AutismKB 2.0

Annotation Detail for PRNP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PRNP ( ASCR,CD230,CJD,GSS,MGC26679,PRIP,PrP,PrP27-30,PrP33-35C,PrPc,prion )
Gene Full Name: prion protein
Band: 20p13
Quick LinksEntrez ID:5621; OMIM: 176640; Uniprot ID:PRIO_HUMAN; ENSEMBL ID: ENSG00000171867; HGNC ID: 9449
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05020Prion diseases
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200021Glypican 1 network
No data
Pathway IDPathway Name
500087NCAM1 interactions
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00061Prion diseases
No data
Desease Name
diverse clinicopathologic phenotypes
Jakob-Creutzfeldt disease
AGING
encephalopathies, transmissible spongiform
Inherited Creutzfeldt-Jakob disease
Alzheimer's disease
Creutzfeldt-Jakob disease
CANCER
PSYCH
Early cognitive decline
NEUROLOGICAL
schizophrenia
Wilson disease
METABOLIC
Epilepsy, Temporal Lobe
cerebral aging
human long-term memory
Sporadic Creutzfeldt-Jakob disease
Desease Name
Creutzfeldt-Jakob disease
Platelet aggregation
Desease Name
Insomnia, fatal familial
Creutzfeldt-Jakob disease
Huntington disease-like 1
Prion disease with protracted course
Gerstmann-Straussler disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of PRNP mRNAincreases expression 20359517
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PRNP mRNAdecreases expression 18648102
C430898 AGN 194204 AGN 194204 results in decreased expression of PRNP mRNAdecreases expression 16339527
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of PRNP mRNAdecreases expression 17023530
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRNP mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of PRNP mRNAincreases expression 20359517
C095105 bexarotene bexarotene results in decreased expression of PRNP mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of PRNP mRNAdecreases expression 20678512
C006780 bisphenol A bisphenol A results in increased expression of PRNP mRNAincreases expression 12075121
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PRNP mRNAincreases expression 15336504
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of PRNP mRNAincreases expression 12760830
D009249 NADP [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein]affects binding|affects cotreatment|increases reaction 16990274
D003300 Copper Copper affects the folding of PRNP proteinaffects folding 16791441
D003300 Copper PRNP protein binds to Copperaffects binding 17112476
D003300 Copper [PRNP protein binds to Copper] which results in increased activity of SOD1 proteinaffects binding|increases activity 17112476
D003300 Copper Copper binds to PRNP proteinaffects binding 17126907
16990274
17257012
16824036
16831968
D003300 Copper PRNP protein binds to Copperaffects binding 17112476
16847141
D003300 Copper [PRNP protein binds to Copper] which results in increased activity of SOD1 proteinaffects binding|increases activity 17112476
D003300 Copper PRNP protein polymorphism binds to Copperaffects binding 16847141
D003300 Copper Copper affects the localization of [GPC1 protein co-treated with PRNP protein]affects cotreatment|affects localization 16923158
D003300 Copper Copper affects the reaction [LRP1 protein results in increased uptake of PRNP protein]affects reaction|increases uptake 17155929
D003300 Copper Copper binds to PRNP proteinaffects binding 16990274
16698781
D003300 Copper Copper results in increased uptake of PRNP proteinincreases uptake 17155929
D003300 Copper PRNP protein binds to Copperaffects binding 16787422
17112476
D003300 Copper PRNP protein results in decreased susceptibility to Copperdecreases response to substance 16787422
D003300 Copper Copper binds to and affects the folding of PRNP protein polymorphismaffects binding|affects folding 16777497
D003300 Copper [Copper binds to PRNP protein polymorphism] which binds to thioflavin Taffects binding 16777497
D003300 Copper Copper results in increased degradation of PRNP proteinincreases degradation 16640559
D003300 Copper Phosphatidylinositols promotes the reaction [Copper results in increased degradation of PRNP protein]increases degradation|increases reaction 16640559
D003300 Copper PRNP protein results in increased reduction of Copperincreases reduction 16640559
D003300 Copper Copper affects the localization of and affects the degradation of PRNP proteinaffects degradation|affects localization 16545469
D003300 Copper Copper binds to PRNP proteinaffects binding 16925523
D003300 Copper PRNP protein binds to and results in decreased activity of Copperaffects binding|decreases activity 17059225
D019327 Copper Sulfate PRNP protein binds to Copper Sulfateaffects binding 16847141
D019327 Copper Sulfate PRNP protein polymorphism binds to Copper Sulfateaffects binding 16847141
D019327 Copper Sulfate PRNP protein binds to Copper Sulfateaffects binding 16787422
D019327 Copper Sulfate PRNP protein results in decreased susceptibility to Copper Sulfatedecreases response to substance 16787422
C029892 cupric chloride [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein]affects binding|affects cotreatment|increases reaction 16990274
C029892 cupric chloride cupric chloride affects the folding of PRNP proteinaffects folding 16855791
D016572 Cyclosporine Cyclosporine results in increased expression of PRNP mRNAincreases expression 20106945
