AutismKB 2.0

Annotation Detail for CPXM1


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Basic Information Top
Gene Symbol:CPXM1 ( CPX1,CPXM )
Gene Full Name: carboxypeptidase X (M14 family), member 1
Band: 20p13
Quick LinksEntrez ID:56265; OMIM: 609555; Uniprot ID:CPXM1_HUMAN; ENSEMBL ID: ENSG00000088882; HGNC ID: 15771
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CPXM1 mRNAaffects expression 17562736
D004317 Doxorubicin Doxorubicin affects the expression of CPXM1 mRNAaffects expression 15205334
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CPXM1 mRNAdecreases expression 17557909
D005472 Fluorouracil Fluorouracil affects the expression of CPXM1 mRNAaffects expression 15205334
D011374 Progesterone Progesterone affects the expression of CPXM1 mRNAaffects expression 17251523
C017947 sodium arsenite sodium arsenite results in decreased expression of CPXM1 mRNAdecreases expression 18812580
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of CPXM1 mRNAaffects expression 16962184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Doxorubicin 7.4717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4714692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.4717638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3516712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D000740 Anemia Fluorouracil 9.5816511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.5811748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0016115903 18695136 15668708 16322301 17369602 15939500 16096432 15994142 18628466 16595493 15136595 16264153 19526202 15634643 11325840 15567936 16935488 18234424 15993339 17983394 16826403 18382427 17426702 15692762
MESH:D001943 Breast Neoplasms Fluorouracil 2.0015136595 18357371 16557594 18608205 16595493 16110121 19217205
MESH:D001943 Breast Neoplasms Progesterone 2.0015562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002276 Carcinoid Tumor Doxorubicin 13.8816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 13.8816051944
MESH:D002277 Carcinoma Fluorouracil 8.9417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.8916234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8916799960 16332177 18930000 17045692 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8916507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.0516201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 7.0518695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 8.016189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 8.0116280240 18986760 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 8.0118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017351982 17308081 16109756 17007740 15505089 16242529 16651473 16455267 16364871 15476868 17519947 17382496 17329180 16731534 17131338 17974986 18627295 17928571 16269455 17924179 15811867 16612575 16952015 16278810 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0217334414 16243910
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1719524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0711677210 17681005 15861022 16919318 16105132 17333356 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2716510598 17287894 15001691 17018589 18772588 16340194 17725105 17169374 17172411 17016597
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7014970324 18802399 15289873 16391804 17016601 15148649 18288408 16524972 17094418 16282729 16303861 17695437 17594712 17401013 17255274 20501625 18949393 18448328 18509181 16331619 17454858 18383874
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5816393943 19923254 19370779 11529661 17522070 11743745 17562736 11287661 15968718 18713872 16485898 10915739 10774834 15619225 12392966 12153990 11421492 19739265 16781746 11739529 16081117 19420014 19416960 14550746 11461765 10663392 18071297 2444490 16109766 12594235 19085960 17906064 14986274 12540782 12958197 19164858 16177239 12705907 11834606 16227642 14725611
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.5817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Doxorubicin 8.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.1517692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004715 Endometriosis Progesterone 9.8216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.829294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5015173087 16785472 16337965 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.5115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.5115162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6717888722 18006777 12587719 16879835 16144979 17875725 16244371 14766674 16330681 16495754 16244372 18674790 16707910
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 8.3117606976 15147373 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 8.3112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2317937319
MESH:D007248 Infertility, Male sodium arsenite 7.2312646999 15346721
MESH:D007249 Inflammation Progesterone 5.4115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 10.9615629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 10.9616775033 15369732 15699352
MESH:D007674 Kidney Diseases sodium arsenite 10.9620008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5416985049
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6819014921 19784758 12969438 12587719 19460945 11587558 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 7.9718383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 7.9716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9716984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.4517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms Doxorubicin 5.0817418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 5.0815246190
MESH:D008175 Lung Neoplasms sodium arsenite 5.0819931552 15276417 16712894 17077188 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7915458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7917203775 11408345
MESH:D008545 Melanoma Doxorubicin 3.5916827129
MESH:D008545 Melanoma sodium arsenite 3.5919082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8416757204 18986760
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0415857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009369 Neoplasms Fluorouracil 5.5918239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 5.5911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009401 Nephrosis Doxorubicin 5.1316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3112854658
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010051 Ovarian Neoplasms Progesterone 5.1916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1915276417 17306315
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7416929163 16500647 19003803 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6016729912 16888761 18437689 15749863 15897917 16868541
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6018626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6016039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2615538739 18722050 18286688 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012509 Sarcoma Doxorubicin 4.2517710206 18313854 17203757 15675481 15625365 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012878 Skin Neoplasms Doxorubicin 10.1515692506
MESH:D012878 Skin Neoplasms sodium arsenite 10.1519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9317203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.6816503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016424979 18567086 18396642 19084572 19015929 17498489 16951190 15786421 17172411 17522103
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5817909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.5717653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.5717306315 16712894 16452187 11723127
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.3816803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.3811813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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