AutismKB 2.0

Annotation Detail for PROC


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Basic Information Top
Gene Symbol:PROC ( APC,PC,PROC1 )
Gene Full Name: protein C (inactivator of coagulation factors Va and VIIIa)
Band: 2q14.3
Quick LinksEntrez ID:5624; OMIM: 612283; Uniprot ID:PROC_HUMAN; ENSEMBL ID: ENSG00000115718; HGNC ID: 9451
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Metabolism of proteins
Hemostasis
No data
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500303Common Pathway
500305Cell surface interactions at the vascular wall
500540Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
500541Gamma-carboxylation of protein precursors
500542Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi appar
500543Removal of aminoterminal propeptides from gamma-carboxylated proteins
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
No data
Desease Name
Venous Thrombosis
CARDIOVASCULAR
Multiple Organ Failure
circulating protein C levels and thrombotic risk
plasma protein C levels and thrombotic risk
PHARMACOGENOMIC
warfarin sensitivity
Hereditary protein C deficiency
sepsis
METABOLIC
Desease Name
Plasma levels of Protein C
Desease Name
Thrombophilia due to protein C deficiency, autosomal recessive
Thrombophilia due to protein C deficiency, autosomal dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PROC mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PROC proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of PROC mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PROC mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of PROC mRNAaffects expression 19483382
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PROC mRNAaffects cotreatment|decreases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PROC mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PROC mRNAincreases expression 20504355
D002994 Clofibrate Clofibrate affects the expression of PROC mRNAaffects expression 19483382
D003276 Contraceptives, Oral Contraceptives, Oral results in decreased expression of PROCdecreases expression 15185533
C034528 CycloProvera CycloProvera results in decreased expression of PROC proteindecreases expression 14561536
D016572 Cyclosporine Cyclosporine affects the expression of PROC mRNAaffects expression 20106945
C023635 dienogest [Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC proteinaffects cotreatment|increases activity 15288212
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of PROC mRNAdecreases expression 19638242
D004317 Doxorubicin Doxorubicin affects the metabolism of PROC proteinaffects metabolic processing 17172434
C418365 estradiol, norethindrone drug combination estradiol, norethindrone drug combination results in decreased expression of PROC proteindecreases expression 14561536
C454300 estradiol valerate-dienogest [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased activity of PROC proteinaffects cotreatment|increases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC proteinaffects binding|increases expression 14561536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC proteinaffects cotreatment|increases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased activity of PROC proteinaffects cotreatment|increases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC proteinaffects cotreatment|affects expression 11720199
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC proteinaffects cotreatment|increases activity 11994571
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROCaffects cotreatment|increases expression 15669648
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC proteinaffects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PROC proteinaffects cotreatment|increases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PROC proteinaffects cotreatment|increases expression 14551147
12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PROC proteinaffects cotreatment|increases expression 12618251
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in decreased expression of PROC proteindecreases expression 15318540
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased activity of PROC proteinincreases activity 11994571
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of PROC proteinincreases expression 14551147
12618251
10928463
D005001 Ethionine Ethionine affects the expression of PROC mRNAaffects expression 19483382
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC proteinaffects cotreatment|affects expression 11720199
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC proteinaffects cotreatment|increases activity 11994571
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROCaffects cotreatment|increases expression 15669648
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC proteinaffects cotreatment|increases expression 12618251
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PROC mRNAaffects cotreatment|decreases expression 17905399
D009640 Norethindrone [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC proteinaffects binding|increases expression 14561536
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PROC proteinaffects cotreatment|increases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PROC proteinaffects cotreatment|increases activity 15288212
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PROC proteinaffects cotreatment|increases expression 14551147
12618251
D009853 Omeprazole Omeprazole affects the expression of PROC mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in decreased expression of PROC mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PROC mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid affects the expression of PROC mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of PROC mRNAaffects expression 19483382