D002945 Cisplatin PRNP protein results in decreased susceptibility to Cisplatindecreases response to substance 15386405
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PRNP mRNAincreases expression 19638242
D002117 Calcitriol Calcitriol results in increased expression of PRNP mRNAincreases expression 16002434
D004317 Doxorubicin PRNP protein results in decreased susceptibility to Doxorubicindecreases response to substance 15386405
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRNP mRNAincreases expression 12075121
C004912 ethylbenzene ethylbenzene results in increased expression of PRNP mRNAincreases expression 20359517
D005047 Etoposide PRNP protein results in decreased susceptibility to Etoposidedecreases response to substance 15386405
D005472 Fluorouracil PRNP protein results in decreased susceptibility to Fluorouracildecreases response to substance 15386405
D019833 Genistein Genistein results in increased expression of PRNP mRNAincreases expression 12075121
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of PRNP mRNAincreases expression 12419474
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PRNP mRNAincreases expression 19339665
D008070 Lipopolysaccharides methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of PRNP mRNA]decreases reaction|increases expression 19339665
C008435 methyldithiocarbamate methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of PRNP mRNA]decreases reaction|increases expression 19339665
D008752 Methylene Chloride Methylene Chloride results in increased expression of PRNP mRNAincreases expression 20359517
C008493 methylselenic acid methylselenic acid results in increased expression of PRNP mRNAincreases expression 18548127
D016685 Mitomycin Mitomycin results in increased expression of PRNP mRNAincreases expression 12760830
D009532 Nickel Nickel binds to PRNP proteinaffects binding 17126907
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PRNP mRNAincreases expression 17616710
D010269 Paraquat PRNP protein results in decreased susceptibility to Paraquatdecreases response to substance 15451062
17896796
D010716 Phosphatidylinositols Phosphatidylinositols promotes the reaction [Copper results in increased degradation of PRNP protein]increases degradation|increases reaction 16640559
D010716 Phosphatidylinositols Phosphatidylinositols promotes the reaction [PRNP protein binds to PRNP protein]affects binding|increases reaction 16640559
C006253 pirinixic acid pirinixic acid results in decreased expression of PRNP mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in increased expression of PRNP mRNAincreases expression 18037150
C017947 sodium arsenite sodium arsenite results in increased expression of PRNP mRNAincreases expression 12760830
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNAaffects cotreatment|increases expression 17942748
D013752 Tetracycline Tetracycline binds to PRNP proteinaffects binding 10903871
D013752 Tetracycline Tetracycline inhibits the reaction [PRNP protein binds to PRNP protein]affects binding|decreases reaction 10903871
C009462 thioflavin T [Copper binds to PRNP protein polymorphism] which binds to thioflavin Taffects binding 16777497
C009462 thioflavin T thioflavin T binds to PRNP proteinaffects binding 16777497
C009462 thioflavin T thioflavin T binds to PRNP protein polymorphismaffects binding 16777497
C009462 thioflavin T [Zinc binds to PRNP protein polymorphism] which binds to thioflavin Taffects binding 16777497
D014050 Toluene Toluene results in increased expression of PRNP mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of PRNP mRNAincreases expression 20359517
D014635 Valproic Acid Valproic Acid results in increased expression of PRNP mRNAincreases expression 19101580
D014750 Vincristine PRNP protein results in decreased susceptibility to Vincristinedecreases response to substance 15386405
D015032 Zinc Zinc binds to PRNP protein polymorphismaffects binding 16777497
D015032 Zinc [Zinc binds to PRNP protein polymorphism] which binds to thioflavin Taffects binding 16777497
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.7415322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 6.748875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5019490988
MESH:D000138 Acidosis Ammonium Chloride 3.0818287403
MESH:D000142 Acidosis, Respiratory Copper Sulfate 5.957265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4617505938
MESH:D000169 Acrodermatitis Zinc 4.9317202136 17190629 16889938
MESH:D058186 Acute Kidney Injury Cisplatin 3.5417670903 12690470 15814532
MESH:D055371 Acute Lung Injury Lipopolysaccharides 12.8318653653 11850527
MESH:D055371 Acute Lung Injury Nickel 12.8316166738
MESH:D055371 Acute Lung Injury pirinixic acid 12.8318653653
MESH:D000230 Adenocarcinoma Cisplatin 15.2517638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 15.2517418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.2514692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.2517638652
MESH:D000230 Adenocarcinoma Genistein 15.2511473722
MESH:D000230 Adenocarcinoma Vincristine 15.2519825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.713712494
MESH:D000236 Adenoma Diethylnitrosamine 5.716695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.5217620307 16434500 18056438 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.5216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.5216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4217306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3011874814
