AutismKB 2.0

Annotation Detail for PRODH


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Basic Information Top
Gene Symbol:PRODH ( FLJ33744,HSPOX2,MGC148078,MGC148079,PIG6,POX,PRODH1,PRODH2,SCZD4,TP53I6 )
Gene Full Name: proline dehydrogenase (oxidase) 1
Band: 22q11.21
Quick LinksEntrez ID:5625; OMIM: 606810; Uniprot ID:PROD_HUMAN; ENSEMBL ID: ENSG00000100033; HGNC ID: 9453
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
CITRULBIO-PWYcitrulline biosynthesis
PROUT-PWYproline degradation
PWY-5004superpathway of citrulline metabolism
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P00029Huntington disease
Pathway IDPathway Name
500951Proline catabolism
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
H00190Hyperprolinemia
Genetic disorders
No data
Desease Name
CATCH 22 syndrome
PSYCH
schizophrenia
No data
Desease Name
Schizophrenia, susceptibility to, 4
Hyperprolinemia, type I
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PRODH mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRODH mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of PRODH mRNAdecreases expression 20106945
D002945 Cisplatin PRODH protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in decreased expression of PRODH mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of PRODH mRNAdecreases expression 19371625
D016291 Dizocilpine Maleate PRODH protein affects the susceptibility to Dizocilpine Maleateaffects response to substance 16234811
D015735 Mifepristone Mifepristone results in decreased expression of PRODH mRNAdecreases expression 17584828
C041786 palm oil palm oil results in decreased expression of PRODH mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PRODH mRNAdecreases expression 17426115
C017947 sodium arsenite sodium arsenite results in increased expression of PRODH mRNAincreases expression 20339138
D018038 Sodium Selenite Sodium Selenite results in decreased expression of PRODH mRNAdecreases expression 16705456
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PRODH mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 11752688 15322242
MESH:D058186 Acute Kidney Injury Cisplatin 4.0412690470 17670903 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5920127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 4.5911798837 17638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0417306315 16712894
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0214601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3617474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 2.3619526202 18382427
MESH:D001943 Breast Neoplasms Dietary Fats 2.3620435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3615324884 17129689
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.7117982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.7116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7115276417 16507464 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0616685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7120419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.7117066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.7118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8412371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.8419524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15668235 15340226 12621046 8697196
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6516002989 12952375
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2919416960 15619225 17522070 12392966 18713872 11529661 11421492 14986274 15968718 12594235 19085960 12540782 17906064 16485898 11461765 17562736 16781746 19923254 14725611 19420014 12705907 19164858 11739529 2444490 19739265 16227642 11287661 16393943 11743745 12958197 18071297 16081117 16177239 14550746 10915739 16109766 10774834 11834606 10663392 19370779 12153990
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Cisplatin 8.3815033597 12649298 12231392 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5115700306 16804899
MESH:D004715 Endometriosis Mifepristone 9.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.419294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6716530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6715464296 16481741 15173087 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 13.5419224547
MESH:D005234 Fatty Liver Dietary Fats 13.5417967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver pirinixic acid 13.5419236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7016513791 16611131 16534752 16002989 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 15.3512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.2116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.2116452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7715464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 16120746 12621046
MESH:D006689 Hodgkin Disease Cisplatin 7.7916170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 7.7912676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5412960047 14722030
OMIM:239500 HYPERPROLINEMIA, TYPE I marker/mechanism
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.6816002989
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007248 Infertility, Male sodium arsenite 3.0415346721 12646999
MESH:D007249 Inflammation Dietary Fats 5.0520412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.6418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 12.6416306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.6414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2715464296
MESH:D007674 Kidney Diseases Acetaminophen 14.8212587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 14.8219839026 15190930 12649298 18289764 12231392
MESH:D007674 Kidney Diseases Cyclosporine 14.8210903974 18776723 8314463
MESH:D007674 Kidney Diseases sodium arsenite 14.8220008137
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.6815003126 14681315 16762066
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9311231351
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1617184923
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6516610002 16611625 12587719 12969438 19014921 19784758 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5521137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.5516712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 14.5515890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 14.5515276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9220464547 18520028 20135361 20869020 18569708 20064080 18816296 17053015 6695378
MESH:D008175 Lung Neoplasms Cisplatin 4.926189445 17225452 11798837
MESH:D008175 Lung Neoplasms sodium arsenite 4.9219931552 17077188 15276417 17306315 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9219555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5315700306
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D008545 Melanoma Cisplatin 3.5816432458 18332650 15577323 12883367 17023156 18176117 16809738 17761969 12393984 16248763 18505091 12374674 11135225
MESH:D008545 Melanoma sodium arsenite 3.5819082730 16487513
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Cisplatin 3.2717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009369 Neoplasms Benzo(a)pyrene 16.1611141357
MESH:D009369 Neoplasms Cisplatin 16.1616773208
MESH:D009369 Neoplasms Diethylstilbestrol 16.1615313581
MESH:D009369 Neoplasms pirinixic acid 16.1617405874
MESH:D009369 Neoplasms sodium arsenite 16.1611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6315464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.9611399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9614600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1912854658
MESH:D009447 Neuroblastoma Cisplatin 3.498761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.818761367
MESH:D009765 Obesity Dietary Fats 4.4921332399 17217161 19632207 18674790 11836018 16723640 18457598 20518802 20132043
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D010051 Ovarian Neoplasms Cisplatin 8.2119769630 15464296 6897625 17225452
MESH:D010051 Ovarian Neoplasms Mifepristone 8.2116525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.2115276417 17306315
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0219003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4015464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7715687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 5.4817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.9617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9611399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0815046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0818760546
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D051437 Renal Insufficiency Cisplatin 4.5115464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.5214601052
MESH:D012559 Schizophrenia marker/mechanism 16234811
MESH:D012640 Seizures Dizocilpine Maleate 4.5217157343 11218047 12660363
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6119755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.6119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6116192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4815464296
MESH:D013088 Spermatocele Diethylstilbestrol 4.8516709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5620155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 2.5618396642 15958060 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.7215464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.2217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 12.2212973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.2216712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.2216452187 17306315 11723127 16712894
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 16.4116803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 16.4116175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.4111813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1616690809 15809267
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014625 Vaginal Neoplasms Cisplatin 11.4315577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 11.4316002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014839 Vomiting Cisplatin 4.8511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33801
    • No data
    No data
    Releated drug ID Related drug Name
    PA451125l-proline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00172 - L-Proline Dietary supplement;Micronutrient;Non-Essential Amino Acids
    Drugbank ID Action Drug Name Description
    DB00172 - L-Proline Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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