AutismKB 2.0

Annotation Detail for PROS1


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Basic Information Top
Gene Symbol:PROS1 ( PROS,PS21,PS22,PS23,PS24,PS25,PSA )
Gene Full Name: protein S (alpha)
Band: 3q11.1
Quick LinksEntrez ID:5627; OMIM: 176880; Uniprot ID:PROS_HUMAN; ENSEMBL ID: ENSG00000184500; HGNC ID: 9456
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Metabolism of proteins
Hemostasis
No data
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500303Common Pathway
500540Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
500541Gamma-carboxylation of protein precursors
500542Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi appar
500543Removal of aminoterminal propeptides from gamma-carboxylated proteins
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
No data
Desease Name
free protein S (type IIa) deficiency
No data
Desease Name
Thrombophilia due to protein S deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PROS1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PROS1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PROS1 mRNAincreases expression 16788091
C430898 AGN 194204 AGN 194204 results in increased expression of PROS1 mRNAincreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PROS1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PROS1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PROS1 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PROS1 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of PROS1 mRNAdecreases expression 16239168
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNAaffects binding|decreases expression 20105288
D003276 Contraceptives, Oral Contraceptives, Oral results in decreased expression of PROS1decreases expression 15185533
D016572 Cyclosporine Cyclosporine results in decreased expression of PROS1 mRNAdecreases expression 20106945
D017135 Desogestrel Desogestrel affects the expression of PROS1 proteinaffects expression 11442481
D002945 Cisplatin PROS1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
C023635 dienogest [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 15288212
D004128 Dimethylnitrosamine Dimethylnitrosamine affects the expression of PROS1 mRNAaffects expression 16995903
D004128 Dimethylnitrosamine Dimethylnitrosamine affects the expression of PROS1 proteinaffects expression 16995903
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PROS1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PROS1 mRNAincreases expression 19619570
C454300 estradiol valerate-dienogest [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 15288212
D004966 Estrogens, Conjugated (USP) Estrogens, Conjugated (USP) results in decreased expression of PROS1 proteindecreases expression 15850603
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 proteinaffects cotreatment|affects expression 11720199
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 proteinaffects cotreatment|decreases activity 11994571
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 12618251
16522526
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS1affects cotreatment|increases expression 15669648
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of PROS1 proteinaffects cotreatment|decreases activity 14551147
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 12618251
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PROS1 proteindecreases expression 17374706
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in decreased activity of PROS1 proteindecreases activity 11994571
14551147
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in decreased expression of PROS1 proteindecreases expression 12618251
10928463
15318540
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 proteinaffects cotreatment|affects expression 11720199
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 proteinaffects cotreatment|decreases activity 11994571
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 12618251
16522526
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS1affects cotreatment|increases expression 15669648
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of PROS1 proteinaffects cotreatment|decreases activity 14551147
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PROS1 proteinaffects cotreatment|decreases expression 12618251
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PROS1 mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of PROS1 proteinaffects expression 15850603
D020849 Raloxifene Raloxifene results in decreased expression of PROS1 proteindecreases expression 16202731
D013629 Tamoxifen Tamoxifen affects the expression of PROS1 proteinaffects expression 15850603
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PROS1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PROS1 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of PROS1 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PROS1 mRNAdecreases expression 18796159
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNAaffects binding|decreases expression 20105288
C002802 tungsten carbide tungsten carbide results in decreased expression of PROS1 mRNAdecreases expression 20105288
D014812 Vitamin K Vitamin K affects the carboxylation of and affects the secretion of PROS1 proteinaffects carboxylation|affects secretion 10706868
D014859 Warfarin PROS1 gene polymorphism affects the susceptibility to Warfarinaffects response to substance 19752777
D014859 Warfarin PROS1 protein affects the susceptibility to Warfarinaffects response to substance 19752777
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.3717505938
MESH:D000152 Acne Vulgaris norgestimate 11.3717505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7115814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Cisplatin 9.5917638652 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.5916033868
MESH:D000230 Adenocarcinoma Estradiol 9.5911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5914692618
MESH:D000236 Adenoma Dimethylnitrosamine 3.3919555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D000419 Albuminuria Raloxifene 4.3317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4915885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6014601052
MESH:D001930 Brain Injuries Raloxifene 4.2016580743
MESH:D001943 Breast Neoplasms Cisplatin 2.8318382427 19526202
MESH:D001943 Breast Neoplasms Cobalt 2.8315986119
MESH:D001943 Breast Neoplasms Estradiol 2.8317261762 14630087 19861407 17018787 12948864 16675129 17289903 18497071
MESH:D001943 Breast Neoplasms Raloxifene 2.8315572757 17595753 17893378 17952589 15758505 16837676 17049068 16912660 17440819 17261762 17242785 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 2.8316873071 19011961 19059307 19189212 19487384 17242785 19410462 16202921 15565566 20135344 19288272 18351453 19289846 19155303 20544844 18855134 21138602 19142967 18425577 19084267 17440819 20065188 16273361 19066611 19115204 20005174 15668708 18984771 20390343 19221464 19244106 11161223 20859285 18629630 19103187 19189210 17261762 18815881 21152245 18821012 17049068 18997820 19200415 16818667 17893378
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.513786805 15700767 18705752 15721981 16097048 16227642 16011737 15673190 16192424 16124888 16050911 10355542
