AutismKB 2.0

Annotation Detail for TRPV5


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Basic Information Top
Gene Symbol:TRPV5 ( CAT2,ECAC1,OTRPC3 )
Gene Full Name: transient receptor potential cation channel, subfamily V, member 5
Band: 7q34
Quick LinksEntrez ID:56302; OMIM: 606679; Uniprot ID:TRPV5_HUMAN; ENSEMBL ID: ENSG00000127412; HGNC ID: 3145
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRPV5 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRPV5 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRPV5 mRNAaffects cotreatment|increases expression 18164116
D002117 Calcitriol Calcitriol results in increased expression of TRPV5 mRNAincreases expression 16857747
D002117 Calcitriol Calcitriol results in increased expression of TRPV5 mRNAincreases expression 15883024
D005665 Furosemide Furosemide results in increased expression of TRPV5 mRNAincreases expression 17652376
D005665 Furosemide Furosemide results in increased expression of TRPV5 proteinincreases expression 17652376
D005839 Gentamicins Gentamicins results in increased expression of TRPV5 mRNAincreases expression 17652376
D005839 Gentamicins Gentamicins results in increased expression of TRPV5 proteinincreases expression 17652376
D007657 Ketone Bodies Ketone Bodies results in decreased expression of TRPV5 mRNAdecreases expression 16807920
C111654 NPS R-467 NPS R-467 results in decreased expression of TRPV5 mRNAdecreases expression 16164647
C111654 NPS R-467 NPS R-467 results in decreased expression of TRPV5 proteindecreases expression 16164647
D014501 Uranium Uranium results in decreased expression of TRPV5 mRNAdecreases expression 17118558
16502312
D014501 Uranium Uranium results in increased expression of TRPV5 mRNAincreases expression 16502312
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D058186 Acute Kidney Injury Gentamicins 4.7511274264
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.256695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1816434500 17620307 19052882 18056438 17162532 19061943
MESH:D001943 Breast Neoplasms Calcitriol 2.2811237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2817474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8618494052 19208518 18788625 18393292 16830150 17173139 16681979 19919837 18056438 19822196 18691550 17978847 20512989 20935162 16698587 16288022 19107877 21159647 18665156 17761372 18971187 17138121 16878318 17428255 20514400 16779866 19383236 20524982 20101231 19171122 20432363 11831363 17162532 16328049 10737359 16569478 16540662 16502159 18978308 19539802 19418558 18210153 20727157 18785209 17055752 20084675 16935385 19394651 10672840 20214788 19701751 19335982 3581430 19052882 18506893 16807293 20007298 3084413 19519916
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6711237771
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.992727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1019107877
MESH:D004362 Drug Toxicity Gentamicins 4.5915033597 11033412
MESH:D004417 Dyspnea Furosemide 5.2616935035
MESH:D004487 Edema Furosemide 4.2111834646
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3920387270 21071580
MESH:D034381 Hearing Loss Furosemide 11.1017868369
MESH:D034381 Hearing Loss Gentamicins 11.1015968427 18024279 17868369 19130971
MESH:D006333 Heart Failure Furosemide 4.1816011733 16845234 12660669
MESH:D006934 Hypercalcemia Furosemide 5.2817652376
MESH:D053565 Hypercalciuria Furosemide 14.4217652376
MESH:D053565 Hypercalciuria Gentamicins 14.4217652376
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 15.9315086907
MESH:D006962 Hyperparathyroidism, Secondary NPS R-467 15.9315086907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.5416612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.9411041285
MESH:D007019 Hypoproteinemia Furosemide 6.1916096441
MESH:D007022 Hypotension Furosemide 4.8411041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.7315811171
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007673 Kidney Cortex Necrosis Gentamicins 6.0418842672
MESH:D007674 Kidney Diseases Furosemide 7.2911041285
MESH:D007674 Kidney Diseases Gentamicins 7.2918289764 19349640 17934191
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.7011231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.6310219319
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9320032147 18407596 19638242 18665156 18522880
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 4.9921295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.992862719 20137499 19850985 21278145 19294768 18644402 19255062 19499222 21071580 16942905 20583210 19427195 21167192 15175105 18978307 19256749 19090486 19812893 20434301 18977376 15885732 20492335 20118626 20405173 19996281 12112319 19551842 19073162 19642983 20101389 2422723 19426721 20501860 10737359 9163691 19690152 21047994 20452335 18754104 19638242 19254457 12771043 18648771 19833225
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.5418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5418282651 18775883 21159647 18544905 19539802 18079962 16842330 18093689 17854601 17942915 17174075 18164116 19519916 19126423 18308698 3124819 2563599 18253720 19004024 9362446 19009564 16267830
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.5918694830
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009397 Nephrocalcinosis Furosemide 15.9315086907
MESH:D009397 Nephrocalcinosis NPS R-467 15.9315086907
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D053206 Nocturnal Enuresis Furosemide 6.1917945291
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D011141 Polyuria Furosemide 5.9417945291
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5112479363 18247401 16289102 15754350 16644109
MESH:D011507 Proteinuria Gentamicins 4.9415033597
MESH:D051437 Renal Insufficiency Gentamicins 5.2517132701 15728788
MESH:D015427 Reperfusion Injury Furosemide 4.0016526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.8416096441 15912074 12394941
MESH:D012173 Retinitis Gentamicins 6.5918644591
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.8518456281
MESH:D013274 Stomach Neoplasms Furosemide 2.8517052386
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D015837 Vestibular Diseases Gentamicins 5.7618776599
Pathway ID Pathway Name
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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