D020849 Raloxifene Raloxifene results in decreased activity of PROC proteindecreases activity 16359964
D013629 Tamoxifen Tamoxifen results in decreased expression of PROC proteindecreases expression 15850603
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PROC mRNAincreases expression 15644576
D013853 Thioacetamide Thioacetamide affects the expression of PROC mRNAaffects expression 19483382
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PROC mRNAaffects cotreatment|decreases expression 17905399
D014859 Warfarin PROC gene polymorphism affects the susceptibility to Warfarinaffects response to substance 17048007
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5311752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.2117505938
MESH:D000152 Acne Vulgaris norgestimate 11.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5420127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 6.5417418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5414692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.006695378
MESH:D000236 Adenoma Diethylnitrosamine 6.006695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.3917620307 16434500 19061943 17162532 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.3916835633
MESH:D000419 Albuminuria Doxorubicin 10.4321441931
MESH:D000419 Albuminuria Raloxifene 10.4317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4715800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000741 Anemia, Aplastic Benzene 4.1217661222 14761424 11369114
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5218218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001167 Arteritis marker/mechanism 17139375
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.6619698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.5419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.5419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.5419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.5419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.5419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.5419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 52.5412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.5419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9016183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3714601052
MESH:D001930 Brain Injuries Raloxifene 4.1616580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.5317150277
MESH:D001943 Breast Neoplasms Benzene 4.4411921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.4420146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.4417474063
MESH:D001943 Breast Neoplasms Doxorubicin 4.4415993339 17369602 18628466 16322301 15994142 19526202 16096432 18382427 15634643 15668708 16595493 16115903 15136595 17426702 18695136 15567936 15939500 11325840 16826403 16935488 15692762 18234424 16264153 17983394
MESH:D001943 Breast Neoplasms Raloxifene 4.4417242785 15775269 16912660 17440819 15758505 17049068 15572757 17261762 17893378 17952589 16837676 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 4.4419084267 18997820 17893378 16202921 19221464 18629630 11161223 18984771 20544844 19066611 17049068 17261762 19011961 20065188 18815881 19244106 20135344 20390343 17440819 18425577 18855134 19289846 19487384 20859285 19115204 18821012 19189212 19288272 21138602 21152245 19410462 19059307 18351453 19200415 15565566 20005174 19189210 19103187 15668708 16818667 19155303 17242785 16873071 19142967 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4420435547
MESH:D001943 Breast Neoplasms Trichloroethylene 4.4415986119
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.1816705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.1812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.181701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.1818393292 17162532 20084675 18788625 18506893 16698587 17173139 16779866 19171122 20432363 20214788 10672840 20524982 19107877 19208518 21159647 16569478 16540662 20727157 17055752 16807293 19919837 19519916 18971187 16288022 19418558 17978847 20007298 19701751 16830150 18210153 18056438 3084413 10737359 17761372 20935162 19539802 18691550 17138121 20512989 16502159 17428255 16328049 18494052 18785209 3581430 19052882 19335982 11831363 18665156 16935385 16681979 19394651 19383236 20514400 19822196 18978308 16878318 20101231
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.1818059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.1816924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.1817997003
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0116201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.366189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.5717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3216455267 17131338 17329180 17382496 16952015 16731534 15792986 17974986 17007740 16109756 17928571 18627295 15811867 17924179 16612575 16651473 16242529 15505089 15476868 16269455 16278810 16364871 17308081 17519947 17351982
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.5915710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.5916243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2215775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.216135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.211399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.2112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.2117174075 21159647 2727394 7505956
MESH:D002543 Cerebral Hemorrhage Warfarin 5.5411061249
