AutismKB 2.0

Annotation Detail for PRLR


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Basic Information Top
Gene Symbol:PRLR ( hPRLrI )
Gene Full Name: prolactin receptor
Band: 5p13.2
Quick LinksEntrez ID:5618; OMIM: 176761; Uniprot ID:PRLR_HUMAN; ENSEMBL ID: ENSG00000113494; HGNC ID: 9446
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200009ErbB4 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of PRLR mRNA]affects expression|affects reaction 19414516
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PRLR mRNAaffects expression 21346803
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of PRLR mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of PRLR mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of PRLR mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRLR mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of PRLR mRNAincreases expression 18191166
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PRLR mRNAaffects cotreatment|increases expression 17905399
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PRLR mRNAaffects cotreatment|decreases expression 18164116
D002118 Calcium Calcium affects the expression of PRLR mRNAaffects expression 15913539
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRLR mRNAaffects expression 12734012
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRLR mRNAaffects cotreatment|affects expression 17602206
D003314 Corn Oil Corn Oil affects the expression of PRLR mRNAaffects expression 16360708
D003474 Curcumin Curcumin results in increased expression of PRLR mRNAincreases expression 18421014
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of PRLR mRNAdecreases expression 15331540
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PRLR mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRLR mRNAaffects cotreatment|affects expression 17602206
C010452 estradiol-17 beta-benzoate estradiol-17 beta-benzoate affects the expression of PRLR mRNAaffects expression 15059950
D004958 Estradiol Estradiol results in increased expression of PRLR mRNAincreases expression 16202921
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PRLR mRNAaffects cotreatment|decreases expression 16107292
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of PRLR mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PRLR mRNAdecreases expression 12655037
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of PRLR mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in decreased expression of PRLR mRNAdecreases expression 18035473
C056933 fumonisin B1 fumonisin B1 results in decreased expression of PRLR mRNAdecreases expression 16221962
C071834 glycidamide glycidamide results in decreased expression of PRLR mRNAdecreases expression 17822822
C010176 halofuginone halofuginone results in increased expression of PRLR mRNAincreases expression 17180598
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PRLR mRNAaffects cotreatment|increases expression 17905399
C025589 ochratoxin A ochratoxin A results in decreased expression of PRLR mRNAdecreases expression 16251485
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of PRLR mRNAdecreases expression 18467677
D010795 Phthalic Acids Phthalic Acids results in decreased expression of PRLR mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRLR mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PRLR mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of PRLR mRNAdecreases expression 18445702
16221962
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in decreased expression of PRLR mRNA]affects reaction|decreases expression 16221962
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PRLR mRNAaffects cotreatment|decreases expression 16107292
D011374 Progesterone Progesterone results in decreased expression of PRLR mRNAdecreases expression 16107292
C488333 Ro 65-7199 Ro 65-7199 affects the expression of PRLR mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 results in increased expression of PRLR mRNAincreases expression 14610520
C017947 sodium arsenite sodium arsenite affects the expression of PRLR mRNAaffects expression 16507464
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PRLR mRNAaffects cotreatment|increases expression 17905399
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.5817676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 9.3418287403
MESH:D000138 Acidosis Ethanol 9.3411192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma Estradiol 3.9111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9114692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.2219389873
MESH:D000236 Adenoma Diethylnitrosamine 6.2210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.9618056438 19061943 17620307 16434500 17162532 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5617306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9715451039 15451040
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7417887948
MESH:D000544 Alzheimer Disease Curcumin 2.5415590663
MESH:D000741 Anemia, Aplastic Benzene 4.1117661222 11369114 14761424
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D000853 Anophthalmos Ethanol 4.4915513904
MESH:D001008 Anxiety Disorders Ethanol 3.7411141031
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.0615014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6516807698
