AutismKB 2.0

Annotation Detail for LGMN


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Basic Information Top
Gene Symbol:LGMN ( AEP,LGMN1,PRSC1 )
Gene Full Name: legumain
Band: 14q32.12
Quick LinksEntrez ID:5641; OMIM: 602620; Uniprot ID:LGMN_HUMAN; ENSEMBL ID: ENSG00000100600; HGNC ID: 9472
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa04612Antigen processing and presentation
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of vitamins and cofactors
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500600Vitamin D (calciferol) metabolism
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LGMN mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LGMN mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LGMN mRNAdecreases expression 15725085
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LGMN mRNAincreases expression 20382639
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]decreases reaction|increases expression 18200517
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of LGMN mRNAincreases expression 17490981
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LGMN mRNAincreases expression 19638242
D004958 Estradiol Estradiol affects the expression of LGMN mRNAaffects expression 15598610
D010615 Phenacetin Phenacetin results in increased expression of LGMN mRNAincreases expression 17698508
C030299 phenylhydrazine phenylhydrazine results in increased expression of LGMN mRNAincreases expression 17698508
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LGMN mRNAdecreases expression 17884332
D014212 Tretinoin Tretinoin results in increased expression of LGMN mRNAincreases expression 16236135
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNAincreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4619825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.4611473722
MESH:D000236 Adenoma Diethylnitrosamine 2.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4518056438 17620307 16434500 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.2217887948
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000740 Anemia Phenacetin 15.602444515
MESH:D000740 Anemia phenylhydrazine 15.602444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 15.6011748828
MESH:D000743 Anemia, Hemolytic Phenacetin 11.3317698508 1949026 17082564
MESH:D000743 Anemia, Hemolytic phenylhydrazine 11.3317082564 17084956 17698508
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7916807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7916292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Curcumin 3.3618704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.6019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.8316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.8312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.8316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D002545 Brain Ischemia Curcumin 4.4516770732
MESH:D001932 Brain Neoplasms Curcumin 4.0117596214
MESH:D001943 Breast Neoplasms Curcumin 2.3518462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3517474063
MESH:D001943 Breast Neoplasms Estradiol 2.3517289903 17261762 12948864 19861407 14630087 16675129 18497071 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3516166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Curcumin 8.5018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.003084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.0011135700 14691202 15073043 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0020214788 20432363 16935385 20935162 20514400 20084675 3084413 18691550 18506893 18785209 19052882 19107877 17173139 20524982 19701751 18971187 16288022 19394651 18210153 20512989 17138121 19919837 19171122 19335982 16502159 20007298 18788625 10737359 16569478 16830150 16328049 11831363 20727157 17162532 19539802 19383236 16878318 21159647 18393292 20101231 17978847 18494052 17761372 16681979 19822196 16807293 19208518 18978308 10672840 16540662 17055752 18056438 19519916 16698587 17428255 18665156 16779866 19418558 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.0016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.001917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0018414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.9018462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002386 Cataract Tretinoin 7.3817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.512727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8712621046 16354765 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Curcumin 16.7916804969 18200517 16782535
MESH:D003092 Colitis Tretinoin 16.7917035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 16.7918023891 11698051 17991707 16804969 16867261 17936198 18200517 16474422 16782535
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4717276891
MESH:D003103 Coloboma Curcumin 4.6318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5116340194 19359593
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.0018497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.809664655 16925845 9224671 10589399 14991402 17551590 9142499 9211117 8800419 9125849
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.2518403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2517107852
MESH:D003928 Diabetic Nephropathies Curcumin 9.2818204486
MESH:D003928 Diabetic Nephropathies Estradiol 9.2819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2611739529 11287661 19923254 14725611 12540782 17522070 14550746 19416960 2444490 14986274 10774834 15968718 19420014 16177239 11834606 16109766 19370779 16781746 17562736 11421492 15619225 17906064 11529661 12705907 16485898 19739265 12594235 10915739 19164858 19085960 16227642 11461765 12392966 16081117 16393943 18071297 11743745 12958197 12153990 10663392 18713872
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1417351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4018230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.5911473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.5916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 13.7215073043
MESH:D005234 Fatty Liver Curcumin 13.7219297423
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7221071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Curcumin 22.1418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.1420067830
MESH:D005355 Fibrosis Tretinoin 22.1417994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 22.1417994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8018462866
MESH:D005909 Glioblastoma Curcumin 7.4617596214
MESH:D005909 Glioblastoma Tretinoin 7.4617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Curcumin 8.0718462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.679664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1417701891
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.8416870215
MESH:D006930 Hyperalgesia Tretinoin 7.8416870215