MESH:D002637 Chest Pain Omeprazole 4.7815447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.5516835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.5518291259
MESH:D002779 Cholestasis Cyclosporine 17.3419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.3416105132 17110522 17681005 15861022 16919318 11677210 17333356
MESH:D002779 Cholestasis Levonorgestrel 17.3415861022
MESH:D002779 Cholestasis pirinixic acid 17.3419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 12621046 16354765 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.3015800139
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D023903 Coronary Restenosis Warfarin 5.3712872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.5220579077 20497562
MESH:D019465 Craniofacial Abnormalities Benzene 2.5715643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5715322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8917474826
MESH:D003872 Dermatitis Benzene 4.4515902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 3.9518772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9317107852
MESH:D003928 Diabetic Nephropathies Raloxifene 13.6817308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6819279558
MESH:D003928 Diabetic Nephropathies Warfarin 13.6812644472
MESH:D004211 Disseminated Intravascular Coagulation marker/mechanism 18376272
MESH:D003875 Drug Eruptions Warfarin 5.6614723717
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 17.0818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.0819107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 17.0817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.0820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 17.0812963478
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 17.087120509
MESH:D004362 Drug Toxicity Doxorubicin 7.3218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0221218061 17151854 16613094 15991576
MESH:D050171 Dyslipidemias Clofibrate 3.8316707586
MESH:D004487 Edema pirinixic acid 9.7612083418
MESH:D004487 Edema Raloxifene 9.7615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.7611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.5612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.5615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.5619031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.8617359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.8620544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.749294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8318037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3916456712
MESH:D005234 Fatty Liver Amiodarone 38.2614986274
MESH:D005234 Fatty Liver Clofibrate 38.2619224547
MESH:D005234 Fatty Liver Cyclosporine 38.2619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 38.2621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.2615345470
MESH:D005234 Fatty Liver pirinixic acid 38.2619236843 20131406
MESH:D005234 Fatty Liver Raloxifene 38.2617473493
MESH:D005234 Fatty Liver Tamoxifen 38.2614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.3519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.3519069698
MESH:D005355 Fibrosis Cyclosporine 7.4312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4320067830
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.3811794436
MESH:D005776 Gaucher Disease Warfarin 5.6512359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.898708960
MESH:D005909 Glioblastoma Doxorubicin 3.1417150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3115692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8710048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 7.0916330681 16244372 17888722 18006777 12587719 14766674 16144979 16495754 16879835 17875725 16244371 16707910 18674790
MESH:D006331 Heart Diseases Raloxifene 7.0911110106
MESH:D006333 Heart Failure Doxorubicin 6.3817481944
MESH:D006333 Heart Failure pirinixic acid 6.3820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6115692506
MESH:D006402 Hematologic Diseases Benzene 4.3516183116
MESH:D006406 Hematoma Warfarin 6.3817493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 9.5411000095
MESH:D006470 Hemorrhage Warfarin 9.5418429757
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2818665440 15929193 17276928
MESH:D006505 Hepatitis Thioacetamide 3.9116456712
MESH:D006529 Hepatomegaly Amiodarone 12.5715265979
MESH:D006529 Hepatomegaly pirinixic acid 12.5719772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.5715340226 16120746 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.1417606976 15147373 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7118606429 15340226 16354765 8697196 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 3.589751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006973 Hypertension Benzene 11.3217940673
MESH:D006973 Hypertension Cyclosporine 11.3210903974
MESH:D006973 Hypertension Raloxifene 11.3215787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.3218670907 18850075
MESH:D006976 Hypertension, Pulmonary Warfarin 4.5812359135
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.5518020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.5518031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2717937319
MESH:D007249 Inflammation Diethylnitrosamine 7.2718785209
MESH:D007249 Inflammation Tamoxifen 7.2719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.2712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.488314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 5.4815699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8616707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.8616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.8612371664
MESH:D007680 Kidney Neoplasms Tamoxifen 10.8618625569