MESH:D000419 Albuminuria Doxorubicin 4.0921441931
MESH:D000544 Alzheimer Disease marker/mechanism 17192785
MESH:D000544 Alzheimer Disease Copper 4.3117119284 16866297 16886094 16410023 16325427 16962711
MESH:D000544 Alzheimer Disease Zinc 4.3116580781 16325427 16410023 17119284
MESH:D000550 Amblyopia Valproic Acid 4.7517688650
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.9910694572
MESH:D000740 Anemia Fluorouracil 7.3116511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.3111748828
MESH:D000741 Anemia, Aplastic Benzene 4.0017661222 14761424 11369114
MESH:D018798 Anemia, Iron-Deficiency Copper 4.4616614410
MESH:D000755 Anemia, Sickle Cell Zinc 4.4516916123
MESH:D000860 Anoxia Copper Sulfate 5.457265320
MESH:D001008 Anxiety Disorders Valproic Acid 3.2017497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3615885639
MESH:D001249 Asthma Zinc 2.8017085522
MESH:D001321 Autistic Disorder Valproic Acid 2.0620603192 17507914 18396377 18985861 18940202 17688650 18177632 18558336 18775368 18316065 19460635 15238991 19232924 17157402 16609825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5311289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.8220046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.3512125929
MESH:D001836 Body Weight Changes 2-xylene 10.497457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.9715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.978888407
MESH:D001855 Bone Marrow Diseases Benzene 4.7416183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 17.5614601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 17.5614601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 17.5614601052
MESH:D001862 Bone Resorption bisphenol A 3.4411985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8517868700
MESH:D001930 Brain Injuries Progesterone 9.5015665606 15380490 15845082
MESH:D001930 Brain Injuries Zinc 9.5017109824
MESH:D001932 Brain Neoplasms Copper 7.8217079463
MESH:D001932 Brain Neoplasms Doxorubicin 7.8217150277
MESH:D001943 Breast Neoplasms Benzene 14.8711921183 17162533
MESH:D001943 Breast Neoplasms bexarotene 14.8716818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 14.8717123778
MESH:D001943 Breast Neoplasms Calcitriol 14.8711237771
MESH:D001943 Breast Neoplasms Cisplatin 14.8719526202 18382427
MESH:D001943 Breast Neoplasms Copper 14.8715986119 17079463
MESH:D001943 Breast Neoplasms Diethylnitrosamine 14.8717474063
MESH:D001943 Breast Neoplasms Doxorubicin 14.8715136595 15567936 15668708 16115903 16096432 17426702 18628466 15634643 19526202 15993339 16826403 17369602 15692762 16935488 16595493 16264153 11325840 18695136 15939500 16322301 15994142 17983394 18382427 18234424
MESH:D001943 Breast Neoplasms Etoposide 14.8716322251
MESH:D001943 Breast Neoplasms Fluorouracil 14.8715136595 18608205 16595493 19217205 16110121 16557594 18357371
MESH:D001943 Breast Neoplasms Genistein 14.8716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylene Chloride 14.8715986119
MESH:D001943 Breast Neoplasms Nickel 14.8715986119
MESH:D001943 Breast Neoplasms Progesterone 14.8715562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 14.8720435547
MESH:D001943 Breast Neoplasms Trichloroethylene 14.8715986119
MESH:D002276 Carcinoid Tumor Doxorubicin 10.7316051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.7316051944
MESH:D002277 Carcinoma Fluorouracil 6.9317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 12.607296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 12.6017982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 12.6020935162 18978308 16779866 19171122 11831363 17173139 20512989 20214788 21159647 16878318 17761372 19539802 19335982 19919837 19418558 20727157 16807293 16935385 20084675 19383236 3581430 20514400 18665156 17055752 18210153 17162532 10737359 19701751 20524982 20101231 3084413 16830150 18056438 16288022 18691550 16569478 16681979 16328049 18785209 19107877 17428255 19208518 20007298 17138121 20432363 16698587 19394651 16502159 19822196 18506893 18971187 18788625 19519916 17978847 19052882 18494052 10672840 16540662 18393292
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 12.6016234567 16023760 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 12.6016332177 16799960 17045692 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 12.6016924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.6016507464 17306315 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.5117123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.2516247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.2516685392 12023789
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 13.447296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 13.4416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 13.4418695887
MESH:D002292 Carcinoma, Renal Cell Vincristine 13.4416201981
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 19.5111237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 19.5117066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 19.516189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 19.5116757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 19.5118572023
MESH:D002294 Carcinoma, Squamous Cell Vincristine 19.516189445
MESH:D002294 Carcinoma, Squamous Cell Zinc 19.5116543248
