AutismKB 2.0

Annotation Detail for MRAP


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Basic Information Top
Gene Symbol:MRAP ( B27,C21orf61,FALP,FGD2,GCCD2 )
Gene Full Name: melanocortin 2 receptor accessory protein
Band: 21q22.11
Quick LinksEntrez ID:56246; OMIM: 609196; Uniprot ID:MRAP_HUMAN; ENSEMBL ID: ENSG00000170262; HGNC ID: 1304
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Glucocorticoid deficiency 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of MRAP mRNA]affects expression|affects reaction 19414516
D000082 Acetaminophen Acetaminophen affects the expression of MRAP mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in increased expression of MRAP mRNAincreases expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MRAP mRNAaffects expression 17484886
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNAaffects cotreatment|decreases expression 16931933
D004041 Dietary Fats Dietary Fats results in decreased expression of MRAP mRNAdecreases expression 18042831
D011345 Fenofibrate Fenofibrate results in increased expression of MRAP mRNAincreases expression 11798191
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNAaffects cotreatment|decreases expression 16931933
C041786 palm oil palm oil results in decreased expression of MRAP mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of MRAP mRNAincreases expression 18301758
18445702
D011374 Progesterone Progesterone affects the expression of MRAP mRNAaffects expression 17251523
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNAaffects cotreatment|decreases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.939612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3517306315
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 16251483 16835338 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D050197 Atherosclerosis Arsenic 3.2912928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2319483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615845082 15665606 15380490
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D001943 Breast Neoplasms Progesterone 2.2515562024 17614352 16175315
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815721981 18705752 15700767 16124888 15673190 16011737 16227642 10355542 16050911 3786805 16192424 16097048
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.6517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6518788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7118922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1518640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5015738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.3816973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8110915739 19420014 11287661 18713872 16081117 12153990 19739265 16485898 11461765 19370779 16781746 12392966 12705907 15619225 16109766 17522070 17906064 11421492 19085960 14550746 11834606 11739529 16177239 10663392 14986274 12540782 19416960 11529661 16227642 10774834 12958197 16393943 18071297 19164858 14725611 2444490 15968718 19923254 11743745 17562736 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8116227642 6884620 19085960 7179309 9327722 3786805 15968718 15027814 2869522 7120509 16177239 6623471 10915739 10092053 4309450 3732212 7440962 21278145 17522070 19336974 15998439 11566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Lamivudine 8.9915040536
MESH:D004362 Drug Toxicity Zidovudine 8.9915040536
MESH:D050171 Dyslipidemias Dietary Fats 9.1518367378
MESH:D050171 Dyslipidemias Fenofibrate 9.1516707586
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8717692515
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.1416569247
MESH:D004715 Endometriosis Progesterone 3.8416134523
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.5112631006 15959796 16239168 16045604 61145 12795759 19224547 17595544
MESH:D005234 Fatty Liver Dietary Fats 19.5118296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 19.5120131406 19236843
MESH:D005234 Fatty Liver Zidovudine 19.5118299183
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1618705752
MESH:D005355 Fibrosis Dietary Fats 9.1618296743
MESH:D005534 Foot Diseases Arsenic 5.696392382
MESH:D005756 Gastritis Acetaminophen 3.8116983495
OMIM:607398 GLUCOCORTICOID DEFICIENCY 2 marker/mechanism
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006402 Hematologic Diseases Zidovudine 4.8012579204
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919110552 19900420
MESH:D006509 Hepatitis B Lamivudine 5.1817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1815274664 15309715 15631357 12044531 16476009
MESH:D006529 Hepatomegaly pirinixic acid 3.1016221962 19176532 19772884 18467677
MESH:D015658 HIV Infections Indinavir 15.8611363243 15388451 11141242
MESH:D015658 HIV Infections Lamivudine 15.8620032539 11141242 17530837 9296927
MESH:D015658 HIV Infections Saquinavir 15.8611141242 15388451
MESH:D015658 HIV Infections Zidovudine 15.8611698656 11363243 17358032 11141242 20032539
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5317050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Arsenic 2.9016076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D006987 Hypesthesia Arsenic 5.6916093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007249 Inflammation Dietary Fats 5.3220412841
MESH:D007249 Inflammation Progesterone 5.3215869954
MESH:D007333 Insulin Resistance Dietary Fats 7.4218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007642 Keratosis Arsenic 5.1116930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D007680 Kidney Neoplasms Zidovudine 3.8512579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4920370541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6017339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7711408273 21278145 16943688 17334410 17174718 17157831 16239168 11903743 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6417805973 17922224 18395914 14512876 18317297 18210741 17944888 16011737 18429990 15673190 18187930 14716496 15362042 17714472 16116963 15959796 18705752 16015684 15057751 17869086 12667390 18006644 17721639 17823541 16192424 12445418 12632512 18472332 17631135 15931870 18279442 14748882 16027843 15730626 15338365 12666154 18339082 18251166 10355542 12632514 15876570 16136751 15123356 16248980 17766677 12389079 20821823 18277467 18481824 17481882 18166357 15925388 11481614 17761835 14724832 16638106 18156304 18263696 12741479 12649538 16033810 18472094 18412020 15818738 18420326 15052691 12586293 17698563 16097048 15370692 14716833 18054572 17900296 12898905 18205269 12546737 12609069 17976157 18395095 18376398 13678700 14620537 18418968 17708605 17525996 17557913 15996030 15650968 12958196 15893842 17640975 17565644 12445421
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 3.6415474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6415474484
MESH:D008107 Liver Diseases Acetaminophen 6.6512587719 16611625 19460945 16610002 11587558 19784758 19014921 12969438
MESH:D008107 Liver Diseases Arsenic 6.6511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6515830285 16964402 17285989 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 11.0116368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0119294768
MESH:D008113 Liver Neoplasms Fenofibrate 11.0118978307
MESH:D008113 Liver Neoplasms pirinixic acid 11.0115890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 6.4918775883 18253720
MESH:D008175 Lung Neoplasms Arsenic 2.9019168569 17306315 17976673
MESH:D008175 Lung Neoplasms Zidovudine 2.9018800350
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9111408345 17203775
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9717358032
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009164 Mycobacterium Infections Indinavir 5.5521442799
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0515371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009436 Neural Tube Defects Arsenic 3.5016620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.4617056641
MESH:D009765 Obesity Dietary Fats 4.4920518802 21332399 11836018 19632207 20132043 18674790 16723640 17217161 18457598
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D010051 Ovarian Neoplasms Arsenic 5.1417306315
MESH:D010051 Ovarian Neoplasms Progesterone 5.1416525653 17393432
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1115371236 6392382 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 3.6016140617
MESH:D011507 Proteinuria Arsenic 4.0921343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012206 Rhabdomyolysis Lamivudine 5.659296927
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012871 Skin Diseases Arsenic 2.7617050553 18709164 17548696 16353154 19834688 17938729 17453740 6392382 15952646 16759981 16702368
MESH:D012878 Skin Neoplasms Arsenic 3.0417976673 15504454 17029826 19538983 16251483 17050553
MESH:D013119 Spinal Cord Injuries Progesterone 4.4015862959 16503802
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8419429237 11144890 18640142 15987713 17306315 17976673 19322015
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8612579204
MESH:D014652 Vascular Diseases Arsenic 4.8517056641
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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