MESH:D007889 Leiomyoma Raloxifene 4.2016973256
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8419248655
MESH:D007938 Leukemia Benzene 3.2317119257 18335105 15935818 14694614
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8316085563
MESH:D007951 Leukemia, Myeloid Benzene 4.0317506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6419478238
MESH:D008064 Lipidoses Amiodarone 7.1517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.1515342952 17567588
MESH:D054068 Livedo Reticularis Warfarin 6.3818280355
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6520032147 18665156 18522880 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.2616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.2618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.2612175628 15316131 12557150 18032466 15716488 18380797 12531686 15078482 10677585 12679928 18458672 15474484 16511523 17292413 16097051 17127702 15334695 15288472 12085344 17355460 18615449 14739098 16489207 18295389 15465738 16343077 16098781 11172339 12891558 15095483 11481614 18263696 15362042 11682029 18395095 17629604 16248980 16126171 18606216 18416461 18031379 15288473 15158331 15075984 17050028
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0017034775
MESH:D008107 Liver Diseases Thioacetamide 4.0018374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.0312479984 15633222 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.917678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.9118177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.9121137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.9115175105 15885732 20137499 19073162 20452335 20434301 20492335 20583210 19426721 19996281 18648771 19255062 21278145 19256749 20101389 19850985 10737359 16942905 18644402 18978307 19294768 20118626 19812893 2422723 19638242 19833225 12771043 9163691 20405173 21047994 19254457 19090486 19690152 20501860 19499222 19551842 18754104 21071580 12112319 21167192 18977376 19642983 2862719 19427195
MESH:D008113 Liver Neoplasms pirinixic acid 19.9120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 19.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.9116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 25.156135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.158603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 25.1512562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.1518079962 19519916 18775883 18093689 18253720 17174075 18544905 19539802 18164116 18282651 17942915 2563599 19004024 17854601 3124819 21159647 16267830 18308698 19009564 9362446 16842330 19126423
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.1516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.1512151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 25.157955063
MESH:D008133 Long QT Syndrome Amiodarone 3.3317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.1612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.3618516814
MESH:D017563 Lung Diseases, Interstitial Benzene 10.3614698565
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.0014755239
MESH:D008175 Lung Neoplasms Benzene 10.0012562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0018816296 20064080 20464547 17053015 20135361 18520028 6695378 20869020 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0021163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Doxorubicin 10.006189445 17418594
MESH:D008175 Lung Neoplasms Tamoxifen 10.0018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0019555203 11884234
MESH:D008223 Lymphoma Benzene 7.0817119257 17584886
MESH:D008223 Lymphoma Doxorubicin 7.0816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2515621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 8.9912562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.9919428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 8.8811921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.8815458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.8816827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.2219453300
MESH:D008545 Melanoma Doxorubicin 3.2116827129
MESH:D008545 Melanoma Tamoxifen 3.2119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8615990972
MESH:D008654 Mesothelioma Doxorubicin 2.9317638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2115792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9416381670
MESH:D052016 Mucositis Doxorubicin 4.4617415656
MESH:D009101 Multiple Myeloma Benzene 6.8517119195
MESH:D009101 Multiple Myeloma Raloxifene 6.8516497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009181 Mycoses Amiodarone 4.5717974566 12754197
MESH:D009203 Myocardial Infarction Contraceptives, Oral 8.9811752354
MESH:D009203 Myocardial Infarction Doxorubicin 8.9815857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 8.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7016411023
MESH:D009232 Myxoma Raloxifene 5.2216343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.8818551238 7678174
MESH:D009336 Necrosis Warfarin 9.8814723717
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.749029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.7418259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.3911141357
MESH:D009369 Neoplasms pirinixic acid 7.3917405874
MESH:D009369 Neoplasms Trichloroethylene 7.3911911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6719189210 19196722 19200415
MESH:D009401 Nephrosis Doxorubicin 4.4516636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3918481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3916889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9114600291
MESH:D009436 Neural Tube Defects Benzene 3.4615643154