MESH:D006332 Cardiomegaly Copper 6.1317327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1316120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.2118627295 17329180 17974986 17131338 17382496 17519947 15792986 15476868 16242529 16455267 17924179 16731534 16952015 16109756 16612575 16269455 16278810 17007740 15811867 16364871 16651473 15505089 17351982 17308081 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7717334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 10.3416332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.3416936243
MESH:D002318 Cardiovascular Diseases Zinc 10.3416936243
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 13.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.2712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.2717174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.2719524636 20056578
MESH:D002547 Cerebral Palsy Toluene 5.379294310
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5220734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.2919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 16.2919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.2916105132 11677210 17333356 15861022 17681005 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 16.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8916354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 3.5017018589 17725105 18772588 16510598 17169374 15001691 17016597 17172411 16340194 17287894
MESH:D003110 Colonic Neoplasms Genistein 3.5017182828
MESH:D015179 Colorectal Neoplasms Cisplatin 3.2415273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.2418802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2417401013 14970324 16524972 16303861 20501625 17255274 18802399 18288408 18448328 17594712 15148649 17016601 16282729 18383874 17695437 15289873 16331619 18949393 18509181 16391804 17094418 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6617141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 6.6415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.6415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 6.649294310
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.6416575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Zinc 6.6419302082
MESH:D007562 Creutzfeldt-Jakob Syndrome marker/mechanism
MESH:D007644 Darier Disease Fluorouracil 4.3116733453
MESH:D003643 Death Toluene 5.186431079
MESH:D003872 Dermatitis Benzene 4.3015902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.748156756 11298694 12868966 8970840 11906362 14531868 2524372 18759878
MESH:D017449 Dermatitis, Allergic Contact Nickel 5.7417244072 19470301 17100760
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 8.082952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 8.082952479
MESH:D003920 Diabetes Mellitus Zinc 3.8016479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.2816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2817107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.0317187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.128291058 1440618 18648102 9328219 18289764 18692083 11289319 9022650 7440962 6482804 16192314 9653073 6679447
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.1219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.1217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.1220420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 16.1217522070
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 16.127120509
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 16.1219641884 1733752
MESH:D004362 Drug Toxicity Cisplatin 11.7119839026 12649298 12231392 15033597
MESH:D004362 Drug Toxicity Doxorubicin 11.7118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 11.7111462148
MESH:D004421 Dystonia Valproic Acid 3.611851702
MESH:D004487 Edema pirinixic acid 5.1612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.1611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 12.7615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.7612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.7617692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.1116402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.6117359293
MESH:D016889 Endometrial Neoplasms Genistein 6.6111473722
MESH:D004715 Endometriosis Progesterone 7.5616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.5610568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6718037988
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9215328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.693659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.4316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.6818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.197562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.593659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 12.283581430
MESH:D004938 Esophageal Neoplasms Cisplatin 12.2815173087 16785472 16481741 17638652 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.2816337965 16481741 16785472 17638652 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.2815547721 15150132 15264214 16704527 15547733 15878914 16510608 16805852 15623463
MESH:D004938 Esophageal Neoplasms Zinc 12.2816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005234 Fatty Liver Cyclosporine 25.2119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 25.2121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2115345470