MESH:D050197 Atherosclerosis Curcumin 3.1218704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1320106747
MESH:D001321 Autistic Disorder marker/mechanism 18207134
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Curcumin 4.1619761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8519483382
MESH:D001855 Bone Marrow Diseases Benzene 4.8816183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9917868700
MESH:D001930 Brain Injuries Progesterone 3.9315665606 15845082 15380490
MESH:D002545 Brain Ischemia Curcumin 3.9916770732
MESH:D001932 Brain Neoplasms Curcumin 3.6517596214
MESH:D001943 Breast Neoplasms Benzene 4.4311921183 17162533
MESH:D001943 Breast Neoplasms Curcumin 4.4318462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.4316978400 11325840 15136595 18234424 12006526 17388661 17020986 18323546 15093573
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.4317474063
MESH:D001943 Breast Neoplasms Estradiol 4.4318497071 17261762 17018787 12948864 17289903 19861407 16675129 14630087
MESH:D001943 Breast Neoplasms ochratoxin A 4.4311921183
MESH:D001943 Breast Neoplasms Progesterone 4.4316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Trichloroethylene 4.4315986119
MESH:D002056 Burns Ethanol 4.3216374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4515721981 16097048 16192424 18705752 10355542 15673190 16011737 16227642 15700767 3786805 16050911 16124888
MESH:D002277 Carcinoma Curcumin 3.5718593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.8316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.833084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.8318788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 15.8319701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.8318506893 18691550 19701751 19335982 16698587 3581430 18788625 18393292 16540662 18210153 19208518 16681979 19919837 11831363 16830150 20007298 16878318 19107877 17173139 18785209 16288022 19052882 18978308 19822196 10672840 20524982 16935385 19394651 17761372 18494052 16569478 20101231 17138121 19539802 19171122 19418558 16502159 18665156 20214788 16807293 20514400 17162532 17978847 18056438 17055752 20084675 20727157 3084413 16328049 10737359 19383236 20512989 16779866 18971187 17428255 20935162 19519916 21159647 20432363
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 15.8315763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.8317306315 15276417 16507464
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.5516152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8618414057
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.3816201981
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.5118462866
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5118572023
MESH:D006332 Cardiomegaly Ethanol 3.2519332462
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.8617174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.8618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.8620056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4019052882
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9117333356 16105132 17681005 15861022 11677210 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 6.9119176532
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 3.0315513904
MESH:D003092 Colitis Curcumin 3.8516804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.2518809619
MESH:D003110 Colonic Neoplasms arsenite 3.8315037631
MESH:D003110 Colonic Neoplasms Curcumin 3.8316340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 4.5618497527
MESH:D019465 Craniofacial Abnormalities Benzene 3.9315643154
MESH:D019465 Craniofacial Abnormalities Ethanol 3.9311198716 15451040 19302082 15451039 10194807 15513904 11873399
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.9320036863
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6818551238
MESH:D003556 Cystitis Cyclophosphamide 4.6410498854 17010015 10700343 18295254 15276878 15643279 18093676 18433785 11948286 16413132 18710439 18483878 12161096 16651033 16989017 12913760 17979934 12388444 16614059 18372110
MESH:D003872 Dermatitis Benzene 4.4315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.7910990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1118772604
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3018403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003928 Diabetic Nephropathies Curcumin 8.0918204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.0919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.9916081117 11287661 19416960 10663392 19370779 15619225 12958197 14550746 12594235 2444490 18071297 19923254 16393943 17906064 19164858 10915739 12705907 12540782 11834606 18713872 14986274 12153990 17562736 11529661 14725611 19420014 16781746 12392966 17522070 11739529 16227642 11743745 16177239 10774834 15968718 19739265 11421492 16485898 19085960 11461765 16109766
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.9919336974 7179309 15027814 19085960 6884620 21278145 6623471 7440962 9327722 15968718 7120509 10915739 4309450 16177239 10092053 17522070 16227642 2869522 3732212 3786805 11566570 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.9919107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 16.9911566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 16.9916221962