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7920387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.629802331
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.2316049721
MESH:D009784 Occupational Diseases Benzene 8.2317119257 17178637 15612468 17479406 15913788 16737584 15727169 15576619 15935809
MESH:D010024 Osteoporosis Levonorgestrel 7.1812665316
MESH:D010024 Osteoporosis Raloxifene 7.1815775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9317823083 15579764 17893378 15758505
MESH:D012516 Osteosarcoma Doxorubicin 3.8615930896
MESH:D010051 Ovarian Neoplasms Benzene 2.8712562636
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8317638057
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.3117105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.042563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8711222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1517292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1516888761 18437689 15749863 16868541 15897917 16729912
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1515731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1515067354
MESH:D020151 Protein C Deficiency marker/mechanism|therapeutic 18376272 14707701
MESH:D020151 Protein C Deficiency Warfarin 6.0218376272
MESH:D011537 Pruritus Ethinyl Estradiol 8.9215861022 16919318
MESH:D011537 Pruritus Levonorgestrel 8.9215861022
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011655 Pulmonary Embolism Warfarin 6.0219300499
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7311597910 12490602 12832656
MESH:D011693 Purpura Raloxifene 5.2215770314
MESH:D055665 Purpura Fulminans marker/mechanism 18376272
MESH:D051437 Renal Insufficiency Doxorubicin 3.9017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012509 Sarcoma Doxorubicin 3.7115625365 17710206 15675481 17203757 16767912 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4617846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3318551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.5512269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.5210029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 8.5215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5216192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2515625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4616709447
MESH:D013088 Spermatocele Tamoxifen 10.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7119457130
MESH:D013272 Stomach Diseases Omeprazole 4.2918545984
MESH:D013274 Stomach Neoplasms Benzene 3.2212562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.222093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2218456281
MESH:D013276 Stomach Ulcer Amiodarone 6.6318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.6316755016 18237397 11906479 15991576 10750652 17977527
MESH:D020521 Stroke Raloxifene 8.4016837676
MESH:D020521 Stroke Warfarin 8.4019300499
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8819225199
MESH:D013923 Thromboembolism Warfarin 5.8318698879 16960144
MESH:D019851 Thrombophilia Ethinyl Estradiol 23.6311994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 23.6311994571
MESH:D019851 Thrombophilia Gestodene 23.6311994571
MESH:D019851 Thrombophilia Warfarin 23.6317493413
OMIM:612304 THROMBOPHILIA, HEREDITARY, DUE TO PROTEIN C DEFICIENCY, AUTOSOMAL RECESSIVE marker/mechanism
MESH:D013927 Thrombosis marker/mechanism 18376272
MESH:D013927 Thrombosis Ethinyl Estradiol 13.9915669648
MESH:D013927 Thrombosis Gestodene 13.9915669648
MESH:D013927 Thrombosis Warfarin 13.9917672075 19300499 17245631 15720958 11518727 11307788
MESH:D013953 Thymus Neoplasms Benzene 4.6310850423
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.697505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.6917909728 16010429
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.6915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5419584973 18020914
MESH:D013978 Tibial Fractures Raloxifene 4.8819048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8717467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.3916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.3917053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.3917653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.3917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.3916712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9910091137
MESH:D014594 Uterine Neoplasms Benzene 8.5412562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5414692618
MESH:D014605 Uveitis Cyclosporine 3.651336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D014657 Vasculitis Warfarin 5.5520337814
MESH:D054556 Venous Thromboembolism Raloxifene 13.2216837676
MESH:D054556 Venous Thromboembolism Warfarin 13.2218776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 22.9415869587 14671159
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 22.9415869587
MESH:D020246 Venous Thrombosis Levonorgestrel 22.9415869587
MESH:D020246 Venous Thrombosis Warfarin 22.9415733061 14723717
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9017334414 17638931 16364871 17678736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1117120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33799
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA451906warfarin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00025 - Antihemophilic Factor Coagulants;Thrombotic Agents
    DB00170 activator Menadione Dietary supplement;Micronutrient;Antifibrinolytic Agents;Vitamins/minerals;Vitamins
    DB00464 inhibitor Sodium Tetradecyl Sulfate Surface-Active Agents;Sclerosing Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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