MESH:D005234 Fatty Liver pirinixic acid 25.2119236843 20131406
MESH:D005234 Fatty Liver Tetracycline 25.2119224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 25.2119224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.6818558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.6011852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.536705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1119069698
MESH:D005355 Fibrosis Cyclosporine 6.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.9520067830
MESH:D005756 Gastritis Zinc 4.3117241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2016452187
MESH:D016098 Gerstmann-Straussler-Scheinker Disease marker/mechanism 10203975
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.748708960
MESH:D005909 Glioblastoma Doxorubicin 6.2717150277
MESH:D005909 Glioblastoma Genistein 6.2716598420
MESH:D005910 Glioma Fluorouracil 2.6716145905
MESH:D005911 Gliosis Paraquat 4.6811124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.607505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1110696789
MESH:D006130 Growth Disorders Zinc 3.6517217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 11.1415464296 15102660
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.1415692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.1418337622 15102660 15162350
MESH:D034381 Hearing Loss Cisplatin 3.9019898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0315464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0710048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.1516330681 16144979 16707910 16244371 16495754 16879835 18674790 14766674 16244372 17875725 17888722 12587719 18006777
MESH:D006333 Heart Failure Doxorubicin 10.1117481944
MESH:D006333 Heart Failure pirinixic acid 10.1120558911
MESH:D006333 Heart Failure Zinc 10.1117162251
MESH:D006335 Heart Injuries Zinc 5.2817074742
MESH:D016481 Helicobacter Infections Zinc 4.0917241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4815692506
MESH:D006402 Hematologic Diseases Benzene 4.2116183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9415720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.066705139
MESH:D006521 Hepatitis, Chronic Copper 4.7917338147
MESH:D006527 Hepatolenticular Degeneration marker/mechanism 16831968
MESH:D006527 Hepatolenticular Degeneration Copper 9.8317109627 17182432 17276780 19888908 16607473
MESH:D006527 Hepatolenticular Degeneration Zinc 9.8317276780
MESH:D006529 Hepatomegaly 2-xylene 11.917457028 7457013
MESH:D006529 Hepatomegaly pirinixic acid 11.9116221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.9115340226 16120746 12621046
MESH:D006561 Herpes Simplex Etoposide 4.0910809021
MESH:D015658 HIV Infections Nickel 3.5617263646
MESH:D006689 Hodgkin Disease Cisplatin 18.7416200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 18.7418501091 15147373 17606976
MESH:D006689 Hodgkin Disease Etoposide 18.7417606976 16135485 16200630 15147373 18180244
MESH:D006689 Hodgkin Disease sodium arsenite 18.7412676792
MESH:D006689 Hodgkin Disease Vincristine 18.7415147373 16794504 17606976 16135485
OMIM:603218 HUNTINGTON DISEASE-LIKE 1 marker/mechanism
MESH:D006849 Hydrocephalus Valproic Acid 4.3917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5615340226 16959395 16354765 8697196 18606429
MESH:D006943 Hyperglycemia pirinixic acid 2.7720558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4715034207
MESH:D006973 Hypertension Benzene 7.4317940673
MESH:D006973 Hypertension Cyclosporine 7.4310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.4318670907 18850075
MESH:D006976 Hypertension, Pulmonary Copper Sulfate 4.737265320
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.3517937319
MESH:D007248 Infertility, Male Paraquat 9.354850670
MESH:D007248 Infertility, Male sodium arsenite 9.3512646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 13.0718785209
MESH:D007249 Inflammation Lipopolysaccharides 13.0712878042 9205823 17237260 17963957 17255318
MESH:D007249 Inflammation Nickel 13.0716166738
MESH:D007249 Inflammation Progesterone 13.0715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.0712200463 12878042
MESH:D034062 Insomnia, Fatal Familial marker/mechanism
MESH:D007333 Insulin Resistance bisphenol A 6.2516393666
MESH:D007333 Insulin Resistance pirinixic acid 6.2516306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1917255318
MESH:D007511 Ischemia Zinc 4.1716584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.539022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9515604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.6515464296
MESH:D007674 Kidney Diseases Cadmium Chloride 20.1416962696
MESH:D007674 Kidney Diseases Cisplatin 20.1412649298 12231392 19839026 18289764 15190930
MESH:D007674 Kidney Diseases Cyclosporine 20.148314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 20.1415699352 16775033 15369732
MESH:D007674 Kidney Diseases sodium arsenite 20.1420008137
MESH:D007674 Kidney Diseases Zinc 20.1416960431
MESH:D007676 Kidney Failure, Chronic Copper 20.3916518626
MESH:D007676 Kidney Failure, Chronic Doxorubicin 20.3916707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 20.3916518626
MESH:D007676 Kidney Failure, Chronic Zinc 20.3916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.176582329
MESH:D007680 Kidney Neoplasms Cyclosporine 10.1712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 10.1716985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3111231351