MESH:D002277 Carcinoma Dimethylnitrosamine 7.6319555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.3416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.3416705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.3418788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.3417982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3416924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3416924424
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 13.3416328049
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9412023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.8117066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.8116033868
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2615775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.436135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.4320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.4312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.4318566989
MESH:D002543 Cerebral Hemorrhage Warfarin 5.5811061249
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Cyclosporine 17.6219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.6216919318 11677210 16105132 17110522 15861022 17681005 17333356
MESH:D002779 Cholestasis Levonorgestrel 17.6215861022
MESH:D002779 Cholestasis pirinixic acid 17.6219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9916354765 8697196 12621046 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.3415800139
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3215273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D023903 Coronary Restenosis Warfarin 5.4112872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.5620497562 20579077
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.9818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.9818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9317474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 3.9718772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 19.5719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 19.5717451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 19.5719279558
MESH:D003928 Diabetic Nephropathies Warfarin 19.5712644472
MESH:D003875 Drug Eruptions Warfarin 5.7114723717
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.0819336974 15027814 3732212 21278145 11566570 10915739 7120509 9327722 6884620 2869522 19085960 10092053 6623471 4309450 3786805 17522070 15998439 16227642 16177239 7440962 15968718 7179309
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 11.088172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.0820420201
MESH:D004362 Drug Toxicity Cisplatin 7.5015033597 19839026 12231392 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5011462148
MESH:D004487 Edema pirinixic acid 10.0012083418
MESH:D004487 Edema Raloxifene 10.0015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.8115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.8119031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.7911473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7916202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9520426865
MESH:D004938 Esophageal Neoplasms Cisplatin 6.9515464296 16481741 17638652 15173087 16785472
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 6.9517016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.4615959796 12795759 16239168 61145 17595544 12631006 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 27.4619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.4615345470
MESH:D005234 Fatty Liver pirinixic acid 27.4620131406 19236843
MESH:D005234 Fatty Liver Raloxifene 27.4617473493
MESH:D005234 Fatty Liver Tamoxifen 27.4619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.1218705752
MESH:D005355 Fibrosis Cyclosporine 13.1212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1220067830
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.4311794436
MESH:D005776 Gaucher Disease Warfarin 5.6912359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.5315102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.0619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1915464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1810048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.3511110106
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006406 Hematoma Warfarin 6.4317493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 9.6711000095
MESH:D006470 Hemorrhage Warfarin 9.6718429757
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.3519176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006689 Hodgkin Disease Cisplatin 3.3716170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16959395 8697196 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006973 Hypertension Cobalt 11.5317039479
MESH:D006973 Hypertension Cyclosporine 11.5310903974
MESH:D006973 Hypertension Raloxifene 11.5315787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.5318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D006976 Hypertension, Pulmonary Warfarin 4.6112359135
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3117937319
MESH:D007249 Inflammation Tamoxifen 4.4119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.5916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.5916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8615464296
MESH:D007674 Kidney Diseases Cisplatin 9.1815190930 12231392 19839026 18289764 12649298
MESH:D007674 Kidney Diseases Cyclosporine 9.188314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 9.1815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 20.9416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 20.9412371664
MESH:D007680 Kidney Neoplasms Estradiol 20.9415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.9418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5111231351
MESH:D007889 Leiomyoma Raloxifene 4.2416973256
MESH:D008064 Lipidoses Tamoxifen 2.9615342952 17567588
MESH:D054068 Livedo Reticularis Warfarin 6.4318280355
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6611408273 17174718 16943688 16221502 17157831 17334410 21278145 16239168 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2414724832 17805973 18263696 15818738 18317297 18279442 18166357 14748882 12586293 17761835 12632512 17557913 15370692 18429990 12649538 12445421 12389079 17640975 15931870 12898905 15123356 18156304 15959796 18472332 20821823 15673190 15925388 18418968 18395095 15338365 12741479 17714472 12609069 10355542 18472094 18251166 18705752 12666154 17922224 17823541 12958196 17721639 15057751 15730626 18420326 18395914 15893842 18210741 11481614 12632514 17481882 16015684 16136751 14716496 17766677 16248980 17900296 12667390 17698563 12546737 14512876 12445418 14620537 18412020 18006644 17708605 18187930 17525996 14716833 18205269 16097048 15876570 17565644 18277467 17631135 18376398 16011737 16027843 16116963 13678700 17869086 18054572 15996030 18339082 16033810 16192424 15052691 15650968 15362042 17976157 17944888 16638106 18481824
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.2415577212 16603200 17432682 15591649 15864749 18567088 15086199 14726149 15492853 15339415 15067225 12918455 17666798 15161499 17719030 15369754 17465448 14643895 16042886 15744066 15942678 15571005 16169303 16570917 15763062 17203207 17196135 12925901 18210741 15842777 17036385 17640959 18364076 15733078 14659978 18629640 16544323 17724770 15298665 15504291 15479170 15723089 14709902 14568256 17198567 16009107 17881167 16270385 15099470 15798949 17348192 15383259 18672772 17534399 18095165 17201889 16627068 18239293 18237412 18637143 15138612 18371158 15081153 15366600 15793283
