007674 Kidney Diseases Vitamin E 7.7812488133
MESH:D007676 Kidney Failure, Chronic Copper 8.4116518626
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.4116707910
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 9.3816762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 9.3815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 9.3818625569
MESH:D007859 Learning Disorders Copper 12.7117134702
MESH:D007859 Learning Disorders Diethylstilbestrol 12.7117184923
MESH:D007859 Learning Disorders Endosulfan 12.718157075
MESH:D007889 Leiomyoma Raloxifene 3.8916973256
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.4916085563
MESH:D007945 Leukemia, Lymphoid Toxaphene 5.6316132792
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 4.2112745335
MESH:D008064 Lipidoses Amiodarone 10.4217567588 15342952
MESH:D008064 Lipidoses Clozapine 10.4217567588
MESH:D008064 Lipidoses Tamoxifen 10.4215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.4217334410 11903743 17174718 17157831 11408273 16239168 21278145 16943688 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.1018263696 15931870 15650968 17823541 17525996 12666154 15893842 17714472 10355542 17481882 15730626 18251166 17721639 12609069 12546737 18054572 15673190 14716833 12958196 16033810 12586293 17922224 15996030 16015684 13678700 17944888 18395914 12445418 12898905 15818738 12741479 18472332 15876570 17900296 18210741 14748882 18429990 16136751 15052691 18705752 18205269 15370692 12445421 18395095 15362042 18412020 18339082 18277467 17565644 18166357 18187930 15925388 12667390 14620537 17557913 16638106 18279442 12649538 16011737 16097048 16116963 17761835 17766677 15057751 16248980 18472094 17976157 18420326 18317297 17698563 15123356 18006644 17805973 15338365 16027843 18376398 12632514 17869086 11481614 18481824 17640975 17708605 18156304 14716496 20821823 14512876 15959796 12389079 14724832 18418968 12632512 16192424 17631135
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 9.1016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.1014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Losartan 9.1015573910 17900296 12445418
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.1018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.1012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 9.1016169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7815720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Phenytoin 3.7814986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.1214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.6819294768
MESH:D008113 Liver Neoplasms Chlordan 20.682422723
MESH:D008113 Liver Neoplasms Copper 20.6820302851
MESH:D008113 Liver Neoplasms Dieldrin 20.688742319 9539021
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.6816712894 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 20.6816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.6816984957
MESH:D008113 Liver Neoplasms Urethane 20.6817559639 16391232 17093202
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 10.5918544905
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.5915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.5916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.0717391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 9.7912587719
MESH:D008171 Lung Diseases Ascorbic Acid 9.7916863852
MESH:D008171 Lung Diseases Vitamin E 9.7916863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.8218516814
MESH:D008175 Lung Neoplasms Ascorbic Acid 7.0616401635
MESH:D008175 Lung Neoplasms Doxorubicin 7.066189445 17418594
MESH:D008175 Lung Neoplasms Tamoxifen 7.0618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.0619555203 11884234
MESH:D008175 Lung Neoplasms Urethane 7.0611323394 7750092 16926031 15166089 14587096 16007126 11552296 11246140 11992545 17093202 12466968 16337739 16289808 12117781 10997738 15902970 12765245 17195641 11307925 10779650 6695378 11497255 12957351 11062179 10822126 10530776 17255336 16788158 11807781 15136453 11544531 16391232 11074608 11893704 16204055
MESH:D008175 Lung Neoplasms Vitamin E 7.0611062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5015166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.1415700306
MESH:D008223 Lymphoma Doxorubicin 6.1416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.2617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.9315621674
MESH:D016778 Malaria, Falciparum Chlorprothixene 5.7016882315
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.8516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.1219428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.8315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.8316891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 17.8315375486
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.8317203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Reserpine 17.8311921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.8319196722 11731420 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 10.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.4519453300
MESH:D008382 Marfan Syndrome Losartan 5.4319430350
MESH:D008545 Melanoma Carmustine 4.3412393984
MESH:D008545 Melanoma Doxorubicin 4.3416827129
MESH:D008545 Melanoma Tamoxifen 4.3419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5315990972
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.2317109627 17268249