MESH:D007859 Learning Disorders Copper 4.3317134702
MESH:D007938 Leukemia Benzene 5.7918335105 15935818 14694614 17119257
MESH:D007938 Leukemia Genistein 5.7917468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6716085563
MESH:D007951 Leukemia, Myeloid Benzene 3.8917506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.7619478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7616294345 17596541
MESH:D007970 Leukopenia Lipopolysaccharides 4.2215821434
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.5518407596 18522880 20032147 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.899327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.9516439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.9517823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.9512878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.9515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.9512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 1.9817034775
MESH:D008113 Liver Neoplasms Copper 18.7820302851
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.7819427195 12112319 20492335 21167192 2862719 19690152 21071580 19426721 19073162 19294768 19642983 20137499 2422723 19638242 18644402 12771043 9163691 20583210 19551842 19255062 20118626 19499222 20405173 19254457 20452335 18648771 18978307 19996281 20434301 15175105 20501860 18977376 18754104 15885732 19850985 20101389 19256749 21278145 19833225 16942905 21047994 10737359 19090486 19812893
MESH:D008113 Liver Neoplasms Fluorouracil 18.7817045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Mitomycin 18.7815113037
MESH:D008113 Liver Neoplasms pirinixic acid 18.7815890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 18.7816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.7816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.386587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Benzene 19.3812562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.3819009564 18253720 21159647 18775883 18282651 18164116 18308698 17942915 16267830 18093689 19539802 18544905 16842330 17854601 18079962 17174075 9362446 19126423 19004024 19519916 2563599 3124819
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.3816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.3812151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 19.387955063
MESH:D008171 Lung Diseases sodium arsenite 2.8519095001
MESH:D017563 Lung Diseases, Interstitial Benzene 9.7714698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.7717228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.5521114838
MESH:D008175 Lung Neoplasms Benzene 16.2712562636
MESH:D008175 Lung Neoplasms bexarotene 16.2717849452
MESH:D008175 Lung Neoplasms Cisplatin 16.2711798837 17225452 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 16.2721163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 16.2717418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 16.2715246190
MESH:D008175 Lung Neoplasms Methylene Chloride 16.2715172992
MESH:D008175 Lung Neoplasms sodium arsenite 16.2719931552 17077188 16712894 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.2719555203 11884234
MESH:D008175 Lung Neoplasms Vincristine 16.2719825857 6189445
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3115086387
MESH:D008223 Lymphoma Benzene 10.7417584886 17119257
MESH:D008223 Lymphoma Doxorubicin 10.7416098063
MESH:D008223 Lymphoma Etoposide 10.7412854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4017654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1015621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6811161223
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.9712562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 19.4911921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 19.4919196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 19.4915458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 19.4914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 19.4917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Zinc 19.4912773700
MESH:D008545 Melanoma Cisplatin 4.6218332650 12374674 17761969 16809738 18505091 18176117 16248763 15577323 11135225 12393984 16432458 17023156 12883367
MESH:D008545 Melanoma Doxorubicin 4.6216827129
MESH:D008545 Melanoma sodium arsenite 4.6219082730 16487513
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.5115990972
MESH:D018328 Melanoma, Amelanotic Vincristine 10.5115990972
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.4017109627 17268249
MESH:D008607 Mental Retardation Toluene 3.479294310
MESH:D008654 Mesothelioma Cisplatin 5.7617638057
MESH:D008654 Mesothelioma Doxorubicin 5.7617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3016801185
MESH:D008881 Migraine Disorders Valproic Acid 2.8518765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0715792986
MESH:D019957 Motor Skills Disorders Toluene 4.799294310
MESH:D009062 Mouth Neoplasms Fluorouracil 3.2716757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.3117415656
MESH:D009101 Multiple Myeloma Benzene 3.3217119195
MESH:D009135 Muscular Diseases pirinixic acid 3.0416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.608888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8717596541
MESH:D009203 Myocardial Infarction Doxorubicin 11.8215857846 19429709