MESH:D006937 Hypercholesterolemia Curcumin 4.1318704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007249 Inflammation Curcumin 8.5818403477 16956363 17151092
MESH:D007249 Inflammation Diethylnitrosamine 8.5818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5812200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.7918200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.7918200517
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 10.3417994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 10.3417994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.2910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.0312587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.0315618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0515610895
MESH:D007889 Leiomyoma Curcumin 4.6618555241
MESH:D007938 Leukemia arsenic trioxide 10.7515070760
MESH:D007938 Leukemia Curcumin 10.7518462866
MESH:D007938 Leukemia Tretinoin 10.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.0412560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 10.0416106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.7519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.7516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9316968895 16467208 20471514 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9317596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.8119225113 19075265 19035177 17649720 11161223 9834237 16966277 15622746 15748426 16112521 16331271 16891316 12679006 15213294 17217047 11468182 12018890 17712046 15336539 12712474 17869043 16823087 16330433 17107899 19642359
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.8117339181 16140955 17712046 17506722 17107899 12679006 16788101 15748426 19035177 16331271 19075265 16766008 16891316 17368321 17294898 17217047 19642359 19225113 16823087 19029980 17361223 16935935 9834237 17301526 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 12.0316882451
MESH:D015458 Leukemia, T-Cell Curcumin 12.0316106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0418006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.6612587719 16611625 12969438 16610002 19014921 19460945 19784758 11587558
MESH:D008107 Liver Diseases Curcumin 6.6616956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6617034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5714682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5719426721 21071580 18644402 19073162 21278145 21047994 12771043 19850985 12112319 19427195 18754104 20583210 19499222 15885732 20137499 2422723 19638242 18978307 18977376 20492335 20452335 19642983 19812893 9163691 19690152 19551842 19294768 20434301 19254457 19256749 18648771 19255062 20101389 10737359 15175105 16942905 19833225 20501860 19090486 2862719 20118626 20405173 19996281 21167192
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.1020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1018282651 16267830 2563599 18775883 18164116 19009564 19519916 18079962 9362446 18544905 16842330 19539802 17854601 18308698 17942915 17174075 3124819 21159647 18253720 18093689 19004024 19126423
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9319825857 11798837
MESH:D008175 Lung Neoplasms Curcumin 4.9319359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9321163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9311884234 19555203
MESH:D008223 Lymphoma Curcumin 3.6418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8016173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Curcumin 3.5218462866 17885582
MESH:D008545 Melanoma Tretinoin 3.5216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008569 Memory Disorders Curcumin 4.2517263510
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008708 Methemoglobinemia Phenacetin 5.041949026 16296465 3537620 4834387
MESH:D009101 Multiple Myeloma arsenic trioxide 7.6319417148 11468182 15949261 19549372 14977855
MESH:D009101 Multiple Myeloma Curcumin 7.6319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0317962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.5416882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.6516624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.6518495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Tretinoin 2.4416594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6712497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 16.9111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9114600291
MESH:D009421 Nervous System Malformations Tretinoin 16.919125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.7618462866
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.479142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity Curcumin 2.7619297423
MESH:D010024 Osteoporosis Curcumin 3.5218719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.5116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 11.5119020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 11.5119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 11.5116936753
MESH:D010146 Pain Acetaminophen 6.8116870215
MESH:D010146 Pain Tretinoin 6.8116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.5815580305
MESH:D010190 Pancreatic Neoplasms Curcumin 12.5817440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.5816540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.5815976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.2917698068
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6019131511
MESH:D011471 Prostatic Neoplasms Curcumin 2.6018769126 11398177 18226269 15129424 12497104 18156803 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.6019168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1110666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012509 Sarcoma Curcumin 4.1918462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D018805 Sepsis Curcumin 4.1418389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4117007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4118456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.4117261132
MESH:D013276 Stomach Ulcer Curcumin 3.5819188055 16631530
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.69978859
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.3519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.357505956
MESH:D013964 Thyroid Neoplasms Tretinoin 12.3517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7712973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.7718593936
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 8.7711144890
MESH:D014565 Urogenital Neoplasms Curcumin 5.3818462866
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
REACT:15314 Hormone biosynthesis
KEGG:04142 Lysosome
REACT:22258 Metabolism of lipids and lipoproteins
REACT:11193 Metabolism of vitamins and cofactors
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30354
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448717calcitriol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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