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 16.997120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004381 Duodenal Ulcer Curcumin 3.7317351913
MESH:D004487 Edema perfluorooctanoic acid 5.9917259670 12083418
MESH:D004487 Edema pirinixic acid 5.9912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.9617692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.7611473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 3.4716134523
MESH:D004802 Eosinophilia Cyclophosphamide 3.8911006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7716302075
MESH:D004938 Esophageal Neoplasms Ethanol 2.6716704527
MESH:D005234 Fatty Liver arsenite 38.0318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 38.0361145 12795759 16239168 12631006 17595544 15959796 19224547 16045604
MESH:D005234 Fatty Liver Curcumin 38.0319297423
MESH:D005234 Fatty Liver Diethylnitrosamine 38.0320387270 21071580
MESH:D005234 Fatty Liver Ethanol 38.0319236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.0315345470
MESH:D005234 Fatty Liver Fish Oils 38.0318620774
MESH:D005234 Fatty Liver pirinixic acid 38.0320131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3217920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9610194807 15451040 15513904 16946407
MESH:D005355 Fibrosis arsenite 13.0518296743
MESH:D005355 Fibrosis Carbon Tetrachloride 13.0518705752
MESH:D005355 Fibrosis Curcumin 13.0518705752
MESH:D005756 Gastritis Acetaminophen 9.9716983495
MESH:D005756 Gastritis Ethanol 9.9715046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3618462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005909 Glioblastoma Curcumin 3.2617596214
MESH:D018316 Gliosarcoma Cyclophosphamide 5.1711389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.7015172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4318462866 18829502
MESH:D006333 Heart Failure pirinixic acid 2.3320558911
MESH:D006402 Hematologic Diseases Benzene 4.3416183116
MESH:D006467 Hemophilia A Cyclophosphamide 4.9611918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.1914986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719900420 19110552
MESH:D006529 Hepatomegaly fumonisin B1 12.7316221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 12.733609246
MESH:D006529 Hepatomegaly pirinixic acid 12.7316221962 19772884 18467677 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7117701891
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.6817606976 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 6.6812676792
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006930 Hyperalgesia Acetaminophen 11.6216870215
MESH:D006930 Hyperalgesia Ethanol 11.6218783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.6212083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006937 Hypercholesterolemia Curcumin 3.7518704882
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006949 Hyperlipidemias Fish Oils 4.4415752949
MESH:D006965 Hyperplasia halofuginone 4.9111874485
MESH:D006968 Hypersensitivity, Delayed Corn Oil 11.5411484837
MESH:D006968 Hypersensitivity, Delayed Fish Oils 11.5411484837
MESH:D006973 Hypertension Benzene 2.9617940673
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 4.9916076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Cyclophosphamide 9.9716517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.9717937319
MESH:D007248 Infertility, Male sodium arsenite 9.9712646999 15346721
MESH:D007249 Inflammation Curcumin 13.9616956363 18403477 17151092
MESH:D007249 Inflammation Diethylnitrosamine 13.9618785209
MESH:D007249 Inflammation Flavonoids 13.9617296493
MESH:D007249 Inflammation perfluorooctanoic acid 13.9612083418
MESH:D007249 Inflammation Progesterone 13.9615869954
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0718596194 18200517
MESH:D007333 Insulin Resistance Estradiol 6.4616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.4616306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.9310783313
MESH:D007569 Jaw Abnormalities Ethanol 4.1015513904
MESH:D007674 Kidney Diseases Acetaminophen 12.8712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 12.8715618244
MESH:D007674 Kidney Diseases ochratoxin A 12.8711409539
MESH:D007674 Kidney Diseases sodium arsenite 12.8720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.0216705839
MESH:D007680 Kidney Neoplasms Estradiol 11.0215610895
MESH:D007680 Kidney Neoplasms ochratoxin A 11.0216251485
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7016316344
MESH:D007859 Learning Disorders Ethanol 3.8815451040
MESH:D007889 Leiomyoma Curcumin 4.2618555241
MESH:D007938 Leukemia Benzene 9.6917119257 14694614 15935818 18335105
MESH:D007938 Leukemia Curcumin 9.6918462866
MESH:D007938 Leukemia Cyclophosphamide 9.6910602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3518172266 17658394 17008537 17802794 18587576 17296974
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9016106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.8410373061
MESH:D007951 Leukemia, Myeloid Benzene 4.0217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6419478238
MESH:D015458 Leukemia, T-Cell Curcumin 4.4416106398
MESH:D007970 Leukopenia Cyclophosphamide 4.6310052129 11830472
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.898812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5717676605