MESH:D001523 Mental Disorders aripiprazole 17.7916856516
MESH:D001523 Mental Disorders Chlorprothixene 17.7916856516
MESH:D001523 Mental Disorders Clozapine 17.7916856516
MESH:D001523 Mental Disorders Haloperidol 17.7916856516
MESH:D001523 Mental Disorders Risperidone 17.7916856516 16596465
MESH:D008607 Mental Retardation aripiprazole 8.4716891339 17069544
MESH:D008607 Mental Retardation Phenytoin 8.479212184
MESH:D008607 Mental Retardation Risperidone 8.4718349709
MESH:D008654 Mesothelioma Atrazine 5.531916698
MESH:D008654 Mesothelioma Doxorubicin 5.5317638057
MESH:D024821 Metabolic Syndrome X Clozapine 8.3919142101
MESH:D024821 Metabolic Syndrome X Risperidone 8.3919142101
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9115792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.8915863610
MESH:D019964 Mood Disorders Risperidone 5.2017019624
MESH:D009041 Motion Sickness Dextroamphetamine 4.861613127
MESH:D052016 Mucositis Doxorubicin 4.1417415656
MESH:D009101 Multiple Myeloma Raloxifene 2.9716497877
MESH:D009175 Mycoplasma Infections Chlorprothixene 6.1710773494
MESH:D009181 Mycoses Amiodarone 4.2412754197 17974566
MESH:D009203 Myocardial Infarction Doxorubicin 5.4319429709 15857846
MESH:D009203 Myocardial Infarction Losartan 5.4312692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7716810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 4.8717484760
MESH:D009224 Myotonia Congenita Phenytoin 4.761896199
MESH:D009232 Myxoma Raloxifene 4.8916343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 4.8418259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.8419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2619410462
MESH:D009369 Neoplasms Dieldrin 11.968820588
MESH:D009369 Neoplasms Diethylstilbestrol 11.9615313581
MESH:D009369 Neoplasms Nitrofurazone 11.9615488632
MESH:D009369 Neoplasms Toxaphene 11.968820588
MESH:D009369 Neoplasms Urethane 11.9615625555
MESH:D009374 Neoplasms, Experimental Urethane 4.0515582191
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3419196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Copper 8.2017308104
MESH:D009389 Neovascularization, Pathologic Estradiol 8.2017289903
MESH:D009401 Nephrosis Doxorubicin 4.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.4516889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 18.4111399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.4111399458
MESH:D009421 Nervous System Malformations Estradiol 18.4111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.4114600291
MESH:D009436 Neural Tube Defects Phenytoin 3.689118846
MESH:D009447 Neuroblastoma Doxorubicin 2.8915555623
MESH:D053206 Nocturnal Enuresis Risperidone 5.6717822346
MESH:D009765 Obesity Ascorbic Acid 4.4917217161
MESH:D009765 Obesity Clozapine 4.4918515891 19142110
MESH:D010018 Osteomalacia Phenytoin 4.7617016548
MESH:D010024 Osteoporosis Raloxifene 2.9717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.6315758505 17893378 17823083 15579764
MESH:D012516 Osteosarcoma Doxorubicin 3.5815930896
MESH:D010049 Ovarian Diseases bisphenol A 4.3411985600
MESH:D010051 Ovarian Neoplasms Estradiol 15.5319401270
MESH:D010051 Ovarian Neoplasms Medroxyprogesterone Acetate 15.5317393432
MESH:D010051 Ovarian Neoplasms Mifepristone 15.5316525653
MESH:D010051 Ovarian Neoplasms Nitrofurazone 15.5311026599
MESH:D010051 Ovarian Neoplasms Progesterone 15.5317393432 16525653
MESH:D010051 Ovarian Neoplasms Urethane 15.5316391232
MESH:D010146 Pain Phenytoin 3.4715215642
MESH:D010195 Pancreatitis Methomyl 4.7816258382 15767733
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0811578682
MESH:D010300 Parkinson Disease Atrazine 7.4617218051
MESH:D010300 Parkinson Disease Bromocriptine 7.4618328768 9918342
MESH:D010300 Parkinson Disease Dieldrin 7.4616809432 17291500 11181820 16112328 11445065
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.4917983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 10.0215687265 16977796
MESH:D010911 Pituitary Neoplasms Urethane 10.0216391232
MESH:D010997 Pleural Neoplasms Doxorubicin 4.4917638057
MESH:D011041 Poisoning Methomyl 4.8411800311
MESH:D017689 Polydactyly Phenytoin 4.499212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9418163543
MESH:D011248 Pregnancy Complications Toxaphene 5.232087686
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 12.5510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 12.5517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.5511399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.6020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.6020887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.1116740699
MESH:D011471 Prostatic Neoplasms Copper 3.1117079463 17308104
MESH:D011471 Prostatic Neoplasms Coumestrol 3.1116921512
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.1115046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.1115749863 16868541 16888761 18437689 15897917 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 3.1116740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.1116220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Simazine 3.1112661182
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1115084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.6716919318 15861022
MESH:D019310 Pseudolymphoma Phenytoin 4.881419762 8603615 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 4.3211575062
MESH:D011618 Psychotic Disorders aripiprazole 16.9116891339
