AutismKB 2.0

Annotation Detail for PARD3


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Basic Information Top
Gene Symbol:PARD3 ( ASIP,Baz,Bazooka,FLJ21015,PAR3,PAR3alpha,PARD3A,SE2-5L16,SE2-5LT1,SE2-5T2 )
Gene Full Name: par-3 partitioning defective 3 homolog (C. elegans)
Band: 10p11.22-p11.21
Quick LinksEntrez ID:56288; OMIM: 606745; Uniprot ID:PARD3_HUMAN; ENSEMBL ID: ENSG00000148498; HGNC ID: 16051
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04144Endocytosis
hsa04530Tight junction
hsa04520Adherens junction
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Cell junction organization
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
Acute lymphoblastic leukemia (childhood)
Desease Name
Emphysema-related traits
Acute lymphoblastic leukemia (childhood)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of PARD3 mRNAdecreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PARD3 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PARD3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PARD3 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PARD3 mRNAdecreases expression 15336504
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PARD3 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PARD3 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PARD3 mRNAdecreases expression 17108234
D005472 Fluorouracil PARD3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas affects the expression of PARD3 mRNAaffects expression 15651846
C004648 testosterone enanthate testosterone enanthate affects the expression of PARD3 mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in increased expression of PARD3 mRNAincreases expression 16236135
D014810 Vitamin E Vitamin E results in decreased expression of PARD3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1614692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.1617638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.786695378
MESH:D000236 Adenoma Diethylnitrosamine 6.786695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0216434500 19061943 17162532 17620307 18056438 19052882
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000740 Anemia Fluorouracil 3.7915504547 17963324 16511603
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Mustard Gas 5.0610378619
MESH:D001249 Asthma Tretinoin 5.0616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6916206674 16197459
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.3711921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3720146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3717474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.3719217205 16595493 18357371 18608205 16110121 15136595 16557594
MESH:D001943 Breast Neoplasms Tretinoin 2.3716166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 3.6317121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6916705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.693581430 19052882 19394651 19418558 19335982 16681979 20524982 20214788 19383236 18971187 19107877 3084413 16779866 19208518 16698587 16935385 17978847 18506893 11831363 18056438 21159647 18210153 17428255 16328049 19822196 20432363 16288022 16569478 19701751 17761372 16830150 10737359 20935162 18691550 20101231 16878318 20007298 20727157 18785209 10672840 20512989 17055752 16807293 18665156 18494052 16502159 18978308 19919837 17138121 20514400 19171122 18393292 16540662 18788625 17173139 19519916 19539802 17162532 20084675
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6917088986 17045692 18930000 17971768 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.691917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.6616757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.6616051514 16096774
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9121159647 7505956 17174075 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9316105132 17681005 16919318 17333356 11677210 15861022 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417172411 15001691 17018589 16510598 16340194 17725105 17169374 17016597 18772588 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018949393 20501625 17016601 18802399 14970324 18383874 17401013 16282729 15289873 17695437 17094418 16303861 17594712 16391804 18448328 16524972 17255274 15148649 16331619 18509181 18288408 17454858
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.719211117 10589399 16925845 8800419 9224671 9125849 14991402 17551590 9142499 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7119769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9619107877
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Mustard Gas 3.3911402378 11428647 9260866 11428631
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1616569247
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5516530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5515173087 16481741 16337965 16785472 17638652
MESH:D005124 Eye Abnormalities Tretinoin 3.649664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 7.9720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9715345470
MESH:D005355 Fibrosis Tretinoin 3.6217994277
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.9718337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4220471113
MESH:D006330 Heart Defects, Congenital Tretinoin 11.429664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.4216080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Diethylnitrosamine 5.3718785209
MESH:D007249 Inflammation Mustard Gas 5.379357497 11428631 8975870 11402378 17524151 16001271 9260866 11428620 11428647
MESH:D007251 Influenza, Human Vitamin E 4.3516624496
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6610783313
MESH:D007569 Jaw Abnormalities Tretinoin 3.9815992940 17551590
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.6115369732
MESH:D007674 Kidney Diseases Vitamin E 6.6112488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7116705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7116985049
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.0916766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.0919035177 17301526 16788101 16891316 19642359 17506722 17712046 16935935 16823087 16140955 17294898 19029980 16766008 17361223 15748426 12679006 9834237 19075265 16331271 19225113 17107899 17217047 17649720 17368321 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718522880 19638242 18407596 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5718397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5716169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6421137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6418754104 12112319 19254457 19427195 18978307 9163691 15175105 19499222 20452335 19996281 2862719 19833225 19090486 15885732 19294768 19850985 19551842 19073162 20501860 19256749 20101389 19255062 19812893 20434301 20118626 21047994 21071580 16942905 18648771 20137499 18644402 19690152 19426721 20405173 19642983 20583210 18977376 10737359 2422723 20492335 21278145 12771043 19638242 21167192
MESH:D008113 Liver Neoplasms Fluorouracil 7.6417045692 15113037 18383874 16603448
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.6818544905 17942915 19004024 18282651 18079962 21159647 9362446 18093689 19539802 19519916 18775883 18308698 16267830 18164116 2563599 17854601 17174075 3124819 19009564 16842330 19126423 18253720
MESH:D008171 Lung Diseases Mustard Gas 7.7218161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.7216863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7020064080 18520028 20135361 18569708 6695378 20464547 18816296 20869020 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.7020970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 6.7015246190
MESH:D008175 Lung Neoplasms Mustard Gas 6.703148597 8781369
MESH:D008175 Lung Neoplasms Vitamin E 6.7011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6311921183
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.7416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.7418986760 16757204
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5011141357
MESH:D009369 Neoplasms Fluorouracil 8.5018600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 8.5016946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.879125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009503 Neutropenia Mustard Gas 4.067688884 16761898
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5012819281 16049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.7916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.7919003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5517292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5518626508 19082440
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5515084515
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.9216919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.9218058305
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9510334151 17894541 17720292 17620002 17266442
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0816160472 18722050 18286688 15538739
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012871 Skin Diseases Mustard Gas 5.0916961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 5.0918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6819755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.688532709
MESH:D012878 Skin Neoplasms Tretinoin 9.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.772093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7719084572 18567086 15786421 18396642 16951190 17522103 19015929 17172411 16424979 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 4.7717261132
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.387505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3816026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0916280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.7116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
REACT:20676 Cell junction organization
KEGG:04062 Chemokine signaling pathway
KEGG:04144 Endocytosis
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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