MESH:D008103 Liver Cirrhosis arsenite 18.7518296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 18.7516221502 11903743 21278145 16943688 17174718 16239168 17334410 11408273 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 18.7518665156 20032147 18522880 18407596 19638242
MESH:D008103 Liver Cirrhosis Ethanol 18.7515289165
MESH:D008103 Liver Cirrhosis halofuginone 18.7517180598
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7618295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.1217714472 14748882 15123356 13678700 12898905 12666154 12632514 17823541 12389079 10355542 12741479 17900296 18395914 17565644 18376398 15959796 17805973 15893842 15338365 18418968 18412020 17640975 18339082 15650968 17922224 17944888 18006644 17976157 17708605 18705752 14620537 18156304 16638106 16015684 15925388 16116963 17631135 12609069 18210741 12667390 18251166 18395095 15818738 17721639 18472094 18472332 12649538 20821823 15931870 18420326 12445418 16097048 17761835 17525996 16248980 18317297 15996030 12445421 15730626 14724832 17869086 11481614 12958196 18429990 12546737 14716833 17481882 15876570 15673190 18279442 15370692 15057751 14512876 16033810 12632512 18205269 16136751 16011737 17557913 15052691 16192424 18166357 17698563 18263696 15362042 18277467 18054572 14716496 18187930 16027843 12586293 18481824 17766677
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.1218705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.1218166357
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 8.1212175628 18458672 14739098 11172339 16489207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1215474484
MESH:D008107 Liver Diseases Acetaminophen 8.5816611625 12969438 19784758 19460945 11587558 19014921 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.5815720792 16964402 17285989 16246199 15830285
MESH:D008107 Liver Diseases Curcumin 8.5816956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.5817034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3217347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4316871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.4316899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 19.8119389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.8119294768
MESH:D008113 Liver Neoplasms Clofibric Acid 19.8117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.8112771043 19551842 19996281 9163691 19294768 19833225 20583210 20118626 21071580 19073162 19426721 15885732 19255062 19090486 19642983 18978307 2862719 18644402 21278145 20492335 15175105 20405173 19499222 21047994 19254457 19690152 21167192 20434301 20137499 2422723 20101389 16942905 19638242 20501860 18977376 18754104 12112319 10737359 19812893 19427195 20452335 19256749 18648771 19850985
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.8114757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 19.8115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 19.8116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Benzene 16.4212562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.4218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.4215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.4218079962 18253720 18775883 2563599 18308698 19126423 19009564 17854601 19519916 3124819 16267830 19004024 16842330 17942915 18282651 18164116 19539802 18093689 9362446 21159647 18544905 17174075
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 16.427955063
MESH:D008171 Lung Diseases sodium arsenite 2.9519095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.4614698565
MESH:D008175 Lung Neoplasms arsenite 6.1216809336
MESH:D008175 Lung Neoplasms Benzene 6.1212562636
MESH:D008175 Lung Neoplasms Curcumin 6.1219359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.126695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 6.1219931552 15276417 16712894 17077188 17306315
MESH:D008223 Lymphoma Benzene 11.3517584886 17119257
MESH:D008223 Lymphoma Curcumin 11.3518462866
MESH:D008223 Lymphoma Cyclophosphamide 11.3512854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.2816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.8911911406
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3616173963
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.1012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 12.5711921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.5711408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 12.5711921183
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.5717203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1419453300
MESH:D008545 Melanoma Curcumin 3.3117885582 18462866
MESH:D008545 Melanoma sodium arsenite 3.3119082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 9.7319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.7316388313
MESH:D008569 Memory Disorders Curcumin 8.6817263510
MESH:D008569 Memory Disorders Ethanol 8.6818411066 15451040
MESH:D008850 Microphthalmos ochratoxin A 5.4720036863
MESH:D009101 Multiple Myeloma Benzene 6.8417119195
MESH:D009101 Multiple Myeloma Curcumin 6.8419372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0019151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5218551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0518495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.439029167 3581430