MESH:D011618 Psychotic Disorders Chlorprothixene 16.9116882315 19708200
MESH:D011618 Psychotic Disorders Clozapine 16.9115331141
MESH:D011618 Psychotic Disorders Haloperidol 16.9111575062
MESH:D011629 Puberty, Precocious bisphenol A 4.1410548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.6714606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.5712490602 12832656 11597910
MESH:D011693 Purpura Raloxifene 4.8915770314
MESH:D012021 Reflex, Abnormal Pentobarbital 5.3710930210
MESH:D051437 Renal Insufficiency Doxorubicin 8.6917922066
MESH:D051437 Renal Insufficiency Losartan 8.6915728788
MESH:D012135 Respiratory Sounds Atrazine 3.8911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2218990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.0916849425
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5818045962
MESH:D012509 Sarcoma Doxorubicin 3.4215625365 16767912 15675481 17203757 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.6314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1417846226
MESH:D012559 Schizophrenia aripiprazole 11.5816891339
MESH:D012559 Schizophrenia Chlorprothixene 11.581830565
MESH:D012559 Schizophrenia Clozapine 11.5818806925 20521326 11763009 17667964 20521320 20452607 17123785 18855531 16141801 17726453 11151749 20580759 19369910 20168265 20107430
MESH:D012559 Schizophrenia Copper 11.5816842975
MESH:D012559 Schizophrenia Haloperidol 11.5819369910 1830565 20107430 18513383
MESH:D012559 Schizophrenia Risperidone 11.5820107430 18278980 19154706
MESH:D012640 Seizures Dizocilpine Maleate 13.8017157343 12660363 11218047
MESH:D012640 Seizures Endosulfan 13.8010698677 7539098
MESH:D012640 Seizures Methomyl 13.8011218047 12660363
MESH:D012640 Seizures Pentobarbital 13.809754883 10087439
MESH:D012640 Seizures Phenytoin 13.803137016 19919933 11044598 16876388 9844417 3691417 10029267 15946322
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.4318724381
MESH:D012871 Skin Diseases Ascorbic Acid 4.4818709164
MESH:D012871 Skin Diseases Vitamin E 4.4818709164
MESH:D012878 Skin Neoplasms Doxorubicin 7.5715692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.5716192470
MESH:D012878 Skin Neoplasms Urethane 7.5711807781
MESH:D012893 Sleep Disorders Risperidone 4.8618278980
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9317203757 16767912 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 16.3216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 16.3216709447
MESH:D013088 Spermatocele Tamoxifen 16.3216709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.7216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.7219457130
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.5220235791
MESH:D013276 Stomach Ulcer Amiodarone 9.0618087811
MESH:D013276 Stomach Ulcer Ascorbic Acid 9.0618726076
MESH:D013276 Stomach Ulcer Nifedipine 9.0614653237
MESH:D020521 Stroke Ascorbic Acid 11.4716403987 16517955
MESH:D020521 Stroke Raloxifene 11.4716837676
MESH:D020521 Stroke Vitamin E 11.4716517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.3416684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.4111529278 9754883
MESH:D013610 Tachycardia Amiodarone 3.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 13.9519225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 13.9520210726
MESH:D017180 Tachycardia, Ventricular Risperidone 13.9520210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6015669648
MESH:D013959 Thyroid Diseases Amiodarone 9.8519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.8512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 2.8816010429 17909728
MESH:D013971 Thyrotoxicosis Amiodarone 4.2218020914 19584973
MESH:D013978 Tibial Fractures Estradiol 11.5119048282
MESH:D013978 Tibial Fractures Raloxifene 11.5119048282
MESH:D016171 Torsades de Pointes Amiodarone 3.5517467628 11989578
MESH:D005879 Tourette Syndrome Risperidone 5.3119154706
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 9.4616712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 9.4617653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 9.4617572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 9.4616712894 8653321 17572228
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.0816487989
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.4716175088
MESH:D014591 Uterine Diseases bisphenol A 11.6214652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.6214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.4316690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.4314692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8016002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9312125929
MESH:D019043 Vascular Neoplasms Urethane 5.2510620525
MESH:D054556 Venous Thromboembolism Raloxifene 4.5516837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.5917638931 17678736 16364871 17334414
MESH:D014846 Vulvar Neoplasms Raloxifene 4.8916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5915886252
MESH:D015430 Weight Gain Clozapine 8.5317502770 16141801 20521320 20107430 16402076 20564506
MESH:D015430 Weight Gain Risperidone 8.5320564506 16379507
MESH:D015431 Weight Loss Clozapine 4.4317933447
MESH:D014947 Wounds and Injuries Nitrofurazone 4.8718222664 18440737
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:30228 Diabetes pathways
KEGG:04630 Jak-STAT signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018