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0216246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0416899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.0417457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.567678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.5619294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 16.5615890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 16.5615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 16.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.712876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.7115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 12.716150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7112151625
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.596434250
MESH:D008175 Lung Neoplasms Cisplatin 4.6017225452 6189445 11798837
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.6016061637 19555203 11884234
MESH:D008175 Lung Neoplasms Tamoxifen 4.6018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6019555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.3816891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.3819196723 11731420 16827153 19196722 14580682
MESH:D020149 Manganese Poisoning Estradiol 11.7019453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7019453300
MESH:D008545 Melanoma Cisplatin 3.3112883367 16248763 15577323 17761969 18332650 17023156 12393984 16809738 18176117 12374674 11135225 16432458 18505091
MESH:D008545 Melanoma Tamoxifen 3.3119393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.5815990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.5815990972
MESH:D008654 Mesothelioma Cisplatin 3.1317638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.2416497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009203 Myocardial Infarction Contraceptives, Oral 6.1311752354
MESH:D009203 Myocardial Infarction pirinixic acid 6.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5516411023
MESH:D009232 Myxoma Raloxifene 5.2716343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 16.2718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 16.2718551238 7678174
MESH:D009336 Necrosis Warfarin 16.2714723717
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Cisplatin 4.6516773208
MESH:D009369 Neoplasms pirinixic acid 4.6517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5814600291
MESH:D009447 Neuroblastoma Cisplatin 3.318761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.428761367
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.0816049721
MESH:D010024 Osteoporosis Levonorgestrel 7.2812665316
MESH:D010024 Osteoporosis Raloxifene 7.2815775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9717823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Cisplatin 4.7015464296 6897625 17225452 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 4.7019401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 2.9019003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.0617638057
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.3517105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9111399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6320887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.1816000583
MESH:D011471 Prostatic Neoplasms Estradiol 2.1816740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1815067354
MESH:D020151 Protein C Deficiency Warfarin 6.0718376272
MESH:D011537 Pruritus Ethinyl Estradiol 9.0716919318 15861022
MESH:D011537 Pruritus Levonorgestrel 9.0715861022
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011655 Pulmonary Embolism Warfarin 6.0719300499
MESH:D011658 Pulmonary Fibrosis Cobalt 3.896434250
MESH:D011693 Purpura Raloxifene 5.2715770314
MESH:D051437 Renal Insufficiency Cisplatin 4.1315464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.1614601052
MESH:D012640 Seizures 2,4-dinitrotoluene 5.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.2518551238
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.5912269725
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.158532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013088 Spermatocele Tamoxifen 10.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7619457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9912587719
MESH:D013274 Stomach Neoplasms Cisplatin 2.8018396642 15958060 17522103
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.8016033868
MESH:D020521 Stroke Raloxifene 8.5216837676
MESH:D020521 Stroke Warfarin 8.5219300499
MESH:D013736 Testicular Neoplasms Cisplatin 4.3717225452 15464296
MESH:D013923 Thromboembolism Warfarin 5.8816960144 18698879
MESH:D019851 Thrombophilia Ethinyl Estradiol 23.9711994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 23.9711994571
MESH:D019851 Thrombophilia Gestodene 23.9711994571
MESH:D019851 Thrombophilia Warfarin 23.9717493413
OMIM:612336 THROMBOPHILIA, HEREDITARY, DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT marker/mechanism
MESH:D013927 Thrombosis Ethinyl Estradiol 14.2115669648
MESH:D013927 Thrombosis Gestodene 14.2115669648
MESH:D013927 Thrombosis Warfarin 14.2119300499 11307788 17245631 17672075 11518727 15720958
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013978 Tibial Fractures Estradiol 12.7619048282
MESH:D013978 Tibial Fractures Raloxifene 12.7619048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.6216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.6216049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.6212973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.6217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.6216712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.0510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.0510091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 3.9716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3415577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D014657 Vasculitis Warfarin 5.5920337814
MESH:D054556 Venous Thromboembolism Raloxifene 13.3816837676
MESH:D054556 Venous Thromboembolism Warfarin 13.3818776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 23.2715869587 14671159
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 23.2715869587
MESH:D020246 Venous Thrombosis Levonorgestrel 23.2715869587
MESH:D020246 Venous Thrombosis Warfarin 23.2714723717 15733061
MESH:D014839 Vomiting Cisplatin 4.4311897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33809
    • No data
    No data
    Releated drug ID Related drug Name
    PA451906warfarin
    PA165290929norelgestromin/ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00025 - Antihemophilic Factor Coagulants;Thrombotic Agents
    DB00055 - Drotrecogin alfa Antisepsis Agents
    DB00170 activator Menadione Dietary supplement;Micronutrient;Antifibrinolytic Agents;Vitamins/minerals;Vitamins
    DB00464 inhibitor Sodium Tetradecyl Sulfate Surface-Active Agents;Sclerosing Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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