MESH:D009203 Myocardial Infarction Genistein 11.8217141266
MESH:D009203 Myocardial Infarction pirinixic acid 11.8219151258
MESH:D009203 Myocardial Infarction Vincristine 11.8217284715
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6412213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.1717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.1716411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.283581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.283581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.2818259882
MESH:D009369 Neoplasms Cisplatin 13.0616773208
MESH:D009369 Neoplasms Fluorouracil 13.0618239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 13.0617405874
MESH:D009369 Neoplasms sodium arsenite 13.0611559025
MESH:D009369 Neoplasms Trichloroethylene 13.0611911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2120056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3019196722
MESH:D009389 Neovascularization, Pathologic Copper 4.4717308104
MESH:D009395 Nephritis, Interstitial Cisplatin 9.2315464296
MESH:D009395 Nephritis, Interstitial Tetracycline 9.239884423
MESH:D009401 Nephrosis Doxorubicin 4.3016899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.9619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.9615640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 3.3516893418
MESH:D009421 Nervous System Malformations bisphenol A 13.7911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 13.7916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.7914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.736679447
MESH:D009436 Neural Tube Defects Benzene 14.7315643154
MESH:D009436 Neural Tube Defects sodium arsenite 14.7312854658
MESH:D009436 Neural Tube Defects Valproic Acid 14.738888407 16359493
MESH:D009447 Neuroblastoma Cisplatin 6.278761367
MESH:D009447 Neuroblastoma Doxorubicin 6.2715555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 2.9620387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.248761367
MESH:D017599 Neuroectodermal Tumors Vincristine 10.2412837982
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1116436463
MESH:D009765 Obesity pirinixic acid 1.6920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.796482804 4026338
MESH:D009784 Occupational Diseases Benzene 7.7915913788 17479406 15612468 15935809 16737584 15576619 17119257 17178637 15727169
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.533988306
MESH:D010024 Osteoporosis Genistein 2.9519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6516169203
MESH:D012516 Osteosarcoma Doxorubicin 3.7315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5111985600
MESH:D010051 Ovarian Neoplasms Benzene 13.1512562636
MESH:D010051 Ovarian Neoplasms Cisplatin 13.1519769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms Genistein 13.1519005980
MESH:D010051 Ovarian Neoplasms Progesterone 13.1516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.1517306315 15276417
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.2919003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.2916540662
MESH:D010190 Pancreatic Neoplasms Etoposide 14.2919003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.2919003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Mitomycin 14.2915113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.787296757
MESH:D010212 Papilloma Hydrogen Peroxide 7.7812065085
MESH:D010300 Parkinson Disease Paraquat 2.6315451049 15824117 12911755 11445065 16510128 11124998 11181820 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9716190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.9511026799
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.8615464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.986228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6717983394
MESH:D010997 Pleural Neoplasms Cisplatin 12.3217638057
MESH:D010997 Pleural Neoplasms Doxorubicin 12.3217638057
MESH:D011014 Pneumonia Lipopolysaccharides 9.5411605937 12224865
MESH:D011014 Pneumonia Paraquat 9.5412504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1118163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.6112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.612563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.3421297632
MESH:D011225 Pre-Eclampsia Zinc 3.8117114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.4910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.4911118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 13.4920603192
MESH:D017096 Prion Diseases marker/mechanism 17257012 17274528
MESH:D017096 Prion Diseases Tetracycline 4.9410903871
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7820887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms AGN 194204 3.9216000583
MESH:D011471 Prostatic Neoplasms bisphenol A 3.9216740699
MESH:D011471 Prostatic Neoplasms Calcitriol 3.9216644109 16289102 15754350 18247401 12479363
MESH:D011471 Prostatic Neoplasms Copper 3.9217308104 17079463
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.9215749863 15897917 16888761 16729912 16868541 18437689
MESH:D011471 Prostatic Neoplasms Etoposide 3.9217172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.9219082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 3.9215378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.9216205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.9216039940
MESH:D011471 Prostatic Neoplasms Zinc 3.9212429649 16606632 16517595 16700911