MESH:D009369 Neoplasms Cyclophosphamide 10.5218854779
MESH:D009369 Neoplasms pirinixic acid 10.5217405874
MESH:D009369 Neoplasms sodium arsenite 10.5211559025
MESH:D009369 Neoplasms Trichloroethylene 10.5211911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3420056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.1912497104
MESH:D009389 Neovascularization, Pathologic arsenite 9.0215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.0217289903
MESH:D009421 Nervous System Malformations Estradiol 3.3316427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.2818462866
MESH:D009436 Neural Tube Defects Benzene 11.1315643154
MESH:D009436 Neural Tube Defects ochratoxin A 11.1320036863
MESH:D009436 Neural Tube Defects sodium arsenite 11.1312854658
MESH:D009447 Neuroblastoma Cyclophosphamide 3.4615176712 16115947 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.2718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.2720387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.5512837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7720387270
MESH:D009503 Neutropenia Cyclophosphamide 4.018291058
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.629802331
MESH:D009765 Obesity Curcumin 4.2919297423
MESH:D009765 Obesity pirinixic acid 4.2920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1916049721 12819281
MESH:D009784 Occupational Diseases Benzene 8.1915576619 16737584 17479406 15935809 17178637 15913788 17119257 15727169 15612468
MESH:D009845 Oligospermia Cyclophosphamide 4.3716517039
MESH:D010024 Osteoporosis Calcium 6.8517882678
MESH:D010024 Osteoporosis Curcumin 6.8518719352
MESH:D010051 Ovarian Neoplasms Benzene 13.7712562636
MESH:D010051 Ovarian Neoplasms Curcumin 13.7718462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 13.7719401270
MESH:D010051 Ovarian Neoplasms Progesterone 13.7716525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.7717306315 15276417
MESH:D010146 Pain Acetaminophen 5.9616870215
MESH:D010146 Pain Cyclophosphamide 5.9612161096 18093676
MESH:D010190 Pancreatic Neoplasms Curcumin 11.3417440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 11.3411332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.3416540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.3412384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D011230 Precancerous Conditions Corn Oil 8.6714668109
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.672563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6121297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.0617132714
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.1918226269 18156803 10851300 18769126 12497104 11398177 15129424
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1917136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1916740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1916039940
MESH:D011537 Pruritus Ethinyl Estradiol 2.9815861022 16919318
MESH:D011656 Pulmonary Emphysema Curcumin 4.2319168576
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1516636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7218379247 10666014
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012509 Sarcoma Curcumin 3.8218462866
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.5116636934
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3418551238
MESH:D012640 Seizures Ethanol 5.349754883
MESH:D018805 Sepsis Curcumin 3.8018389075
MESH:D012871 Skin Diseases halofuginone 3.4211874485
MESH:D012878 Skin Neoplasms sodium arsenite 2.5418572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6016709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.1716517039
MESH:D013119 Spinal Cord Injuries Progesterone 3.9415862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013274 Stomach Neoplasms Benzene 3.3112562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3118456281
MESH:D013274 Stomach Neoplasms Ethanol 3.3118456281
MESH:D013276 Stomach Ulcer Curcumin 6.5616631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 6.5617918041 16755016 17189318 9211565 11906479 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.969754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.7212837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013953 Thymus Neoplasms Benzene 4.6210850423
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.737505956
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.8316049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.8318593936
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 10.8314692829
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.8316712894 17306315 11723127 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 4.9218462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9710091137
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4711813266
MESH:D014594 Uterine Neoplasms Benzene 8.5012562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5014692618
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2415869587 14671159
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00052 - Somatropin recombinant Anabolic Agents;Hormone Replacement Agents
DB01185 antagonist Fluoxymesterone Anabolic Agents;Antineoplastic Agents, Hormonal
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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