AutismKB 2.0

Annotation Detail for LTB4R2


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Basic Information Top
Gene Symbol:LTB4R2 ( BLT2,BLTR2,JULF2,KPG_004,LTB4-R 2,LTB4-R2,NOP9 )
Gene Full Name: leukotriene B4 receptor 2
Band: 14q12
Quick LinksEntrez ID:56413; OMIM: 605773; Uniprot ID:LT4R2_HUMAN; ENSEMBL ID: ENSG00000213906; HGNC ID: 19260
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
2112Ovary cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031571 5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid 5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid binds to LTB4R2 proteinaffects binding 11006272
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LTB4R2 mRNAaffects expression 16483693
D001095 Arachidonic Acids Arachidonic Acids binds to LTB4R2 proteinaffects binding 11006272
D005419 Flavonoids Flavonoids results in increased expression of LTB4R2 mRNAincreases expression 18035473
D007975 Leukotriene B4 Leukotriene B4 binds to LTB4R2 proteinaffects binding 11006272
D006893 Hydroxyeicosatetraenoic Acids Hydroxyeicosatetraenoic Acids binds to LTB4R2 proteinaffects binding 11006272
C040212 leukotriene B5 leukotriene B5 binds to LTB4R2 proteinaffects binding 11006272
C025299 polyphenols polyphenols results in decreased expression of LTB4R2 mRNAdecreases expression 16293270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D011125 Adenomatous Polyposis Coli Leukotriene B4 5.6717942926
MESH:D001168 Arthritis Leukotriene B4 6.4611006272
MESH:D001249 Asthma Leukotriene B4 4.1319667530 11006272
MESH:D001250 Asthma, Exercise-Induced Leukotriene B4 6.2919667531
MESH:D016535 Bronchial Hyperreactivity Leukotriene B4 5.3012794006 12654629
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D003715 Dengue Hydroxyeicosatetraenoic Acids 7.1919427377
MESH:D003967 Diarrhea Arachidonic Acids 6.427237001
MESH:D056486 Drug-Induced Liver Injury polyphenols 2.7919370779
MESH:D007249 Inflammation Flavonoids 5.8117296493
MESH:D007249 Inflammation polyphenols 5.8116366677
MESH:D015212 Inflammatory Bowel Diseases Leukotriene B4 4.5411006272
MESH:D008107 Liver Diseases polyphenols 2.8316698588
MESH:D009503 Neutropenia Leukotriene B4 5.598305713
MESH:D011565 Psoriasis Leukotriene B4 4.4011006272
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6317997062
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134910672
    • No data
    Releated disease ID Related disease Name
    PA447279Rhinitis, Allergic, Seasonal
    PA445558Rhinitis, Allergic, Perennial
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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