MESH:D011537 Pruritus Ethinyl Estradiol 2.8416919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.0612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0516882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3110548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7216324872 17997886
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6116160472 18722050 15538739 18286688
MESH:D051437 Renal Insufficiency Cisplatin 8.8315464296
MESH:D051437 Renal Insufficiency Doxorubicin 8.8317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.1419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.4711700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4110835634
MESH:D012135 Respiratory Sounds Paraquat 3.5911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 12.903692021
MESH:D012162 Retinal Degeneration Paraquat 12.9016458197
MESH:D012162 Retinal Degeneration Zinc 12.9016584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7319155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6718045962
MESH:D012509 Sarcoma Doxorubicin 3.5817203757 16767912 17710206 15625365 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Cisplatin 14.7714601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 14.7716326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 14.7714601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3117846226
MESH:D012559 Schizophrenia Copper 3.6616842975
MESH:D012559 Schizophrenia Valproic Acid 3.6615737665 19110320
MESH:D012640 Seizures Toluene 5.299294310 6431079
MESH:D012640 Seizures Valproic Acid 5.2914763951 3137016 16876388 11044598 17978042 1511512 15475178 11738929
MESH:D012878 Skin Neoplasms Doxorubicin 15.3515692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.3512065085
MESH:D012878 Skin Neoplasms sodium arsenite 15.3518572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.358532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.3516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.8615464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1017203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8015862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 8.3212854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.3219490988
OMIM:606688 SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES marker/mechanism
MESH:D013226 Status Epilepticus Valproic Acid 4.0612833885
MESH:D013274 Stomach Neoplasms Benzene 5.7712562636
MESH:D013274 Stomach Neoplasms Cisplatin 5.7717522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.7718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 5.7716951190 19084572 19015929 15786421 17522103 18567086 18396642 17498489 16424979 17172411
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 5.7712958204 17575124
MESH:D019966 Substance-Related Disorders bisphenol A 3.5116045194 16684133
MESH:D015173 Supratentorial Neoplasms Vincristine 5.4012837982
MESH:D013733 Testicular Diseases Toluene 4.4810048760 10514026
MESH:D013736 Testicular Neoplasms Cisplatin 4.1917225452 15464296
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7515669648
MESH:D013953 Thymus Neoplasms Benzene 4.4810850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 9.896582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.897505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.8916010429 17909728
MESH:D014062 Tongue Neoplasms Fluorouracil 8.6816280240
MESH:D014062 Tongue Neoplasms Zinc 8.6816543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.043119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.258074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 10.2512973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.2517653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.2517306315 16712894 16452187 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.188888407
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.5416803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.5416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.5411813266
MESH:D014591 Uterine Diseases bisphenol A 4.5214652134
MESH:D014594 Uterine Neoplasms Benzene 8.0712562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.0714692618
MESH:D014605 Uveitis Cyclosporine 3.501336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.1515577323
MESH:D014652 Vascular Diseases sodium arsenite 3.9517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.7617334414 16364871 17678736 17638931
MESH:D014839 Vomiting Cisplatin 4.2311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7615886252
MESH:D014985 Xerophthalmia Cyclosporine 3.9517120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:00480 Glutathione metabolism
KEGG:01100 Metabolic pathways
KEGG:05020 Prion diseases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33796
    • No data
    Releated disease ID Related disease Name
    PA446850Blindness, Cortical
    PA443970Dystonia
    PA445021Myoclonus
    PA446858Neurodegenerative Diseases
    PA165110266Posterior Cortical Atrophy
    PA443450Asthma
    PA444647Creutzfeldt-Jakob Syndrome
    PA444647Creutzfeldt-Jakob Syndrome
    PA444699Kuru
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00759 antagonist P Onytricin P Anti-Bacterial Agents;Antiprotozoals;Tetracyclines;Protein Synthesis Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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