AutismKB 2.0

Annotation Detail for PPAN


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Basic Information Top
Gene Symbol:PPAN ( BXDC3,MGC14226,MGC45852,SSF,SSF-1,SSF1,SSF2 )
Gene Full Name: peter pan homolog (Drosophila)
Band: 19p13.2
Quick LinksEntrez ID:56342; OMIM: 607793; Uniprot ID:SSF1_HUMAN; ENSEMBL ID: ENSG00000130810,ENSG00000243207; HGNC ID: 9227
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of PPAN mRNAaffects expression 18343893
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPAN mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPAN mRNAaffects expression 17562736
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PPAN mRNAaffects cotreatment|increases expression 19684285
D016572 Cyclosporine Cyclosporine results in increased expression of PPAN mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PPAN mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPAN mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPAN mRNAaffects cotreatment|increases expression 17942748
D013629 Tamoxifen Tamoxifen affects the expression of PPAN mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PPAN mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPAN mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of PPAN mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPAN mRNAaffects cotreatment|increases expression 17942748
D014415 Tunicamycin Tunicamycin results in increased expression of PPAN mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9417440819 19103187 18997820 20135344 19487384 19142967 16873071 15668708 19410462 18425577 16273361 19084267 21138602 20005174 18815881 19289846 17049068 19155303 17242785 18629630 20859285 18351453 16818667 20544844 17893378 18984771 19189210 19011961 20065188 11161223 19244106 18855134 19059307 16202921 19189212 20390343 19115204 21152245 15565566 19288272 19200415 19221464 18821012 17261762 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6716924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 8.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2817681005 11677210 17110522 15861022 16105132 17333356 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 16354765 12621046 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4210663392 16177239 10915739 16081117 12540782 16227642 2444490 11834606 11529661 15968718 12153990 12392966 19164858 19370779 18713872 10774834 11739529 16485898 12594235 17562736 14550746 12958197 17906064 19085960 16393943 16109766 12705907 19739265 15619225 16781746 11287661 14725611 11743745 11421492 19923254 19416960 19420014 17522070 18071297 11461765 14986274
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1717893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 14.2919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2915345470
MESH:D005234 Fatty Liver Tamoxifen 14.2919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 9.3612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 7.3111294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.3111294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.4012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4018625569
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 11587558 19014921 16610002 19460945 19784758 12587719 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Tamoxifen 4.6216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7419196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2716049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2716712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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